1,471
Views
35
CrossRef citations to date
0
Altmetric
Research Paper

Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro

, , , , , , , , , , , & show all
Pages 797-805 | Received 02 Feb 2014, Accepted 16 Mar 2014, Published online: 21 Mar 2014

References

  • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127:2893 - 917; http://dx.doi.org/10.1002/ijc.25516; PMID: 21351269
  • Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60:277 - 300; http://dx.doi.org/10.3322/caac.20073; PMID: 20610543
  • Kols A. Breast cancer: increasing incidence. Limited Options. Outlook 2002; 19:1 - 8
  • Jung S, Lee S, Lee J, Li C, Ohk JY, Jeong HK, Lee S, Kim S, Choi Y, Kim S, et al. Protein expression pattern in response to ionizing radiation in MCF-7 human breast cancer cells. Oncol Lett 2012; 3:147 - 54; PMID: 22740871
  • Tassone P, Tagliaferri P, Perricelli A, Blotta S, Quaresima B, Martelli ML, Goel A, Barbieri V, Costanzo F, Boland CR, et al. BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. Br J Cancer 2003; 88:1285 - 91; http://dx.doi.org/10.1038/sj.bjc.6600859; PMID: 12698198
  • Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B. Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J Biol Chem 2007; 282:10922 - 34; http://dx.doi.org/10.1074/jbc.M610157200; PMID: 17303574
  • Maceyka M, Payne SG, Milstien S, Spiegel S. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta 2002; 1585:193 - 201; http://dx.doi.org/10.1016/S1388-1981(02)00341-4; PMID: 12531554
  • Taha TA, Kitatani K, El-Alwani M, Bielawski J, Hannun YA, Obeid LM. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J 2006; 20:482 - 4; PMID: 16507765
  • Pchejetski D, Golzio M, Bonhoure E, Calvet C, Doumerc N, Garcia V, Mazerolles C, Rischmann P, Teissié J, Malavaud B, et al. Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. Cancer Res 2005; 65:11667 - 75; http://dx.doi.org/10.1158/0008-5472.CAN-05-2702; PMID: 16357178
  • Chiba K. FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. Pharmacol Ther 2005; 108:308 - 19; http://dx.doi.org/10.1016/j.pharmthera.2005.05.002; PMID: 15951022
  • Kappos L, Antel J, Comi G, Montalban X, O’Connor P, Polman CH, Haas T, Korn AA, Karlsson G, Radue EW, FTY720 D2201 Study Group. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006; 355:1124 - 40; http://dx.doi.org/10.1056/NEJMoa052643; PMID: 16971719
  • Yasui H, Hideshima T, Raje N, Roccaro AM, Shiraishi N, Kumar S, Hamasaki M, Ishitsuka K, Tai YT, Podar K, et al. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res 2005; 65:7478 - 84; http://dx.doi.org/10.1158/0008-5472.CAN-05-0850; PMID: 16103102
  • Wang JD, Takahara S, Nonomura N, Ichimaru N, Toki K, Azuma H, Matsumiya K, Okuyama A, Suzuki S. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation. Prostate 1999; 40:50 - 5; http://dx.doi.org/10.1002/(SICI)1097-0045(19990615)40:1<50::AID-PROS6>3.0.CO;2-N; PMID: 10344723
  • Azuma H, Horie S, Muto S, Otsuki Y, Matsumoto K, Morimoto J, Gotoh R, Okuyama A, Suzuki S, Katsuoka Y, et al. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity. Anticancer Res 2003; 23:3183 - 93; PMID: 12926052
  • Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, et al. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Res 2007; 27:1A 75 - 88; PMID: 17352219
  • Tanaka T, Takahara S, Hatori M, Suzuki K, Wang J, Ichimaru N, Suzuki S, Morozumi K, Okuyama A, Yamanaka H. A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine. Cancer Lett 2002; 181:165 - 71; http://dx.doi.org/10.1016/S0304-3835(01)00799-6; PMID: 12175531
  • Jin S, White E. Tumor suppression by autophagy through the management of metabolic stress. Autophagy 2008; 4:563 - 6; PMID: 18326941
  • Cutuli B. [Radiotherapy for breast cancer: which strategy in 2012?]. Cancer Radiother 2012; 16:493 - 502; http://dx.doi.org/10.1016/j.canrad.2012.07.185; PMID: 22925489
  • Begg AC, Stewart FA, Vens C. Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer 2011; 11:239 - 53; http://dx.doi.org/10.1038/nrc3007; PMID: 21430696
  • Takabe K, Paugh SW, Milstien S, Spiegel S. “Inside-out” signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev 2008; 60:181 - 95; http://dx.doi.org/10.1124/pr.107.07113; PMID: 18552276
  • Pyne S, Bittman R, Pyne NJ. Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. Cancer Res 2011; 71:6576 - 82; http://dx.doi.org/10.1158/0008-5472.CAN-11-2364; PMID: 21940750
  • Ruckhäberle E, Rody A, Engels K, Gaetje R, von Minckwitz G, Schiffmann S, Grösch S, Geisslinger G, Holtrich U, Karn T, et al. Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res Treat 2008; 112:41 - 52; http://dx.doi.org/10.1007/s10549-007-9836-9; PMID: 18058224
  • Guan H, Song L, Cai J, Huang Y, Wu J, Yuan J, Li J, Li M. Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells. PLoS One 2011; 6:e19946; http://dx.doi.org/10.1371/journal.pone.0019946; PMID: 21625639
  • Shida D, Takabe K, Kapitonov D, Milstien S, Spiegel S. Targeting SphK1 as a new strategy against cancer. Curr Drug Targets 2008; 9:662 - 73; http://dx.doi.org/10.2174/138945008785132402; PMID: 18691013
  • Stevenson CE, Takabe K, Nagahashi M, Milstien S, Spiegel S. Targeting sphingosine-1-phosphate in hematologic malignancies. [Review] Anticancer Agents Med Chem 2011; 11:794 - 8; http://dx.doi.org/10.2174/187152011797655122; PMID: 21707492
  • Chautard E, Loubeau G, Tchirkov A, Chassagne J, Vermot-Desroches C, Morel L, Verrelle P. Akt signaling pathway: a target for radiosensitizing human malignant glioma. Neuro Oncol 2010; 12:434 - 43; PMID: 20406894
  • Toker A, Yoeli-Lerner M. Akt signaling and cancer: surviving but not moving on. [Review] Cancer Res 2006; 66:3963 - 6; http://dx.doi.org/10.1158/0008-5472.CAN-06-0743; PMID: 16618711
  • Rödel F, Hoffmann J, Distel L, Herrmann M, Noisternig T, Papadopoulos T, Sauer R, Rödel C. Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res 2005; 65:4881 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-04-3028; PMID: 15930309
  • Asanuma K, Kobayashi D, Furuya D, Tsuji N, Yagihashi A, Watanabe N. A role for survivin in radioresistance of pancreatic cancer cells. Jpn J Cancer Res 2002; 93:1057 - 62; http://dx.doi.org/10.1111/j.1349-7006.2002.tb02483.x; PMID: 12359060
  • Shen S, Kepp O, Kroemer G. The end of autophagic cell death?. Autophagy 2012; 8:1 - 3; http://dx.doi.org/10.4161/auto.8.1.16618; PMID: 22082964
  • Zhang N, Qi Y, Wadham C, Wang L, Warren A, Di W, Xia P. FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. Autophagy 2010; 6:1157 - 67; http://dx.doi.org/10.4161/auto.6.8.13614; PMID: 20935520
  • Wallington-Beddoe CT, Hewson J, Bradstock KF, Bendall LJ. FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy 2011; 7:707 - 15; http://dx.doi.org/10.4161/auto.7.7.15154; PMID: 21460633
  • Liao AJ, Hu R, Li YC, Yao K, Wang HH, Zhang R, Yang W, Liu ZG. [The study of FTY720 on inducing apoptosis and autophagy in multiple myeloma cell line U266]. Zhonghua Xue Ye Xue Za Zhi 2011; 32:664 - 7; PMID: 22339823
  • Liao A, Hu R, Zhao Q, Li J, Li Y, Yao K, Zhang R, Wang H, Yang W, Liu Z. Autophagy induced by FTY720 promotes apoptosis in U266 cells. Eur J Pharm Sci 2012; 45:600 - 5; http://dx.doi.org/10.1016/j.ejps.2011.12.014; PMID: 22281442
  • Young MM, Kester M, Wang HG. Sphingolipids: regulators of crosstalk between apoptosis and autophagy. J Lipid Res 2013; 54:5 - 19; http://dx.doi.org/10.1194/jlr.R031278; PMID: 23152582
  • Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290:1717 - 21; http://dx.doi.org/10.1126/science.290.5497.1717; PMID: 11099404
  • Meijer AJ, Codogno P. Regulation and role of autophagy in mammalian cells. Int J Biochem Cell Biol 2004; 36:2445 - 62; http://dx.doi.org/10.1016/j.biocel.2004.02.002; PMID: 15325584
  • Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, Levine B. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 2007; 128:931 - 46; http://dx.doi.org/10.1016/j.cell.2006.12.044; PMID: 17350577
  • Tassone P, Blotta S, Palmieri C, Masciari S, Quaresima B, Montagna M, D’Andrea E, Eramo OP, Migale L, Costanzo F, et al. Differential sensitivity of BRCA1-mutated HCC1937 human breast cancer cells to microtubule-interfering agents. Int J Oncol 2005; 26:1257 - 63; PMID: 15809716
  • Marvaso G, Barone A, Vaccaro C, Bruzzaniti V, Grespi S, Scotti V, Bianco C. Repeat stereotactic radiosurgery in the management of brain metastases from NSCLC: A case report and review of the literature. Oncol Lett 2013; 6:897 - 900; PMID: 24137433
  • Amodio N, Di Martino MT, Foresta U, Leone E, Lionetti M, Leotta M, Gullà AM, Pitari MR, Conforti F, Rossi M, et al. miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell Death Dis 2012; 3:e436; http://dx.doi.org/10.1038/cddis.2012.175; PMID: 23190608
  • Tagliaferri P, Katsaros D, Clair T, Neckers L, Robins RK, Cho-Chung YS. Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs. J Biol Chem 1988; 263:409 - 16; PMID: 2826444
  • Amodio N, Leotta M, Bellizzi D, Di Martino MT, D’Aquila P, Lionetti M, Fabiani F, Leone E, Gullà AM, Passarino G, et al. DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma. Oncotarget 2012; 3:1246 - 58; PMID: 23100393
  • Amodio N, Scrima M, Palaia L, Salman AN, Quintiero A, Franco R, Botti G, Pirozzi P, Rocco G, De Rosa N, et al. Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas. Am J Pathol 2010; 177:2622 - 34; http://dx.doi.org/10.2353/ajpath.2010.091075; PMID: 20889565

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.