PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b

References

• Sherr CJ, Roberts JM. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes and Dev 1999; 13:1501 - 1512
   PubMed Web of Science ®Google Scholar
• Fu M, Wang C, Li Z, Sakamaki T, Pestell RG. Minireview: Cyclin D1: Normal and Abnormal Functions. Endocrinology 2004; 145:5439 - 5447
   PubMed Web of Science ®Google Scholar
• Wang C, Li Z, Lu Y, Du R, Katiyar S, Yang J, et al. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci USA 2006; 103:11567 - 11572
   PubMed Web of Science ®Google Scholar
• Mahony D, Parry DA, Lees E. Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells. Oncogene 1998; 16:603 - 611
   PubMed Web of Science ®Google Scholar
• Stepanova L, Leng X, Parker SB, Harper JW. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev 1996; 10:1491 - 1502
   PubMed Web of Science ®Google Scholar
• Cheng M, Sexl V, Sherr CJ, Roussel MF. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc Natl Acad Sci USA 1998; 95:1091 - 1096
   PubMed Web of Science ®Google Scholar
• Kato Jy, Matsuoka M, Stromm DK, Sherr CJ. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol Cell Biol 1994; 14:2713 - 2721
   PubMed Web of Science ®Google Scholar
• LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, et al. New functional activities for the p21 family of CDK inhibitors. Genes Dev 1997; 11:847 - 862
   PubMed Web of Science ®Google Scholar
• McConnell BB, Gregory FJ, Stott FJ, Hara E, Peters G. Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol Cell Biol 1999; 19:1981 - 1989
   PubMed Web of Science ®Google Scholar
• Parry D, Mahony D, Wills K, Lees E. Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol Cell Biol 1999; 19:1775 - 1783
   PubMed Web of Science ®Google Scholar
• Diehl JA, Yang W, Rimerman RA, Xiao H, Emili A. Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase. Mol Cell Biol 2003; 23:1764 - 1774
   PubMed Web of Science ®Google Scholar
• Hulit J, Wang C, Li Z, Albanese C, Rao M, Di Vizio D, et al. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol 2004; 24:7598 - 7611
   PubMed Web of Science ®Google Scholar
• Lee RJ, Albanese C, Fu M, D'Amico M, Lin B, Watanabe G, et al. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol 2000; 20:672 - 683
   PubMed Web of Science ®Google Scholar
• Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001; 411:1017 - 1021
   PubMed Web of Science ®Google Scholar
• Albanese C, Wu K, D'Amico M, Jarrett C, Joyce D, Hughes J, et al. IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell 2003; 14:585 - 599
   PubMed Web of Science ®Google Scholar
• Sakamaki T, Liu M, Ju X, Zhang X, Li A, Joyce D, Albanese C, Pestell RG. NFκB induction by ErbB2 mediates DNA synthesis and breast turmor growth. Mol Cell Biol 2006;
   PubMed Web of Science ®Google Scholar
• Neumeister P, Pixley FJ, Xiong Y, Xie H, Wu K, Ashton A, et al. Cyclin D1 governs adhesion and motility of macrophages. Mol Biol Cell 2003; 14:2005 - 2015
   PubMed Web of Science ®Google Scholar
• Wang C, Pattabiraman N, Zhou JN, Fu M, Sakamaki T, Albanese C, et al. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol 2003; 23:6159 - 6173
   PubMed Web of Science ®Google Scholar
• Fu M, Wang C, Rao M, Wu X, Bouras T, Zhang X, et al. Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J Biol Chem 2005; 280:29728 - 29742
   PubMed Web of Science ®Google Scholar
• Fu M, Rao M, Bouras T, Wang C, Wu K, Zhang X, et al. Cyclin D1 inhibits PPARgamma-mediated adipogenesis through HDAC recruitment. J Biol Chem 2005; 280:16934 - 16941
   PubMed Web of Science ®Google Scholar
• Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, et al. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature 2010; 463:374 - 378
   PubMed Web of Science ®Google Scholar
• Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WDJ, Heighway J. Alternate splicing produces a novel cyclin D1 transcript. Oncogene 1995; 11:1005 - 1011
   PubMed Web of Science ®Google Scholar
• Hosokawa Y, Arnold A. Mechanism of cyclin D1 (CCND1, PRAD1) overexpression in human cancer cells: analysis of allele-specific expression. Genes Chromosomes Cancer 1998; 22:66 - 71
   PubMed Web of Science ®Google Scholar
• Li Z, Wang C, Jiao X, Katiyar S, Casimiro MC, Prendergast GC, et al. Alternate Cyclin D1 mRNA Splicing Modulates p27KIP1 Binding and Cell Migration. J Biol Chem 2008; 283:7007 - 7015
   PubMed Web of Science ®Google Scholar
• Li Z, Jiao X, Wang C, Ju X, Lu Y, Yuan L, et al. Cyclin D1 induction of cellular migration requires p27(KIP1). Cancer Res 2006; 66:9986 - 9994
   PubMed Web of Science ®Google Scholar
• Li Z, Wang C, Jiao X, Lu Y, Fu M, Quong AA, et al. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 2006; 26:4240 - 4256
   PubMed Web of Science ®Google Scholar
• Plomann MMM, Schael S. The PACSIN proteins and their role in membrane trafficking. Landes Bioscience 2009;
   Google Scholar
• Reutens AT, Fu M, Wang C, Albanese C, McPhaul MJ, Sun Z, et al. Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner. Mol Endocrinol 2001; 15:797 - 811
   PubMed Web of Science ®Google Scholar
• Kessels MM, Qualmann B. Syndapin oligomers interconnect the machineries for endocytic vesicle formation and actin polymerization. J Biol Chem 2006; 281:13285 - 13299
   PubMed Web of Science ®Google Scholar
• Halbach A, Morgelin M, Baumgarten M, Milbrandt M, Paulsson M, Plomann M. PACSIN 1 forms tetramers via its N-terminal F-BAR domain. FEBS J 2007; 274:773 - 782
   PubMed Web of Science ®Google Scholar
• Wang Q, Navarro MV, Peng G, Molinelli E, Lin Goh S, Judson BL, et al. Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. Proc Natl Acad Sci USA 2009; 106:12700 - 12705
   PubMed Web of Science ®Google Scholar
• Fankhauser C, Reymond A, Cerutti L, Utzig S, Hofmann K, Simanis V. The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis. Cell 1995; 82:435 - 444
   PubMed Web of Science ®Google Scholar
• Sherr CJ. Cancer cell cycles. Science 1996; 274:1672 - 1677
   PubMed Web of Science ®Google Scholar
• Wang C, Fan S, Li Z, Fu M, Rao M, Ma Y, et al. Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. Cancer Res 2005; 65:6557 - 6567
   PubMed Web of Science ®Google Scholar
• Holley SL, Parkes G, Matthias C, Bockmuhl U, Jahnke V, Leder K, et al. Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck. Am J Pathol 2001; 159:1917 - 1924
   PubMed Web of Science ®Google Scholar
• Millar EK, Dean JL, McNeil CM, O'Toole SA, Henshall SM, Tran T, et al. Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome. Oncogene 2009; 28:1812 - 1820
   PubMed Web of Science ®Google Scholar
• Li Z, Jiang J, Wang Z, Zhang J, Xiao M, Wang C, et al. Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis. Cancer Res 2008; 68:8687 - 8694
   PubMed Web of Science ®Google Scholar
• Holnthoner W, Pillinger M, Groger M, Wolff K, Ashton AW, Albanese C, et al. Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells. J Biol Chem 2002; 277:45847 - 45853
   PubMed Web of Science ®Google Scholar
• Qualmann B, Roos J, DiGregorio PJ, Kelly RB. Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein. Mol Biol Cell 1999; 10:501 - 513
   PubMed Web of Science ®Google Scholar
• Modregger J, Ritter B, Witter B, Paulsson M, Plomann M. All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. J Cell Sci 2000; 113:4511 - 4521
   PubMed Web of Science ®Google Scholar
• Qualmann B, Kelly RB. Syndapin isoforms participate in receptor-mediated endocytosis and actin organization. J Cell Biol 2000; 148:1047 - 1062
   PubMed Web of Science ®Google Scholar
• Cousin H, Gaultier A, Bleux C, Darribere T, Alfandari D. PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13. Dev Biol 2000; 227:197 - 210
   PubMed Web of Science ®Google Scholar
• Simpson F, Hussain NK, Qualmann B, Kelly RB, Kay BK, McPherson PS, et al. SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nat Cell Biol 1999; 1:119 - 124
   PubMed Web of Science ®Google Scholar
• Ritter B, Modregger J, Paulsson M, Plomann M. PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins. FEBS Lett 1999; 454:356 - 362
   PubMed Web of Science ®Google Scholar
• Balicki D, Reisfeld RA, Pertl U, Beutler E, Lode HN. Histone H2A-mediated transient cytokine gene delivery induces efficient antitumor responses in murine neuroblastoma. Proc Natl Acad Sci USA 2000; 97:11500 - 11504
   PubMed Web of Science ®Google Scholar
• Li Y, Dowbenko D, Lasky LA. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 2002; 277:11352 - 11361
   PubMed Web of Science ®Google Scholar
• Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, et al. SIRT1 deacetylation and repression of P300 involves lysine residues 1,020/1,024 within the cell cycle regulatory domain 1. J Biol Chem 2005; 280:10264 - 10276
   PubMed Web of Science ®Google Scholar
• Katiyar S, Jiao X, Wagner E, Lisanti MP, Pestell RG. Somatic excision demonstrates c-Jun induces cellular migration and invasion through induction of stem cell factor. Mol Cell Biol 2007; 27:1356 - 1369
   PubMed Web of Science ®Google Scholar