“Micromanaging” metabolic syndrome

References

• Maxfield FR, Tabas I. Role of cholesterol and lipid organization in disease. Nature 2005; 438:612 - 621; PMID: 16319881; http://dx.doi.org/10.1038/nature04399
   PubMed Web of Science ®Google Scholar
• Grundy SM. Absorption and metabolism of dietary cholesterol. Annu Rev Nutr 1983; 3:71 - 96; PMID: 6357243; http://dx.doi.org/10.1146/annurev.nu.03.070183.000443
   PubMed Web of Science ®Google Scholar
• Brown MS, Goldstein JL. Receptor-mediated control of cholesterol metabolism. Science 1976; 191:150 - 154; PMID: 174194; http://dx.doi.org/10.1126/science.174194
   PubMed Web of Science ®Google Scholar
• Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997; 89:331 - 340; PMID: 9150132; http://dx.doi.org/10.1016/S0092-8674(00)80213-5
   PubMed Web of Science ®Google Scholar
• Horton JD. Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc Trans 2002; 30:1091 - 1095; PMID: 12440980; http://dx.doi.org/10.1042/BST0301091
   PubMed Web of Science ®Google Scholar
• Osborne TF. Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J Biol Chem 2000; 275:32379 - 32382; PMID: 10934219; http://dx.doi.org/10.1074/jbc.R000017200
   PubMed Web of Science ®Google Scholar
• Peet DJ, Janowski BA, Mangelsdorf DJ. The LXRs: a new class of oxysterol receptors. Curr Opin Genet Dev 1998; 8:571 - 575; PMID: 9794827; http://dx.doi.org/10.1016/S0959-437X(98)80013-0
   PubMed Web of Science ®Google Scholar
• Eberhard Y, Gronda M, Hurren R, Datti A, MacLean N, Ketela T, et al. Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget 2011; 2:186 - 196; PMID: 21406729
   PubMed Web of Science ®Google Scholar
• Tall AR. Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins. J Intern Med 2008; 263:256 - 273; PMID: 18271871; http://dx.doi.org/10.1111/j.1365-2796.2007.01898.x
   PubMed Web of Science ®Google Scholar
• Tall AR, Yvan-Charvet L, Terasaka N, Pagler T, Wang N. HDL, ABC transporters and cholesterol efflux: implications for the treatment of atherosclerosis. Cell Metab 2008; 7:365 - 375; PMID: 18460328; http://dx.doi.org/10.1016/j.cmet.2008.03.001
   PubMed Web of Science ®Google Scholar
• Linsel-Nitschke P, Tall AR. HDL as a target in the treatment of atherosclerotic cardiovascular disease. Nat Rev Drug Discov 2005; 4:193 - 205; PMID: 15738977; http://dx.doi.org/10.1038/nrd1658
   PubMed Web of Science ®Google Scholar
• Ambros V. MicroRNA pathways in flies and worms: growth, death, fat, stress and timing. Cell 2003; 113:673 - 676; PMID: 12809598; http://dx.doi.org/10.1016/S0092-8674(03)00428-8
   PubMed Web of Science ®Google Scholar
• Ambros V. The functions of animal microRNAs. Nature 2004; 431:350 - 355; PMID: 15372042; http://dx.doi.org/10.1038/nature02871
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215 - 233; PMID: 19167326; http://dx.doi.org/10.1016/j.cell.2009.01.002
   PubMed Web of Science ®Google Scholar
• Herrera-Merchan A, Cerrato C, Luengo G, Dominguez O, Piris MA, Serrano M, et al. miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal. Cell Cycle 2010; 9:3277 - 3285; PMID: 20703086; http://dx.doi.org/10.4161/cc.9.16.12598
   PubMed Web of Science ®Google Scholar
• Dang CV. MYC, microRNAs and glutamine addiction in cancers. Cell Cycle 2009; 8:3243 - 3245; PMID: 19806017; http://dx.doi.org/10.4161/cc.8.20.9522
   PubMed Web of Science ®Google Scholar
• Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006; 3:87 - 98; PMID: 16459310; http://dx.doi.org/10.1016/j.cmet.2006.01.005
   PubMed Web of Science ®Google Scholar
• Gerin I, Bommer GT, McCoin CS, Sousa KM, Krishnan V, MacDougald OA. Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis. Am J Physiol Endocrinol Metab 2010; 299:198 - 206; PMID: 20484008
   PubMed Web of Science ®Google Scholar
• Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol 2002; 12:735 - 739; PMID: 12007417; http://dx.doi.org/10.1016/S0960-9822(02)00809-6
   PubMed Web of Science ®Google Scholar
• Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, et al. The upregulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. Biochem Biophys Res Commun 2009; 385:492 - 496; PMID: 19460359; http://dx.doi.org/10.1016/j.bbrc.2009.05.058
   PubMed Web of Science ®Google Scholar
• Elmén J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, et al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to upregulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res 2008; 36:1153 - 1162; PMID: 18158304; http://dx.doi.org/10.1093/nar/gkm1113
   PubMed Web of Science ®Google Scholar
• Rayner KJ, Suarez Y, Davalos A, Parathath S, Fitzgerald ML, Tamehiro N, et al. MiR-33 contributes to the regulation of cholesterol homeostasis. Science 2010; 328:1570 - 1573; PMID: 20466885; http://dx.doi.org/10.1126/science.1189862
   PubMed Web of Science ®Google Scholar
• Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, et al. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 2010; 328:1566 - 1569; PMID: 20466882; http://dx.doi.org/10.1126/science.1189123
   PubMed Web of Science ®Google Scholar
• Marquart TJ, Allen RM, Ory DS, Baldan A. miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci USA 2010; 107:12228 - 12232; PMID: 20566875; http://dx.doi.org/10.1073/pnas.1005191107
   PubMed Web of Science ®Google Scholar
• Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, et al. MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Proc Natl Acad Sci USA 2010; 107:17321 - 17326; PMID: 20855588; http://dx.doi.org/10.1073/pnas.1008499107
   PubMed Web of Science ®Google Scholar
• Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem 2010; 285:33652 - 33661; PMID: 20732877; http://dx.doi.org/10.1074/jbc.M110.152090
   PubMed Web of Science ®Google Scholar
• Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, et al. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest 2011; 121:2921 - 2931; PMID: 21646721; http://dx.doi.org/10.1172/JCI57275
   PubMed Web of Science ®Google Scholar
• Daválos A, Goedeke L, Smibert P, Ramirez CM, Warrier NP, Andreo U, et al. miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci USA 2011; 108:9232 - 9237; PMID: 21576456; http://dx.doi.org/10.1073/pnas.1102281108
   PubMed Web of Science ®Google Scholar
• Saunders LR, Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 2007; 26:5489 - 5504; PMID: 17694089; http://dx.doi.org/10.1038/sj.onc.1210616
   PubMed Web of Science ®Google Scholar
• Haigis MC, Guarente LP. Mammalian sirtuins—emerging roles in physiology, aging and calorie restriction. Genes Dev 2006; 20:2913 - 2921; PMID: 17079682; http://dx.doi.org/10.1101/gad.1467506
   PubMed Web of Science ®Google Scholar
• Guarente L. Sirtuins in aging and disease. Cold Spring Harb Symp Quant Biol 2007; 72:483 - 488; PMID: 18419308; http://dx.doi.org/10.1101/sqb.2007.72.024
   PubMedGoogle Scholar
• Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009; 460:587 - 591; PMID: 19641587; http://dx.doi.org/10.1038/nature08197
   PubMed Web of Science ®Google Scholar
• Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, et al. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci USA 2008; 105:14447 - 14452; PMID: 18794531; http://dx.doi.org/10.1073/pnas.0803790105
   PubMed Web of Science ®Google Scholar
• Deng CX. SIRT1, is it a tumor promoter or tumor suppressor?. Int J Biol Sci 2009; 5:147 - 152; PMID: 19173036
   PubMed Web of Science ®Google Scholar
• Lee J, Kemper JK. Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging 2010; 2:527 - 534; PMID: 20689156
   PubMedGoogle Scholar
• Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, et al. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging 2010; 2:415 - 431; PMID: 20634564
   PubMedGoogle Scholar
• Kim HS, Xiao C, Wang RH, Lahusen T, Xu X, Vassilopoulos A, et al. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab 2010; 12:224 - 236; PMID: 20816089; http://dx.doi.org/10.1016/j.cmet.2010.06.009
   PubMed Web of Science ®Google Scholar
• Xiao C, Kim HS, Lahusen T, Wang RH, Xu X, Gavrilova O, et al. SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem 2010; 285:36776 - 36784; PMID: 20847051; http://dx.doi.org/10.1074/jbc.M110.168039
   PubMed Web of Science ®Google Scholar
• Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, et al. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 2009; 326:437 - 440; PMID: 19833968; http://dx.doi.org/10.1126/science.1172156
   PubMed Web of Science ®Google Scholar
• Gachon F, Bonnefont X. Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation?. Aging 2010; 2:101 - 106; PMID: 20354271
   PubMedGoogle Scholar