1,462
Views
31
CrossRef citations to date
0
Altmetric
Report

TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes

Pages 109-118 | Received 25 Jul 2011, Accepted 19 Oct 2011, Published online: 01 Jan 2012

References

  • Glass CK, Witztum JL. Atherosclerosis. the road ahead. Cell 2001; 104:503 - 516; PMID: 11239408; http://dx.doi.org/10.1016/S0092-8674(01)00238-0
  • Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature 2011; 473:317 - 325; PMID: 21593864; http://dx.doi.org/10.1038/nature10146
  • Soufi M, Sattler AM, Maisch B, Schaefer JR. Molecular mechanisms involved in atherosclerosis. Herz 2002; 27:637 - 648; PMID: 12439635; http://dx.doi.org/10.1007/s00059-002-2431-2
  • Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992; 267:10931 - 10934; PMID: 1375931
  • Marx SO, Totary-Jain H, Marks AR. Vascular smooth muscle cell proliferation in restenosis. Circ Cardiovasc Interv 2011; 4:104 - 111; PMID: 21325199; http://dx.doi.org/10.1161/CIRCINTERVENTIONS.110.957332
  • Abedi H, Zachary I. Signalling mechanisms in the regulation of vascular cell migration. Cardiovasc Res 1995; 30:544 - 556; PMID: 8575003
  • Schwartz RS, Huber KC, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE, et al. Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J Am Coll Cardiol 1992; 19:267 - 274; PMID: 1732351; http://dx.doi.org/10.1016/0735-1097(92)90476-4
  • Losordo DW, Isner JM, Diaz-Sandoval LJ. Endothelial recovery: the next target in restenosis prevention. Circulation 2003; 107:2635 - 2637; PMID: 12782613; http://dx.doi.org/10.1161/01.CIR.0000071083.31270.C3
  • Ait-Oufella H, Taleb S, Mallat Z, Tedgui A. Recent advances on the role of cytokines in atherosclerosis. Arterioscler Thromb Vasc Biol 2011; 31:969 - 979; PMID: 21508343; http://dx.doi.org/10.1161/ATVBAHA.110.207415
  • Rudijanto A. The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis. Acta Med Indones 2007; 39:86 - 93; PMID: 17933075
  • Ferns GA, Raines EW, Sprugel KH, Motani AS, Reidy MA, Ross R. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 1991; 253:1129 - 1132; PMID: 1653454; http://dx.doi.org/10.1126/science.1653454
  • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362:801 - 809; PMID: 8479518; http://dx.doi.org/10.1038/362801a0
  • Bilder G, Amin D, Morgan L, McVey M, Needle S, Galczenski H, et al. Stent-induced restenosis in the swine coronary artery is inhibited by a platelet-derived growth factor receptor tyrosine kinase inhibitor, TKI963. J Cardiovasc Pharmacol 2003; 41:817 - 829; PMID: 12775958; http://dx.doi.org/10.1097/00005344-200306000-00001
  • Boucher P, Gotthardt M, Li WP, Anderson RG, Herz J. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 2003; 300:329 - 332; PMID: 12690199; http://dx.doi.org/10.1126/science.1082095
  • Yoshimura H, Nariai Y, Terashima M, Mitani T, Tanigawa Y. Taurine suppresses platelet-derived growth factor (PDGF) BB-induced PDGFbeta receptor phosphorylation by protein tyrosine phosphatase-mediated dephosphorylation in vascular smooth muscle cells. Biochim Biophys Acta 2005; 1745:350 - 360; PMID: 16112211; http://dx.doi.org/10.1016/j.bbamcr.2005.07.005
  • Bilder G, Wentz T, Leadley R, Amin D, Byan L, O'Conner B, et al. Restenosis following angioplasty in the swine coronary artery is inhibited by an orally active PDGF-receptor tyrosine kinase inhibitor, RPR101511A. Circulation 1999; 99:3292 - 3299; PMID: 10385505
  • Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 2004; 84:767 - 801; PMID: 15269336; http://dx.doi.org/10.1152/physrev.00041.2003
  • Beg AA, Baltimore D. An essential role for NFkappaB in preventing TNFalpha-induced cell death. Science 1996; 274:782 - 784; PMID: 8864118; http://dx.doi.org/10.1126/science.274.5288.782
  • Wang X, Yue TL, Barone FC, White RF, Gagnon RC, Feuerstein GZ. Concomitant cortical expression of TNFalpha and IL-1beta mRNAs follows early response gene expression in transient focal ischemia. Mol Chem Neuropathol 1994; 23:103 - 114; PMID: 7702701; http://dx.doi.org/10.1007/BF02815404
  • Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer 2009; 9:361 - 371; PMID: 19343034; http://dx.doi.org/10.1038/nrc2628
  • Prins JB, Ledgerwood EC, Ameloot P, Vandenabeele P, Faraco PR, Bright NA, et al. Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II. Biosci Rep 1998; 18:329 - 340; PMID: 10357175; http://dx.doi.org/10.1023/A:1020261316486
  • Rakesh K, Agrawal DK. Cytokines and growth factors involved in apoptosis and proliferation of vascular smooth muscle cells. Int Immunopharmacol 2005; 5:1487 - 1506; PMID: 16023601; http://dx.doi.org/10.1016/j.intimp.2005.05.003
  • McKellar GE, McCarey DW, Sattar N, McInnes IB. Role for TNF in atherosclerosis? Lessons from autoimmune disease. Nat Rev Cardiol 2009; 6:410 - 417; PMID: 19421244; http://dx.doi.org/10.1038/nrcardio.2009.57
  • Sprague AH, Khalil RA. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 2009; 78:539 - 552; PMID: 19413999; http://dx.doi.org/10.1016/j.bcp.2009.04.029
  • Kleinbongard P, Heusch G, Schulz R. TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failure. Pharmacol Ther 2010; 127:295 - 314; PMID: 20621692; http://dx.doi.org/10.1016/j.pharmthera.2010.05.002
  • Selzman CH, Shames BD, McIntyre RC Jr, Banerjee A, Harken AH. The NFkappaB inhibitory peptide, IkappaBalpha, prevents human vascular smooth muscle proliferation. Ann Thorac Surg 1999; 67:1227 - 1231; PMID: 10355388; http://dx.doi.org/10.1016/S0003-4975(99)00252-0
  • Zhang H, Park Y, Wu J, Chen X, Lee S, Yang J, et al. Role of TNFalpha in vascular dysfunction. Clin Sci (Lond) 2009; 116:219 - 230; PMID: 19118493; http://dx.doi.org/10.1042/CS20080196
  • Geng YJ, Wu Q, Muszynski M, Hansson GK, Libby P. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factoralpha and interleukin-1beta. Arterioscler Thromb Vasc Biol 1996; 16:19 - 27; PMID: 8548421; http://dx.doi.org/10.1161/01.ATV.16.1.19
  • Sawada H, Kan M, McKeehan WL. Opposite effects of monokines (interleukin-1 and tumor necrosis factor) on proliferation and heparin-binding (fibroblast) growth factor binding to human aortic endothelial and smooth muscle cells. In Vitro Cell Dev Biol 1990; 26:213 - 216; PMID: 2312505; http://dx.doi.org/10.1007/BF02624115
  • Goetze S, Xi XP, Kawano Y, Kawano H, Fleck E, Hsueh WA, et al. TNFalpha-induced migration of vascular smooth muscle cells is MAPK dependent. Hypertension 1999; 33:183 - 189; PMID: 9931102
  • O'Donnell MA, Ting AT. Chronicles of a death foretold: dual sequential cell death checkpoints in TNF signaling. Cell Cycle 2010; 9:1065 - 1071; PMID: 20237426; http://dx.doi.org/10.4161/cc.9.6.10982
  • Chen G, Goeddel DV. TNF-R1 signaling: a beautiful pathway. Science 2002; 296:1634 - 1635; PMID: 12040173; http://dx.doi.org/10.1126/science.1071924
  • Choy JC, Granville DJ, Hunt DW, McManus BM. Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol 2001; 33:1673 - 1690; PMID: 11549346; http://dx.doi.org/10.1006/jmcc.2001.1419
  • Madge LA, Pober JS. TNF signaling in vascular endothelial cells. Exp Mol Pathol 2001; 70:317 - 325; PMID: 11418010; http://dx.doi.org/10.1006/exmp.2001.2368
  • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998; 281:1305 - 1308; PMID: 9721089; http://dx.doi.org/10.1126/science.281.5381.1305
  • Ichijo H. Molecular mechanisms for cell life and cell death. Kokubyo Gakkai Zasshi 1998; 65:155 - 163; PMID: 9711034; http://dx.doi.org/10.5357/koubyou.65.155
  • Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 1997; 275:90 - 94; PMID: 8974401; http://dx.doi.org/10.1126/science.275.5296.90
  • Matsuzawa A, Ichijo H. Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1. J Biochem 2001; 130:1 - 8; PMID: 11432772
  • Takeda K, Matsuzawa A, Nishitoh H, Ichijo H. Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct Funct 2003; 28:23 - 29; PMID: 12655147; http://dx.doi.org/10.1247/csf.28.23
  • Selzman CH, Shames BD, Reznikov LL, Miller SA, Meng X, Barton HA, et al. Liposomal delivery of purified inhibitory-kappaBalpha inhibits tumor necrosis factor-alpha-induced human vascular smooth muscle proliferation. Circ Res 1999; 84:867 - 875; PMID: 10222332
  • Weber JD, Raben DM, Phillips PJ, Baldassare JJ. Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J 1997; 326:61 - 68; PMID: 9337851
  • Peeper DS, Upton TM, Ladha MH, Neuman E, Zalvide J, Bernards R, et al. Ras signalling linked to the cell cycle machinery by the retinoblastoma protein. Nature 1997; 386:177 - 181; PMID: 9062190; http://dx.doi.org/10.1038/386177a0
  • Ouyang P, Peng LS, Yang H, Peng WL, Wu WY, Xu AL. Recombinant human interleukin-10 inhibits proliferation of vascular smooth muscle cells stimulated by advanced glycation end products and neointima hyperplasia after carotid injury in the rat. Sheng Li Xue Bao 2003; 55:128 - 134; PMID: 12715099
  • Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995; 81:323 - 330; PMID: 7736585; http://dx.doi.org/10.1016/0092-8674(95)90385-2
  • Burkhart DL, Sage J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 2008; 8:671 - 682; PMID: 18650841; http://dx.doi.org/10.1038/nrc2399
  • Cobrinik D. Pocket proteins and cell cycle control. Oncogene 2005; 24:2796 - 2809; PMID: 15838516; http://dx.doi.org/10.1038/sj.onc.1208619
  • Nevins JR. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 1992; 258:424 - 429; PMID: 1411535; http://dx.doi.org/10.1126/science.1411535
  • DeGregori J. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim Biophys Acta 2002; 1602:131 - 150; PMID: 12020800
  • Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 2002; 3:11 - 20; PMID: 11823794; http://dx.doi.org/10.1038/nrm714
  • Sun B, Wingate H, Swisher SG, Keyomarsi K, Hunt KK. Absence of pRb facilitates E2F1-induced apoptosis in breast cancer cells. Cell Cycle 2010; 9:1122 - 1130; PMID: 20237430; http://dx.doi.org/10.4161/cc.9.6.10990
  • Rogoff HA, Kowalik TF. Life, death and E2F: linking proliferation control and DNA damage signaling via E2F1. Cell Cycle 2004; 3:845 - 846; PMID: 15190206; http://dx.doi.org/10.4161/cc.3.7.975
  • Dasgupta P, Sun J, Wang S, Fusaro G, Betts V, Padmanabhan J, et al. Disruption of the Rb-Raf-1 interaction inhibits tumor growth and angiogenesis. Mol Cell Biol 2004; 24:9527 - 9541; PMID: 15485920; http://dx.doi.org/10.1128/MCB.24.21.9527-41.2004
  • Kinkade R, Dasgupta P, Carie A, Pernazza D, Carless M, Pillai S, et al. A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis and growth of human tumor xenografts in nude mice. Cancer Res 2008; 68:3810 - 3818; PMID: 18483265; http://dx.doi.org/10.1158/0008-5472.CAN-07-6672
  • Dasgupta P, Betts V, Rastogi S, Joshi B, Morris M, Brennan B, et al. Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery. J Biol Chem 2004; 279:38762 - 38769; PMID: 15210709; http://dx.doi.org/10.1074/jbc.M312273200
  • Dasgupta P, Chellappan SP. Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story. Cell Cycle 2006; 5:2324 - 2328; PMID: 17102610; http://dx.doi.org/10.4161/cc.5.20.3366
  • Kyriakis JM. Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family. Gene Expr 1999; 7:217 - 231; PMID: 10440223
  • Kyriakis JM. Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses. Biochem Soc Symp 1999; 64:29 - 48; PMID: 10207619
  • Leppä S, Bohmann D. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene 1999; 18:6158 - 6162; PMID: 10557107; http://dx.doi.org/10.1038/sj.onc.1203173
  • Kolch W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 2000; 351:289 - 305; PMID: 11023813; http://dx.doi.org/10.1042/0264-6021:3510289
  • Kinkade R, Dasgupta P, Chellappan S. The ABC's of Targeting Raf: Novel Approaches to Cancer Therapy. Curr Can Ther Rev 2006; 2:305 - 314; http://dx.doi.org/10.2174/157339406778699204
  • Libby P. Vascular biology of atherosclerosis: overview and state of the art. Am J Cardiol 2003; 91:3 - 6; PMID: 12645637; http://dx.doi.org/10.1016/S0002-9149(02)03143-0
  • Rastogi S, Rizwani W, Joshi B, Kunigal S, Chellappan SP. TNFalpha response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73. Cell Death Differ 2011; In press PMID: 21738216; http://dx.doi.org/10.1038/cdd.2011.93
  • Chau BN, Chen TT, Wan YY, DeGregori J, Wang JY. Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Mol Cell Biol 2004; 24:4438 - 4447; PMID: 15121862; http://dx.doi.org/10.1128/MCB.24.10.4438-47.2004
  • Piguet PF, Vesin C, Guo J, Donati Y, Barazzone C. TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53. Eur J Immunol 1998; 28:3499 - 3505; PMID: 9842892; http://dx.doi.org/10.1002/(SICI)1521-4141(199811)28:11<3499::AIDIMMU3499>3.0.CO;2-Q
  • Wang S, Nath N, Minden A, Chellappan S. Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. EMBO J 1999; 18:1559 - 1570; PMID: 10075927; http://dx.doi.org/10.1093/emboj/18.6.1559
  • Goetze S, Kintscher U, Kaneshiro K, Meehan WP, Collins A, Fleck E, et al. TNFalpha induces expression of transcription factors c-fos, Egr-1 and Ets-1 in vascular lesions through extracellular signal-regulated kinases 1/2. Atherosclerosis 2001; 159:93 - 101; PMID: 11689211; http://dx.doi.org/10.1016/S0021-9150(01)00497-X
  • Ehrenreiter K, Piazzolla D, Velamoor V, Sobczak I, Small JV, Takeda J, et al. Raf-1 regulates Rho signaling and cell migration. J Cell Biol 2005; 168:955 - 964; PMID: 15753127; http://dx.doi.org/10.1083/jcb.200409162
  • Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, et al. Raf family kinases: old dogs have learned new tricks. Genes Cancer 2011; 2:232 - 260; PMID: 21779496; http://dx.doi.org/10.1177/1947601911407323
  • McClellan KA, Ruzhynsky VA, Douda DN, Vanderluit JL, Ferguson KL, Chen D, et al. Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Mol Cell Biol 2007; 27:4825 - 4843; PMID: 17452454; http://dx.doi.org/10.1128/MCB.02100-06
  • Li J, Hu SX, Perng GS, Zhou Y, Xu K, Zhang C, et al. Expression of the retinoblastoma (RB) tumor suppressor gene inhibits tumor cell invasion in vitro. Oncogene 1996; 13:2379 - 2386; PMID: 8957079
  • Andrusiak MG, McClellan KA, Dugal-Tessier D, Julian LM, Rodrigues SP, Park DS, et al. Rb/E2F regulates expression of neogenin during neuronal migration. Mol Cell Biol 2011; 31:238 - 247; PMID: 21059867; http://dx.doi.org/10.1128/MCB.00378-10
  • Pillai S, Dasgupta P, Chellappan SP. Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. Methods Mol Biol 2009; 523:323 - 339; PMID: 19381928; http://dx.doi.org/10.1007/978-1-59745-190-1_22
  • Rastogi S, Joshi B, Dasgupta P, Morris M, Wright K, Chellappan S. Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol Cell Biol 2006; 26:4161 - 4171; PMID: 16705168; http://dx.doi.org/10.1128/MCB.02142-05

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.