Developmental decisions

References

• Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell 2008; 134:703 - 7; http://dx.doi.org/10.1016/j.cell.2008.08.021; PMID: 18775299
   PubMed Web of Science ®Google Scholar
• Sulston JE, Horvitz HR. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.. Dev Biol 1977; 56:110 - 56; http://dx.doi.org/10.1016/0012-1606(77)90158-0; PMID: 838129
   PubMed Web of Science ®Google Scholar
• Sulston JE, Schierenberg E, White JG, Thomson JN. The embryonic cell lineage of the nematode Caenorhabditis elegans.. Dev Biol 1983; 100:64 - 119; http://dx.doi.org/10.1016/0012-1606(83)90201-4; PMID: 6684600
   PubMed Web of Science ®Google Scholar
• Conradt B, Xue D. Programmed cell death. WormBook 2005; 1 - 13; PMID: 18061982
   PubMedGoogle Scholar
• van den Heuvel S. Cell-cycle regulation. WormBook 2005; 1 - 16; PMID: 18050422
   PubMedGoogle Scholar
• Sternberg PW, Félix MA. Evolution of cell lineage. Curr Opin Genet Dev 1997; 7:543 - 50; http://dx.doi.org/10.1016/S0959-437X(97)80084-6; PMID: 9309188
   PubMed Web of Science ®Google Scholar
• Bertrand V, Hobert O. Lineage programming: navigating through transient regulatory states via binary decisions. Curr Opin Genet Dev 2010; 20:362 - 8; http://dx.doi.org/10.1016/j.gde.2010.04.010; PMID: 20537527
   PubMed Web of Science ®Google Scholar
• Golden JW, Riddle DL. The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature. Dev Biol 1984; 102:368 - 78; http://dx.doi.org/10.1016/0012-1606(84)90201-X; PMID: 6706004
   PubMed Web of Science ®Google Scholar
• Muñoz MJ, Riddle DL. Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Genetics 2003; 163:171 - 80; PMID: 12586705
   PubMed Web of Science ®Google Scholar
• Fukuyama M, Rougvie AE, Rothman JH. C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline. Curr Biol 2006; 16:773 - 9; http://dx.doi.org/10.1016/j.cub.2006.02.073; PMID: 16631584
   PubMed Web of Science ®Google Scholar
• Hong Y, Roy R, Ambros V. Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans.. Development 1998; 125:3585 - 97; PMID: 9716524
   PubMed Web of Science ®Google Scholar
• Stiernagle T. Maintenance of C. elegans.. WormBook 2006; 1 - 11; PMID: 18050451
   PubMedGoogle Scholar
• Hu PJ. Dauer. WormBook 2007; 1 - 19; PMID: 17988074
   PubMedGoogle Scholar
• Kirienko NV, Mani K, Fay DS. Cancer models in Caenorhabditis elegans.. Dev Dyn 2010; 239:1413 - 48; PMID: 20175192
   PubMed Web of Science ®Google Scholar
• Landis JN, Murphy CT. Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev Dyn 2010; 239:1405 - 12; PMID: 20140911
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay A, Oh SW, Tissenbaum HA. Worming pathways to and from DAF-16/FOXO. Exp Gerontol 2006; 41:928 - 34; http://dx.doi.org/10.1016/j.exger.2006.05.020; PMID: 16839734
   PubMed Web of Science ®Google Scholar
• Gami MS, Wolkow CA. Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan. Aging Cell 2006; 5:31 - 7; http://dx.doi.org/10.1111/j.1474-9726.2006.00188.x; PMID: 16441841
   PubMed Web of Science ®Google Scholar
• Baumeister R, Schaffitzel E, Hertweck M. Endocrine signaling in Caenorhabditis elegans controls stress response and longevity. J Endocrinol 2006; 190:191 - 202; http://dx.doi.org/10.1677/joe.1.06856; PMID: 16899554
   PubMed Web of Science ®Google Scholar
• Murphy CT. The search for DAF-16/FOXO transcriptional targets: approaches and discoveries. Exp Gerontol 2006; 41:910 - 21; http://dx.doi.org/10.1016/j.exger.2006.06.040; PMID: 16934425
   PubMed Web of Science ®Google Scholar
• Amrit FR, May RC. Younger for longer: insulin signalling, immunity and ageing. Curr Aging Sci 2010; 3:166 - 76; http://dx.doi.org/10.2174/1874609811003030166; PMID: 20735349
   PubMedGoogle Scholar
• Kaletsky R, Murphy CT. The role of insulin/IGF-like signaling in C. elegans longevity and aging. Dis Model Mech 2010; 3:415 - 9; http://dx.doi.org/10.1242/dmm.001040; PMID: 20354111
   PubMed Web of Science ®Google Scholar
• Kleemann GA, Murphy CT. The endocrine regulation of aging in Caenorhabditis elegans.. Mol Cell Endocrinol 2009; 299:51 - 7; http://dx.doi.org/10.1016/j.mce.2008.10.048; PMID: 19059305
   PubMed Web of Science ®Google Scholar
• Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev 2001; 15:672 - 86; http://dx.doi.org/10.1101/gad.867301; PMID: 11274053
   PubMed Web of Science ®Google Scholar
• Li W, Kennedy SG, Ruvkun G. daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev 2003; 17:844 - 58; http://dx.doi.org/10.1101/gad.1066503; PMID: 12654727
   PubMed Web of Science ®Google Scholar
• Murphy CT, Lee SJ, Kenyon C. Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.. Proc Natl Acad Sci U S A 2007; 104:19046 - 50; http://dx.doi.org/10.1073/pnas.0709613104; PMID: 18025456
   PubMed Web of Science ®Google Scholar
• Kawano T, Ito Y, Ishiguro M, Takuwa K, Nakajima T, Kimura Y. Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans.. Biochem Biophys Res Commun 2000; 273:431 - 6; http://dx.doi.org/10.1006/bbrc.2000.2971; PMID: 10873623
   PubMed Web of Science ®Google Scholar
• Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.. Science 1997; 277:942 - 6; http://dx.doi.org/10.1126/science.277.5328.942; PMID: 9252323
   PubMed Web of Science ®Google Scholar
• Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.. Nature 1996; 382:536 - 9; http://dx.doi.org/10.1038/382536a0; PMID: 8700226
   PubMed Web of Science ®Google Scholar
• Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun GA. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 1999; 13:1438 - 52; http://dx.doi.org/10.1101/gad.13.11.1438; PMID: 10364160
   PubMed Web of Science ®Google Scholar
• Hertweck M, Göbel C, Baumeister RC. C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 2004; 6:577 - 88; http://dx.doi.org/10.1016/S1534-5807(04)00095-4; PMID: 15068796
   PubMed Web of Science ®Google Scholar
• Ogg S, Ruvkun G. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell 1998; 2:887 - 93; http://dx.doi.org/10.1016/S1097-2765(00)80303-2; PMID: 9885576
   PubMed Web of Science ®Google Scholar
• Lin K, Dorman JB, Rodan A, Kenyon C. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.. Science 1997; 278:1319 - 22; http://dx.doi.org/10.1126/science.278.5341.1319; PMID: 9360933
   PubMed Web of Science ®Google Scholar
• Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.. Nature 1997; 389:994 - 9; http://dx.doi.org/10.1038/40194; PMID: 9353126
   PubMed Web of Science ®Google Scholar
• Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 1998; 12:2488 - 98; http://dx.doi.org/10.1101/gad.12.16.2488; PMID: 9716402
   PubMed Web of Science ®Google Scholar
• Henderson ST, Johnson TE. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.. Curr Biol 2001; 11:1975 - 80; http://dx.doi.org/10.1016/S0960-9822(01)00594-2; PMID: 11747825
   PubMed Web of Science ®Google Scholar
• Murakami S, Johnson TE. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans.. Genetics 1996; 143:1207 - 18; PMID: 8807294
   PubMed Web of Science ®Google Scholar
• Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang RA. A C. elegans mutant that lives twice as long as wild type. Nature 1993; 366:461 - 4; http://dx.doi.org/10.1038/366461a0; PMID: 8247153
   PubMed Web of Science ®Google Scholar
• Baugh LR, Sternberg PW. DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest. Curr Biol 2006; 16:780 - 5; http://dx.doi.org/10.1016/j.cub.2006.03.021; PMID: 16631585
   PubMed Web of Science ®Google Scholar
• Narbonne P, Roy R. Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development 2006; 133:611 - 9; http://dx.doi.org/10.1242/dev.02232; PMID: 16407400
   PubMed Web of Science ®Google Scholar
• Watanabe S, Yamamoto TG, Kitagawa R. Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans.. EMBO J 2008; 27:1085 - 96; http://dx.doi.org/10.1038/emboj.2008.32; PMID: 18309291
   PubMed Web of Science ®Google Scholar
• Dijkers PF, Medema RH, Pals C, Banerji L, Thomas NS, Lam EW, et al. Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol Cell Biol 2000; 20:9138 - 48; http://dx.doi.org/10.1128/MCB.20.24.9138-9148.2000; PMID: 11094066
   PubMed Web of Science ®Google Scholar
• Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007; 9:218 - 24; http://dx.doi.org/10.1038/ncb1537; PMID: 17237771
   PubMed Web of Science ®Google Scholar
• Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000; 404:782 - 7; http://dx.doi.org/10.1038/35008115; PMID: 10783894
   PubMed Web of Science ®Google Scholar
• Fukuyama M, Gendreau SB, Derry WB, Rothman JH. Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans.. Dev Biol 2003; 260:273 - 86; http://dx.doi.org/10.1016/S0012-1606(03)00239-2; PMID: 12885569
   PubMed Web of Science ®Google Scholar
• Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 2007; 8:379 - 93; http://dx.doi.org/10.1038/nrm2163; PMID: 17426725
   PubMed Web of Science ®Google Scholar
• Kitagawa R, Law E, Tang L, Rose AM. The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans.. Curr Biol 2002; 12:2118 - 23; http://dx.doi.org/10.1016/S0960-9822(02)01392-1; PMID: 12498686
   PubMed Web of Science ®Google Scholar
• Michaelson D, Korta DZ, Capua Y, Hubbard EJ. Insulin signaling promotes germline proliferation in C. elegans.. Development 2010; 137:671 - 80; http://dx.doi.org/10.1242/dev.042523; PMID: 20110332
   PubMed Web of Science ®Google Scholar
• Francis R, Barton MK, Kimble J, Schedl T. gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans.. Genetics 1995; 139:579 - 606; PMID: 7713419
   PubMed Web of Science ®Google Scholar
• Pinkston JM, Garigan D, Hansen M, Kenyon C. Mutations that increase the life span of C. elegans inhibit tumor growth. Science 2006; 313:971 - 5; http://dx.doi.org/10.1126/science.1121908; PMID: 16917064
   PubMed Web of Science ®Google Scholar
• Pinkston-Gosse J, Kenyon C. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.. Nat Genet 2007; 39:1403 - 9; http://dx.doi.org/10.1038/ng.2007.1; PMID: 17934462
   PubMed Web of Science ®Google Scholar
• Hardie DG. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev 2011; 25:1895 - 908; http://dx.doi.org/10.1101/gad.17420111; PMID: 21937710
   PubMed Web of Science ®Google Scholar
• Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, et al. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem 1996; 271:27879 - 87; http://dx.doi.org/10.1074/jbc.271.44.27879; PMID: 8910387
   PubMed Web of Science ®Google Scholar
• Stein SC, Woods A, Jones NA, Davison MD, Carling D. The regulation of AMP-activated protein kinase by phosphorylation. Biochem J 2000; 345:437 - 43; http://dx.doi.org/10.1042/0264-6021:3450437; PMID: 10642499
   PubMed Web of Science ®Google Scholar
• Apfeld J, O’Connor G, McDonagh T, DiStefano PS, Curtis R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.. Genes Dev 2004; 18:3004 - 9; http://dx.doi.org/10.1101/gad.1255404; PMID: 15574588
   PubMed Web of Science ®Google Scholar
• Curtis R, O’Connor G, DiStefano PS. Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. Aging Cell 2006; 5:119 - 26; http://dx.doi.org/10.1111/j.1474-9726.2006.00205.x; PMID: 16626391
   PubMed Web of Science ®Google Scholar
• Beale EG. 5′-AMP-activated protein kinase signaling in Caenorhabditis elegans.. Exp Biol Med (Maywood) 2008; 233:12 - 20; http://dx.doi.org/10.3181/0705-MR-117; PMID: 18156301
   PubMed Web of Science ®Google Scholar
• Imamura K, Ogura T, Kishimoto A, Kaminishi M, Esumi H. Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun 2001; 287:562 - 7; http://dx.doi.org/10.1006/bbrc.2001.5627; PMID: 11554766
   PubMed Web of Science ®Google Scholar
• Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 2005; 18:283 - 93; http://dx.doi.org/10.1016/j.molcel.2005.03.027; PMID: 15866171
   PubMed Web of Science ®Google Scholar
• Tiainen M, Ylikorkala A, Mäkelä TP. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci U S A 1999; 96:9248 - 51; http://dx.doi.org/10.1073/pnas.96.16.9248; PMID: 10430928
   PubMed Web of Science ®Google Scholar
• Tiainen M, Vaahtomeri K, Ylikorkala A, Mäkelä TP. Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). Hum Mol Genet 2002; 11:1497 - 504; http://dx.doi.org/10.1093/hmg/11.13.1497; PMID: 12045203
   PubMed Web of Science ®Google Scholar
• Waters K, Yang AZ, Reinke V. Genome-wide analysis of germ cell proliferation in C.elegans identifies VRK-1 as a key regulator of CEP-1/p53. Dev Biol 2010; 344:1011 - 25; http://dx.doi.org/10.1016/j.ydbio.2010.06.022; PMID: 20599896
   PubMed Web of Science ®Google Scholar
• Albert PS, Riddle DL. Mutants of Caenorhabditis elegans that form dauer-like larvae. Dev Biol 1988; 126:270 - 93; http://dx.doi.org/10.1016/0012-1606(88)90138-8; PMID: 3350212
   PubMed Web of Science ®Google Scholar
• Narbonne P, Hyenne V, Li S, Labbé JC, Roy R. Differential requirements for STRAD in LKB1-dependent functions in C. elegans.. Development 2010; 137:661 - 70; http://dx.doi.org/10.1242/dev.042044; PMID: 20110331
   PubMed Web of Science ®Google Scholar
• Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, et al. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.. Curr Biol 2007; 17:1646 - 56; http://dx.doi.org/10.1016/j.cub.2007.08.047; PMID: 17900900
   PubMed Web of Science ®Google Scholar
• Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, et al. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 2007; 282:30107 - 19; http://dx.doi.org/10.1074/jbc.M705325200; PMID: 17711846
   PubMed Web of Science ®Google Scholar
• Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 2010; 468:701 - 4; http://dx.doi.org/10.1038/nature09595; PMID: 21124456
   PubMed Web of Science ®Google Scholar
• Nakada D, Saunders TL, Morrison SJ. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010; 468:653 - 8; http://dx.doi.org/10.1038/nature09571; PMID: 21124450
   PubMed Web of Science ®Google Scholar
• Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 2010; 468:659 - 63; http://dx.doi.org/10.1038/nature09572; PMID: 21124451
   PubMed Web of Science ®Google Scholar