From oncogene to tumor suppressor

References

• Patel JH, Loboda AP, Showe MK, Showe LC, McMahon SB. Analysis of genomic targets reveals complex functions of MYC. Nat Rev Cancer 2004; 4:562 - 8; http://dx.doi.org/10.1038/nrc1393; PMID: 15229481
   PubMed Web of Science ®Google Scholar
• Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H. Sequence-specific DNA binding by the c-Myc protein. Science 1990; 250:1149 - 51; http://dx.doi.org/10.1126/science.2251503; PMID: 2251503
   PubMed Web of Science ®Google Scholar
• Blackwood EM, Eisenman RN. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 1991; 251:1211 - 7; http://dx.doi.org/10.1126/science.2006410; PMID: 2006410
   PubMed Web of Science ®Google Scholar
• Amati B, Alevizopoulos K, Vlach J. Myc and the cell cycle. Front Biosci 1998; 3:d250 - 68; PMID: 9468463
   PubMed Web of Science ®Google Scholar
• Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999; 19:1 - 11; PMID: 9858526
   PubMed Web of Science ®Google Scholar
• Eilers M. Control of cell proliferation by Myc family genes. Mol Cells 1999; 9:1 - 6; PMID: 10102563
   PubMed Web of Science ®Google Scholar
• Seoane J, Pouponnot C, Staller P, Schader M, Eilers M, Massagué J. TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol 2001; 3:400 - 8; http://dx.doi.org/10.1038/35070086; PMID: 11283614
   PubMed Web of Science ®Google Scholar
• Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, et al. Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol 2001; 3:392 - 9; http://dx.doi.org/10.1038/35070076; PMID: 11283613
   PubMed Web of Science ®Google Scholar
• Inghirami G, Grignani F, Sternas L, Lombardi L, Knowles DM, Dalla-Favera R. Down-regulation of LFA-1 adhesion receptors by C-myc oncogene in human B lymphoblastoid cells. Science 1990; 250:682 - 6; http://dx.doi.org/10.1126/science.2237417; PMID: 2237417
   PubMed Web of Science ®Google Scholar
• Seoane J, Le HV, Massagué J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 2002; 419:729 - 34; http://dx.doi.org/10.1038/nature01119; PMID: 12384701
   PubMed Web of Science ®Google Scholar
• Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, et al. Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell 2002; 10:509 - 21; http://dx.doi.org/10.1016/S1097-2765(02)00633-0; PMID: 12408820
   PubMed Web of Science ®Google Scholar
• Yang W, Shen J, Wu M, Arsura M, FitzGerald M, Suldan Z, et al. Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc. Oncogene 2001; 20:1688 - 702; http://dx.doi.org/10.1038/sj.onc.1204245; PMID: 11313917
   PubMed Web of Science ®Google Scholar
• Knoepfler PS, Cheng PF, Eisenman RN. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev 2002; 16:2699 - 712; http://dx.doi.org/10.1101/gad.1021202; PMID: 12381668
   PubMed Web of Science ®Google Scholar
• Arnold I, Watt FM. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol 2001; 11:558 - 68; http://dx.doi.org/10.1016/S0960-9822(01)00154-3; PMID: 11369200
   PubMed Web of Science ®Google Scholar
• Waikel RL, Kawachi Y, Waikel PA, Wang XJ, Roop DR. Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 2001; 28:165 - 8; http://dx.doi.org/10.1038/88889; PMID: 11381265
   PubMed Web of Science ®Google Scholar
• Watt FM, Frye M, Benitah SA. MYC in mammalian epidermis: how can an oncogene stimulate differentiation?. Nat Rev Cancer 2008; 8:234 - 42; http://dx.doi.org/10.1038/nrc2328; PMID: 18292777
   PubMed Web of Science ®Google Scholar
• Gallant P, Steiger D. Myc’s secret life without Max. Cell Cycle 2009; 8:3848 - 53; http://dx.doi.org/10.4161/cc.8.23.10088; PMID: 19887915
   PubMed Web of Science ®Google Scholar
• Steiger D, Furrer M, Schwinkendorf D, Gallant P. Max-independent functions of Myc in Drosophila melanogaster. Nat Genet 2008; 40:1084 - 91; http://dx.doi.org/10.1038/ng.178; PMID: 19165923
   PubMed Web of Science ®Google Scholar
• Adhikary S, Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 2005; 6:635 - 45; http://dx.doi.org/10.1038/nrm1703; PMID: 16064138
   PubMed Web of Science ®Google Scholar
• Roy AL, Carruthers C, Gutjahr T, Roeder RG. Direct role for Myc in transcription initiation mediated by interactions with TFII-I. Nature 1993; 365:359 - 61; http://dx.doi.org/10.1038/365359a0; PMID: 8377829
   PubMed Web of Science ®Google Scholar
• Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science 1993; 262:1889 - 92; http://dx.doi.org/10.1126/science.8266081; PMID: 8266081
   PubMed Web of Science ®Google Scholar
• Gartel AL, Ye X, Goufman E, Shianov P, Hay N, Najmabadi F, et al. Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A 2001; 98:4510 - 5; http://dx.doi.org/10.1073/pnas.081074898; PMID: 11274368
   PubMed Web of Science ®Google Scholar
• Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K. Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor. J Cell Sci 2001; 114:1533 - 44; PMID: 11282029
   PubMed Web of Science ®Google Scholar
• Huang Z, Traugh JA, Bishop JM. Negative control of the Myc protein by the stress-responsive kinase Pak2. Mol Cell Biol 2004; 24:1582 - 94; http://dx.doi.org/10.1128/MCB.24.4.1582-1594.2004; PMID: 14749374
   PubMed Web of Science ®Google Scholar
• Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 1995; 377:397 - 404; http://dx.doi.org/10.1038/377397a0; PMID: 7566114
   PubMed Web of Science ®Google Scholar
• Chen JD, Evans RM. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 1995; 377:454 - 7; http://dx.doi.org/10.1038/377454a0; PMID: 7566127
   PubMed Web of Science ®Google Scholar
• Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 1996; 85:403 - 14; http://dx.doi.org/10.1016/S0092-8674(00)81118-6; PMID: 8616895
   PubMed Web of Science ®Google Scholar
• Chakravarti D, LaMorte VJ, Nelson MC, Nakajima T, Schulman IG, Juguilon H, et al. Role of CBP/P300 in nuclear receptor signalling. Nature 1996; 383:99 - 103; http://dx.doi.org/10.1038/383099a0; PMID: 8779723
   PubMed Web of Science ®Google Scholar
• Heinzel T, Lavinsky RM, Mullen TM, Söderstrom M, Laherty CD, Torchia J, et al. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 1997; 387:43 - 8; http://dx.doi.org/10.1038/387043a0; PMID: 9139820
   PubMed Web of Science ®Google Scholar
• Kurland JF, Tansey WP. Myc-mediated transcriptional repression by recruitment of histone deacetylase. Cancer Res 2008; 68:3624 - 9; http://dx.doi.org/10.1158/0008-5472.CAN-07-6552; PMID: 18483244
   PubMed Web of Science ®Google Scholar
• Vervoorts J, Lüscher-Firzlaff JM, Rottmann S, Lilischkis R, Walsemann G, Dohmann K, et al. Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep 2003; 4:484 - 90; http://dx.doi.org/10.1038/sj.embor.embor821; PMID: 12776737
   PubMed Web of Science ®Google Scholar
• Gratas C, Menot ML, Dresch C, Chomienne C. Retinoid acid supports granulocytic but not erythroid differentiation of myeloid progenitors in normal bone marrow cells. Leukemia 1993; 7:1156 - 62; PMID: 8350615
   PubMed Web of Science ®Google Scholar
• Larsson LG, Henriksson MA. The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy. Exp Cell Res 2010; 316:1429 - 37; http://dx.doi.org/10.1016/j.yexcr.2010.03.025; PMID: 20382143
   PubMed Web of Science ®Google Scholar
• Leon J, Ferrandiz N, Acosta JC, Delgado MD. Inhibition of cell differentiation: a critical mechanism for MYC-mediated carcinogenesis?. Cell Cycle 2009; 8:1148 - 57; http://dx.doi.org/10.4161/cc.8.8.8126; PMID: 19282668
   PubMed Web of Science ®Google Scholar
• Uribesalgo I, Buschbeck M, Gutiérrez A, Teichmann S, Demajo S, Kuebler B, et al. E-box-independent regulation of transcription and differentiation by MYC. Nat Cell Biol 2011; 13:1443 - 9; http://dx.doi.org/10.1038/ncb2355; PMID: 22020439
   PubMed Web of Science ®Google Scholar
• Yung BY. c-Myc-mediated expression of nucleophosmin/B23 decreases during retinoic acid-induced differentiation of human leukemia HL-60 cells. FEBS Lett 2004; 578:211 - 6; http://dx.doi.org/10.1016/j.febslet.2004.08.089; PMID: 15589822
   PubMed Web of Science ®Google Scholar
• Nisimoto Y, Ogawa H. Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid. Eur J Biochem 2002; 269:2622 - 9; http://dx.doi.org/10.1046/j.1432-1033.2002.02939.x; PMID: 12027902
   PubMedGoogle Scholar
• Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, et al. Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell 2011; 19:776 - 91; http://dx.doi.org/10.1016/j.ccr.2011.05.008; PMID: 21665151
   PubMed Web of Science ®Google Scholar
• Miralles F, Posern G, Zaromytidou AI, Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 2003; 113:329 - 42; http://dx.doi.org/10.1016/S0092-8674(03)00278-2; PMID: 12732141
   PubMed Web of Science ®Google Scholar
• Vartiainen MK, Guettler S, Larijani B, Treisman R. Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL. Science 2007; 316:1749 - 52; http://dx.doi.org/10.1126/science.1141084; PMID: 17588931
   PubMed Web of Science ®Google Scholar
• Medjkane S, Perez-Sanchez C, Gaggioli C, Sahai E, Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol 2009; 11:257 - 68; http://dx.doi.org/10.1038/ncb1833; PMID: 19198601
   PubMed Web of Science ®Google Scholar
• Connelly JT, Gautrot JE, Trappmann B, Tan DW, Donati G, Huck WT, et al. Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol 2010; 12:711 - 8; http://dx.doi.org/10.1038/ncb2074; PMID: 20581838
   PubMed Web of Science ®Google Scholar
• Connelly JT, Mishra A, Gautrot JE, Watt FM. Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PLoS One 2011; 6:e27259; http://dx.doi.org/10.1371/journal.pone.0027259; PMID: 22073300
   PubMed Web of Science ®Google Scholar
• Roig J, Traugh JA. p21-activated protein kinase gamma-PAK is activated by ionizing radiation and other DNA-damaging agents. Similarities and differences to alpha-PAK. J Biol Chem 1999; 274:31119 - 22; http://dx.doi.org/10.1074/jbc.274.44.31119; PMID: 10531298
   PubMed Web of Science ®Google Scholar
• Roig J, Huang Z, Lytle C, Traugh JA. p21-activated protein kinase gamma-PAK is translocated and activated in response to hyperosmolarity. Implication of Cdc42 and phosphoinositide 3-kinase in a two-step mechanism for gamma-PAK activation. J Biol Chem 2000; 275:16933 - 40; http://dx.doi.org/10.1074/jbc.M001627200; PMID: 10748040
   PubMed Web of Science ®Google Scholar
• Roig J, Traugh JA. Cytostatic p21 G protein-activated protein kinase gamma-PAK. Vitam Horm 2001; 62:167 - 98; http://dx.doi.org/10.1016/S0083-6729(01)62004-1; PMID: 11345898
   PubMed Web of Science ®Google Scholar
• Nebreda AR, Porras A. p38 MAP kinases: beyond the stress response. Trends Biochem Sci 2000; 25:257 - 60; http://dx.doi.org/10.1016/S0968-0004(00)01595-4; PMID: 10838561
   PubMed Web of Science ®Google Scholar
• Dawson MA, Bannister AJ, Göttgens B, Foster SD, Bartke T, Green AR, et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 2009; 461:819 - 22; http://dx.doi.org/10.1038/nature08448; PMID: 19783980
   PubMed Web of Science ®Google Scholar
• Li J, Gorospe M, Hutter D, Barnes J, Keyse SM, Liu Y. Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. Mol Cell Biol 2001; 21:8213 - 24; http://dx.doi.org/10.1128/MCB.21.23.8213-8224.2001; PMID: 11689710
   PubMed Web of Science ®Google Scholar
• Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, et al. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J 2003; 22:2788 - 97; http://dx.doi.org/10.1093/emboj/cdg273; PMID: 12773393
   PubMed Web of Science ®Google Scholar
• Simone C, Forcales SV, Hill DA, Imbalzano AN, Latella L, Puri PL. p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci. Nat Genet 2004; 36:738 - 43; http://dx.doi.org/10.1038/ng1378; PMID: 15208625
   PubMed Web of Science ®Google Scholar
• Illi B, Scopece A, Nanni S, Farsetti A, Morgante L, Biglioli P, et al. Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. Circ Res 2005; 96:501 - 8; http://dx.doi.org/10.1161/01.RES.0000159181.06379.63; PMID: 15705964
   PubMed Web of Science ®Google Scholar
• Schmeck B, Beermann W, van Laak V, Zahlten J, Opitz B, Witzenrath M, et al. Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification. J Immunol 2005; 175:2843 - 50; PMID: 16116170
   PubMed Web of Science ®Google Scholar
• Pokholok DK, Zeitlinger J, Hannett NM, Reynolds DB, Young RA. Activated signal transduction kinases frequently occupy target genes. Science 2006; 313:533 - 6; http://dx.doi.org/10.1126/science.1127677; PMID: 16873666
   PubMed Web of Science ®Google Scholar
• Vicent GP, Ballaré C, Nacht AS, Clausell J, Subtil-Rodríguez A, Quiles I, et al. Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3. Mol Cell 2006; 24:367 - 81; http://dx.doi.org/10.1016/j.molcel.2006.10.011; PMID: 17081988
   PubMed Web of Science ®Google Scholar
• Lee ER, McCool KW, Murdoch FE, Fritsch MK. Dynamic changes in histone H3 phosphoacetylation during early embryonic stem cell differentiation are directly mediated by mitogen- and stress-activated protein kinase 1 via activation of MAPK pathways. J Biol Chem 2006; 281:21162 - 72; http://dx.doi.org/10.1074/jbc.M602734200; PMID: 16728397
   PubMed Web of Science ®Google Scholar
• Li F, Adam L, Vadlamudi RK, Zhou H, Sen S, Chernoff J, et al. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep 2002; 3:767 - 73; http://dx.doi.org/10.1093/embo-reports/kvf157; PMID: 12151336
   PubMed Web of Science ®Google Scholar
• Benitah SA, Frye M, Glogauer M, Watt FM. Stem cell depletion through epidermal deletion of Rac1. Science 2005; 309:933 - 5; http://dx.doi.org/10.1126/science.1113579; PMID: 16081735
   PubMed Web of Science ®Google Scholar
• Smith AP, Verrecchia A, Fagà G, Doni M, Perna D, Martinato F, et al. A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition. Oncogene 2009; 28:422 - 30; http://dx.doi.org/10.1038/onc.2008.395; PMID: 18978814
   PubMed Web of Science ®Google Scholar
• Perna D, Fagà G, Verrecchia A, Gorski MM, Barozzi I, Narang V, et al. Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts. Oncogene 2011; http://dx.doi.org/10.1038/onc.2011.359; PMID: 21860422
   PubMed Web of Science ®Google Scholar
• Gebhardt A, Frye M, Herold S, Benitah SA, Braun K, Samans B, et al. Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1. J Cell Biol 2006; 172:139 - 49; http://dx.doi.org/10.1083/jcb.200506057; PMID: 16391002
   PubMed Web of Science ®Google Scholar
• Frye M, Watt FM. The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. Curr Biol 2006; 16:971 - 81; http://dx.doi.org/10.1016/j.cub.2006.04.027; PMID: 16713953
   PubMed Web of Science ®Google Scholar
• Nascimento EM, Cox CL, MacArthur S, Hussain S, Trotter M, Blanco S, et al. The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis. Nat Cell Biol 2011; 13:1395 - 405; http://dx.doi.org/10.1038/ncb2385; PMID: 22101514
   PubMed Web of Science ®Google Scholar
• Jensen KB, Collins CA, Nascimento E, Tan DW, Frye M, Itami S, et al. Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell 2009; 4:427 - 39; http://dx.doi.org/10.1016/j.stem.2009.04.014; PMID: 19427292
   PubMed Web of Science ®Google Scholar
• Murphy MJ, Wilson A, Trumpp A. More than just proliferation: Myc function in stem cells. Trends Cell Biol 2005; 15:128 - 37; http://dx.doi.org/10.1016/j.tcb.2005.01.008; PMID: 15752976
   PubMed Web of Science ®Google Scholar
• Wilson A, Murphy MJ, Oskarsson T, Kaloulis K, Bettess MD, Oser GM, et al. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev 2004; 18:2747 - 63; http://dx.doi.org/10.1101/gad.313104; PMID: 15545632
   PubMed Web of Science ®Google Scholar
• Williams DA, Zheng Y, Cancelas JA. Rho GTPases and regulation of hematopoietic stem cell localization. Methods Enzymol 2008; 439:365 - 93; http://dx.doi.org/10.1016/S0076-6879(07)00427-2; PMID: 18374178
   PubMed Web of Science ®Google Scholar
• Purton LE, Bernstein ID, Collins SJ. All-trans retinoic acid delays the differentiation of primitive hematopoietic precursors (lin-c-kit+Sca-1(+)) while enhancing the terminal maturation of committed granulocyte/monocyte progenitors. Blood 1999; 94:483 - 95; PMID: 10397716
   PubMed Web of Science ®Google Scholar
• Purton LE, Bernstein ID, Collins SJ. All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells. Blood 2000; 95:470 - 7; PMID: 10627451
   PubMed Web of Science ®Google Scholar
• Conacci-Sorrell M, Ngouenet C, Eisenman RN. Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell 2010; 142:480 - 93; http://dx.doi.org/10.1016/j.cell.2010.06.037; PMID: 20691906
   PubMed Web of Science ®Google Scholar
• Zhu GH, Huang J, Bi Y, Su Y, Tang Y, He BC, et al. Activation of RXR and RAR signaling promotes myogenic differentiation of myoblastic C2C12 cells. Differentiation 2009; 78:195 - 204; http://dx.doi.org/10.1016/j.diff.2009.06.001; PMID: 19560855
   PubMed Web of Science ®Google Scholar
• Nowak D, Stewart D, Koeffler HP. Differentiation therapy of leukemia: 3 decades of development. Blood 2009; 113:3655 - 65; http://dx.doi.org/10.1182/blood-2009-01-198911; PMID: 19221035
   PubMed Web of Science ®Google Scholar
• Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988; 72:567 - 72; PMID: 3165295
   PubMed Web of Science ®Google Scholar
• Di Croce L, Raker VA, Corsaro M, Fazi F, Fanelli M, Faretta M, et al. Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 2002; 295:1079 - 82; http://dx.doi.org/10.1126/science.1065173; PMID: 11834837
   PubMed Web of Science ®Google Scholar
• Di Croce L. Chromatin modifying activity of leukaemia associated fusion proteins. Hum Mol Genet 2005; 14:Spec No 1 R77 - 84; http://dx.doi.org/10.1093/hmg/ddi109; PMID: 15809276
   PubMedGoogle Scholar
• Uribesalgo I, Di Croce L. Dynamics of epigenetic modifications in leukemia. Brief Funct Genomics 2011; 10:18 - 29; http://dx.doi.org/10.1093/bfgp/elr002; PMID: 21258047
   PubMed Web of Science ®Google Scholar
• Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 2011; 478:524 - 8; http://dx.doi.org/10.1038/nature10334; PMID: 21814200
   PubMed Web of Science ®Google Scholar
• Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 2011; 478:529 - 33; http://dx.doi.org/10.1038/nature10509; PMID: 21964340
   PubMed Web of Science ®Google Scholar
• Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011; 146:904 - 17; http://dx.doi.org/10.1016/j.cell.2011.08.017; PMID: 21889194
   PubMed Web of Science ®Google Scholar
• Mertz JA, Conery AR, Bryant BM, Sandy P, Balasubramanian S, Mele DA, et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci U S A 2011; 108:16669 - 74; http://dx.doi.org/10.1073/pnas.1108190108; PMID: 21949397
   PubMed Web of Science ®Google Scholar
• Slavutsky I, de Vinuesa ML, Larripa I, Dupont J, de Salum SB. Translocation (2;3) in hematologic malignancies. Cancer Genet Cytogenet 1986; 21:335 - 42; http://dx.doi.org/10.1016/0165-4608(86)90214-1; PMID: 3456824
   PubMed Web of Science ®Google Scholar
• Dierlamm J, Rosenberg C, Stul M, Pittaluga S, Wlodarska I, Michaux L, et al. Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization. Leukemia 1997; 11:747 - 58; http://dx.doi.org/10.1038/sj.leu.2400635; PMID: 9180302
   PubMed Web of Science ®Google Scholar
• Lafage-Pochitaloff M, Courcoul M, Simonetti J, Sainty D, Dastugue N, Tabilio A, et al. Expression of the ETS2 and transferrin receptor genes in Philadelphia-positive chronic myeloid leukemia patients with a reciprocal t(3;21). Genes Chromosomes Cancer 1992; 5:1 - 13; http://dx.doi.org/10.1002/gcc.2870050102; PMID: 1384656
   PubMed Web of Science ®Google Scholar
• Perlman EJ, Lumadue JA, Hawkins AL, Cohen K, Colombani P, Griffin CA. Primary cutaneous neuroendocrine tumors. Diagnostic use of cytogenetic and MIC2 analysis. Cancer Genet Cytogenet 1995; 82:30 - 4; http://dx.doi.org/10.1016/0165-4608(94)00271-C; PMID: 7627931
   PubMed Web of Science ®Google Scholar
• Soucek L, Helmer-Citterich M, Sacco A, Jucker R, Cesareni G, Nasi S. Design and properties of a Myc derivative that efficiently homodimerizes. Oncogene 1998; 17:2463 - 72; http://dx.doi.org/10.1038/sj.onc.1202199; PMID: 9824157
   PubMed Web of Science ®Google Scholar
• Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, et al. Modelling Myc inhibition as a cancer therapy. Nature 2008; 455:679 - 83; http://dx.doi.org/10.1038/nature07260; PMID: 18716624
   PubMed Web of Science ®Google Scholar
• Amati B, Brooks MW, Levy N, Littlewood TD, Evan GI, Land H. Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 1993; 72:233 - 45; http://dx.doi.org/10.1016/0092-8674(93)90663-B; PMID: 8425220
   PubMed Web of Science ®Google Scholar
• Amati B, Littlewood TD, Evan GI, Land H. The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J 1993; 12:5083 - 7; PMID: 8262051
   PubMed Web of Science ®Google Scholar
• Yuan Y, Zhou L, Miyamoto T, Iwasaki H, Harakawa N, Hetherington CJ, et al. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci U S A 2001; 98:10398 - 403; http://dx.doi.org/10.1073/pnas.171321298; PMID: 11526243
   PubMed Web of Science ®Google Scholar
• Villa R, Pasini D, Gutierrez A, Morey L, Occhionorelli M, Viré E, et al. Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell 2007; 11:513 - 25; http://dx.doi.org/10.1016/j.ccr.2007.04.009; PMID: 17560333
   PubMed Web of Science ®Google Scholar
• Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367:645 - 8; http://dx.doi.org/10.1038/367645a0; PMID: 7509044
   PubMed Web of Science ®Google Scholar
• Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3:730 - 7; http://dx.doi.org/10.1038/nm0797-730; PMID: 9212098
   PubMed Web of Science ®Google Scholar