Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

References

• Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012; 21:297 - 308; http://dx.doi.org/10.1016/j.ccr.2012.02.014; PMID: 22439925
   PubMed Web of Science ®Google Scholar
• Warburg O. On the origin of cancer cells. Science 1956; 123:309 - 14; http://dx.doi.org/10.1126/science.123.3191.309; PMID: 13298683
   PubMed Web of Science ®Google Scholar
• Salem AF, Whitaker-Menezes D, Lin Z, Martinez-Outschoorn UE, Tanowitz HB, Al-Zoubi MS, et al. Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle 2012; 11:2545 - 56; http://dx.doi.org/10.4161/cc.20920; PMID: 22722266
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Power surge: supporting cells “fuel” cancer cell mitochondria. Cell Metab 2012; 15:4 - 5; http://dx.doi.org/10.1016/j.cmet.2011.12.011; PMID: 22225869
   PubMed Web of Science ®Google Scholar
• Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, et al. Evidence for a stromal-epithelial “lactate shuttle” in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle 2011; 10:1772 - 83; http://dx.doi.org/10.4161/cc.10.11.15659; PMID: 21558814
   PubMed Web of Science ®Google Scholar
• Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, et al. Evidence for a stromal-epithelial “lactate shuttle” in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle 2011; 10:1772 - 83; http://dx.doi.org/10.4161/cc.10.11.15659; PMID: 21558814
   PubMed Web of Science ®Google Scholar
• Colca JR, McDonald WG, Waldon DJ, Leone JW, Lull JM, Bannow CA, et al. Identification of a novel mitochondrial protein (“mitoNEET”) cross-linked specifically by a thiazolidinedione photoprobe. Am J Physiol Endocrinol Metab 2004; 286:E252 - 60; http://dx.doi.org/10.1152/ajpendo.00424.2003; PMID: 14570702
   PubMed Web of Science ®Google Scholar
• Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci USA 2007; 104:5318 - 23; http://dx.doi.org/10.1073/pnas.0701078104; PMID: 17376863
   PubMed Web of Science ®Google Scholar
• Liu C, Lin JD. PGC-1 coactivators in the control of energy metabolism. Acta Biochim Biophys Sin (Shanghai) 2011; 43:248 - 57; http://dx.doi.org/10.1093/abbs/gmr007; PMID: 21325336
   PubMed Web of Science ®Google Scholar
• Scarpulla RC. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta 2011; 1813:1269 - 78; http://dx.doi.org/10.1016/j.bbamcr.2010.09.019; PMID: 20933024
   PubMed Web of Science ®Google Scholar
• Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem 2002; 277:1645 - 8; http://dx.doi.org/10.1074/jbc.C100631200; PMID: 11733490
   PubMed Web of Science ®Google Scholar
• Arnold JJ, Smidansky ED, Moustafa IM, Cameron CE. Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition. Biochim Biophys Acta 2012; 1819:948 - 60; http://dx.doi.org/10.1016/j.bbagrm.2012.04.002; PMID: 22551784
   PubMed Web of Science ®Google Scholar
• Wanrooij S, Falkenberg M. The human mitochondrial replication fork in health and disease. Biochim Biophys Acta 2010; 1797:1378 - 88; http://dx.doi.org/10.1016/j.bbabio.2010.04.015; PMID: 20417176
   PubMed Web of Science ®Google Scholar
• Scarpulla RC. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 2008; 88:611 - 38; http://dx.doi.org/10.1152/physrev.00025.2007; PMID: 18391175
   PubMed Web of Science ®Google Scholar
• Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, et al. Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle 2011; 10:4047 - 64; http://dx.doi.org/10.4161/cc.10.23.18151; PMID: 22134189
   PubMed Web of Science ®Google Scholar
• Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA 2009; 106:20405 - 10; http://dx.doi.org/10.1073/pnas.0911570106; PMID: 19918075
   PubMed Web of Science ®Google Scholar
• Asin-Cayuela J, Gustafsson CM. Mitochondrial transcription and its regulation in mammalian cells. Trends Biochem Sci 2007; 32:111 - 7; http://dx.doi.org/10.1016/j.tibs.2007.01.003; PMID: 17291767
   PubMed Web of Science ®Google Scholar
• Salem AF, Whitaker-Menezes D, Lin Z, Martinez-Outschoorn UE, Tanowitz HB, Al-Zoubi MS, et al. Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle 2012; 11:2545 - 56; http://dx.doi.org/10.4161/cc.20920; PMID: 22722266
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Power surge: supporting cells “fuel” cancer cell mitochondria. Cell Metab 2012; 15:4 - 5; http://dx.doi.org/10.1016/j.cmet.2011.12.011; PMID: 22225869
   PubMed Web of Science ®Google Scholar
• Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol 2010; 30:1303 - 18; http://dx.doi.org/10.1128/MCB.01101-09; PMID: 20100866
   PubMed Web of Science ®Google Scholar
• Funes JM, Quintero M, Henderson S, Martinez D, Qureshi U, Westwood C, et al. Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci USA 2007; 104:6223 - 8; http://dx.doi.org/10.1073/pnas.0700690104; PMID: 17384149
   PubMed Web of Science ®Google Scholar
• Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 2006; 27:728 - 35; PMID: 17018837
   PubMed Web of Science ®Google Scholar
• Deblois G, Chahrour G, Perry MC, Sylvain-Drolet G, Muller WJ, Giguère V. Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis. Cancer Res 2010; 70:10277 - 87; http://dx.doi.org/10.1158/0008-5472.CAN-10-2840; PMID: 20961995
   PubMed Web of Science ®Google Scholar
• Shiota M, Yokomizo A, Tada Y, Inokuchi J, Tatsugami K, Kuroiwa K, et al. Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR. Mol Endocrinol 2010; 24:114 - 27; http://dx.doi.org/10.1210/me.2009-0302; PMID: 19884383
   PubMed Web of Science ®Google Scholar
• Chen SD, Yang DI, Lin TK, Shaw FZ, Liou CW, Chuang YC. Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia. Int J Mol Sci 2011; 12:7199 - 215; http://dx.doi.org/10.3390/ijms12107199; PMID: 22072942
   PubMed Web of Science ®Google Scholar
• St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006; 127:397 - 408; http://dx.doi.org/10.1016/j.cell.2006.09.024; PMID: 17055439
   PubMed Web of Science ®Google Scholar
• Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 2005; 54:8 - 14; http://dx.doi.org/10.2337/diabetes.54.1.8; PMID: 15616005
   PubMed Web of Science ®Google Scholar
• Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002; 51:2944 - 50; http://dx.doi.org/10.2337/diabetes.51.10.2944; PMID: 12351431
   PubMed Web of Science ®Google Scholar
• Rabøl R, Boushel R, Almdal T, Hansen CN, Ploug T, Haugaard SB, et al. Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes. Diabetes Obes Metab 2010; 12:806 - 14; http://dx.doi.org/10.1111/j.1463-1326.2010.01237.x; PMID: 20649633
   PubMed Web of Science ®Google Scholar
• Mensink M, Hesselink MK, Russell AP, Schaart G, Sels JP, Schrauwen P. Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus. Int J Obes (Lond) 2007; 31:1302 - 10; http://dx.doi.org/10.1038/sj.ijo.0803567; PMID: 17310221
   PubMed Web of Science ®Google Scholar
• Arnold JJ, Smidansky ED, Moustafa IM, Cameron CE. Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition. Biochim Biophys Acta 2012; 1819:948 - 60; http://dx.doi.org/10.1016/j.bbagrm.2012.04.002; PMID: 22551784
   PubMed Web of Science ®Google Scholar
• Fusté JM, Wanrooij S, Jemt E, Granycome CE, Cluett TJ, Shi Y, et al. Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. Mol Cell 2010; 37:67 - 78; http://dx.doi.org/10.1016/j.molcel.2009.12.021; PMID: 20129056
   PubMed Web of Science ®Google Scholar
• Li Z, Chen B, Wu Y, Jin F, Xia Y, Liu X. Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors. BMC Cancer 2010; 10:98; http://dx.doi.org/10.1186/1471-2407-10-98; PMID: 20230646
   PubMed Web of Science ®Google Scholar
• Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402:672 - 6; http://dx.doi.org/10.1038/45257; PMID: 10604474
   PubMed Web of Science ®Google Scholar
• Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100:15077 - 82; http://dx.doi.org/10.1073/pnas.2436255100; PMID: 14657337
   PubMed Web of Science ®Google Scholar
• Bonuccelli G, Casimiro MC, Sotgia F, Wang C, Liu M, Katiyar S, et al. Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature. Am J Pathol 2009; 174:1650 - 62; http://dx.doi.org/10.2353/ajpath.2009.080648; PMID: 19395651
   PubMed Web of Science ®Google Scholar