JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic

References

• Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, et al. Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol 2011; 31:95 - 107; PMID: 21321970
   PubMed Web of Science ®Google Scholar
• Bhattacharya P, Welch AH, Stollenwerk KG, McLaughlin MJ, Bundschuh J, Panaullah G. Arsenic in the environment: Biology and Chemistry. Sci Total Environ 2007; 379:109 - 20; http://dx.doi.org/10.1016/j.scitotenv.2007.02.037; PMID: 17434206
   PubMed Web of Science ®Google Scholar
• Nordstrom DK. Public health. Worldwide occurrences of arsenic in ground water. Science 2002; 296:2143 - 5; http://dx.doi.org/10.1126/science.1072375; PMID: 12077387
   PubMed Web of Science ®Google Scholar
• Gibb H, Haver C, Gaylor D, Ramasamy S, Lee JS, Lobdell D, et al. Utility of recent studies to assess the National Research Council 2001 estimates of cancer risk from ingested arsenic. Environ Health Perspect 2011; 119:284 - 90; http://dx.doi.org/10.1289/ehp.1002427; PMID: 21030336
   PubMed Web of Science ®Google Scholar
• Tokar EJ, Benbrahim-Tallaa L, Ward JM, Lunn R, Sams RL 2nd, Waalkes MP. Cancer in experimental animals exposed to arsenic and arsenic compounds. Crit Rev Toxicol 2010; 40:912 - 27; http://dx.doi.org/10.3109/10408444.2010.506641; PMID: 20812815
   PubMed Web of Science ®Google Scholar
• Qian Y, Castranova V, Shi X. New perspectives in arsenic-induced cell signal transduction. J Inorg Biochem 2003; 96:271 - 8; http://dx.doi.org/10.1016/S0162-0134(03)00235-6; PMID: 12888263
   PubMed Web of Science ®Google Scholar
• Zhang Y, Bhatia D, Xia H, Castranova V, Shi X, Chen F. Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA. Nucleic Acids Res 2006; 34:485 - 95; http://dx.doi.org/10.1093/nar/gkj459; PMID: 16421274
   PubMed Web of Science ®Google Scholar
• Wang Z, Yang J, Fisher T, Xiao H, Jiang Y, Yang C. Akt activation is responsible for enhanced migratory and invasive behavior of arsenic-transformed human bronchial epithelial cells. Environ Health Perspect 2012; 120:92 - 7; http://dx.doi.org/10.1289/ehp.1104061; PMID: 21954225
   PubMed Web of Science ®Google Scholar
• Beezhold K, Liu J, Kan H, Meighan T, Castranova V, Shi X, et al. miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis. Toxicol Sci 2011; 123:411 - 20; http://dx.doi.org/10.1093/toxsci/kfr188; PMID: 21750348
   PubMed Web of Science ®Google Scholar
• Liu J, Chen B, Lu Y, Guan Y, Chen F. JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure. Toxicol Sci 2012; 129:363 - 71; http://dx.doi.org/10.1093/toxsci/kfs199; PMID: 22696236
   PubMed Web of Science ®Google Scholar
• Chang CJ, Hung MC. The role of EZH2 in tumour progression. Br J Cancer 2012; 106:243 - 7; http://dx.doi.org/10.1038/bjc.2011.551; PMID: 22187039
   PubMed Web of Science ®Google Scholar
• Islam AB, Richter WF, Lopez-Bigas N, Benevolenskaya EV. Selective targeting of histone methylation. Cell Cycle 2011; 10:413 - 24; http://dx.doi.org/10.4161/cc.10.3.14705; PMID: 21270517
   PubMed Web of Science ®Google Scholar
• Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002; 419:624 - 9; http://dx.doi.org/10.1038/nature01075; PMID: 12374981
   PubMed Web of Science ®Google Scholar
• Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 2003; 100:11606 - 11; http://dx.doi.org/10.1073/pnas.1933744100; PMID: 14500907
   PubMed Web of Science ®Google Scholar
• Chang Q, Zhang Y, Beezhold KJ, Bhatia D, Zhao H, Chen J, et al. Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. J Hepatol 2009; 50:323 - 33; http://dx.doi.org/10.1016/j.jhep.2008.07.037; PMID: 19041150
   PubMed Web of Science ®Google Scholar
• Asangani IA, Harms PW, Dodson L, Pandhi M, Kunju LP, Maher CA, et al. Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma. Oncotarget 2012; 3:1011 - 25; PMID: 22948084
   PubMed Web of Science ®Google Scholar
• Koh CM, Iwata T, Zheng Q, Bethel C, Yegnasubramanian S, De Marzo AM. Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms. Oncotarget 2011; 2:669 - 83; PMID: 21941025
   PubMed Web of Science ®Google Scholar
• Hou P, Liu D, Dong J, Xing M. The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cells. Cell Cycle 2012; 11:286 - 95; http://dx.doi.org/10.4161/cc.11.2.18707; PMID: 22189819
   PubMed Web of Science ®Google Scholar
• Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev 2007; 21:49 - 54; http://dx.doi.org/10.1101/gad.1499407; PMID: 17210787
   PubMed Web of Science ®Google Scholar
• Gonzalez ME, DuPrie ML, Krueger H, Merajver SD, Ventura AC, Toy KA, et al. Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer. Cancer Res 2011; 71:2360 - 70; http://dx.doi.org/10.1158/0008-5472.CAN-10-1933; PMID: 21406404
   PubMed Web of Science ®Google Scholar
• Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, et al. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 2005; 310:306 - 10; http://dx.doi.org/10.1126/science.1118947; PMID: 16224021
   PubMed Web of Science ®Google Scholar
• Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol 2010; 24:993 - 1006; http://dx.doi.org/10.1210/me.2009-0438; PMID: 20351197
   PubMed Web of Science ®Google Scholar
• Chang Q, Pan J, Wang X, Zhang Z, Chen F, Shi X. Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells. Cancer Res 2010; 70:5127 - 35; http://dx.doi.org/10.1158/0008-5472.CAN-10-0007; PMID: 20516118
   PubMed Web of Science ®Google Scholar
• Chen F, Lu Y, Zhang Z, Vallyathan V, Ding M, Castranova V, et al. Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite. J Biol Chem 2001; 276:11414 - 9; http://dx.doi.org/10.1074/jbc.M011682200; PMID: 11150309
   PubMed Web of Science ®Google Scholar
• Bogoyevitch MA, Arthur PG. Inhibitors of c-Jun N-terminal kinases: JuNK no more?. Biochim Biophys Acta 2008; 1784:76 - 93; http://dx.doi.org/10.1016/j.bbapap.2007.09.013; PMID: 17964301
   PubMed Web of Science ®Google Scholar
• Fayard E, Xue G, Parcellier A, Bozulic L, Hemmings BA. Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway. Curr Top Microbiol Immunol 2010; 346:31 - 56; http://dx.doi.org/10.1007/82_2010_58; PMID: 20517722
   PubMed Web of Science ®Google Scholar
• Ke B, Shen XD, Ji H, Kamo N, Gao F, Freitas MC, et al. HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling. J Hepatol 2012; 56:359 - 66; http://dx.doi.org/10.1016/j.jhep.2011.05.023; PMID: 21756853
   PubMed Web of Science ®Google Scholar
• Blando JM, Carbajal S, Abel E, Beltran L, Conti C, Fischer S, et al. Cooperation between Stat3 and Akt signaling leads to prostate tumor development in transgenic mice. Neoplasia 2011; 13:254 - 65; PMID: 21390188
   PubMed Web of Science ®Google Scholar
• Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K. STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell 2010; 39:493 - 506; http://dx.doi.org/10.1016/j.molcel.2010.07.023; PMID: 20797623
   PubMed Web of Science ®Google Scholar
• Zhang Y, Liu G, Dong Z. MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells. J Biol Chem 2001; 276:42534 - 42; http://dx.doi.org/10.1074/jbc.M106044200; PMID: 11553624
   PubMed Web of Science ®Google Scholar
• He G, Karin M. NF-κB and STAT3 - key players in liver inflammation and cancer. Cell Res 2011; 21:159 - 68; http://dx.doi.org/10.1038/cr.2010.183; PMID: 21187858
   PubMed Web of Science ®Google Scholar
• Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008; 27:2128 - 36; http://dx.doi.org/10.1038/sj.onc.1210856; PMID: 17968323
   PubMed Web of Science ®Google Scholar
• Sayed D, Rane S, Lypowy J, He M, Chen IY, Vashistha H, et al. MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. Mol Biol Cell 2008; 19:3272 - 82; http://dx.doi.org/10.1091/mbc.E08-02-0159; PMID: 18508928
   PubMed Web of Science ®Google Scholar
• Lee SA, Ladu S, Evert M, Dombrowski F, De Murtas V, Chen X, et al. Synergistic role of Sprouty2 inactivation and c-Met up-regulation in mouse and human hepatocarcinogenesis. Hepatology 2010; 52:506 - 17; http://dx.doi.org/10.1002/hep.23681; PMID: 20683950
   PubMed Web of Science ®Google Scholar
• Chen F, Castranova V, Li Z, Karin M, Shi X. Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. Cancer Res 2003; 63:7689 - 93; PMID: 14633691
   PubMed Web of Science ®Google Scholar
• Chen F, Zhang Z, Bower J, Lu Y, Leonard SS, Ding M, et al. Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 2002; 99:1990 - 5; http://dx.doi.org/10.1073/pnas.032428899; PMID: 11842186
   PubMed Web of Science ®Google Scholar
• Zhang D, Li J, Gao J, Huang C. c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells. Toxicol Appl Pharmacol 2009; 235:18 - 24; http://dx.doi.org/10.1016/j.taap.2008.11.002; PMID: 19059425
   PubMed Web of Science ®Google Scholar
• Chen F. JNK-induced apoptosis, compensatory growth, and cancer stem cells. Cancer Res 2012; 72:379 - 86; http://dx.doi.org/10.1158/0008-5472.CAN-11-1982; PMID: 22253282
   PubMed Web of Science ®Google Scholar
• Suissa Y, Ziv O, Dinur T, Arama E, Gerlitz O. The NAB-Brk signal bifurcates at JNK to independently induce apoptosis and compensatory proliferation. J Biol Chem 2011; 286:15556 - 64; http://dx.doi.org/10.1074/jbc.M110.193235; PMID: 21385866
   PubMed Web of Science ®Google Scholar
• Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, et al. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci USA 2011; 108:6474 - 9; http://dx.doi.org/10.1073/pnas.1016132108; PMID: 21464307
   PubMed Web of Science ®Google Scholar
• Guo JP, Coppola D, Cheng JQ. IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation. J Biol Chem 2011; 286:37389 - 98; http://dx.doi.org/10.1074/jbc.M111.287433; PMID: 21908616
   PubMed Web of Science ®Google Scholar
• Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, et al. IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer. Oncogene 2012; In press http://dx.doi.org/10.1038/onc.2012.39; PMID: 22330135
   PubMed Web of Science ®Google Scholar
• Crea F. Histone code, human growth and cancer. Oncotarget 2012; 3:1 - 2; PMID: 22287500
   PubMed Web of Science ®Google Scholar
• Villasante A, Piazzolla D, Li H, Gomez-Lopez G, Djabali M, Serrano M. Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells. Cell Cycle 2011; 10:1488 - 98; http://dx.doi.org/10.4161/cc.10.9.15658; PMID: 21490431
   PubMed Web of Science ®Google Scholar
• Zeng X, Chen S, Huang H. Phosphorylation of EZH2 by CDK1 and CDK2: a possible regulatory mechanism of transmission of the H3K27me3 epigenetic mark through cell divisions. Cell Cycle 2011; 10:579 - 83; http://dx.doi.org/10.4161/cc.10.4.14722; PMID: 21278485
   PubMed Web of Science ®Google Scholar
• Wu SC, Zhang Y. Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability. J Biol Chem 2011; 286:28511 - 9; http://dx.doi.org/10.1074/jbc.M111.240515; PMID: 21659531
   PubMed Web of Science ®Google Scholar
• Kaneko S, Li G, Son J, Xu CF, Margueron R, Neubert TA, et al. Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev 2010; 24:2615 - 20; http://dx.doi.org/10.1101/gad.1983810; PMID: 21123648
   PubMed Web of Science ®Google Scholar
• Chen S, Bohrer LR, Rai AN, Pan Y, Gan L, Zhou X, et al. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nat Cell Biol 2010; 12:1108 - 14; http://dx.doi.org/10.1038/ncb2116; PMID: 20935635
   PubMed Web of Science ®Google Scholar
• Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, et al. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol 2011; 13:87 - 94; http://dx.doi.org/10.1038/ncb2139; PMID: 21131960
   PubMed Web of Science ®Google Scholar
• Marchesi I, Fiorentino FP, Rizzolio F, Giordano A, Bagella L. The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. Cell Cycle 2012; 11:3828 - 36; http://dx.doi.org/10.4161/cc.22025; PMID: 22983009
   PubMed Web of Science ®Google Scholar
• Chen F, Shi X. Intracellular signal transduction of cells in response to carcinogenic metals. Crit Rev Oncol Hematol 2002; 42:105 - 21; http://dx.doi.org/10.1016/S1040-8428(01)00211-6; PMID: 11923072
   PubMed Web of Science ®Google Scholar
• Su IH, Dobenecker MW, Dickinson E, Oser M, Basavaraj A, Marqueron R, et al. Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell 2005; 121:425 - 36; http://dx.doi.org/10.1016/j.cell.2005.02.029; PMID: 15882624
   PubMed Web of Science ®Google Scholar
• Hobert O, Jallal B, Ullrich A. Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol Cell Biol 1996; 16:3066 - 73; PMID: 8649418
   PubMed Web of Science ®Google Scholar