DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells

References

• Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008; 40:499 - 507; http://dx.doi.org/10.1038/ng.127; PMID: 18443585
   PubMed Web of Science ®Google Scholar
• Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005; 5:275 - 84; http://dx.doi.org/10.1038/nrc1590; PMID: 15803154
   PubMed Web of Science ®Google Scholar
• Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med 2006; 355:1253 - 61; http://dx.doi.org/10.1056/NEJMra061808; PMID: 16990388
   PubMed Web of Science ®Google Scholar
• Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414:105 - 11; http://dx.doi.org/10.1038/35102167; PMID: 11689955
   PubMed Web of Science ®Google Scholar
• Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005; 122:947 - 56; http://dx.doi.org/10.1016/j.cell.2005.08.020; PMID: 16153702
   PubMed Web of Science ®Google Scholar
• Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861 - 72; http://dx.doi.org/10.1016/j.cell.2007.11.019; PMID: 18035408
   PubMed Web of Science ®Google Scholar
• Huangfu DW, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 2008; 26:1269 - 75; http://dx.doi.org/10.1038/nbt.1502; PMID: 18849973
   PubMed Web of Science ®Google Scholar
• Ge N, Lin HX, Xiao XS, Guo L, Xu HM, Wang X, et al. Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma. J Transl Med 2010; 8:94; http://dx.doi.org/10.1186/1479-5876-8-94; PMID: 20937145
   PubMed Web of Science ®Google Scholar
• Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Ioue Y, et al. Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann Surg Oncol 2009; 16:3488 - 98; http://dx.doi.org/10.1245/s10434-009-0617-z; PMID: 19657699
   PubMed Web of Science ®Google Scholar
• Xiang R, Liao D, Cheng T, Zhou H, Shi Q, Chuang TS, et al. Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br J Cancer 2011; 104:1410 - 7; http://dx.doi.org/10.1038/bjc.2011.94; PMID: 21468047
   PubMed Web of Science ®Google Scholar
• Salmina K, Jankevics E, Huna A, Perminov D, Radovica I, Klymenko T, et al. Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells. Exp Cell Res 2010; 316:2099 - 112; http://dx.doi.org/10.1016/j.yexcr.2010.04.030; PMID: 20457152
   PubMed Web of Science ®Google Scholar
• Banito A, Rashid ST, Acosta JC, Li S, Pereira CF, Geti I, et al. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev 2009; 23:2134 - 9; http://dx.doi.org/10.1101/gad.1811609; PMID: 19696146
   PubMed Web of Science ®Google Scholar
• Huna A, Salmina K, Jascenko E, Duburs G, Inashkina I, Erenpreisa J. Self-Renewal signalling in presenescent tetraploid IMR90 cells. J Aging Res 2011; 2011:103253; http://dx.doi.org/10.4061/2011/103253; PMID: 21629737
   PubMedGoogle Scholar
• Blagosklonny MV. Cell senescence and hypermitogenic arrest. EMBO Rep 2003; 4:358 - 62; http://dx.doi.org/10.1038/sj.embor.embor806; PMID: 12671679
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany NY) 2010; 2:924 - 35; PMID: 21212465
   PubMedGoogle Scholar
• Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV. Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci USA 2010; 107:9660 - 4; http://dx.doi.org/10.1073/pnas.1002298107; PMID: 20457898
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Cell cycle arrest is not senescence. Aging (Albany NY) 2011; 3:94 - 101; PMID: 21297220
   PubMedGoogle Scholar
• Boheler KR. Stem cell pluripotency: a cellular trait that depends on transcription factors, chromatin state and a checkpoint deficient cell cycle. J Cell Physiol 2009; 221:10 - 7; http://dx.doi.org/10.1002/jcp.21866; PMID: 19562686
   PubMed Web of Science ®Google Scholar
• Rich JN. Cancer stem cells in radiation resistance. Cancer Res 2007; 67:8980 - 4; http://dx.doi.org/10.1158/0008-5472.CAN-07-0895; PMID: 17908997
   PubMed Web of Science ®Google Scholar
• Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, et al. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci USA 2003; 100:13350 - 5; http://dx.doi.org/10.1073/pnas.2235735100; PMID: 14595015
   PubMed Web of Science ®Google Scholar
• Josephson R, Ording CJ, Liu Y, Shin S, Lakshmipathy U, Toumadje A, et al. Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research. Stem Cells 2007; 25:437 - 46; http://dx.doi.org/10.1634/stemcells.2006-0236; PMID: 17284651
   PubMed Web of Science ®Google Scholar
• te Poele RH, Okorokov AL, Jardine L, Cummings J, Joel SP. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 2002; 62:1876 - 83; PMID: 11912168
   PubMed Web of Science ®Google Scholar
• Sabisz M, Skladanowski A. Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models. Cell Cycle 2009; 8:3208 - 17; http://dx.doi.org/10.4161/cc.8.19.9758; PMID: 19738435
   PubMed Web of Science ®Google Scholar
• Lifantseva N, Koltsova A, Krylova T, Yakovleva T, Poljanskaya G, Gordeeva O. Expression patterns of cancer-testis antigens in human embryonic stem cells and their cell derivatives indicate lineage tracks. Stem Cells Int 2011; 2011:795239; http://dx.doi.org/10.4061/2011/795239; PMID: 21785609
   PubMed Web of Science ®Google Scholar
• Sarraf S, Tejada R, Abawi M, Oberst M, Dennis T, Simon KC, et al. The human ovarian teratocarcinoma cell line PA-1 demonstrates a single translocation: analysis with fluorescence in situ hybridization, spectral karyotyping, and bacterial artificial chromosome microarray. Cancer Genet Cytogenet 2005; 161:63 - 9; http://dx.doi.org/10.1016/j.cancergencyto.2005.01.003; PMID: 16080959
   PubMed Web of Science ®Google Scholar
• Gao C, Miyazaki M, Li JW, Tsuji T, Inoue Y, Namba M. Cytogenetic characteristics and p53 gene status of human teratocarcinoma PA-1 cells in 407-445 passages. Int J Mol Med 1999; 4:597 - 600; PMID: 10567668
   PubMed Web of Science ®Google Scholar
• Zhang XN, Jaramillo M, Singh S, Kumta P, Banerjee I. Analysis of regulatory network involved in mechanical induction of embryonic stem cell differentiation. PLoS One 2012; 7:e35700; http://dx.doi.org/10.1371/journal.pone.0035700; PMID: 22558203
   PubMed Web of Science ®Google Scholar
• Chiodi I, Mondello C. Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. Front Oncol 2012; 2:133; http://dx.doi.org/10.3389/fonc.2012.00133; PMID: 23061047
   PubMedGoogle Scholar
• Erenpreisa J, Salmina K, Huna A, Kosmacek EA, Cragg MS, Ianzini F, et al. Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation. Cell Biol Int 2011; 35:687 - 95; http://dx.doi.org/10.1042/CBI20100762; PMID: 21250945
   PubMed Web of Science ®Google Scholar
• Atlasi Y, Mowla SJ, Ziaee SAM, Gokhale PJ, Andrews PW. OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells. Stem Cells 2008; 26:3068 - 74; http://dx.doi.org/10.1634/stemcells.2008-0530; PMID: 18787205
   PubMed Web of Science ®Google Scholar
• Asadi MH, Mowla SJ, Fathi F, Aleyasin A, Asadzadeh J, Atlasi Y. OCT4B1, a novel spliced variant of OCT4, is highly expressed in gastric cancer and acts as an antiapoptotic factor. Int J Cancer 2011; 128:2645 - 52; http://dx.doi.org/10.1002/ijc.25643; PMID: 20824712
   PubMed Web of Science ®Google Scholar
• Singh AM, Hamazaki T, Hankowski KE, Terada N. A heterogeneous expression pattern for NANOG in embryonic stem cells. Stem Cells 2007; 25:2534 - 42; http://dx.doi.org/10.1634/stemcells.2007-0126; PMID: 17615266
   PubMed Web of Science ®Google Scholar
• Kalmar T, Lim C, Hayward P, Muñoz-Descalzo S, Nichols J, Garcia-Ojalvo J, et al. Regulated fluctuations in NANOG expression mediate cell fate decisions in embryonic stem cells. PLoS Biol 2009; 7:e1000149; http://dx.doi.org/10.1371/journal.pbio.1000149; PMID: 19582141
   PubMed Web of Science ®Google Scholar
• Chambers I, Silva J, Colby D, Nichols J, Nijmeijer B, Robertson M, et al. Nanog safeguards pluripotency and mediates germline development. Nature 2007; 450:1230 - 4; http://dx.doi.org/10.1038/nature06403; PMID: 18097409
   PubMed Web of Science ®Google Scholar
• Lev Bar-Or R, Maya R, Segel LA, Alon U, Levine AJ, Oren M. Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci USA 2000; 97:11250 - 5; http://dx.doi.org/10.1073/pnas.210171597; PMID: 11016968
   PubMed Web of Science ®Google Scholar
• Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, et al. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet 2004; 36:147 - 50; http://dx.doi.org/10.1038/ng1293; PMID: 14730303
   PubMed Web of Science ®Google Scholar
• Weaver BAA, Cleveland DW. Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell 2005; 8:7 - 12; http://dx.doi.org/10.1016/j.ccr.2005.06.011; PMID: 16023594
   PubMed Web of Science ®Google Scholar
• Levasseur DN, Wang J, Dorschner MO, Stamatoyannopoulos JA, Orkin SH. Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes Dev 2008; 22:575 - 80; http://dx.doi.org/10.1101/gad.1606308; PMID: 18283123
   PubMed Web of Science ®Google Scholar
• Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E, et al. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 2005; 7:165 - 71; http://dx.doi.org/10.1038/ncb1211; PMID: 15619621
   PubMed Web of Science ®Google Scholar
• Huang S. Non-genetic heterogeneity of cells in development: more than just noise. Development 2009; 136:3853 - 62; http://dx.doi.org/10.1242/dev.035139; PMID: 19906852
   PubMed Web of Science ®Google Scholar
• Godar S, Ince TA, Bell GW, Feldser D, Donaher JL, Bergh J, et al. Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell 2008; 134:62 - 73; http://dx.doi.org/10.1016/j.cell.2008.06.006; PMID: 18614011
   PubMed Web of Science ®Google Scholar
• Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 2003; 9:493 - 501; http://dx.doi.org/10.1261/rna.2192803; PMID: 12649500
   PubMed Web of Science ®Google Scholar
• Zhao SD, Yuan QH, Hao HB, Guo YJ, Liu SM, Zhang YM, et al. Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma. J Pathol 2011; 223:672 - 82; http://dx.doi.org/10.1002/path.2827; PMID: 21341266
   PubMed Web of Science ®Google Scholar
• Erenpreisa J, Cragg MS, Salmina K, Hausmann M, Scherthan H. The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells. Exp Cell Res 2009; 315:2593 - 603; http://dx.doi.org/10.1016/j.yexcr.2009.05.011; PMID: 19463812
   PubMed Web of Science ®Google Scholar