Pharmacological blockade of a β₂AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model

References

• Selye H. A Syndrome Produced by Diverse Nocuous Agents. Nature 1936; 138:32; http://dx.doi.org/10.1038/138032a0
   Web of Science ®Google Scholar
• Charmandari E, Tsigos C, Chrousos G. Endocrinology of the stress response. Annu Rev Physiol 2005; 67:259 - 84; http://dx.doi.org/10.1146/annurev.physiol.67.040403.120816; PMID: 15709959
   PubMed Web of Science ®Google Scholar
• Norton MC, Smith KR, Østbye T, Tschanz JT, Schwartz S, Corcoran C, et al, Cache County Investigators. Early parental death and remarriage of widowed parents as risk factors for Alzheimer disease: the Cache County study. Am J Geriatr Psychiatry 2011; 19:814 - 24; http://dx.doi.org/10.1097/JGP.0b013e3182011b38; PMID: 21873837
   PubMed Web of Science ®Google Scholar
• Pouwer F, Kupper N, Adriaanse MC. Does emotional stress cause type 2 diabetes mellitus? A review from the European Depression in Diabetes (EDID) Research Consortium. Discov Med 2010; 9:112 - 8; PMID: 20193636
   PubMed Web of Science ®Google Scholar
• Figueredo VM. The time has come for physicians to take notice: the impact of psychosocial stressors on the heart. Am J Med 2009; 122:704 - 12; http://dx.doi.org/10.1016/j.amjmed.2009.05.001; PMID: 19635269
   PubMed Web of Science ®Google Scholar
• Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, et al. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 2006; 6:240 - 8; http://dx.doi.org/10.1038/nrc1820; PMID: 16498446
   PubMed Web of Science ®Google Scholar
• Wohleb ES, Hanke ML, Corona AW, Powell ND, Stiner LM, Bailey MT, et al. β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J Neurosci 2011; 31:6277 - 88; http://dx.doi.org/10.1523/JNEUROSCI.0450-11.2011; PMID: 21525267
   PubMed Web of Science ®Google Scholar
• Vaiva G, Ducrocq F, Jezequel K, Averland B, Lestavel P, Brunet A, et al. Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biol Psychiatry 2003; 54:947 - 9; http://dx.doi.org/10.1016/S0006-3223(03)00412-8; PMID: 14573324
   PubMed Web of Science ®Google Scholar
• Cerione RA, Strulovici B, Benovic JL, Lefkowitz RJ, Caron MG. Pure beta-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase. Nature 1983; 306:562 - 6; http://dx.doi.org/10.1038/306562a0; PMID: 6316161
   PubMed Web of Science ®Google Scholar
• Dixon RA, Kobilka BK, Strader DJ, Benovic JL, Dohlman HG, Frielle T, et al. Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature 1986; 321:75 - 9; http://dx.doi.org/10.1038/321075a0; PMID: 3010132
   PubMed Web of Science ®Google Scholar
• Lefkowitz RJ. Seven transmembrane receptors: something old, something new. Acta Physiol (Oxf) 2007; 190:9 - 19; http://dx.doi.org/10.1111/j.1365-201X.2007.01693.x; PMID: 17428228
   PubMed Web of Science ®Google Scholar
• Rainbow TC, Parsons B, Wolfe BB. Quantitative autoradiography of beta 1- and beta 2-adrenergic receptors in rat brain. Proc Natl Acad Sci USA 1984; 81:1585 - 9; http://dx.doi.org/10.1073/pnas.81.5.1585; PMID: 6324206
   PubMed Web of Science ®Google Scholar
• Regard JB, Sato IT, Coughlin SR. Anatomical profiling of G protein-coupled receptor expression. Cell 2008; 135:561 - 71; http://dx.doi.org/10.1016/j.cell.2008.08.040; PMID: 18984166
   PubMed Web of Science ®Google Scholar
• Arnold A, McAuliff JP, Colella DF, O’Connor WV, Brown TG Jr.. The beta-2 receptor mediated glycogenolytic responses to catecholamines in the dog. Arch Int Pharmacodyn Ther 1968; 176:451 - 7; PMID: 5718970
   PubMedGoogle Scholar
• Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG Jr.. Differentiation of receptor systems activated by sympathomimetic amines. Nature 1967; 214:597 - 8; http://dx.doi.org/10.1038/214597a0; PMID: 6036174
   PubMed Web of Science ®Google Scholar
• Mukherjee C, Caron MG, Coverstone M, Lefkowitz RJ. Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. J Biol Chem 1975; 250:4869 - 76; PMID: 238972
   PubMed Web of Science ®Google Scholar
• Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci USA 1986; 83:2797 - 801; http://dx.doi.org/10.1073/pnas.83.9.2797; PMID: 2871555
   PubMed Web of Science ®Google Scholar
• Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science 1990; 248:1547 - 50; http://dx.doi.org/10.1126/science.2163110; PMID: 2163110
   PubMed Web of Science ®Google Scholar
• Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 1999; 283:655 - 61; http://dx.doi.org/10.1126/science.283.5402.655; PMID: 9924018
   PubMed Web of Science ®Google Scholar
• Reiter E, Ahn S, Shukla AK, Lefkowitz RJ. Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol 2012; 52:179 - 97; http://dx.doi.org/10.1146/annurev.pharmtox.010909.105800; PMID: 21942629
   PubMed Web of Science ®Google Scholar
• Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 2001; 294:1307 - 13; http://dx.doi.org/10.1126/science.1063866; PMID: 11588219
   PubMed Web of Science ®Google Scholar
• Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, et al. A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature 2011; 477:349 - 53; http://dx.doi.org/10.1038/nature10368; PMID: 21857681
   PubMed Web of Science ®Google Scholar
• Moniri NH, Daaka Y. Agonist-stimulated reactive oxygen species formation regulates beta2-adrenergic receptor signal transduction. Biochem Pharmacol 2007; 74:64 - 73; http://dx.doi.org/10.1016/j.bcp.2007.03.016; PMID: 17451656
   PubMed Web of Science ®Google Scholar
• Yan L, Vatner DE, O’Connor JP, Ivessa A, Ge H, Chen W, et al. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 2007; 130:247 - 58; http://dx.doi.org/10.1016/j.cell.2007.05.038; PMID: 17662940
   PubMed Web of Science ®Google Scholar
• Yamauchi N, Shibasaki T, Wakabayashi I, Demura H. Brain beta-endorphin and other opioids are involved in restraint stress-induced stimulation of the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system, and the adrenal medulla in the rat. Brain Res 1997; 777:140 - 6; PMID: 9449422
   PubMed Web of Science ®Google Scholar
• Arnsten AF. Stress signalling pathways that impair prefrontal cortex structure and function. Nat Rev Neurosci 2009; 10:410 - 22; http://dx.doi.org/10.1038/nrn2648; PMID: 19455173
   PubMed Web of Science ®Google Scholar
• Cahill L, Prins B, Weber M, McGaugh JL. Beta-adrenergic activation and memory for emotional events. Nature 1994; 371:702 - 4; http://dx.doi.org/10.1038/371702a0; PMID: 7935815
   PubMed Web of Science ®Google Scholar
• Feng Z, Liu L, Zhang C, Zheng T, Wang J, Lin M, et al. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci USA 2012; 109:7013 - 8; http://dx.doi.org/10.1073/pnas.1203930109; PMID: 22509031
   PubMed Web of Science ®Google Scholar
• Hu W, Feng Z, Levine AJ. The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer 2012; 3:199 - 208; http://dx.doi.org/10.1177/1947601912454734; PMID: 23150753
   PubMedGoogle Scholar
• Rajagopal S, Rajagopal K, Lefkowitz RJ. Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov 2010; 9:373 - 86; http://dx.doi.org/10.1038/nrd3024; PMID: 20431569
   PubMed Web of Science ®Google Scholar
• Perron L, Bairati I, Harel F, Meyer F. Antihypertensive drug use and the risk of prostate cancer (Canada). Cancer Causes Control 2004; 15:535 - 41; http://dx.doi.org/10.1023/B:CACO.0000036152.58271.5e; PMID: 15280632
   PubMed Web of Science ®Google Scholar
• Powe DG, Entschladen F. Targeted therapies: Using β-blockers to inhibit breast cancer progression. Nat Rev Clin Oncol 2011; 8:511 - 2; http://dx.doi.org/10.1038/nrclinonc.2011.123; PMID: 21808268
   PubMed Web of Science ®Google Scholar
• Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taïeb A. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008; 358:2649 - 51; http://dx.doi.org/10.1056/NEJMc0708819; PMID: 18550886
   PubMed Web of Science ®Google Scholar
• Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 2006; 12:939 - 44; http://dx.doi.org/10.1038/nm1447; PMID: 16862152
   PubMed Web of Science ®Google Scholar
• Han RQ, Ouyang YB, Xu L, Agrawal R, Patterson AJ, Giffard RG. Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor. Anesth Analg 2009; 108:280 - 7; http://dx.doi.org/10.1213/ane.0b013e318187ba6b; PMID: 19095863
   PubMed Web of Science ®Google Scholar
• Sood R, Ritov G, Richter-Levin G, Barki-Harrington L. Selective increase in the association of the β2 adrenergic receptor, β Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma. Behav Brain Res 2012; 240C:26 - 8; PMID: 23174211
   PubMed Web of Science ®Google Scholar
• Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, et al. Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J Biol Chem 2003; 278:6363 - 70; http://dx.doi.org/10.1074/jbc.M210350200; PMID: 12488444
   PubMed Web of Science ®Google Scholar
• Boularan C, Scott MG, Bourougaa K, Bellal M, Esteve E, Thuret A, et al. beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53. Proc Natl Acad Sci USA 2007; 104:18061 - 6; http://dx.doi.org/10.1073/pnas.0705550104; PMID: 17984062
   PubMed Web of Science ®Google Scholar
• Ahn S, Wei H, Garrison TR, Lefkowitz RJ. Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. J Biol Chem 2004; 279:7807 - 11; http://dx.doi.org/10.1074/jbc.C300443200; PMID: 14711824
   PubMed Web of Science ®Google Scholar
• Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ. Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell 2009; 17:443 - 58; http://dx.doi.org/10.1016/j.devcel.2009.09.011; PMID: 19853559
   PubMed Web of Science ®Google Scholar
• Beaulieu JM, Caron MG. Beta-arrestin goes nuclear. Cell 2005; 123:755 - 7; http://dx.doi.org/10.1016/j.cell.2005.11.010; PMID: 16325568
   PubMed Web of Science ®Google Scholar
• Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, et al. A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 2005; 123:833 - 47; http://dx.doi.org/10.1016/j.cell.2005.09.011; PMID: 16325578
   PubMed Web of Science ®Google Scholar
• Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, et al. Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol 2007; 8:817 - 24; http://dx.doi.org/10.1038/ni1489; PMID: 17618287
   PubMed Web of Science ®Google Scholar
• Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, et al. Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell 2009; 139:535 - 46; http://dx.doi.org/10.1016/j.cell.2009.08.038; PMID: 19879840
   PubMed Web of Science ®Google Scholar
• Levine AJ, Oren M. The first 30 years of p53: growing ever more complex. Nat Rev Cancer 2009; 9:749 - 58; http://dx.doi.org/10.1038/nrc2723; PMID: 19776744
   PubMed Web of Science ®Google Scholar
• Sengupta S, Harris CC. p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol 2005; 6:44 - 55; http://dx.doi.org/10.1038/nrm1546; PMID: 15688066
   PubMed Web of Science ®Google Scholar
• Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001; 7:673 - 82; http://dx.doi.org/10.1016/S1097-2765(01)00213-1; PMID: 11463391
   PubMed Web of Science ®Google Scholar
• Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7:683 - 94; http://dx.doi.org/10.1016/S1097-2765(01)00214-3; PMID: 11463392
   PubMed Web of Science ®Google Scholar
• Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006; 126:107 - 20; http://dx.doi.org/10.1016/j.cell.2006.05.036; PMID: 16839880
   PubMed Web of Science ®Google Scholar
• Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, et al. p53 regulates mitochondrial respiration. Science 2006; 312:1650 - 3; http://dx.doi.org/10.1126/science.1126863; PMID: 16728594
   PubMed Web of Science ®Google Scholar
• Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF. Abnormal centrosome amplification in the absence of p53. Science 1996; 271:1744 - 7; http://dx.doi.org/10.1126/science.271.5256.1744; PMID: 8596939
   PubMed Web of Science ®Google Scholar
• Hu W, Feng Z, Teresky AK, Levine AJ. p53 regulates maternal reproduction through LIF. Nature 2007; 450:721 - 4; http://dx.doi.org/10.1038/nature05993; PMID: 18046411
   PubMed Web of Science ®Google Scholar
• Suh EK, Yang A, Kettenbach A, Bamberger C, Michaelis AH, Zhu Z, et al. p63 protects the female germ line during meiotic arrest. Nature 2006; 444:624 - 8; http://dx.doi.org/10.1038/nature05337; PMID: 17122775
   PubMed Web of Science ®Google Scholar
• Kruse JP, Gu W. Modes of p53 regulation. Cell 2009; 137:609 - 22; http://dx.doi.org/10.1016/j.cell.2009.04.050; PMID: 19450511
   PubMed Web of Science ®Google Scholar
• Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, et al. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell 1998; 2:405 - 15; http://dx.doi.org/10.1016/S1097-2765(00)80140-9; PMID: 9809062
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998; 92:725 - 34; http://dx.doi.org/10.1016/S0092-8674(00)81401-4; PMID: 9529249
   PubMed Web of Science ®Google Scholar
• Pomerantz J, Schreiber-Agus N, Liégeois NJ, Silverman A, Alland L, Chin L, et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53. Cell 1998; 92:713 - 23; http://dx.doi.org/10.1016/S0092-8674(00)81400-2; PMID: 9529248
   PubMed Web of Science ®Google Scholar
• Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, et al. beta-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem 2005; 280:24412 - 9; http://dx.doi.org/10.1074/jbc.M501129200; PMID: 15878855
   PubMed Web of Science ®Google Scholar
• Salcedo A, Mayor F Jr., Penela P. Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J 2006; 25:4752 - 62; http://dx.doi.org/10.1038/sj.emboj.7601351; PMID: 17006543
   PubMed Web of Science ®Google Scholar
• Lakshmikanthan V, Zou L, Kim JI, Michal A, Nie Z, Messias NC, et al. Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer. Proc Natl Acad Sci USA 2009; 106:9379 - 84; http://dx.doi.org/10.1073/pnas.0900258106; PMID: 19458261
   PubMed Web of Science ®Google Scholar
• Lin CH, MacGurn JA, Chu T, Stefan CJ, Emr SD. Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell 2008; 135:714 - 25; http://dx.doi.org/10.1016/j.cell.2008.09.025; PMID: 18976803
   PubMed Web of Science ®Google Scholar
• Conner DA, Mathier MA, Mortensen RM, Christe M, Vatner SF, Seidman CE, et al. beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation. Circ Res 1997; 81:1021 - 6; http://dx.doi.org/10.1161/01.RES.81.6.1021; PMID: 9400383
   PubMed Web of Science ®Google Scholar
• Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, et al. GammaH2AX and cancer. Nat Rev Cancer 2008; 8:957 - 67; http://dx.doi.org/10.1038/nrc2523; PMID: 19005492
   PubMed Web of Science ®Google Scholar