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Rapamycin regulates biochemical metabolites

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Pages 2454-2467 | Received 07 May 2013, Accepted 18 Jun 2013, Published online: 28 Jun 2013

References

  • Markert EK, Levine AJ, Vazquez A. Proliferation and tissue remodeling in cancer: the hallmarks revisited. Cell Death Dis 2012; 3:e397; http://dx.doi.org/10.1038/cddis.2012.140; PMID: 23034332
  • Lyssiotis CA, Vander-Heiden MG, Muñoz-Pinedo C, Emerling BM. Emerging concepts: linking hypoxic signaling and cancer metabolism. Cell Death Dis 2012; 3:e303; http://dx.doi.org/10.1038/cddis.2012.41; PMID: 22552280
  • Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004; 6:91 - 9; http://dx.doi.org/10.1016/j.ccr.2004.06.007; PMID: 15261145
  • Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37:19 - 24; http://dx.doi.org/10.1038/ng1494; PMID: 15624019
  • Inoki K, Guan KL. Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet 2009; 18:R1 R94 - 100; http://dx.doi.org/10.1093/hmg/ddp032; PMID: 19297407
  • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 2006; 6:729 - 34; http://dx.doi.org/10.1038/nrc1974; PMID: 16915295
  • Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 2012; 485:109 - 13; http://dx.doi.org/10.1038/nature11083; PMID: 22552098
  • Shahbazian D, Parsyan A, Petroulakis E, Topisirovic I, Martineau Y, Gibbs BF, et al. Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B. Mol Cell Biol 2010; 30:1478 - 85; http://dx.doi.org/10.1128/MCB.01218-09; PMID: 20086100
  • Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012; 19:107 - 20; http://dx.doi.org/10.1038/cdd.2011.96; PMID: 21760595
  • Vandenabeele P, Melino G. The flick of a switch: which death program to choose?. Cell Death Differ 2012; 19:1093 - 5; http://dx.doi.org/10.1038/cdd.2012.65; PMID: 22684093
  • Marcel V, Dichtel-Danjoy ML, Sagne C, Hafsi H, Ma D, Ortiz-Cuaran S, et al. Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ 2011; 18:1815 - 24; http://dx.doi.org/10.1038/cdd.2011.120; PMID: 21941372
  • Marcel V, Petit I, Murray-Zmijewski F, Goullet de Rugy T, Fernandes K, Meuray V, et al. Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity. Cell Death Differ 2012; 19:816 - 26; http://dx.doi.org/10.1038/cdd.2011.152; PMID: 22075982
  • Nayak G, Cooper GM. p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling. Cell Death Dis 2012; 3:e400; http://dx.doi.org/10.1038/cddis.2012.138; PMID: 23059819
  • Rufini A, Tucci P, Celardo I, Melino G. Senescence and aging: the critical roles of p53. Oncogene 2013; http://dx.doi.org/10.1038/onc.2012.640; PMID: 23416979
  • Tucci P. Caloric restriction: is mammalian life extension linked to p53?. Aging (Albany NY) 2012; 4:525 - 34; PMID: 22983298
  • Melino G. Journal club. A cancer biologist weighs up p53, metabolism and cancer. Nature 2010; 466:905; http://dx.doi.org/10.1038/466905d; PMID: 20725003
  • Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ 2011; 18:1487 - 99; http://dx.doi.org/10.1038/cdd.2011.81; PMID: 21760596
  • Shalom-Feuerstein R, Lena AM, Zhou H, De La Forest Divonne S, Van Bokhoven H, Candi E, et al. ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ 2011; 18:887 - 96; http://dx.doi.org/10.1038/cdd.2010.159; PMID: 21127502
  • Ben-Sahra I, Dirat B, Laurent K, Puissant A, Auberger P, Budanov A, et al. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death Differ 2013; 20:611 - 9; http://dx.doi.org/10.1038/cdd.2012.157; PMID: 23238567
  • Salah Z, Bar-mag T, Kohn Y, Pichiorri F, Palumbo T, Melino G, et al. Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy. Cell Death Dis 2013; 4:e480; http://dx.doi.org/10.1038/cddis.2013.6; PMID: 23370280
  • Leonard MK, Kommagani R, Payal V, Mayo LD, Shamma HN, Kadakia MP. ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ 2011; 18:1924 - 33; http://dx.doi.org/10.1038/cdd.2011.73; PMID: 21637289
  • Levine AJ, Tomasini R, McKeon FD, Mak TW, Melino G. The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol 2011; 12:259 - 65; http://dx.doi.org/10.1038/nrm3086; PMID: 21427767
  • Tomasini R, Mak TW, Melino G. The impact of p53 and p73 on aneuploidy and cancer. Trends Cell Biol 2008; 18:244 - 52; http://dx.doi.org/10.1016/j.tcb.2008.03.003; PMID: 18406616
  • Notari M, Hu Y, Koch S, Lu M, Ratnayaka I, Zhong S, et al. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification. Proc Natl Acad Sci U S A 2011; 108:16645 - 50; http://dx.doi.org/10.1073/pnas.1102292108; PMID: 21930934
  • Candi E, Rufini A, Terrinoni A, Giamboi-Miraglia A, Lena AM, Mantovani R, et al. DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A 2007; 104:11999 - 2004; http://dx.doi.org/10.1073/pnas.0703458104; PMID: 17626181
  • Rivetti di Val Cervo P, Lena AM, Nicoloso M, Rossi S, Mancini M, Zhou H, et al. p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A 2012; 109:1133 - 8; http://dx.doi.org/10.1073/pnas.1112257109; PMID: 22228303
  • Tucci P, Agostini M, Grespi F, Markert EK, Terrinoni A, Vousden KH, et al. Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A 2012; 109:15312 - 7; http://dx.doi.org/10.1073/pnas.1110977109; PMID: 22949650
  • Müller M, Schilling T, Sayan AE, Kairat A, Lorenz K, Schulze-Bergkamen H, et al. TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death Differ 2005; 12:1564 - 77; http://dx.doi.org/10.1038/sj.cdd.4401774; PMID: 16195739
  • Wang J, Liu YX, Hande MP, Wong AC, Jin YJ, Yin Y. TAp73 is a downstream target of p53 in controlling the cellular defense against stress. J Biol Chem 2007; 282:29152 - 62; http://dx.doi.org/10.1074/jbc.M703408200; PMID: 17693405
  • Grob TJ, Novak U, Maisse C, Barcaroli D, Lüthi AU, Pirnia F, et al. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ 2001; 8:1213 - 23; http://dx.doi.org/10.1038/sj.cdd.4400962; PMID: 11753569
  • Gong JG, Costanzo A, Yang HQ, Melino G, Kaelin WG Jr., Levrero M, et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 1999; 399:806 - 9; http://dx.doi.org/10.1038/21690; PMID: 10391249
  • Rossi M, De Laurenzi V, Munarriz E, Green DR, Liu Y-C, Vousden KH, et al. The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 2005; 24:836 - 48; http://dx.doi.org/10.1038/sj.emboj.7600444; PMID: 15678106
  • Rossi M, Aqeilan RI, Neale M, Candi E, Salomoni P, Knight RA, et al. The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A 2006; 103:12753 - 8; http://dx.doi.org/10.1073/pnas.0603449103; PMID: 16908849
  • Peschiaroli A, Scialpi F, Bernassola F, Pagano M, Melino G. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene 2009; 28:3157 - 66; http://dx.doi.org/10.1038/onc.2009.177; PMID: 19581926
  • Dulloo I, Gopolan G, Melino G, Sabapathy S. The DeltaNp73 oncogene is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway. Proc Natl Acad Sci USA 2010; 107:4902 - 7; http://dx.doi.org/10.1073/pnas.0906782107; PMID: 20185758
  • Sayan BS, Yang AL, Conforti F, Tucci P, Piro MC, Browne GJ, et al. Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proc Natl Acad Sci U S A 2010; 107:12877 - 82; http://dx.doi.org/10.1073/pnas.0911828107; PMID: 20615966
  • Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC, et al. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 2008; 22:2677 - 91; http://dx.doi.org/10.1101/gad.1695308; PMID: 18805989
  • Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, et al. TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev 2012; 26:2009 - 14; http://dx.doi.org/10.1101/gad.197640.112; PMID: 22987635
  • Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev 2010; 24:549 - 60; http://dx.doi.org/10.1101/gad.1873910; PMID: 20194434
  • Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, et al. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 2000; 404:99 - 103; http://dx.doi.org/10.1038/35003607; PMID: 10716451
  • Pozniak CD, Radinovic S, Yang A, McKeon F, Kaplan DR, Miller FD. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 2000; 289:304 - 6; http://dx.doi.org/10.1126/science.289.5477.304; PMID: 10894779
  • Billon N, Terrinoni A, Jolicoeur C, McCarthy A, Richardson WD, Melino G, et al. Roles for p53 and p73 during oligodendrocyte development. Development 2004; 131:1211 - 20; http://dx.doi.org/10.1242/dev.01035; PMID: 14960496
  • Agostini M, Tucci P, Killick R, Candi E, Sayan BS, Rivetti di Val Cervo P, et al. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A 2011; 108:21093 - 8; http://dx.doi.org/10.1073/pnas.1112061109; PMID: 22160687
  • Agostini M, Tucci P, Steinert JR, Shalom-Feuerstein R, Rouleau M, Aberdam D, et al. microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A 2011; 108:21099 - 104; http://dx.doi.org/10.1073/pnas.1112063108; PMID: 22160706
  • Tomasini R, Tsuchihara K, Tsuda C, Lau SK, Wilhelm M, Ruffini A, et al. TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A 2009; 106:797 - 802; http://dx.doi.org/10.1073/pnas.0812096106; PMID: 19139399
  • Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004; 4:335 - 48; http://dx.doi.org/10.1038/nrc1362; PMID: 15122205
  • Tucci P, Porta G, Agostini M, Dinsdale D, Iavicoli I, Cain K, et al. Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes. Cell Death Dis 2013; 4e:549; http://dx.doi.org/10.1038/cddis.2013.76; PMID: 23519118
  • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471 - 84; http://dx.doi.org/10.1016/j.cell.2006.01.016; PMID: 16469695
  • Hands SL, Proud CG, Wyttenbach A. mTOR’s role in ageing: protein synthesis or autophagy?. Aging (Albany NY) 2009; 1:586 - 97; PMID: 20157541
  • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27 - 42; http://dx.doi.org/10.1016/j.cell.2007.12.018; PMID: 18191218
  • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069 - 75; http://dx.doi.org/10.1038/nature06639; PMID: 18305538
  • Newbold A, Vervoort SJ, Martin BP, Bots M, Johnstone RW. Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors. Cell Death Dis 2012; 3:e387; http://dx.doi.org/10.1038/cddis.2012.128; PMID: 22951984
  • Melino G, Knight RA, Nicotera P. How many ways to die? How many different models of cell death?. Cell Death Differ 2005; 12:Suppl 2 1457 - 62; http://dx.doi.org/10.1038/sj.cdd.4401781; PMID: 16247490
  • Rosenbluth JM, Mays DJ, Pino MF, Tang LJ, Pietenpol JA. A gene signature-based approach identifies mTOR as a regulator of p73. Mol Cell Biol 2008; 28:5951 - 64; http://dx.doi.org/10.1128/MCB.00305-08; PMID: 18678646
  • Rosenbluth JM, Mays DJ, Jiang A, Shyr Y, Pietenpol JA. Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis. Proc Natl Acad Sci U S A 2011; 108:2076 - 81; http://dx.doi.org/10.1073/pnas.1011936108; PMID: 21245298
  • Hu W, Zhang C, Wu R, Sun Y, Levine AJ, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A 2010; 107:7455 - 60; http://dx.doi.org/10.1073/pnas.1001006107; PMID: 20378837
  • Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, et al. Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A 2010; 107:7461 - 6; http://dx.doi.org/10.1073/pnas.1002459107; PMID: 20351271
  • Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, et al. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A 2012; 109:6904 - 9; http://dx.doi.org/10.1073/pnas.1204176109; PMID: 22509023
  • Maddocks ODK, Berkers CR, Mason SM, Zheng L, Blyth K, Gottlieb E, et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 2013; 493:542 - 6; http://dx.doi.org/10.1038/nature11743; PMID: 23242140
  • Leontieva OV, Gudkov AV, Blagosklonny MV. Weak p53 permits senescence during cell cycle arrest. Cell Cycle 2010; 9:4323 - 7; http://dx.doi.org/10.4161/cc.9.21.13584; PMID: 21051933
  • Korotchkina LG, Leontieva OV, Bukreeva EI, Demidenko ZN, Gudkov AV, Blagosklonny MV. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY) 2010; 2:344 - 52; PMID: 20606252
  • Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV. Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci U S A 2010; 107:9660 - 4; http://dx.doi.org/10.1073/pnas.1002298107; PMID: 20457898