2,050
Views
18
CrossRef citations to date
0
Altmetric
Perspective

Resveratrol–zinc combination for prostate cancer management

, &
Pages 1867-1874 | Received 02 Apr 2014, Accepted 22 May 2014, Published online: 27 May 2014

References

  • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11 - 30; http://dx.doi.org/10.3322/caac.21166; PMID: 23335087
  • Kelleher SL, McCormick NH, Velasquez V, Lopez V. Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland. Adv Nutr 2011; 2:101 - 11; http://dx.doi.org/10.3945/an.110.000232; PMID: 22332039
  • Chasapis CT, Loutsidou AC, Spiliopoulou CA, Stefanidou ME. Zinc and human health: an update. Arch Toxicol 2012; 86:521 - 34; http://dx.doi.org/10.1007/s00204-011-0775-1; PMID: 22071549
  • Puca R, Nardinocchi L, Porru M, Simon AJ, Rechavi G, Leonetti C, Givol D, D’Orazi G. Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs. Cell Cycle 2011; 10:1679 - 89; http://dx.doi.org/10.4161/cc.10.10.15642; PMID: 21508668
  • Norelli G, Bossi G. Zinc, a promising mineral for misfolded p53 reactivation. Cell Cycle 2011; 10:2415 - 6; http://dx.doi.org/10.4161/cc.10.15.15931; PMID: 21734452
  • D’Orazi G, Givol D. p53 reactivation: the link to zinc. Cell Cycle 2012; 11:2581 - 2; http://dx.doi.org/10.4161/cc.21020; PMID: 22751437
  • Morita A, Ariyasu S, Ohya S, Takahashi I, Wang B, Tanaka K, Uchida T, Okazaki H, Hanaya K, Enomoto A, et al. Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis. Oncotarget 2013; 4:2439 - 50; PMID: 24280450
  • Spina R, Filocamo G, Iaccino E, Scicchitano S, Lupia M, Chiarella E, Mega T, Bernaudo F, Pelaggi D, Mesuraca M, et al. Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells. Oncotarget 2013; 4:1280 - 92; PMID: 23907569
  • Sheffer M, Simon AJ, Jacob-Hirsch J, Rechavi G, Domany E, Givol D, D’Orazi G. Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation. Oncotarget 2011; 2:1191 - 202; PMID: 22202117
  • Costello LC, Franklin RB. The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots. Mol Cancer 2006; 5:17; http://dx.doi.org/10.1186/1476-4598-5-17; PMID: 16700911
  • Costello LC, Franklin RB. Zinc is decreased in prostate cancer: an established relationship of prostate cancer!. J Biol Inorg Chem 2011; 16:3 - 8; http://dx.doi.org/10.1007/s00775-010-0736-9; PMID: 21140181
  • Zaichick VYe, Sviridova TV, Zaichick SV. Zinc in the human prostate gland: normal, hyperplastic and cancerous. Int Urol Nephrol 1997; 29:565 - 74; http://dx.doi.org/10.1007/BF02552202; PMID: 9413764
  • Franklin RB, Feng P, Milon B, Desouki MM, Singh KK, Kajdacsy-Balla A, Bagasra O, Costello LC. hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. Mol Cancer 2005; 4:32; http://dx.doi.org/10.1186/1476-4598-4-32; PMID: 16153295
  • Desouki MM, Geradts J, Milon B, Franklin RB, Costello LC. hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. Mol Cancer 2007; 6:37; http://dx.doi.org/10.1186/1476-4598-6-37; PMID: 17550612
  • Chen QG, Zhang Z, Yang Q, Shan GY, Yu XY, Kong CZ. The role of zinc transporter ZIP4 in prostate carcinoma. Urol Oncol 2012; 30:906 - 11; http://dx.doi.org/10.1016/j.urolonc.2010.11.010; PMID: 21803616
  • Zhang JJ, Wu M, Schoene NW, Cheng W-H, Wang TTY, Alshatwi AA, Alsaif M, Lei KY. Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells. Am J Physiol Cell Physiol 2009; 297:C632 - 44; http://dx.doi.org/10.1152/ajpcell.00139.2009; PMID: 19553565
  • Wagner SE, Burch JB, Hussey J, Temples T, Bolick-Aldrich S, Mosley-Broughton C, Liu Y, Hebert JR. Soil zinc content, groundwater usage, and prostate cancer incidence in South Carolina. Cancer Causes Control 2009; 20:345 - 53; http://dx.doi.org/10.1007/s10552-008-9248-0; PMID: 18949566
  • Costello LC, Franklin RB. Cytotoxic/tumor suppressor role of zinc for the treatment of cancer: an enigma and an opportunity. Expert Rev Anticancer Ther 2012; 12:121 - 8; http://dx.doi.org/10.1586/era.11.190; PMID: 22149438
  • Kolenko V, Teper E, Kutikov A, Uzzo R. Zinc and zinc transporters in prostate carcinogenesis. Nat Rev Urol 2013; 10:219 - 26; http://dx.doi.org/10.1038/nrurol.2013.43; PMID: 23478540
  • Epstein MM, Kasperzyk JL, Andrén O, Giovannucci EL, Wolk A, Håkansson N, Andersson SO, Johansson JE, Fall K, Mucci LA. Dietary zinc and prostate cancer survival in a Swedish cohort. Am J Clin Nutr 2011; 93:586 - 93; http://dx.doi.org/10.3945/ajcn.110.004804; PMID: 21228268
  • Gonzalez A, Peters U, Lampe JW, White E. Zinc intake from supplements and diet and prostate cancer. Nutr Cancer 2009; 61:206 - 15; http://dx.doi.org/10.1080/01635580802419749; PMID: 19235036
  • Gallus S, Foschi R, Negri E, Talamini R, Franceschi S, Montella M, Ramazzotti V, Tavani A, Dal Maso L, La Vecchia C. Dietary zinc and prostate cancer risk: a case-control study from Italy. Eur Urol 2007; 52:1052 - 6; http://dx.doi.org/10.1016/j.eururo.2007.01.094; PMID: 17292532
  • Leitzmann MF, Stampfer MJ, Wu K, Colditz GA, Willett WC, Giovannucci EL. Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst 2003; 95:1004 - 7; http://dx.doi.org/10.1093/jnci/95.13.1004; PMID: 12837837
  • Costello LC, Franklin RB, Tan MT. A Critical Assessment of Epidemiology Studies Regarding Dietary/Supplemental Zinc and Prostate Cancer Risk. Open Urol Nephrol J 2008; 1; http://dx.doi.org/10.2174/1874303X00801010026; PMID: 24204440
  • Rishi I, Baidouri H, Abbasi JA, Bullard-Dillard R, Kajdacsy-Balla A, Pestaner JP, Skacel M, Tubbs R, Bagasra O. Prostate cancer in African American men is associated with downregulation of zinc transporters. Appl Immunohistochem Mol Morphol 2003; 11:253 - 60; http://dx.doi.org/10.1097/00129039-200309000-00009; PMID: 12966353
  • NIH. . The Office of Dietary Supplements (ODS) [ods.od.nih.gov/factsheets/Zinc-HealthProfessional/]
  • Trumbo P, Yates AA, Schlicker S, Poos M. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc 2001; 101:294 - 301; http://dx.doi.org/10.1016/S0002-8223(01)00078-5; PMID: 11269606
  • Liang J-H, Liu Y-Y, Franklin RB, Costello LC, Feng P. Inhibitrory effet of zinc on human prostatic carcinoma cell growth. Prostate 1999; 40:200 - 7
  • Uzzo RG, Leavis P, Hatch W, Gabai VL, Dulin N, Zvartau N, Kolenko VM. Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents. Clin Cancer Res 2002; 8:3579 - 83; PMID: 12429649
  • Wong P-F, Abubakar S. Comparative transcriptional study of the effects of high intracellular zinc on prostate carcinoma cells. Oncol Rep 2010; 23:1501 - 16; PMID: 20428803
  • Prasad AS, Mukhtar H, Beck FW, Adhami VM, Siddiqui IA, Din M, Hafeez BB, Kucuk O. Dietary zinc and prostate cancer in the TRAMP mouse model. J Med Food 2010; 13:70 - 6; http://dx.doi.org/10.1089/jmf.2009.0042; PMID: 20136438
  • Shah MR, Kriedt CL, Lents NH, Hoyer MK, Jamaluddin N, Klein C, Baldassare J. Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer. J Exp Clin Cancer Res 2009; 28:84; http://dx.doi.org/10.1186/1756-9966-28-84; PMID: 19534805
  • Murakami M, Hirano T. Intracellular zinc homeostasis and zinc signaling. Cancer Sci 2008; 99:1515 - 22; http://dx.doi.org/10.1111/j.1349-7006.2008.00854.x; PMID: 18754861
  • Franklin RB, Milon B, Feng P, Costello LC. Zinc and zinc transporters in normal prostate and the pathogenesis of prostate cancer. Front Biosci 2005; 10:2230 - 9; http://dx.doi.org/10.2741/1692; PMID: 15970489
  • Franklin RB, Ma J, Zou J, Guan Z, Kukoyi BI, Feng P, Costello LC. Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. J Inorg Biochem 2003; 96:435 - 42; http://dx.doi.org/10.1016/S0162-0134(03)00249-6; PMID: 12888280
  • Huang L, Tepaamorndech S. The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles. Mol Aspects Med 2013; 34:548 - 60; http://dx.doi.org/10.1016/j.mam.2012.05.008; PMID: 23506888
  • Johnson LA, Kanak MA, Kajdacsy-Balla A, Pestaner JP, Bagasra O. Differential zinc accumulation and expression of human zinc transporter 1 (hZIP1) in prostate glands. Methods 2010; 52:316 - 21; http://dx.doi.org/10.1016/j.ymeth.2010.08.004; PMID: 20705137
  • Cui X, Zhang Y, Yang J, Sun X, Hagan JP, Guha S, Li M. ZIP4 confers resistance to zinc deficiency-induced apoptosis in pancreatic cancer. Cell Cycle 2014; 13:1180 - 6; http://dx.doi.org/10.4161/cc.28111; PMID: 24553114
  • Cousins RJ. Gastrointestinal factors influencing zinc absorption and homeostasis. Int J Vitam Nutr Res 2010; 80:243 - 8; http://dx.doi.org/10.1024/0300-9831/a000030; PMID: 21462106
  • Wang F, Kim BE, Petris MJ, Eide DJ. The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J Biol Chem 2004; 279:51433 - 41; http://dx.doi.org/10.1074/jbc.M408361200; PMID: 15322118
  • Lopez V, Kelleher SL. Zip6-attenuation promotes epithelial-to-mesenchymal transition in ductal breast tumor (T47D) cells. Exp Cell Res 2010; 316:366 - 75; http://dx.doi.org/10.1016/j.yexcr.2009.10.011; PMID: 19852955
  • Huang L, Kirschke CP, Zhang Y, Yu YY. The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. J Biol Chem 2005; 280:15456 - 63; http://dx.doi.org/10.1074/jbc.M412188200; PMID: 15705588
  • Hogstrand C, Kille P, Nicholson RI, Taylor KM. Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. Trends Mol Med 2009; 15:101 - 11; http://dx.doi.org/10.1016/j.molmed.2009.01.004; PMID: 19246244
  • Wang CY, Jenkitkasemwong S, Duarte S, Sparkman BK, Shawki A, Mackenzie B, Knutson MD. ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading. J Biol Chem 2012; 287:34032 - 43; http://dx.doi.org/10.1074/jbc.M112.367284; PMID: 22898811
  • Jenkitkasemwong S, Wang CY, Mackenzie B, Knutson MD. Physiologic implications of metal-ion transport by ZIP14 and ZIP8. Biometals 2012; 25:643 - 55; http://dx.doi.org/10.1007/s10534-012-9526-x; PMID: 22318508
  • Taniguchi M, Fukunaka A, Hagihara M, Watanabe K, Kamino S, Kambe T, Enomoto S, Hiromura M. Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells. PLoS One 2013; 8:e58022; http://dx.doi.org/10.1371/journal.pone.0058022; PMID: 23505453
  • Kagara N, Tanaka N, Noguchi S, Hirano T. Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. Cancer Sci 2007; 98:692 - 7; http://dx.doi.org/10.1111/j.1349-7006.2007.00446.x; PMID: 17359283
  • Yu Y, Wu A, Zhang Z, Yan G, Zhang F, Zhang L, Shen X, Hu R, Zhang Y, Zhang K, et al. Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc transporter. J Nutr Biochem 2013; 24:1697 - 708; http://dx.doi.org/10.1016/j.jnutbio.2013.02.010; PMID: 23643525
  • Chowanadisai W, Graham DM, Keen CL, Rucker RB, Messerli MA. Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A 2013; 110:9903 - 8; http://dx.doi.org/10.1073/pnas.1222142110; PMID: 23716681
  • Jeong J, Walker JM, Wang F, Park JG, Palmer AE, Giunta C, Rohrbach M, Steinmann B, Eide DJ. Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome. Proc Natl Acad Sci U S A 2012; 109:E3530 - 8; http://dx.doi.org/10.1073/pnas.1211775110; PMID: 23213233
  • Franklin RB, Levy BA, Zou J, Hanna N, Desouki MM, Bagasra O, Johnson LA, Costello LC. ZIP14 zinc transporter downregulation and zinc depletion in the development and progression of hepatocellular cancer. J Gastrointest Cancer 2012; 43:249 - 57; http://dx.doi.org/10.1007/s12029-011-9269-x; PMID: 21373779
  • Urani C, Melchioretto P, Gribaldo L. Regulation of metallothioneins and ZnT-1 transporter expression in human hepatoma cells HepG2 exposed to zinc and cadmium. Toxicol In Vitro 2010; 24:370 - 4; http://dx.doi.org/10.1016/j.tiv.2009.11.003; PMID: 19900532
  • Hasumi M, Suzuki K, Matsui H, Koike H, Ito K, Yamanaka H. Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues. Cancer Lett 2003; 200:187 - 95; http://dx.doi.org/10.1016/S0304-3835(03)00441-5; PMID: 14568174
  • Song Y, Elias V, Wong CP, Scrimgeour AG, Ho E. Zinc transporter expression profiles in the rat prostate following alterations in dietary zinc. Biometals 2010; 23:51 - 8; http://dx.doi.org/10.1007/s10534-009-9266-8; PMID: 19760107
  • Smidt K, Rungby J. ZnT3: a zinc transporter active in several organs. Biometals 2012; 25:1 - 8; http://dx.doi.org/10.1007/s10534-011-9490-x; PMID: 21866305
  • Beck FW, Prasad AS, Butler CE, Sakr WA, Kucuk O, Sarkar FH. Differential expression of hZnT-4 in human prostate tissues. Prostate 2004; 58:374 - 81; http://dx.doi.org/10.1002/pros.10344; PMID: 14968438
  • Coneyworth LJ, Mathers JC, Ford D. Does promoter methylation of the SLC30A5 (ZnT5) zinc transporter gene contribute to the ageing-related decline in zinc status?. Proc Nutr Soc 2009; 68:142 - 7; http://dx.doi.org/10.1017/S0029665109001104; PMID: 19245740
  • Huang L, Kirschke CP, Gitschier J. Functional characterization of a novel mammalian zinc transporter, ZnT6. J Biol Chem 2002; 277:26389 - 95; http://dx.doi.org/10.1074/jbc.M200462200; PMID: 11997387
  • Tepaamorndech S, Huang L, Kirschke CP. A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model. Cancer Lett 2011; 308:33 - 42; http://dx.doi.org/10.1016/j.canlet.2011.04.011; PMID: 21621325
  • Lefebvre B, Vandewalle B, Balavoine AS, Queniat G, Moerman E, Vantyghem MC, Le Bacquer O, Gmyr V, Pawlowski V, Kerr-Conte J, et al. Regulation and functional effects of ZNT8 in human pancreatic islets. J Endocrinol 2012; 214:225 - 32; http://dx.doi.org/10.1530/JOE-12-0071; PMID: 22582094
  • Overbeck S, Uciechowski P, Ackland ML, Ford D, Rink L. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukoc Biol 2008; 83:368 - 80; http://dx.doi.org/10.1189/jlb.0307148; PMID: 17971500
  • Bosomworth HJ, Thornton JK, Coneyworth LJ, Ford D, Valentine RA. Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis. Metallomics 2012; 4:771 - 9; http://dx.doi.org/10.1039/c2mt20088k; PMID: 22706290
  • Zhang S, Qian X, Redman C, Bliskovski V, Ramsay ES, Lowy DR, Mock BA. p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB. Oncogene 2003; 22:2285 - 95; http://dx.doi.org/10.1038/sj.onc.1206257; PMID: 12700664
  • Milon BC, Agyapong A, Bautista R, Costello LC, Franklin RB. Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells. Prostate 2010; 70:288 - 96; PMID: 19802870
  • Zou J, Milon BC, Desouki MM, Costello LC, Franklin RB. hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1). Prostate 2011; 71:1518 - 24; PMID: 21360563
  • Vašák M, Meloni G. Chemistry and biology of mammalian metallothioneins. J Biol Inorg Chem 2011; 16:1067 - 78; http://dx.doi.org/10.1007/s00775-011-0799-2; PMID: 21647776
  • Wei H, Desouki MM, Lin S, Xiao D, Franklin RB, Feng P. Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues. Mol Cancer 2008; 7:7; http://dx.doi.org/10.1186/1476-4598-7-7; PMID: 18208603
  • Hadler-Olsen E, Winberg JO, Uhlin-Hansen L. Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets. Tumour Biol 2013; 34:2041 - 51; http://dx.doi.org/10.1007/s13277-013-0842-8; PMID: 23681802
  • Ozden F, Saygin C, Uzunaslan D, Onal B, Durak H, Aki H. Expression of MMP-1, MMP-9 and TIMP-2 in prostate carcinoma and their influence on prognosis and survival. J Cancer Res Clin Oncol 2013; 139:1373 - 82; http://dx.doi.org/10.1007/s00432-013-1453-x; PMID: 23708302
  • Makhov PB, Golovine KV, Kutikov A, Canter DJ, Rybko VA, Roshchin DA, Matveev VB, Uzzo RG, Kolenko VM. Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells. Carcinogenesis 2011; 32:1773 - 81; http://dx.doi.org/10.1093/carcin/bgr212; PMID: 21940908
  • Cucciolla V, Borriello A, Oliva A, Galletti P, Zappia V, Della Ragione F. Resveratrol: from basic science to the clinic. Cell Cycle 2007; 6:2495 - 510; http://dx.doi.org/10.4161/cc.6.20.4815; PMID: 17726376
  • Pervaiz S, Holme AL. Resveratrol: its biologic targets and functional activity. Antioxid Redox Signal 2009; 11:2851 - 97; http://dx.doi.org/10.1089/ars.2008.2412; PMID: 19432534
  • Harikumar KB, Aggarwal BB. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 2008; 7:1020 - 35; http://dx.doi.org/10.4161/cc.7.8.5740; PMID: 18414053
  • Valenzano DR, Cellerino A. Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule. Cell Cycle 2006; 5:1027 - 32; http://dx.doi.org/10.4161/cc.5.10.2739; PMID: 16687936
  • Jasiński M, Jasińska L, Ogrodowczyk M. Resveratrol in prostate diseases - a short review. Cent European J Urol 2013; 66:144 - 9; PMID: 24579014
  • Aziz MH, Nihal M, Fu VX, Jarrard DF, Ahmad N. Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3′-kinase/Akt pathway and Bcl-2 family proteins. Mol Cancer Ther 2006; 5:1335 - 41; http://dx.doi.org/10.1158/1535-7163.MCT-05-0526; PMID: 16731767
  • Baptista T, Graça I, Sousa EJ, Oliveira AI, Costa NR, Costa-Pinheiro P, Amado F, Henrique R, Jerónimo C. Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer. Oncotarget 2013; 4:1673 - 85; PMID: 24127549
  • Yilmaz MI, Saglam K, Sonmez A, Gok DE, Basal S, Kilic S, Akay C, Kocar IH. Antioxidant system activation in prostate cancer. Biol Trace Elem Res 2004; 98:13 - 9; http://dx.doi.org/10.1385/BTER:98:1:13; PMID: 15051896
  • Harper CE, Patel BB, Wang J, Arabshahi A, Eltoum IA, Lamartiniere CA. Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis 2007; 28:1946 - 53; http://dx.doi.org/10.1093/carcin/bgm144; PMID: 17675339
  • Seeni A, Takahashi S, Takeshita K, Tang M, Sugiura S, Sato SY, Shirai T. Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Asian Pac J Cancer Prev 2008; 9:7 - 14; PMID: 18439064
  • Singh CK, George J, Ahmad N. Resveratrol-based combinatorial strategies for cancer management. Ann N Y Acad Sci 2013; 1290:113 - 21; http://dx.doi.org/10.1111/nyas.12160; PMID: 23855473
  • Kavas GO, Aribal-Kocatürk P, Büyükkağnici DI. Resveratrol: is there any effect on healthy subject?. Biol Trace Elem Res 2007; 118:250 - 4; http://dx.doi.org/10.1007/s12011-007-0033-9; PMID: 17916928
  • Dias K, Nikolaou S. Does the combination of resveratrol with Al (III) and Zn (II) improve its antioxidant activity?. Nat Prod Commun 2011; 6:1673 - 6; PMID: 22224286
  • Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res 2010; 70:9003 - 11; http://dx.doi.org/10.1158/0008-5472.CAN-10-2364; PMID: 20935227
  • Tompkins TA, Renard NE, Kiuchi A. Clinical evaluation of the bioavailability of zinc-enriched yeast and zinc gluconate in healthy volunteers. Biol Trace Elem Res 2007; 120:28 - 35; http://dx.doi.org/10.1007/s12011-007-0072-2; PMID: 17916952
  • Kahmann L, Uciechowski P, Warmuth S, Plümäkers B, Gressner AM, Malavolta M, Mocchegiani E, Rink L. Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions. Rejuvenation Res 2008; 11:227 - 37; http://dx.doi.org/10.1089/rej.2007.0613; PMID: 18279033
  • Huang L, Kirschke CP, Zhang Y. Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression. Cancer Cell Int 2006; 6:10; http://dx.doi.org/10.1186/1475-2867-6-10; PMID: 16579854
  • Malhotra A, Nair P, Dhawan DK. Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis. Eur J Cancer Prev 2011; 20:411 - 6; http://dx.doi.org/10.1097/CEJ.0b013e3283481d71; PMID: 21633290
  • Quesada IM, Bustos M, Blay M, Pujadas G, Ardèvol A, Salvadó MJ, Bladé C, Arola L, Fernández-Larrea J. Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells. J Nutr Biochem 2011; 22:153 - 63; http://dx.doi.org/10.1016/j.jnutbio.2009.12.009; PMID: 20471814
  • Sreenivasulu K, Raghu P, Nair KM. Polyphenol-rich beverages enhance zinc uptake and metallothionein expression in Caco-2 cells. J Food Sci 2010; 75:H123 - 8; http://dx.doi.org/10.1111/j.1750-3841.2010.01582.x; PMID: 20546406

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.