A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis

References

• Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res 2010; 20:1352 - 60; http://dx.doi.org/10.1101/gr.107920.110; PMID: 20736230
   PubMed Web of Science ®Google Scholar
• Holick MF. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Mol Aspects Med 2008; 29:361 - 8; http://dx.doi.org/10.1016/j.mam.2008.08.008; PMID: 18801384
   PubMed Web of Science ®Google Scholar
• Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 2005; 29:21 - 30; http://dx.doi.org/10.1016/j.jchemneu.2004.08.006; PMID: 15589699
   PubMed Web of Science ®Google Scholar
• Adams JS, Hewison M. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase. Arch Biochem Biophys 2012; 523:95 - 102; http://dx.doi.org/10.1016/j.abb.2012.02.016; PMID: 22446158
   PubMed Web of Science ®Google Scholar
• Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol 2013; 34:47 - 64; http://dx.doi.org/10.1016/j.yfrne.2012.07.001; PMID: 22796576
   PubMed Web of Science ®Google Scholar
• Hewison M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf) 2012; 76:315 - 25; http://dx.doi.org/10.1111/j.1365-2265.2011.04261.x; PMID: 21995874
   PubMed Web of Science ®Google Scholar
• Holick MF. Evidence-based D-bate on health benefits of vitamin D revisited. Dermatoendocrinol 2012; 4:183 - 90; http://dx.doi.org/10.4161/derm.20015; PMID: 22928075
   PubMedGoogle Scholar
• IOM (Institute of Medicine). Dietary reference intakes for calcium and vitamin D. Committee to Review Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press. 2011.
   Google Scholar
• Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003; 77:204 - 10; PMID: 12499343
   PubMed Web of Science ®Google Scholar
• Lagishetty V, Liu NQ, Hewison M. Vitamin D metabolism and innate immunity. Mol Cell Endocrinol 2011; 347:97 - 105; http://dx.doi.org/10.1016/j.mce.2011.04.015; PMID: 21664425
   PubMed Web of Science ®Google Scholar
• Sterling KA, Eftekhari P, Girndt M, Kimmel PL, Raj DS. The immunoregulatory function of vitamin D: implications in chronic kidney disease. Nat Rev Nephrol 2012; 8:403 - 12; http://dx.doi.org/10.1038/nrneph.2012.93; PMID: 22614789
   PubMed Web of Science ®Google Scholar
• Patel S, Farragher T, Berry J, Bunn D, Silman A, Symmons D. Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis. Arthritis Rheum 2007; 56:2143 - 9; http://dx.doi.org/10.1002/art.22722; PMID: 17599737
   PubMed Web of Science ®Google Scholar
• Smolders J, Menheere P, Kessels A, Damoiseaux J, Hupperts R. Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis. Mult Scler 2008; 14:1220 - 4; http://dx.doi.org/10.1177/1352458508094399; PMID: 18653736
   PubMed Web of Science ®Google Scholar
• Amital H, Szekanecz Z, Szücs G, Dankó K, Nagy E, Csépány T, et al. Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D?. Ann Rheum Dis 2010; 69:1155 - 7; http://dx.doi.org/10.1136/ard.2009.120329; PMID: 20439290
   PubMed Web of Science ®Google Scholar
• Haque UJ, Bartlett SJ. Relationships among vitamin D, disease activity, pain and disability in rheumatoid arthritis. Clin Exp Rheumatol 2010; 28:745 - 7; PMID: 20883640
   PubMed Web of Science ®Google Scholar
• Mowry EM, Krupp LB, Milazzo M, Chabas D, Strober JB, Belman AL, et al. Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol 2010; 67:618 - 24; PMID: 20437559
   PubMed Web of Science ®Google Scholar
• Ulitsky A, Ananthakrishnan AN, Naik A, Skaros S, Zadvornova Y, Binion DG, et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr 2011; 35:308 - 16; http://dx.doi.org/10.1177/0148607110381267; PMID: 21527593
   PubMed Web of Science ®Google Scholar
• Weinstock-Guttman B, Zivadinov R, Qu J, Cookfair D, Duan X, Bang E, et al. Vitamin D metabolites are associated with clinical and MRI outcomes in multiple sclerosis patients. J Neurol Neurosurg Psychiatry 2011; 82:189 - 95; http://dx.doi.org/10.1136/jnnp.2010.227942; PMID: 21047880
   PubMed Web of Science ®Google Scholar
• Runia TF, Hop WC, de Rijke YB, Buljevac D, Hintzen RQ. Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology 2012; 79:261 - 6; http://dx.doi.org/10.1212/WNL.0b013e31825fdec7; PMID: 22700811
   PubMed Web of Science ®Google Scholar
• Correale J, Ysrraelit MC, Gaitán MI. Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain 2009; 132:1146 - 60; http://dx.doi.org/10.1093/brain/awp033; PMID: 19321461
   PubMed Web of Science ®Google Scholar
• Bruce D, Yu S, Ooi JH, Cantorna MT. Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling. Int Immunol 2011; 23:519 - 28; http://dx.doi.org/10.1093/intimm/dxr045; PMID: 21697289
   PubMed Web of Science ®Google Scholar
• Daniel C, Sartory NA, Zahn N, Radeke HH, Stein JM. Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther 2008; 324:23 - 33; http://dx.doi.org/10.1124/jpet.107.127209; PMID: 17911375
   PubMed Web of Science ®Google Scholar
• Chang JH, Cha HR, Lee DS, Seo KY, Kweon MN. 1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis. PLoS One 2010; a 5:e12925; http://dx.doi.org/10.1371/journal.pone.0012925; PMID: 20886077
   PubMed Web of Science ®Google Scholar
• Chang SH, Chung Y, Dong C. Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J Biol Chem 2010; b 285:38751 - 5; http://dx.doi.org/10.1074/jbc.C110.185777; PMID: 20974859
   PubMed Web of Science ®Google Scholar
• Hegyi Z, Zwicker S, Bureik D, Peric M, Koglin S, Batycka-Baran A, et al. Vitamin D analog calcipotriol suppresses the Th17 cytokine-induced proinflammatory S100 “alarmins” psoriasin (S100A7) and koebnerisin (S100A15) in psoriasis. J Invest Dermatol 2012; 132:1416 - 24; http://dx.doi.org/10.1038/jid.2011.486; PMID: 22402441
   PubMed Web of Science ®Google Scholar
• Waite JC, Skokos D. Th17 response and inflammatory autoimmune diseases. Int J Inflam 2012; 2012:819467; http://dx.doi.org/10.1155/2012/819467; PMID: 22229105
   PubMedGoogle Scholar
• Chambers ES, Hawrylowicz CM. The impact of vitamin D on regulatory T cells. Curr Allergy Asthma Rep 2011; 11:29 - 36; http://dx.doi.org/10.1007/s11882-010-0161-8; PMID: 21104171
   PubMed Web of Science ®Google Scholar
• Pani MA, Regulla K, Segni M, Krause M, Hofmann S, Hufner M, et al. Vitamin D 1alpha-hydroxylase (CYP1alpha) polymorphism in Graves’ disease, Hashimoto’s thyroiditis and type 1 diabetes mellitus. Eur J Endocrinol 2002; 146:777 - 81; http://dx.doi.org/10.1530/eje.0.1460777; PMID: 12039697
   PubMed Web of Science ®Google Scholar
• Sundqvist E, Bäärnhielm M, Alfredsson L, Hillert J, Olsson T, Kockum I. Confirmation of association between multiple sclerosis and CYP27B1. Eur J Hum Genet 2010; 18:1349 - 52; http://dx.doi.org/10.1038/ejhg.2010.113; PMID: 20648053
   PubMed Web of Science ®Google Scholar
• Vieth R, Fraser D. Kinetic behavior of 25-hydroxyvitamin D-1-hydroxylase and -24-hydroxylase in rat kidney mitochondria. J Biol Chem 1979; 254:12455 - 60; PMID: 500724
   PubMed Web of Science ®Google Scholar
• Vieth R, McCarten K, Norwich KH. Role of 25-hydroxyvitamin D3 dose in determining rat 1,25-dihydroxyvitamin D3 production. Am J Physiol 1990; 258:E780 - 9; PMID: 2185661
   PubMedGoogle Scholar
• Rodríguez-Antona C, Donato MT, Pareja E, Gómez-Lechón MJ, Castell JV. Cytochrome P-450 mRNA expression in human liver and its relationship with enzyme activity. Arch Biochem Biophys 2001; 393:308 - 15; http://dx.doi.org/10.1006/abbi.2001.2499; PMID: 11556818
   PubMed Web of Science ®Google Scholar
• Nebert DW, Russell DW. Clinical importance of the cytochromes P450. Lancet 2002; 360:1155 - 62; http://dx.doi.org/10.1016/S0140-6736(02)11203-7; PMID: 12387968
   PubMed Web of Science ®Google Scholar
• Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther 2007; 116:496 - 526; http://dx.doi.org/10.1016/j.pharmthera.2007.09.004; PMID: 18001838
   PubMed Web of Science ®Google Scholar
• Zhou SF, Liu JP, Chowbay B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev 2009; 41:89 - 295; http://dx.doi.org/10.1080/03602530902843483; PMID: 19514967
   PubMed Web of Science ®Google Scholar
• Vieth R. Toxicity of Vitamin D. In: Holick MF, ed. Vitamin D. New York, NY: Humana Press, 2010:603-612.
   Google Scholar
• Cusano NE, Thys-Jacobs S, Bilezikian JP. Hypercalcemia due to vitamin D toxicity. In: Feldman D, Pike JW, Adams JS, ed. Vitamin D. San Diego, CA: Academic Press, 2011:1381–1402.
   Google Scholar
• Silverberg JI, Silverberg AI, Malka E, Silverberg NB. A pilot study assessing the role of 25 hydroxy vitamin D levels in patients with vitiligo vulgaris. J Am Acad Dermatol 2010; 62:937 - 41; http://dx.doi.org/10.1016/j.jaad.2009.11.024; PMID: 20466170
   PubMed Web of Science ®Google Scholar
• Benrashid M, Moyers K, Mohty M, Savani BN. Vitamin D deficiency, autoimmunity, and graft-versus-host-disease risk: Implication for preventive therapy. Exp Hematol 2012; 40:263 - 7; http://dx.doi.org/10.1016/j.exphem.2012.01.006; PMID: 22265707
   PubMed Web of Science ®Google Scholar
• Gisondi P, Rossini M, Di Cesare A, Idolazzi L, Farina S, Beltrami G, et al. Vitamin D status in patients with chronic plaque psoriasis. Br J Dermatol 2012; 166:505 - 10; http://dx.doi.org/10.1111/j.1365-2133.2011.10699.x; PMID: 22013980
   PubMed Web of Science ®Google Scholar
• Orgaz-Molina J, Buendía-Eisman A, Arrabal-Polo MA, Ruiz JC, Arias-Santiago S. Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study. J Am Acad Dermatol 2012; 67:931 - 8; http://dx.doi.org/10.1016/j.jaad.2012.01.040; PMID: 22387034
   PubMed Web of Science ®Google Scholar
• Byers SW, Rowlands T, Beildeck M, Bong YS. Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment. Rev Endocr Metab Disord 2012; 13:31 - 8; http://dx.doi.org/10.1007/s11154-011-9196-y; PMID: 21861107
   PubMed Web of Science ®Google Scholar
• Muscogiuri G, Sorice GP, Ajjan R, Mezza T, Pilz S, Prioletta A, et al. Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives. Nutr Metab Cardiovasc Dis 2012; 22:81 - 7; http://dx.doi.org/10.1016/j.numecd.2011.11.001; PMID: 22265795
   PubMed Web of Science ®Google Scholar
• Rothman KJ, Michels KB. The continuing unethical use of placebo controls. N Engl J Med 1994; 331:394 - 8; http://dx.doi.org/10.1056/NEJM199408113310611; PMID: 8028622
   PubMed Web of Science ®Google Scholar
• Kavanaugh A. Ethical and practical issues in conducting clinical trials in psoriasis and psoriatic arthritis. Ann Rheum Dis 2005; 64:Suppl 2 ii46 - 8; http://dx.doi.org/10.1136/ard.2004.030817; PMID: 15708936
   PubMedGoogle Scholar
• Resnik DB. Ethical dilemmas in communicating medical information to the public. Health Policy 2001; 55:129 - 49; http://dx.doi.org/10.1016/S0168-8510(00)00121-4; PMID: 11163652
   PubMed Web of Science ®Google Scholar
• Simon R. Are placebo-controlled clinical trials ethical or needed when alternative treatment exists?. Ann Intern Med 2000; 133:474 - 5; http://dx.doi.org/10.7326/0003-4819-133-6-200009190-00017; PMID: 10975967
   PubMed Web of Science ®Google Scholar
• Zhang F, Moayyeri A, Spector TD. Genetic influences on circulating vitamin D level: a review. Curr Cardiovasc Risk Rep. 2012; 6:549 - 55; http://dx.doi.org/10.1007/s12170-012-0278-5
   Google Scholar
• Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 2008; 88:582S - 6S; PMID: 18689406
   PubMed Web of Science ®Google Scholar
• Hewison M. Vitamin D and immune function: an overview. Proc Nutr Soc 2012; 71:50 - 61; http://dx.doi.org/10.1017/S0029665111001650; PMID: 21849106
   PubMed Web of Science ®Google Scholar
• Henry HL. Regulation of vitamin D metabolism. Best Pract Res Clin Endocrinol Metab 2011; 25:531 - 41; http://dx.doi.org/10.1016/j.beem.2011.05.003; PMID: 21872796
   PubMed Web of Science ®Google Scholar
• Bikle DD. Vitamin D and immune function: understanding common pathways. Curr Osteoporos Rep 2009; 7:58 - 63; http://dx.doi.org/10.1007/s11914-009-0011-6; PMID: 19631030
   PubMedGoogle Scholar
• Beckman MJ, Horst RL, Reinhardt TA, Beitz DC. Up-regulation of the intestinal 1,25-dihydroxyvitamin D receptor during hypervitaminosis D: a comparison between vitamin D2 and vitamin D3. Biochem Biophys Res Commun 1990; 169:910 - 5; http://dx.doi.org/10.1016/0006-291X(90)91979-3; PMID: 2163637
   PubMed Web of Science ®Google Scholar
• Buckle RM, Gamlen TR, Pullen IM. Vitamin D intoxication treated with porcine calcitonin. Br Med J 1972; 3:205 - 7; http://dx.doi.org/10.1136/bmj.3.5820.205; PMID: 4261142
   PubMed Web of Science ®Google Scholar
• Selby PL, Davies M, Marks JS, Mawer EB. Vitamin D intoxication causes hypercalcaemia by increased bone resorption which responds to pamidronate. Clin Endocrinol (Oxf) 1995; 43:531 - 6; http://dx.doi.org/10.1111/j.1365-2265.1995.tb02916.x; PMID: 8548936
   PubMed Web of Science ®Google Scholar
• Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev 2008; 13:6 - 20; PMID: 18377099
   PubMed Web of Science ®Google Scholar
• Tsai KS, Wahner HW, Offord KP, Melton LJ 3rd, Kumar R, Riggs BL. Effect of aging on vitamin D stores and bone density in women. Calcif Tissue Int 1987; 40:241 - 3; http://dx.doi.org/10.1007/BF02555255; PMID: 3107776
   PubMed Web of Science ®Google Scholar
• Hariri A, Mount DB, Rastegar A. Disorders of calcium, phosphate, and magnesium metabolism. In: Mount DB, Sayegh MH, Singh AK, ed. Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance. New York, NY: Springer US, 2013:103-146.
   Google Scholar
• Duhra P, Foulds IS. Persistent vitiligo induced by diphencyprone. Br J Dermatol 1990; 123:415 - 6; http://dx.doi.org/10.1111/j.1365-2133.1990.tb06306.x; PMID: 2206982
   PubMed Web of Science ®Google Scholar
• Basavaraj KH, Ashok NM, Rashmi R, Praveen TK. The role of drugs in the induction and/or exacerbation of psoriasis. Int J Dermatol 2010; 49:1351 - 61; http://dx.doi.org/10.1111/j.1365-4632.2010.04570.x; PMID: 21091671
   PubMed Web of Science ®Google Scholar
• Fredriksson T, Pettersson U. Severe psoriasis--oral therapy with a new retinoid. Dermatologica 1978; 157:238 - 44; http://dx.doi.org/10.1159/000250839; PMID: 357213
   PubMedGoogle Scholar
• Shin J, Lee JS, Hann SK, Oh SH. Combination treatment by 10 600 nm ablative fractional carbon dioxide laser and narrowband ultraviolet B in refractory nonsegmental vitiligo: a prospective, randomized half-body comparative study. Br J Dermatol 2012; 166:658 - 61; http://dx.doi.org/10.1111/j.1365-2133.2011.10723.x; PMID: 22050270
   PubMed Web of Science ®Google Scholar