Epigenetic modulation of the immune function

References

• Rodriguez-Cortez VC, Hernando H, de la Rica L, Vento R, Ballestar E. Epigenomic deregulation in the immune system. Epigenomics 2011; 3:697 - 713; http://dx.doi.org/10.2217/epi.11.99; PMID: 22126290
   PubMed Web of Science ®Google Scholar
• Suarez-Alvarez B, Rodriguez RM, Fraga MF, López-Larrea C. DNA methylation: a promising landscape for immune system-related diseases. Trends Genet 2012; 28:506 - 14; http://dx.doi.org/10.1016/j.tig.2012.06.005; PMID: 22824525
   PubMed Web of Science ®Google Scholar
• Schildberg FA, Hagmann CA, Böhnert V, Tolba RH. Improved transplantation outcome by epigenetic changes. Transpl Immunol 2010; 23:104 - 10; http://dx.doi.org/10.1016/j.trim.2010.05.001; PMID: 20471480
   PubMed Web of Science ®Google Scholar
• McCaughan JA, McKnight AJ, Courtney AE, Maxwell AP. Epigenetics: time to translate into transplantation. Transplantation 2012; 94:1 - 7; http://dx.doi.org/10.1097/TP.0b013e31824db9bd; PMID: 22437848
   PubMed Web of Science ®Google Scholar
• Rodriguez RM, Suarez-Alvarez B, Salvanés R, Muro M, Martínez-Camblor P, Colado E, et al. DNA methylation dynamics in blood after hematopoietic cell transplant. PLoS One 2013; 8:e56931; http://dx.doi.org/10.1371/journal.pone.0056931; PMID: 23451113
   PubMedGoogle Scholar
• Kulis M, Esteller M. DNA methylation and cancer. Adv Genet 2010; 70:27 - 56; http://dx.doi.org/10.1016/B978-0-12-380866-0.60002-2; PMID: 20920744
   PubMed Web of Science ®Google Scholar
• Bannister AJ, Kouzarides T. Regulation of chromatin by histone modifications. Cell Res 2011; 21:381 - 95; http://dx.doi.org/10.1038/cr.2011.22; PMID: 21321607
   PubMed Web of Science ®Google Scholar
• Dunham I, Kundaje A, Aldred SF, Collins PJ, Davis CA, Doyle F, et al, ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 2012; 489:57 - 74; http://dx.doi.org/10.1038/nature11247; PMID: 22955616
   PubMed Web of Science ®Google Scholar
• Chadwick LH. The NIH Roadmap Epigenomics Program data resource. Epigenomics 2012; 4:317 - 24; http://dx.doi.org/10.2217/epi.12.18; PMID: 22690667
   PubMed Web of Science ®Google Scholar
• Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, et al. BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol 2012; 30:224 - 6; http://dx.doi.org/10.1038/nbt.2153; PMID: 22398613
   PubMed Web of Science ®Google Scholar
• Merad M, Collin M, Bromberg J. Dendritic cell homeostasis and trafficking in transplantation. Trends Immunol 2007; 28:353 - 9; http://dx.doi.org/10.1016/j.it.2007.06.003; PMID: 17618832
   PubMed Web of Science ®Google Scholar
• Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 2007; 449:419 - 26; http://dx.doi.org/10.1038/nature06175; PMID: 17898760
   PubMed Web of Science ®Google Scholar
• Bullwinkel J, Lüdemann A, Debarry J, Singh PB. Epigenotype switching at the CD14 and CD209 genes during differentiation of human monocytes to dendritic cells. Epigenetics 2011; 6:45 - 51; http://dx.doi.org/10.4161/epi.6.1.13314; PMID: 20818162
   PubMed Web of Science ®Google Scholar
• Huang Y, Min S, Lui Y, Sun J, Su X, Liu Y, et al. Global mapping of H3K4me3 and H3K27me3 reveals chromatin state-based regulation of human monocyte-derived dendritic cells in different environments. Genes Immun 2012; 13:311 - 20; http://dx.doi.org/10.1038/gene.2011.87; PMID: 22278394
   PubMed Web of Science ®Google Scholar
• Moreau A, Varey E, Bouchet-Delbos L, Cuturi MC. Cell therapy using tolerogenic dendritic cells in transplantation. Transplant Res 2012; 1:13; http://dx.doi.org/10.1186/2047-1440-1-13; PMID: 23369513
   PubMedGoogle Scholar
• Frikeche J, Peric Z, Brissot E, Grégoire M, Gaugler B, Mohty M. Impact of HDAC inhibitors on dendritic cell functions. Exp Hematol 2012; 40:783 - 91; http://dx.doi.org/10.1016/j.exphem.2012.06.008; PMID: 22728031
   PubMed Web of Science ®Google Scholar
• Nencioni A, Beck J, Werth D, Grünebach F, Patrone F, Ballestrero A, et al. Histone deacetylase inhibitors affect dendritic cell differentiation and immunogenicity. Clin Cancer Res 2007; 13:3933 - 41; http://dx.doi.org/10.1158/1078-0432.CCR-06-2903; PMID: 17606727
   PubMed Web of Science ®Google Scholar
• Wang B, Morinobu A, Horiuchi M, Liu J, Kumagai S. Butyrate inhibits functional differentiation of human monocyte-derived dendritic cells. Cell Immunol 2008; 253:54 - 8; http://dx.doi.org/10.1016/j.cellimm.2008.04.016; PMID: 18522857
   PubMed Web of Science ®Google Scholar
• Villagra A, Cheng F, Wang HW, Suarez I, Glozak M, Maurin M, et al. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat Immunol 2009; 10:92 - 100; http://dx.doi.org/10.1038/ni.1673; PMID: 19011628
   PubMed Web of Science ®Google Scholar
• Luckheeram RV, Zhou R, Verma AD, Xia B. CD4⁺T cells: differentiation and functions. Clin Dev Immunol 2012; 2012:925135; http://dx.doi.org/10.1155/2012/925135; PMID: 22474485
   PubMed Web of Science ®Google Scholar
• Wilson CB, Rowell E, Sekimata M. Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol 2009; 9:91 - 105; http://dx.doi.org/10.1038/nri2487; PMID: 19151746
   PubMed Web of Science ®Google Scholar
• Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 2009; 30:155 - 67; http://dx.doi.org/10.1016/j.immuni.2008.12.009; PMID: 19144320
   PubMed Web of Science ®Google Scholar
• Schoenborn JR, Dorschner MO, Sekimata M, Santer DM, Shnyreva M, Fitzpatrick DR, et al. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol 2007; 8:732 - 42; http://dx.doi.org/10.1038/ni1474; PMID: 17546033
   PubMed Web of Science ®Google Scholar
• Santangelo S, Cousins DJ, Winkelmann N, Triantaphyllopoulos K, Staynov DZ. Chromatin structure and DNA methylation of the IL-4 gene in human T(H)2 cells. Chromosome Res 2009; 17:485 - 96; http://dx.doi.org/10.1007/s10577-009-9040-3; PMID: 19521787
   PubMed Web of Science ®Google Scholar
• Aune TM, Collins PL, Chang S. Epigenetics and T helper 1 differentiation. Immunology 2009; 126:299 - 305; http://dx.doi.org/10.1111/j.1365-2567.2008.03026.x; PMID: 19178593
   PubMed Web of Science ®Google Scholar
• Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, et al. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature 2012; 487:249 - 53; http://dx.doi.org/10.1038/nature11173; PMID: 22763435
   PubMed Web of Science ®Google Scholar
• Muranski P, Restifo NP. Essentials of Th17 cell commitment and plasticity. Blood 2013; 121:2402 - 14; http://dx.doi.org/10.1182/blood-2012-09-378653; PMID: 23325835
   PubMed Web of Science ®Google Scholar
• Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 2012; 37:785 - 99; http://dx.doi.org/10.1016/j.immuni.2012.09.010; PMID: 23123060
   PubMed Web of Science ®Google Scholar
• Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D’Addio F, Mfarrej B, Donnarumma M, et al. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 2008; 205:3133 - 44; http://dx.doi.org/10.1084/jem.20081937; PMID: 19047438
   PubMed Web of Science ®Google Scholar
• Hanidziar D, Koulmanda M. Inflammation and the balance of Treg and Th17 cells in transplant rejection and tolerance. Curr Opin Organ Transplant 2010; 15:411 - 5; http://dx.doi.org/10.1097/MOT.0b013e32833b7929; PMID: 20613526
   PubMed Web of Science ®Google Scholar
• Issa F, Chandrasekharan D, Wood KJ. Regulatory T cells as modulators of chronic allograft dysfunction. Curr Opin Immunol 2011; 23:648 - 54; http://dx.doi.org/10.1016/j.coi.2011.06.005; PMID: 21752619
   PubMed Web of Science ®Google Scholar
• Cohen CJ, Crome SQ, MacDonald KG, Dai EL, Mager DL, Levings MK. Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci. J Immunol 2011; 187:5615 - 26; http://dx.doi.org/10.4049/jimmunol.1101058; PMID: 22048764
   PubMed Web of Science ®Google Scholar
• Josefowicz SZ, Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009; 30:616 - 25; http://dx.doi.org/10.1016/j.immuni.2009.04.009; PMID: 19464984
   PubMed Web of Science ®Google Scholar
• Baron U, Floess S, Wieczorek G, Baumann K, Grützkau A, Dong J, et al. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol 2007; 37:2378 - 89; http://dx.doi.org/10.1002/eji.200737594; PMID: 17694575
   PubMed Web of Science ®Google Scholar
• Lal G, Zhang N, van der Touw W, Ding Y, Ju W, Bottinger EP, et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol 2009; 182:259 - 73; PMID: 19109157
   PubMed Web of Science ®Google Scholar
• van Loosdregt J, Vercoulen Y, Guichelaar T, Gent YY, Beekman JM, van Beekum O, et al. Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood 2010; 115:965 - 74; http://dx.doi.org/10.1182/blood-2009-02-207118; PMID: 19996091
   PubMed Web of Science ®Google Scholar
• Nakayamada S, Takahashi H, Kanno Y, O’Shea JJ. Helper T cell diversity and plasticity. Curr Opin Immunol 2012; 24:297 - 302; http://dx.doi.org/10.1016/j.coi.2012.01.014; PMID: 22341735
   PubMed Web of Science ®Google Scholar
• Hirahara K, Vahedi G, Ghoreschi K, Yang XP, Nakayamada S, Kanno Y, et al. Helper T-cell differentiation and plasticity: insights from epigenetics. Immunology 2011; 134:235 - 45; http://dx.doi.org/10.1111/j.1365-2567.2011.03483.x; PMID: 21977994
   PubMed Web of Science ®Google Scholar
• Murphy KM, Stockinger B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol 2010; 11:674 - 80; http://dx.doi.org/10.1038/ni.1899; PMID: 20644573
   PubMed Web of Science ®Google Scholar
• Zhou L, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009; 30:646 - 55; http://dx.doi.org/10.1016/j.immuni.2009.05.001; PMID: 19464987
   PubMed Web of Science ®Google Scholar
• Ye J, Su X, Hsueh EC, Zhang Y, Koenig JM, Hoft DF, et al. Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-γ+ and FOXP3+ T cells with potent suppressive function. Eur J Immunol 2011; 41:936 - 51; http://dx.doi.org/10.1002/eji.201040682; PMID: 21381020
   PubMed Web of Science ®Google Scholar
• Issa F, Robb RJ, Wood KJ. The where and when of T cell regulation in transplantation. Trends Immunol 2013; 34:107 - 13; http://dx.doi.org/10.1016/j.it.2012.11.003; PMID: 23228885
   PubMed Web of Science ®Google Scholar
• Schmidl C, Hansmann L, Andreesen R, Edinger M, Hoffmann P, Rehli M. Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg. Eur J Immunol 2011; 41:1491 - 8; http://dx.doi.org/10.1002/eji.201041067; PMID: 21469109
   PubMed Web of Science ®Google Scholar
• Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, et al. Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 2012; 36:262 - 75; http://dx.doi.org/10.1016/j.immuni.2011.12.012; PMID: 22326580
   PubMed Web of Science ®Google Scholar
• Bestard O, Cuñetti L, Cruzado JM, Lucia M, Valdez R, Olek S, et al. Intragraft regulatory T cells in protocol biopsies retain foxp3 demethylation and are protective biomarkers for kidney graft outcome. Am J Transplant 2011; 11:2162 - 72; http://dx.doi.org/10.1111/j.1600-6143.2011.03633.x; PMID: 21749644
   PubMed Web of Science ®Google Scholar
• Beier UH, Wang L, Han R, Akimova T, Liu Y, Hancock WW. Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Sci Signal 2012; 5:ra45; http://dx.doi.org/10.1126/scisignal.2002873; PMID: 22715468
   PubMed Web of Science ®Google Scholar
• Beier UH, Wang L, Hancock WW. Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function. Cell Cycle 2012; 11:3351 - 2; http://dx.doi.org/10.4161/cc.21876; PMID: 22918251
   PubMed Web of Science ®Google Scholar
• Page AJ, Ford ML, Kirk AD. Memory T-cell-specific therapeutics in organ transplantation. Curr Opin Organ Transplant 2009; 14:643 - 9; http://dx.doi.org/10.1097/MOT.0b013e328332bd4a; PMID: 19779342
   PubMed Web of Science ®Google Scholar
• Weng NP, Araki Y, Subedi K. The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation. Nat Rev Immunol 2012; 12:306 - 15; http://dx.doi.org/10.1038/nri3173; PMID: 22421787
   PubMed Web of Science ®Google Scholar
• Steinfelder S, Floess S, Engelbert D, Haeringer B, Baron U, Rivino L, et al. Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells. Blood 2011; 117:2839 - 46; http://dx.doi.org/10.1182/blood-2010-06-293027; PMID: 21228329
   PubMed Web of Science ®Google Scholar
• Araki Y, Fann M, Wersto R, Weng NP. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). J Immunol 2008; 180:8102 - 8; PMID: 18523274
   PubMed Web of Science ®Google Scholar
• Araki Y, Wang Z, Zang C, Wood WH 3rd, Schones D, Cui K, et al. Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity 2009; 30:912 - 25; http://dx.doi.org/10.1016/j.immuni.2009.05.006; PMID: 19523850
   PubMed Web of Science ®Google Scholar
• Youngblood B, Oestreich KJ, Ha SJ, Duraiswamy J, Akondy RS, West EE, et al. Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity 2011; 35:400 - 12; http://dx.doi.org/10.1016/j.immuni.2011.06.015; PMID: 21943489
   PubMed Web of Science ®Google Scholar
• Youngblood B, Wherry EJ, Ahmed R. Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells. Curr Opin HIV AIDS 2012; 7:50 - 7; http://dx.doi.org/10.1097/COH.0b013e32834ddcf2; PMID: 22134341
   PubMedGoogle Scholar
• Villard J. The role of natural killer cells in human solid organ and tissue transplantation. J Innate Immun 2011; 3:395 - 402; http://dx.doi.org/10.1159/000324400; PMID: 21411978
   PubMed Web of Science ®Google Scholar
• Ogbomo H, Michaelis M, Kreuter J, Doerr HW, Cinatl J Jr.. Histone deacetylase inhibitors suppress natural killer cell cytolytic activity. FEBS Lett 2007; 581:1317 - 22; http://dx.doi.org/10.1016/j.febslet.2007.02.045; PMID: 17349632
   PubMed Web of Science ®Google Scholar
• Schmiedel BJ, Arélin V, Gruenebach F, Krusch M, Schmidt SM, Salih HR. Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation. Int J Cancer 2011; 128:2911 - 22; http://dx.doi.org/10.1002/ijc.25635; PMID: 20960460
   PubMed Web of Science ®Google Scholar
• Li G, Yu M, Weyand CM, Goronzy JJ. Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells. Blood 2009; 114:3422 - 30; http://dx.doi.org/10.1182/blood-2009-01-200170; PMID: 19628706
   PubMed Web of Science ®Google Scholar
• Fernández-Sánchez A, Baragaño Raneros A, Carvajal Palao R, Sanz AB, Ortiz A, Ortega F, et al. DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8+ T and NK cells. Epigenetics 2013; 8:66 - 78; http://dx.doi.org/10.4161/epi.23115; PMID: 23235109
   PubMed Web of Science ®Google Scholar
• Zarkhin V, Sarwal MM. The coin toss of B cells in rejection and tolerance: danger versus defense. Semin Immunol 2012; 24:86 - 91; http://dx.doi.org/10.1016/j.smim.2011.09.003; PMID: 22035649
   PubMed Web of Science ®Google Scholar
• Newell KA, Asare A, Kirk AD, Gisler TD, Bourcier K, Suthanthiran M, et al, Immune Tolerance Network ST507 Study Group. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010; 120:1836 - 47; http://dx.doi.org/10.1172/JCI39933; PMID: 20501946
   PubMed Web of Science ®Google Scholar
• Ramírez J, Lukin K, Hagman J. From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment. Curr Opin Immunol 2010; 22:177 - 84; http://dx.doi.org/10.1016/j.coi.2010.02.003; PMID: 20207529
   PubMed Web of Science ®Google Scholar
• Santos P, Arumemi F, Park KS, Borghesi L, Milcarek C. Transcriptional and epigenetic regulation of B cell development. Immunol Res 2011; 50:105 - 12; http://dx.doi.org/10.1007/s12026-011-8225-y; PMID: 21717070
   PubMed Web of Science ®Google Scholar
• Parra M. Epigenetic events during B lymphocyte development. Epigenetics 2009; 4:462 - 8; http://dx.doi.org/10.4161/epi.4.7.10052; PMID: 19875937
   PubMed Web of Science ®Google Scholar
• Lee ST, Xiao Y, Muench MO, Xiao J, Fomin ME, Wiencke JK, et al. A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. Nucleic Acids Res 2012; 40:11339 - 51; http://dx.doi.org/10.1093/nar/gks957; PMID: 23074194
   PubMed Web of Science ®Google Scholar
• McManus S, Ebert A, Salvagiotto G, Medvedovic J, Sun Q, Tamir I, et al. The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. EMBO J 2011; 30:2388 - 404; http://dx.doi.org/10.1038/emboj.2011.140; PMID: 21552207
   PubMed Web of Science ®Google Scholar
• Amaravadi L, Klemsz MJ. DNA methylation and chromatin structure regulate PU.1 expression. DNA Cell Biol 1999; 18:875 - 84; http://dx.doi.org/10.1089/104454999314737; PMID: 10619599
   PubMed Web of Science ®Google Scholar
• Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, et al. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol 2004; 5:1069 - 77; http://dx.doi.org/10.1038/ni1119; PMID: 15361869
   PubMed Web of Science ®Google Scholar
• Walter K, Bonifer C, Tagoh H. Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus. Blood 2008; 112:1673 - 82; http://dx.doi.org/10.1182/blood-2008-02-142786; PMID: 18552207
   PubMed Web of Science ®Google Scholar
• Matheson LS, Corcoran AE. Local and global epigenetic regulation of V(D)J recombination. Curr Top Microbiol Immunol 2012; 356:65 - 89; http://dx.doi.org/10.1007/82_2011_137; PMID: 21695632
   PubMed Web of Science ®Google Scholar
• Shaknovich R, Cerchietti L, Tsikitas L, Kormaksson M, De S, Figueroa ME, et al. DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood 2011; 118:3559 - 69; http://dx.doi.org/10.1182/blood-2011-06-357996; PMID: 21828137
   PubMed Web of Science ®Google Scholar
• Teperek-Tkacz M, Pasque V, Gentsch G, Ferguson-Smith AC. Epigenetic reprogramming: is deamination key to active DNA demethylation?. Reproduction 2011; 142:621 - 32; http://dx.doi.org/10.1530/REP-11-0148; PMID: 21911441
   PubMed Web of Science ®Google Scholar
• Kuraoka M, Holl TM, Liao D, Womble M, Cain DW, Reynolds AE, et al. Activation-induced cytidine deaminase mediates central tolerance in B cells. Proc Natl Acad Sci U S A 2011; 108:11560 - 5; http://dx.doi.org/10.1073/pnas.1102571108; PMID: 21700885
   PubMed Web of Science ®Google Scholar
• Su ST, Ying HY, Chiu YK, Lin FR, Chen MY, Lin KI. Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. Mol Cell Biol 2009; 29:1421 - 31; http://dx.doi.org/10.1128/MCB.01158-08; PMID: 19124609
   PubMed Web of Science ®Google Scholar
• Roedder S, Vitalone M, Khatri P, Sarwal MM. Biomarkers in solid organ transplantation: establishing personalized transplantation medicine. Genome Med 2011; 3:37; http://dx.doi.org/10.1186/gm253; PMID: 21658299
   PubMed Web of Science ®Google Scholar
• Naesens M, Sarwal MM. Molecular diagnostics in transplantation. Nat Rev Nephrol 2010; 6:614 - 28; http://dx.doi.org/10.1038/nrneph.2010.113; PMID: 20736923
   PubMed Web of Science ®Google Scholar
• Viklicky O, Krystufkova E, Brabcova I, Sekerkova A, Wohlfahrt P, Hribova P, et al. B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients. Transplantation 2013; 95:148 - 54; http://dx.doi.org/10.1097/TP.0b013e3182789a24; PMID: 23222918
   PubMed Web of Science ®Google Scholar
• Chowdhury P, Hernandez-Fuentes MP. Non-invasive biomarkers to guide management following renal transplantation: the need for a multiplatform approach. Curr Opin Organ Transplant 2013; 18:1 - 5; http://dx.doi.org/10.1097/MOT.0b013e32835c8025; PMID: 23283248
   PubMed Web of Science ®Google Scholar
• Li L, Khatri P, Sigdel TK, Tran T, Ying L, Vitalone MJ, et al. A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant 2012; 12:2710 - 8; http://dx.doi.org/10.1111/j.1600-6143.2012.04253.x; PMID: 23009139
   PubMed Web of Science ®Google Scholar
• Londoño MC, Danger R, Giral M, Soulillou JP, Sánchez-Fueyo A, Brouard S. A need for biomarkers of operational tolerance in liver and kidney transplantation. Am J Transplant 2012; 12:1370 - 7; http://dx.doi.org/10.1111/j.1600-6143.2012.04035.x; PMID: 22486792
   PubMed Web of Science ®Google Scholar
• Lozano JJ, Pallier A, Martinez-Llordella M, Danger R, López M, Giral M, et al. Comparison of transcriptional and blood cell-phenotypic markers between operationally tolerant liver and kidney recipients. Am J Transplant 2011; 11:1916 - 26; http://dx.doi.org/10.1111/j.1600-6143.2011.03638.x; PMID: 21827613
   PubMed Web of Science ®Google Scholar
• Heyn H, Esteller M. DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet 2012; 13:679 - 92; http://dx.doi.org/10.1038/nrg3270; PMID: 22945394
   PubMed Web of Science ®Google Scholar
• Ho AS, Turcan S, Chan TA. Epigenetic therapy: use of agents targeting deacetylation and methylation in cancer management. Onco Targets Ther 2013; 6:223 - 32; PMID: 23569385
   PubMed Web of Science ®Google Scholar
• Wu SL, Pan CE, Yu L, Meng KW. Immunosuppression by combined use of cyclosporine and resveratrol in a rat liver transplantation model. Transplant Proc 2005; 37:2354 - 9; http://dx.doi.org/10.1016/j.transproceed.2005.03.112; PMID: 15964415
   PubMed Web of Science ®Google Scholar
• Kinugasa F, Nagatomi I, Nakanishi T, Noto T, Mori H, Matsuoka H, et al. Effect of the immunosuppressant histone deacetylase inhibitor FR276457 in a canine renal transplant model. Transpl Immunol 2009; 21:198 - 202; http://dx.doi.org/10.1016/j.trim.2009.04.006; PMID: 19409992
   PubMed Web of Science ®Google Scholar
• Zhang X, Han S, Kang Y, Guo M, Hong S, Liu F, et al. SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection. Cell Mol Immunol 2012; 9:390 - 8; http://dx.doi.org/10.1038/cmi.2012.28; PMID: 22922441
   PubMed Web of Science ®Google Scholar
• Bharti AC, Panigrahi A, Sharma PK, Gupta N, Kumar R, Shukla S, et al. Clinical relevance of curcumin-induced immunosuppression in living-related donor renal transplant: an in vitro analysis. Exp Clin Transplant 2010; 8:161 - 71; PMID: 20565374
   PubMed Web of Science ®Google Scholar
• Wood KJ, Bushell A, Hester J. Regulatory immune cells in transplantation. Nat Rev Immunol 2012; 12:417 - 30; http://dx.doi.org/10.1038/nri3227; PMID: 22627860
   PubMed Web of Science ®Google Scholar
• Sagoo P, Lombardi G, Lechler RI. Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation. Front Immunol 2012; 3:184; http://dx.doi.org/10.3389/fimmu.2012.00184; PMID: 22811678
   PubMed Web of Science ®Google Scholar
• Ohkura N, Kitagawa Y, Sakaguchi S. Development and maintenance of regulatory T cells. Immunity 2013; 38:414 - 23; http://dx.doi.org/10.1016/j.immuni.2013.03.002; PMID: 23521883
   PubMed Web of Science ®Google Scholar
• Casiraghi F, Perico N, Remuzzi G. Mesenchymal stromal cells to promote solid organ transplantation tolerance. Curr Opin Organ Transplant 2013; 18:51 - 8; http://dx.doi.org/10.1097/MOT.0b013e32835c5016; PMID: 23254705
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen T, Yan H, Qi H, Deng C, Ye T, et al. Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells. [Epub ahead of print] J Cell Biochem 2013; http://dx.doi.org/10.1002/jcb.24569; PMID: 23564418
   PubMed Web of Science ®Google Scholar
• Nicodeme E, Jeffrey KL, Schaefer U, Beinke S, Dewell S, Chung CW, et al. Suppression of inflammation by a synthetic histone mimic. Nature 2010; 468:1119 - 23; http://dx.doi.org/10.1038/nature09589; PMID: 21068722
   PubMed Web of Science ®Google Scholar
• Gregory DJ, Mikhaylova L, Fedulov AV. Selective DNA demethylation by fusion of TDG with a sequence-specific DNA-binding domain. Epigenetics 2012; 7:344 - 9; http://dx.doi.org/10.4161/epi.19509; PMID: 22419066
   PubMed Web of Science ®Google Scholar
• Dalton SR, Bellacosa A. DNA demethylation by TDG. Epigenomics 2012; 4:459 - 67; http://dx.doi.org/10.2217/epi.12.36; PMID: 22920184
   PubMed Web of Science ®Google Scholar
• Rivenbark AG, Stolzenburg S, Beltran AS, Yuan X, Rots MG, Strahl BD, et al. Epigenetic reprogramming of cancer cells via targeted DNA methylation. Epigenetics 2012; 7:350 - 60; http://dx.doi.org/10.4161/epi.19507; PMID: 22419067
   PubMed Web of Science ®Google Scholar