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Review

Chromatin remodeling by the small RNA machinery in mammalian cells

Pages 45-52 | Received 09 Sep 2013, Accepted 15 Oct 2013, Published online: 22 Oct 2013

References

  • Cabili MN, Trapnell C, Goff L, Koziol M, Tazon-Vega B, Regev A, Rinn JL. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev 2011; 25:1915 - 27; http://dx.doi.org/10.1101/gad.17446611; PMID: 21890647
  • Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010; 464:1071 - 6; http://dx.doi.org/10.1038/nature08975; PMID: 20393566
  • Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F, Shi Y, Segal E, Chang HY. Long noncoding RNA as modular scaffold of histone modification complexes. Science 2010; 329:689 - 93; http://dx.doi.org/10.1126/science.1192002; PMID: 20616235
  • Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell 2011; 43:904 - 14; http://dx.doi.org/10.1016/j.molcel.2011.08.018; PMID: 21925379
  • Liu J, Rivas FV, Wohlschlegel J, Yates JR 3rd, Parker R, Hannon GJ. A role for the P-body component GW182 in microRNA function. Nat Cell Biol 2005; 7:1261 - 6; http://dx.doi.org/10.1038/ncb1333; PMID: 16284623
  • Ambros V. The functions of animal microRNAs. Nature 2004; 431:350 - 5; http://dx.doi.org/10.1038/nature02871; PMID: 15372042
  • Bartel DP, Chen CZ. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 2004; 5:396 - 400; http://dx.doi.org/10.1038/nrg1328; PMID: 15143321
  • Iorio MV, Croce CM. microRNA involvement in human cancer. Carcinogenesis 2012; 33:1126 - 33; http://dx.doi.org/10.1093/carcin/bgs140; PMID: 22491715
  • Su H, Trombly MI, Chen J, Wang X. Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev 2009; 23:304 - 17; http://dx.doi.org/10.1101/gad.1749809; PMID: 19174539
  • Frank-Kamenetsky M, Grefhorst A, Anderson NN, Racie TS, Bramlage B, Akinc A, Butler D, Charisse K, Dorkin R, Fan Y, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A 2008; 105:11915 - 20; http://dx.doi.org/10.1073/pnas.0805434105; PMID: 18695239
  • Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell 2004; 15:185 - 97; http://dx.doi.org/10.1016/j.molcel.2004.07.007; PMID: 15260970
  • Lee JT, Bartolomei MS. X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell 2013; 152:1308 - 23; http://dx.doi.org/10.1016/j.cell.2013.02.016; PMID: 23498939
  • Franke A, Baker BS. The rox1 and rox2 RNAs are essential components of the compensasome, which mediates dosage compensation in Drosophila. Mol Cell 1999; 4:117 - 22; http://dx.doi.org/10.1016/S1097-2765(00)80193-8; PMID: 10445033
  • Wassenegger M, Heimes S, Riedel L, Sänger HL. RNA-directed de novo methylation of genomic sequences in plants. Cell 1994; 76:567 - 76; http://dx.doi.org/10.1016/0092-8674(94)90119-8; PMID: 8313476
  • Volpe TA, Kidner C, Hall IM, Teng G, Grewal SI, Martienssen RA. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 2002; 297:1833 - 7; http://dx.doi.org/10.1126/science.1074973; PMID: 12193640
  • Pal-Bhadra M, Leibovitch BA, Gandhi SG, Chikka MR, Bhadra U, Birchler JA, Elgin SC. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 2004; 303:669 - 72; http://dx.doi.org/10.1126/science.1092653; PMID: 14752161
  • Sijen T, Plasterk RH. Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi. Nature 2003; 426:310 - 4; http://dx.doi.org/10.1038/nature02107; PMID: 14628056
  • Morris KV, Chan SW, Jacobsen SE, Looney DJ. Small interfering RNA-induced transcriptional gene silencing in human cells. Science 2004; 305:1289 - 92; http://dx.doi.org/10.1126/science.1101372; PMID: 15297624
  • Li LC. The multifaceted small RNAs. RNA Biol 2008; 5:61 - 4; http://dx.doi.org/10.4161/rna.5.2.5989; PMID: 18398309
  • Janowski BA, Huffman KE, Schwartz JC, Ram R, Hardy D, Shames DS, Minna JD, Corey DR. Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs. Nat Chem Biol 2005; 1:216 - 22; http://dx.doi.org/10.1038/nchembio725; PMID: 16408038
  • Janowski BA, Younger ST, Hardy DB, Ram R, Huffman KE, Corey DR. Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nat Chem Biol 2007; 3:166 - 73; http://dx.doi.org/10.1038/nchembio860; PMID: 17259978
  • Kim DH, Villeneuve LM, Morris KV, Rossi JJ. Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. Nat Struct Mol Biol 2006; 13:793 - 7; http://dx.doi.org/10.1038/nsmb1142; PMID: 16936726
  • Mondal T, Rasmussen M, Pandey GK, Isaksson A, Kanduri C. Characterization of the RNA content of chromatin. Genome Res 2010; 20:899 - 907; http://dx.doi.org/10.1101/gr.103473.109; PMID: 20404130
  • Rodríguez-Campos A, Azorín F. RNA is an integral component of chromatin that contributes to its structural organization. PLoS One 2007; 2:e1182; http://dx.doi.org/10.1371/journal.pone.0001182; PMID: 18000552
  • Ohrt T, Mütze J, Staroske W, Weinmann L, Höck J, Crell K, Meister G, Schwille P. Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells. Nucleic Acids Res 2008; 36:6439 - 49; http://dx.doi.org/10.1093/nar/gkn693; PMID: 18842624
  • Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Res 2012; 40:1695 - 707; http://dx.doi.org/10.1093/nar/gkr934; PMID: 22053081
  • Ahlenstiel CL, Lim HG, Cooper DA, Ishida T, Kelleher AD, Suzuki K. Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells. Nucleic Acids Res 2012; 40:1579 - 95; http://dx.doi.org/10.1093/nar/gkr891; PMID: 22064859
  • Liao JY, Ma LM, Guo YH, Zhang YC, Zhou H, Shao P, Chen YQ, Qu LH. Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3′ trailers. PLoS One 2010; 5:e10563; http://dx.doi.org/10.1371/journal.pone.0010563; PMID: 20498841
  • Huang V, Zheng J, Qi Z, Wang J, Place RF, Yu J, Li H, Li LC. Ago1 Interacts with RNA Polymerase II and Binds to the Promoters of Actively Transcribed Genes in Human Cancer Cells. PLoS Genet 2013; 9:e1003821; http://dx.doi.org/10.1371/journal.pgen.1003821; PMID: 24086155
  • Chu Y, Yue X, Younger ST, Janowski BA, Corey DR. Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter. Nucleic Acids Res 2010; 38:7736 - 48; http://dx.doi.org/10.1093/nar/gkq648; PMID: 20675357
  • Zardo G, Ciolfi A, Vian L, Starnes LM, Billi M, Racanicchi S, Maresca C, Fazi F, Travaglini L, Noguera N, et al. Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression. Blood 2012; 119:4034 - 46; http://dx.doi.org/10.1182/blood-2011-08-371344; PMID: 22327224
  • Li LC, Okino ST, Zhao H, Pookot D, Place RF, Urakami S, Enokida H, Dahiya R. Small dsRNAs induce transcriptional activation in human cells. Proc Natl Acad Sci U S A 2006; 103:17337 - 42; http://dx.doi.org/10.1073/pnas.0607015103; PMID: 17085592
  • Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci U S A 2008; 105:1608 - 13; http://dx.doi.org/10.1073/pnas.0707594105; PMID: 18227514
  • Matsui M, Sakurai F, Elbashir S, Foster DJ, Manoharan M, Corey DR. Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter. Chem Biol 2010; 17:1344 - 55; http://dx.doi.org/10.1016/j.chembiol.2010.10.009; PMID: 21168770
  • Ren S, Kang MR, Wang J, Huang V, Place RF, Sun Y, Li LC. Targeted induction of endogenous NKX3-1 by small activating RNA inhibits prostate tumor growth. Prostate 2013; 73:1591 - 601; http://dx.doi.org/10.1002/pros.22709; PMID: 23836514
  • Francia S, Michelini F, Saxena A, Tang D, de Hoon M, Anelli V, Mione M, Carninci P, d’Adda di Fagagna F. Site-specific DICER and DROSHA RNA products control the DNA-damage response. Nature 2012; 488:231 - 5; http://dx.doi.org/10.1038/nature11179; PMID: 22722852
  • Ameyar-Zazoua M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil R, Descostes N, Andrau JC, et al. Argonaute proteins couple chromatin silencing to alternative splicing. Nat Struct Mol Biol 2012; 19:998 - 1004; http://dx.doi.org/10.1038/nsmb.2373; PMID: 22961379
  • Ting AH, Schuebel KE, Herman JG, Baylin SB. Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat Genet 2005; 37:906 - 10; http://dx.doi.org/10.1038/ng1611; PMID: 16025112
  • Corey DR. Regulating mammalian transcription with RNA. Trends Biochem Sci 2005; 30:655 - 8; http://dx.doi.org/10.1016/j.tibs.2005.09.007; PMID: 16226463
  • Jiang G, Zheng L, Pu J, Mei H, Zhao J, Huang K, Zeng F, Tong Q. Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells. PLoS One 2012; 7:e31379; http://dx.doi.org/10.1371/journal.pone.0031379; PMID: 22363633
  • Suzuki K, Shijuuku T, Fukamachi T, Zaunders J, Guillemin G, Cooper D, Kelleher A. Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region. J RNAi Gene Silencing 2005; 1:66 - 78; PMID: 19771207
  • Yamagishi M, Ishida T, Miyake A, Cooper DA, Kelleher AD, Suzuki K, Watanabe T. Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription. Microbes Infect 2009; 11:500 - 8; http://dx.doi.org/10.1016/j.micinf.2009.02.003; PMID: 19233310
  • Park HK, Min BY, Kim NY, Jang ES, Shin CM, Park YS, Hwang JH, Jeong SH, Kim N, Lee DH, et al. Short hairpin RNA induces methylation of hepatitis B virus covalently closed circular DNA in human hepatoma cells. Biochem Biophys Res Commun 2013; 436:152 - 5; http://dx.doi.org/10.1016/j.bbrc.2013.04.108; PMID: 23727428
  • Aravin AA, Sachidanandam R, Bourc’his D, Schaefer C, Pezic D, Toth KF, Bestor T, Hannon GJ. A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell 2008; 31:785 - 99; http://dx.doi.org/10.1016/j.molcel.2008.09.003; PMID: 18922463
  • Watanabe T, Tomizawa S, Mitsuya K, Totoki Y, Yamamoto Y, Kuramochi-Miyagawa S, Iida N, Hoki Y, Murphy PJ, Toyoda A, et al. Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science 2011; 332:848 - 52; http://dx.doi.org/10.1126/science.1203919; PMID: 21566194
  • Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB. A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. Cancer Res 2008; 68:2570 - 5; http://dx.doi.org/10.1158/0008-5472.CAN-07-6405; PMID: 18413723
  • Chen L, Dahlstrom JE, Lee SH, Rangasamy D. Naturally occurring endo-siRNA silences LINE-1 retrotransposons in human cells through DNA methylation. Epigenetics 2012; 7:758 - 71; http://dx.doi.org/10.4161/epi.20706; PMID: 22647391
  • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411:494 - 8; http://dx.doi.org/10.1038/35078107; PMID: 11373684
  • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391:806 - 11; http://dx.doi.org/10.1038/35888; PMID: 9486653
  • Portnoy V, Huang V, Place RF, Li LC. Small RNA and transcriptional upregulation. Wiley Interdiscip Rev RNA 2011; 2:748 - 60; http://dx.doi.org/10.1002/wrna.90; PMID: 21823233
  • Suzuki K, Juelich T, Lim H, Ishida T, Watanebe T, Cooper DA, Rao S, Kelleher AD. Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region. J Biol Chem 2008; 283:23353 - 63; http://dx.doi.org/10.1074/jbc.M709651200; PMID: 18519571
  • Place RF, Noonan EJ, Földes-Papp Z, Li LC. Defining features and exploring chemical modifications to manipulate RNAa activity. Curr Pharm Biotechnol 2010; 11:518 - 26; http://dx.doi.org/10.2174/138920110791591463; PMID: 20662764
  • Wang X, Wang J, Huang V, Place RF, Li LC. Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation. Biochem J 2012; 443:821 - 8; http://dx.doi.org/10.1042/BJ20111491; PMID: 22339500
  • Hawkins PG, Santoso S, Adams C, Anest V, Morris KV. Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells. Nucleic Acids Res 2009; 37:2984 - 95; http://dx.doi.org/10.1093/nar/gkp127; PMID: 19304753
  • Turner AM, Ackley AM, Matrone MA, Morris KV. Characterization of an HIV-targeted transcriptional gene-silencing RNA in primary cells. Hum Gene Ther 2012; 23:473 - 83; http://dx.doi.org/10.1089/hum.2011.165; PMID: 22122263
  • Singh A, Palanichamy JK, Ramalingam P, Kassab MA, Bhagat M, Andrabi R, Luthra K, Sinha S, Chattopadhyay P. Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA. J Antimicrob Chemother 2013; Forthcoming http://dx.doi.org/10.1093/jac/dkt348; PMID: 24022068
  • Yue X, Schwartz JC, Chu Y, Younger ST, Gagnon KT, Elbashir S, Janowski BA, Corey DR. Transcriptional regulation by small RNAs at sequences downstream from 3′ gene termini. Nat Chem Biol 2010; 6:621 - 9; http://dx.doi.org/10.1038/nchembio.400; PMID: 20581822
  • Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Rational siRNA design for RNA interference. Nat Biotechnol 2004; 22:326 - 30; http://dx.doi.org/10.1038/nbt936; PMID: 14758366
  • Li LC, Zhao H, Nakajima K, Oh BR, Ribeiro Filho LA, Carroll P, Dahiya R. Methylation of the E-cadherin gene promoter correlates with progression of prostate cancer. J Urol 2001; 166:705 - 9; http://dx.doi.org/10.1016/S0022-5347(05)66047-8; PMID: 11458121
  • Turunen MP, Lehtola T, Heinonen SE, Assefa GS, Korpisalo P, Girnary R, Glass CK, Väisänen S, Ylä-Herttuala S. Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. Circ Res 2009; 105:604 - 9; http://dx.doi.org/10.1161/CIRCRESAHA.109.200774; PMID: 19696410
  • Alló M, Buggiano V, Fededa JP, Petrillo E, Schor I, de la Mata M, Agirre E, Plass M, Eyras E, Elela SA, et al. Control of alternative splicing through siRNA-mediated transcriptional gene silencing. Nat Struct Mol Biol 2009; 16:717 - 24; http://dx.doi.org/10.1038/nsmb.1620; PMID: 19543290
  • Liu J, Hu J, Corey DR. Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing. Nucleic Acids Res 2012; 40:1240 - 50; http://dx.doi.org/10.1093/nar/gkr780; PMID: 21948593
  • Younger ST, Pertsemlidis A, Corey DR. Predicting potential miRNA target sites within gene promoters. Bioorg Med Chem Lett 2009; 19:3791 - 4; http://dx.doi.org/10.1016/j.bmcl.2009.04.032; PMID: 19423343
  • Huang V, Li LC. miRNA goes nuclear. RNA Biol 2012; 9:269 - 73; http://dx.doi.org/10.4161/rna.19354; PMID: 22336708
  • Matsui M, Chu Y, Zhang H, Gagnon KT, Shaikh S, Kuchimanchi S, Manoharan M, Corey DR, Janowski BA. Promoter RNA links transcriptional regulation of inflammatory pathway genes. Nucleic Acids Res 2013; Forthcoming http://dx.doi.org/10.1093/nar/gkt777; PMID: 23999091
  • Kim DH, Saetrom P, Snøve O Jr., Rossi JJ. MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc Natl Acad Sci U S A 2008; 105:16230 - 5; http://dx.doi.org/10.1073/pnas.0808830105; PMID: 18852463
  • Younger ST, Corey DR. Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters. Nucleic Acids Res 2011; 39:5682 - 91; http://dx.doi.org/10.1093/nar/gkr155; PMID: 21427083
  • Tan Y, Zhang B, Wu T, Skogerbø G, Zhu X, Guo X, He S, Chen R. Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells. BMC Mol Biol 2009; 10:12; http://dx.doi.org/10.1186/1471-2199-10-12; PMID: 19232136
  • Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, Nervi C, Bozzoni I. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 2005; 123:819 - 31; http://dx.doi.org/10.1016/j.cell.2005.09.023; PMID: 16325577
  • Cam HP, Sugiyama T, Chen ES, Chen X, FitzGerald PC, Grewal SI. Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome. Nat Genet 2005; 37:809 - 19; http://dx.doi.org/10.1038/ng1602; PMID: 15976807
  • Zofall M, Grewal SI. RNAi-mediated heterochromatin assembly in fission yeast. Cold Spring Harb Symp Quant Biol 2006; 71:487 - 96; http://dx.doi.org/10.1101/sqb.2006.71.059; PMID: 17381331
  • Moshkovich N, Nisha P, Boyle PJ, Thompson BA, Dale RK, Lei EP. RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function. Genes Dev 2011; 25:1686 - 701; http://dx.doi.org/10.1101/gad.16651211; PMID: 21852534
  • Cernilogar FM, Onorati MC, Kothe GO, Burroughs AM, Parsi KM, Breiling A, Lo Sardo F, Saxena A, Miyoshi K, Siomi H, et al. Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila. Nature 2011; 480:391 - 5; http://dx.doi.org/10.1038/nature10492; PMID: 22056986
  • Benhamed M, Herbig U, Ye T, Dejean A, Bischof O. Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells. Nat Cell Biol 2012; 14:266 - 75; http://dx.doi.org/10.1038/ncb2443; PMID: 22366686
  • Gu S, Jin L, Huang Y, Zhang F, Kay MA. Slicing-independent RISC activation requires the argonaute PAZ domain. Curr Biol 2012; 22:1536 - 42; http://dx.doi.org/10.1016/j.cub.2012.06.040; PMID: 22795694
  • Okamura K, Ladewig E, Zhou L, Lai EC. Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes Dev 2013; 27:778 - 92; http://dx.doi.org/10.1101/gad.211698.112; PMID: 23535236
  • Yan KS, Yan S, Farooq A, Han A, Zeng L, Zhou MM. Structure and conserved RNA binding of the PAZ domain. Nature 2003; 426:468 - 74; http://dx.doi.org/10.1038/nature02129; PMID: 14615802
  • Polikepahad S, Corry DB. Profiling of T helper cell-derived small RNAs reveals unique antisense transcripts and differential association of miRNAs with argonaute proteins 1 and 2. Nucleic Acids Res 2013; 41:1164 - 77; http://dx.doi.org/10.1093/nar/gks1098; PMID: 23185045
  • Jacquier A. The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs. Nat Rev Genet 2009; 10:833 - 44; http://dx.doi.org/10.1038/nrg2683; PMID: 19920851
  • Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ. Argonaute2 is the catalytic engine of mammalian RNAi. Science 2004; 305:1437 - 41; http://dx.doi.org/10.1126/science.1102513; PMID: 15284456
  • Wang B, Li S, Qi HH, Chowdhury D, Shi Y, Novina CD. Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins. Nat Struct Mol Biol 2009; 16:1259 - 66; http://dx.doi.org/10.1038/nsmb.1712; PMID: 19946268
  • Czech B, Hannon GJ. Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet 2011; 12:19 - 31; http://dx.doi.org/10.1038/nrg2916; PMID: 21116305
  • Napoli S, Pastori C, Magistri M, Carbone GM, Catapano CV. Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells. EMBO J 2009; 28:1708 - 19; http://dx.doi.org/10.1038/emboj.2009.139; PMID: 19461583
  • Rand TA, Petersen S, Du F, Wang X. Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell 2005; 123:621 - 9; http://dx.doi.org/10.1016/j.cell.2005.10.020; PMID: 16271385
  • Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 2005; 123:607 - 20; http://dx.doi.org/10.1016/j.cell.2005.08.044; PMID: 16271386