Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy

References

• Bennett HA, Einarson A, Taddio A, Koren G, Einarson TR. Prevalence of depression during pregnancy: systematic review. Obstet Gynecol 2004; 103:698 - 709; http://dx.doi.org/10.1097/01.AOG.0000116689.75396.5f; PMID: 15051562
   PubMed Web of Science ®Google Scholar
• Ross LE, McLean LM. Anxiety disorders during pregnancy and the postpartum period: A systematic review. J Clin Psychiatry 2006; 67:1285 - 98; http://dx.doi.org/10.4088/JCP.v67n0818; PMID: 16965210
   PubMed Web of Science ®Google Scholar
• Grigoriadis S, VonderPorten EH, Mamisashvili L, Tomlinson G, Dennis CL, Koren G, Steiner M, Mousmanis P, Cheung A, Radford K, et al. The impact of maternal depression during pregnancy on perinatal outcomes: a systematic review and meta-analysis. J Clin Psychiatry 2013; 74:e321 - 41; http://dx.doi.org/10.4088/JCP.12r07968; PMID: 23656857
   PubMed Web of Science ®Google Scholar
• Hoffman S, Hatch MC. Depressive symptomatology during pregnancy: evidence for an association with decreased fetal growth in pregnancies of lower social class women. Health Psychol 2000; 19:535 - 43; http://dx.doi.org/10.1037/0278-6133.19.6.535; PMID: 11129356
   PubMed Web of Science ®Google Scholar
• Field T, Diego M, Hernandez-Reif M, Schanberg S, Kuhn C, Yando R, Bendell D. Pregnancy anxiety and comorbid depression and anger: effects on the fetus and neonate. Depress Anxiety 2003; 17:140 - 51; http://dx.doi.org/10.1002/da.10071; PMID: 12768648
   PubMed Web of Science ®Google Scholar
• Nulman I, Koren G, Rovet J, Barrera M, Pulver A, Streiner D, Feldman B. Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression. Am J Psychiatry 2012; 169:1165 - 74; http://dx.doi.org/10.1176/appi.ajp.2012.11111721; PMID: 23128923
   PubMed Web of Science ®Google Scholar
• Andrade SE, Raebel MA, Brown J, Lane K, Livingston J, Boudreau D, Rolnick SJ, Roblin D, Smith DH, Willy ME, et al. Use of antidepressant medications during pregnancy: a multisite study. Am J Obstet Gynecol 2008; 198:e1 - 5; http://dx.doi.org/10.1016/j.ajog.2007.07.036; PMID: 17905176
   PubMedGoogle Scholar
• Oberlander TF, Warburton W, Misri S, Aghajanian J, Hertzman C. Effects of timing and duration of gestational exposure to serotonin reuptake inhibitor antidepressants: population-based study. Br J Psychiatry 2008; 192:338 - 43; http://dx.doi.org/10.1192/bjp.bp.107.037101; PMID: 18450656
   PubMed Web of Science ®Google Scholar
• Oberlander TF, Warburton W, Misri S, Aghajanian J, Hertzman C. Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiatry 2006; 63:898 - 906; http://dx.doi.org/10.1001/archpsyc.63.8.898; PMID: 16894066
   PubMed Web of Science ®Google Scholar
• Ross LE, Grigoriadis S, Mamisashvili L, Vonderporten EH, Roerecke M, Rehm J, Dennis CL, Koren G, Steiner M, Mousmanis P, et al. Selected pregnancy and delivery outcomes after exposure to antidepressant medication: a systematic review and meta-analysis. JAMA Psychiatry 2013; 70:436 - 43; http://dx.doi.org/10.1001/jamapsychiatry.2013.684; PMID: 23446732
   PubMed Web of Science ®Google Scholar
• Moses-Kolko EL, Bogen D, Perel J, Bregar A, Uhl K, Levin B, Wisner KL. Neonatal signs after late in utero exposure to serotonin reuptake inhibitors: literature review and implications for clinical applications. JAMA 2005; 293:2372 - 83; http://dx.doi.org/10.1001/jama.293.19.2372; PMID: 15900008
   PubMed Web of Science ®Google Scholar
• Lattimore KA, Donn SM, Kaciroti N, Kemper AR, Neal CR Jr., Vazquez DM. Selective serotonin reuptake inhibitor (SSRI) use during pregnancy and effects on the fetus and newborn: a meta-analysis. J Perinatol 2005; 25:595 - 604; http://dx.doi.org/10.1038/sj.jp.7211352; PMID: 16015372
   PubMedGoogle Scholar
• Kim J, Riggs KW, Misri S, Kent N, Oberlander TF, Grunau RE, Fitzgerald C, Rurak DW. Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feeding. Br J Clin Pharmacol 2006; 61:155 - 63; http://dx.doi.org/10.1111/j.1365-2125.2005.02538.x; PMID: 16433870
   PubMed Web of Science ®Google Scholar
• Foley DL, Craig JM, Morley R, Olsson CA, Dwyer T, Smith K, Saffery R. Prospects for epigenetic epidemiology. Am J Epidemiol 2009; 169:389 - 400; http://dx.doi.org/10.1093/aje/kwn380; PMID: 19139055
   PubMed Web of Science ®Google Scholar
• Jensen Peña C, Monk C, Champagne FA. Epigenetic effects of prenatal stress on 11β-hydroxysteroid dehydrogenase-2 in the placenta and fetal brain. PLoS One 2012; 7:e39791; http://dx.doi.org/10.1371/journal.pone.0039791; PMID: 22761903
   PubMed Web of Science ®Google Scholar
• Weaver IC, Cervoni N, Champagne FA, D’Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. Epigenetic programming by maternal behavior. Nat Neurosci 2004; 7:847 - 54; http://dx.doi.org/10.1038/nn1276; PMID: 15220929
   PubMed Web of Science ®Google Scholar
• Bjartmar L, Johansson IM, Marcusson J, Ross SB, Seckl JR, Olsson T. Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat. Psychopharmacology (Berl) 2000; 151:7 - 12; http://dx.doi.org/10.1007/s002130000468; PMID: 10958110
   PubMed Web of Science ®Google Scholar
• Yau JL, Hibberd C, Noble J, Seckl JR. The effect of chronic fluoxetine treatment on brain corticosteroid receptor mRNA expression and spatial memory in young and aged rats. Brain Res Mol Brain Res 2002; 106:117 - 23; http://dx.doi.org/10.1016/S0169-328X(02)00418-7; PMID: 12393271
   PubMedGoogle Scholar
• Cassel S, Carouge D, Gensburger C, Anglard P, Burgun C, Dietrich JB, Aunis D, Zwiller J. Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Mol Pharmacol 2006; 70:487 - 92; http://dx.doi.org/10.1124/mol.106.022301; PMID: 16670375
   PubMed Web of Science ®Google Scholar
• Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet 2008; 147B:543 - 9; http://dx.doi.org/10.1002/ajmg.b.30657; PMID: 17987668
   PubMed Web of Science ®Google Scholar
• Fuchikami M, Morinobu S, Segawa M, Okamoto Y, Yamawaki S, Ozaki N, Inoue T, Kusumi I, Koyama T, Tsuchiyama K, et al. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS One 2011; 6:e23881; http://dx.doi.org/10.1371/journal.pone.0023881; PMID: 21912609
   PubMed Web of Science ®Google Scholar
• Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM. Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 2008; 3:97 - 106; http://dx.doi.org/10.4161/epi.3.2.6034; PMID: 18536531
   PubMed Web of Science ®Google Scholar
• Devlin AM, Brain U, Austin J, Oberlander TF. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS One 2010; 5:e12201; http://dx.doi.org/10.1371/journal.pone.0012201; PMID: 20808944
   PubMed Web of Science ®Google Scholar
• Schroeder JW, Smith AK, Brennan PA, Conneely KN, Kilaru V, Knight BT, Newport DJ, Cubells JF, Stowe ZN. DNA methylation in neonates born to women receiving psychiatric care. Epigenetics 2012; 7:409 - 14; http://dx.doi.org/10.4161/epi.19551; PMID: 22419064
   PubMed Web of Science ®Google Scholar
• Claus R, Lucas DM, Stilgenbauer S, Ruppert AS, Yu L, Zucknick M, Mertens D, Bühler A, Oakes CC, Larson RA, et al. Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia. J Clin Oncol 2012; 30:2483 - 91; http://dx.doi.org/10.1200/JCO.2011.39.3090; PMID: 22564988
   PubMed Web of Science ®Google Scholar
• Sohn BH, Park IY, Lee JJ, Yang SJ, Jang YJ, Park KC, Kim DJ, Lee DC, Sohn HA, Kim TW, et al. Functional switching of TGF-β1 signaling in liver cancer via epigenetic modulation of a single CpG site in TTP promoter. Gastroenterology 2010; 138:1898 - 908, e12; http://dx.doi.org/10.1053/j.gastro.2009.12.044; PMID: 20038433
   PubMed Web of Science ®Google Scholar
• Wertheim-Tysarowska K, Sobczyńska-Tomaszewska A, Kowalewski C, Skroński M, Swięćkowski G, Kutkowska-Kaźmierczak A, Woźniak K, Bal J. The COL7A1 mutation database. Hum Mutat 2012; 33:327 - 31; http://dx.doi.org/10.1002/humu.21651; PMID: 22058051
   PubMed Web of Science ®Google Scholar
• Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 2006; 31:89 - 97; http://dx.doi.org/10.1016/j.tibs.2005.12.008; PMID: 16403636
   PubMed Web of Science ®Google Scholar
• Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 2012; 13:484 - 92; http://dx.doi.org/10.1038/nrg3230; PMID: 22641018
   PubMed Web of Science ®Google Scholar
• Essex MJ, Boyce WT, Hertzman C, Lam LL, Armstrong JM, Neumann SM, Kobor MS. Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence. Child Dev 2013; 84:58 - 75; http://dx.doi.org/10.1111/j.1467-8624.2011.01641.x; PMID: 21883162
   PubMed Web of Science ®Google Scholar
• Borghol N, Suderman M, McArdle W, Racine A, Hallett M, Pembrey M, Hertzman C, Power C, Szyf M. Associations with early-life socio-economic position in adult DNA methylation. Int J Epidemiol 2012; 41:62 - 74; http://dx.doi.org/10.1093/ije/dyr147; PMID: 22422449
   PubMed Web of Science ®Google Scholar
• Conradt E, Lester BM, Appleton AA, Armstrong DA, Marsit CJ. The roles of DNA methylation of NR3C1 and 11β-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior. Epigenetics 2013; 8:1321 - 9; http://dx.doi.org/10.4161/epi.26634; PMID: 24135662
   PubMed Web of Science ®Google Scholar
• Liu Y, Murphy SK, Murtha AP, Fuemmeler BF, Schildkraut J, Huang Z, Overcash F, Kurtzberg J, Jirtle R, Iversen ES, et al. Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics 2012; 7:735 - 46; http://dx.doi.org/10.4161/epi.20734; PMID: 22677950
   PubMed Web of Science ®Google Scholar
• Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS, National Comorbidity Survey Replication. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003; 289:3095 - 105; http://dx.doi.org/10.1001/jama.289.23.3095; PMID: 12813115
   PubMed Web of Science ®Google Scholar
• Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol 2012; 13:R43; http://dx.doi.org/10.1186/gb-2012-13-6-r43; PMID: 22703893
   PubMed Web of Science ®Google Scholar
• Hendrick V, Stowe ZN, Altshuler LL, Hwang S, Lee E, Haynes D. Placental passage of antidepressant medications. Am J Psychiatry 2003; 160:993 - 6; http://dx.doi.org/10.1176/appi.ajp.160.5.993; PMID: 12727706
   PubMed Web of Science ®Google Scholar
• Capello CF, Bourke CH, Ritchie JC, Stowe ZN, Newport DJ, Nemeroff A, Owens MJ. Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk. J Pharmacol Exp Ther 2011; 339:275 - 85; http://dx.doi.org/10.1124/jpet.111.183855; PMID: 21775476
   PubMed Web of Science ®Google Scholar
• Michels KB, Harris HR, Barault L. Birthweight, maternal weight trajectories and global DNA methylation of LINE-1 repetitive elements. PLoS One 2011; 6:e25254; http://dx.doi.org/10.1371/journal.pone.0025254; PMID: 21980406
   PubMed Web of Science ®Google Scholar
• Bibikova M, Le J, Barnes B, Saedinia-Melnyk S, Zhou L, Shen R, Gunderson KL. Genome-wide DNA methylation profiling using Infinium® assay. Epigenomics 2009; 1:177 - 200; http://dx.doi.org/10.2217/epi.09.14; PMID: 22122642
   PubMed Web of Science ®Google Scholar
• Ban L, Gibson JE, West J, Fiaschi L, Oates MR, Tata LJ. Impact of socioeconomic deprivation on maternal perinatal mental illnesses presenting to UK general practice. Br J Gen Pract 2012; 62:e671 - 8; http://dx.doi.org/10.3399/bjgp12X656801; PMID: 23265226
   PubMedGoogle Scholar
• Bodnar LM, Wisner KL, Moses-Kolko E, Sit DK, Hanusa BH. Prepregnancy body mass index, gestational weight gain, and the likelihood of major depressive disorder during pregnancy. J Clin Psychiatry 2009; 70:1290 - 6; http://dx.doi.org/10.4088/JCP.08m04651; PMID: 19607761
   PubMed Web of Science ®Google Scholar
• Gemma C, Sookoian S, Alvariñas J, García SI, Quintana L, Kanevsky D, González CD, Pirola CJ. Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns. Obesity (Silver Spring) 2009; 17:1032 - 9; http://dx.doi.org/10.1038/oby.2008.605; PMID: 19148128
   PubMed Web of Science ®Google Scholar
• Adkins RM, Thomas F, Tylavsky FA, Krushkal J. Parental ages and levels of DNA methylation in the newborn are correlated. BMC Med Genet 2011; 12:47; http://dx.doi.org/10.1186/1471-2350-12-47; PMID: 21453505
   PubMed Web of Science ®Google Scholar
• McGowan PO, Sasaki A, D’Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009; 12:342 - 8; http://dx.doi.org/10.1038/nn.2270; PMID: 19234457
   PubMed Web of Science ®Google Scholar
• Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci 2013; 16:33 - 41; http://dx.doi.org/10.1038/nn.3275; PMID: 23201972
   PubMed Web of Science ®Google Scholar
• Keller S, Sarchiapone M, Zarrilli F, Videtic A, Ferraro A, Carli V, Sacchetti S, Lembo F, Angiolillo A, Jovanovic N, et al. Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 2010; 67:258 - 67; http://dx.doi.org/10.1001/archgenpsychiatry.2010.9; PMID: 20194826
   PubMed Web of Science ®Google Scholar
• Wang D, Szyf M, Benkelfat C, Provençal N, Turecki G, Caramaschi D, Côté SM, Vitaro F, Tremblay RE, Booij L. Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PLoS One 2012; 7:e39501; http://dx.doi.org/10.1371/journal.pone.0039501; PMID: 22745770
   PubMed Web of Science ®Google Scholar
• Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W, Gillespie CF, Berg T, Evces M, Newport DJ, et al. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 2008; 65:190 - 200; http://dx.doi.org/10.1001/archgenpsychiatry.2007.26; PMID: 18250257
   PubMed Web of Science ®Google Scholar
• Wolf JM, Rohleder N, Bierhaus A, Nawroth PP, Kirschbaum C. Determinants of the NF-kappaB response to acute psychosocial stress in humans. Brain Behav Immun 2009; 23:742 - 9; http://dx.doi.org/10.1016/j.bbi.2008.09.009; PMID: 18848620
   PubMed Web of Science ®Google Scholar