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Brief Communication

MAP kinase phosphorylation is dispensable for cell division, but required for cell growth in Drosophila

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Pages 204-212 | Received 11 Feb 2010, Accepted 09 Apr 2010, Published online: 01 Jul 2010

References

  • Mitin N, Rossman KL, Der CJ. Signaling interplay in Ras superfamily function. Curr Biol 2005; 15:R563 - 74; http://dx.doi.org/10.1016/j.cub.2005.07.010; PMID: 16051167
  • Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 1999; 19:2435 - 44; PMID: 10082509
  • Simon MA. Receptor tyrosine kinases: specific outcomes from general signals. Cell 2000; 103:13 - 5; http://dx.doi.org/10.1016/S0092-8674(00)00100-8; PMID: 11051543
  • Shilo BZ. Signaling by the Drosophila epidermal growth factor receptor pathway during development. Exp Cell Res 2003; 284:140 - 9; http://dx.doi.org/10.1016/S0014-4827(02)00094-0; PMID: 12648473
  • Cobb MH, Goldsmith EJ. Dimerization in MAP-kinase signaling. Trends Biochem Sci 2000; 25:7 - 9; http://dx.doi.org/10.1016/S0968-0004(99)01508-X; PMID: 10637602
  • Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouysségur J. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J 1999; 18:664 - 74; http://dx.doi.org/10.1093/emboj/18.3.664; PMID: 9927426
  • Chen R-H, Sarnecki C, Blenis J. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 1992; 12:915 - 27; PMID: 1545823
  • Khokhlatchev AV, Canagarajah B, Wilsbacher J, Robinson M, Atkinson M, Goldsmith E, et al. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell 1998; 93:605 - 15; http://dx.doi.org/10.1016/S0092-8674(00)81189-7; PMID: 9604935
  • Lenormand P, Sardet C, Pagès G, L’Allemain G, Brunet A, Pouysségur J. Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. J Cell Biol 1993; 122:1079 - 88; http://dx.doi.org/10.1083/jcb.122.5.1079; PMID: 8394845
  • Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999; 286:1358 - 62; http://dx.doi.org/10.1126/science.286.5443.1358; PMID: 10558990
  • Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. J Cell Sci 2004; 117:4619 - 28; http://dx.doi.org/10.1242/jcs.01481; PMID: 15371522
  • Shilo BZ. Regulating the dynamics of EGF receptor signaling in space and time. Development 2005; 132:4017 - 27; http://dx.doi.org/10.1242/dev.02006; PMID: 16123311
  • Ebisuya M, Kondoh K, Nishida E. The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity. J Cell Sci 2005; 118:2997 - 3002; http://dx.doi.org/10.1242/jcs.02505; PMID: 16014377
  • Kumar JP, Tio M, Hsiung F, Akopyan S, Gabay L, Seger R, et al. Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 1998; 125:3875 - 85; PMID: 9729495
  • Kumar JP, Hsiung F, Powers MA, Moses K. Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye. Development 2003; 130:3703 - 14; http://dx.doi.org/10.1242/dev.00556; PMID: 12835387
  • Marenda DR, Vrailas AD, Rodrigues AB, Cook S, Powers MA, Lorenzen JA, et al. MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing. Development 2006; 133:43 - 51; http://dx.doi.org/10.1242/dev.02168; PMID: 16308331
  • Vrailas AD, Marenda DR, Cook SE, Powers MA, Lorenzen JA, Perkins LA, et al. smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye. Development 2006; 133:1485 - 94; http://dx.doi.org/10.1242/dev.02334; PMID: 16540506
  • Lorenzen JA, Baker SE, Denhez F, Melnick MB, Brower DL, Perkins LA. Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin.. Development 2001; 128:1403 - 14; PMID: 11262240
  • Morata G, Ripoll P. Minutes: mutants of drosophila autonomously affecting cell division rate. Dev Biol 1975; 42:211 - 21; http://dx.doi.org/10.1016/0012-1606(75)90330-9; PMID: 1116643
  • Freeman M. Misexpression of the Drosophila argos gene, a secreted regulator of cell determination. Development 1994; 120:2297 - 304; PMID: 7925030
  • Freeman M. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 1996; 87:651 - 60; http://dx.doi.org/10.1016/S0092-8674(00)81385-9; PMID: 8929534
  • Martín-Blanco E. Regulatory control of signal transduction during morphogenesis in Drosophila. Int J Dev Biol 1998; 42:363 - 8; PMID: 9654020
  • Karim FD, Chang HC, Therrien M, Wassarman DA, Laverty T, Rubin GM. A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics 1996; 143:315 - 29; PMID: 8722784
  • Newsome TP, Asling B, Dickson BJ. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 2000; 127:851 - 60; PMID: 10648243
  • Brand AH, Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993; 118:401 - 15; PMID: 8223268
  • Xu T, Rubin GM. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 1993; 117:1223 - 37; PMID: 8404527
  • Tio M, Moses K. The Drosophila TGF alpha homolog Spitz acts in photoreceptor recruitment in the developing retina. Development 1997; 124:343 - 51; PMID: 9053310
  • Tseng AS, Tapon N, Kanda H, Cigizoglu S, Edelmann L, Pellock B, et al. Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Curr Biol 2007; 17:728 - 33; http://dx.doi.org/10.1016/j.cub.2007.03.023; PMID: 17398096
  • Marenda DR, Zraly CB, Feng Y, Egan S, Dingwall AK. The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complex. Mol Cell Biol 2003; 23:289 - 305; http://dx.doi.org/10.1128/MCB.23.1.289-305.2003; PMID: 12482982
  • Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA. Argos inhibits epidermal growth factor receptor signalling by ligand sequestration. Nature 2004; 430:1040 - 4; http://dx.doi.org/10.1038/nature02840; PMID: 15329724
  • Klein DE, Stayrook SE, Shi F, Narayan K, Lemmon MA. Structural basis for EGFR ligand sequestration by Argos. Nature 2008; 453:1271 - 5; http://dx.doi.org/10.1038/nature06978; PMID: 18500331
  • Gabay L, Seger R, Shilo B-Z. In situ activation pattern of Drosophila EGF receptor pathway during development. Science 1997; 277:1103 - 6; http://dx.doi.org/10.1126/science.277.5329.1103; PMID: 9262480
  • Sawamoto K, Okano H, Kobayakawa Y, Hayashi S, Mikoshiba K, Tanimura T. The function of argos in regulating cell fate decisions during Drosophila eye and wing vein development. Dev Biol 1994; 164:267 - 76; http://dx.doi.org/10.1006/dbio.1994.1197; PMID: 8026629
  • Meyer CA, Jacobs HW, Datar SA, Du W, Edgar BA, Lehner CF. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J 2000; 19:4533 - 42; http://dx.doi.org/10.1093/emboj/19.17.4533; PMID: 10970847
  • Sturtevant MA, Roark M, Bier E. The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev 1993; 7:961 - 73; http://dx.doi.org/10.1101/gad.7.6.961; PMID: 8504935
  • Hsu JC, Perrimon N. A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases. Genes Dev 1994; 8:2176 - 87; http://dx.doi.org/10.1101/gad.8.18.2176; PMID: 7958887
  • Tsuda L, Inoue YH, Yoo M-A, Mizuno M, Hata M, Lim Y-M, et al. A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell 1993; 72:407 - 14; http://dx.doi.org/10.1016/0092-8674(93)90117-9; PMID: 8381718
  • Lim YM, Nishizawa K, Nishi Y, Tsuda L, Inoue YH, Nishida Y. Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase. Genetics 1999; 153:763 - 71; PMID: 10511556
  • Tseng AS, Tapon N, Kanda H, Cigizoglu S, Edelmann L, Pellock B, et al. Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Curr Biol 2007; 17:728 - 33; http://dx.doi.org/10.1016/j.cub.2007.03.023; PMID: 17398096
  • Adachi M, Fukuda M, Nishida E. Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO J 1999; 18:5347 - 58; http://dx.doi.org/10.1093/emboj/18.19.5347; PMID: 10508167
  • Yazicioglu MN, Goad DL, Ranganathan A, Whitehurst AW, Goldsmith EJ, Cobb MH. Mutations in ERK2 binding sites affect nuclear entry. J Biol Chem 2007; 282:28759 - 67; http://dx.doi.org/10.1074/jbc.M703460200; PMID: 17656361
  • Matsubayashi Y, Fukuda M, Nishida E. Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells. J Biol Chem 2001; 276:41755 - 60; http://dx.doi.org/10.1074/jbc.M106012200; PMID: 11546808
  • Neufeld TP, de la Cruz AF, Johnston LA, Edgar BA. Coordination of growth and cell division in the Drosophila wing. Cell 1998; 93:1183 - 93; http://dx.doi.org/10.1016/S0092-8674(00)81462-2; PMID: 9657151
  • Prober DA, Edgar BA. Ras1 promotes cellular growth in the Drosophila wing. Cell 2000; 100:435 - 46; http://dx.doi.org/10.1016/S0092-8674(00)80679-0; PMID: 10693760
  • Hu S, Xie Z, Onishi A, Yu X, Jiang L, Lin J, et al. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell 2009; 139:610 - 22; http://dx.doi.org/10.1016/j.cell.2009.08.037; PMID: 19879846
  • Bianco R, Gelardi T, Damiano V, Ciardiello F, Tortora G. Rational bases for the development of EGFR inhibitors for cancer treatment. Int J Biochem Cell Biol 2007; 39:1416 - 31; http://dx.doi.org/10.1016/j.biocel.2007.05.008; PMID: 17596994
  • Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 2007; 318:287 - 90; http://dx.doi.org/10.1126/science.1142946; PMID: 17872411

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