Gut microbial communities modulating brain development and function

References

• Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, et al. Diversity of the human intestinal microbial flora. Science 2005; 308:1635 - 8; http://dx.doi.org/10.1126/science.1110591; PMID: 15831718
   PubMed Web of Science ®Google Scholar
• Korecka A, Arulampalam V. The gut microbiome: scourge, sentinel or spectator?. J Oral Microbiol 2012; 4:9367; PMID: 22368769
   PubMedGoogle Scholar
• Reyes A, Haynes M, Hanson N, Angly FE, Heath AC, Rohwer F, et al. Viruses in the faecal microbiota of monozygotic twins and their mothers. Nature 2010; 466:334 - 8; http://dx.doi.org/10.1038/nature09199; PMID: 20631792
   PubMed Web of Science ®Google Scholar
• Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, et al. Enterotypes of the human gut microbiome. Nature 2011; 473:174; http://dx.doi.org/10.1038/nature09944; PMID: 21270879
   PubMed Web of Science ®Google Scholar
• Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science 2001; 292:1115 - 8; http://dx.doi.org/10.1126/science.1058709; PMID: 11352068
   PubMed Web of Science ®Google Scholar
• Amaral FA, Sachs D, Costa VV, Fagundes CT, Cisalpino D, Cunha TM, et al. Commensal microbiota is fundamental for the development of inflammatory pain. Proc Natl Acad Sci USA 2008; 105:2193 - 7; http://dx.doi.org/10.1073/pnas.0711891105; PMID: 18268332
   PubMed Web of Science ®Google Scholar
• Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 2006; 103:12511 - 6; http://dx.doi.org/10.1073/pnas.0601056103; PMID: 16895997
   PubMed Web of Science ®Google Scholar
• Aronsson L, Huang Y, Parini P, Korach-André M, Håkansson J, Gustafsson JA, et al. Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). PLoS ONE 2010; 5:5; http://dx.doi.org/10.1371/journal.pone.0013087; PMID: 20927337
   PubMed Web of Science ®Google Scholar
• Hawrelak JA, Myers SP. The causes of intestinal dysbiosis: a review. Altern Med Rev 2004; 9:180 - 97; PMID: 15253677
   PubMedGoogle Scholar
• Daneman R, Rescigno M. The gut immune barrier and the blood-brain barrier: are they so different?. Immunity 2009; 31:722 - 35; http://dx.doi.org/10.1016/j.immuni.2009.09.012; PMID: 19836264
   PubMed Web of Science ®Google Scholar
• Lepage P, Colombet J, Marteau P, Sime-Ngando T, Doré J, Leclerc M. Dysbiosis in inflammatory bowel disease: a role for bacteriophages?. Gut 2008; 57:424 - 5; http://dx.doi.org/10.1136/gut.2007.134668; PMID: 18268057
   PubMed Web of Science ®Google Scholar
• Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG. The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. J Psychiatr Res 2008; 43:164 - 74; http://dx.doi.org/10.1016/j.jpsychires.2008.03.009; PMID: 18456279
   PubMed Web of Science ®Google Scholar
• Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, et al. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 2004; 558:263 - 75; http://dx.doi.org/10.1113/jphysiol.2004.063388; PMID: 15133062
   PubMed Web of Science ®Google Scholar
• Neufeld KM, Kang N, Bienenstock J, Foster JA. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 2011; 23:255 - 64, e119; http://dx.doi.org/10.1111/j.1365-2982.2010.01620.x; PMID: 21054680
   PubMed Web of Science ®Google Scholar
• Li W, Dowd SE, Scurlock B, Acosta-Martinez V, Lyte M. Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria. Physiol Behav 2009; 96:557 - 67; http://dx.doi.org/10.1016/j.physbeh.2008.12.004; PMID: 19135464
   PubMed Web of Science ®Google Scholar
• Berthoud HR. Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterol Motil 2008; 20:Suppl 1 64 - 72; http://dx.doi.org/10.1111/j.1365-2982.2008.01104.x; PMID: 18402643
   PubMedGoogle Scholar
• Drossman DA. What does the future hold for irritable bowel syndrome and the functional gastrointestinal disorders?. J Clin Gastroenterol 2005; 39:Suppl 3 S251 - 6; http://dx.doi.org/10.1097/01.mcg.0000156107.13247.69; PMID: 15798493
   PubMed Web of Science ®Google Scholar
• Shanahan F. Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology. Semin Gastrointest Dis 1999; 10:8 - 13; PMID: 10065767
   PubMedGoogle Scholar
• Mayer EA. Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci 2011; 12:453 - 66; http://dx.doi.org/10.1038/nrn3071; PMID: 21750565
   PubMed Web of Science ®Google Scholar
• Van Oudenhove L, Demyttenaere K, Tack J, Aziz Q. Central nervous system involvement in functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004; 18:663 - 80; http://dx.doi.org/10.1016/j.bpg.2004.04.010; PMID: 15324706
   PubMed Web of Science ®Google Scholar
• Morgan MY. The treatment of chronic hepatic encephalopathy. Hepatogastroenterology 1991; 38:377 - 87; PMID: 1662661
   PubMed Web of Science ®Google Scholar
• Morgan MY, Blei A, Grüngreiff K, Jalan R, Kircheis G, Marchesini G, et al. The treatment of hepatic encephalopathy. Metab Brain Dis 2007; 22:389 - 405; http://dx.doi.org/10.1007/s11011-007-9060-7; PMID: 17846875
   PubMed Web of Science ®Google Scholar
• Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?. Gastroenterology 2002; 122:1140 - 56; http://dx.doi.org/10.1053/gast.2002.32392; PMID: 11910364
   PubMed Web of Science ®Google Scholar
• Garakani A, Win T, Virk S, Gupta S, Kaplan D, Masand PS. Comorbidity of irritable bowel syndrome in psychiatric patients: a review. Am J Ther 2003; 10:61 - 7; http://dx.doi.org/10.1097/00045391-200301000-00014; PMID: 12522523
   PubMedGoogle Scholar
• Lyte M, Li W, Opitz N, Gaykema RP, Goehler LE. Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium. Physiol Behav 2006; 89:350 - 7; http://dx.doi.org/10.1016/j.physbeh.2006.06.019; PMID: 16887154
   PubMed Web of Science ®Google Scholar
• Yu F, Takahashi T, Moriya J, Kawaura K, Yamakawa J, Kusaka K, et al. Traditional Chinese medicine and Kampo: a review from the distant past for the future. J Int Med Res 2006; 34:231 - 9; PMID: 16866016
   PubMed Web of Science ®Google Scholar
• Bischoff SC. 'Gut health': a new objective in medicine?. BMC Med 2011; 9; PMID: 21269451
   PubMed Web of Science ®Google Scholar
• Heijtz RD, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, et al. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci USA 2011; 108:3047 - 52; http://dx.doi.org/10.1073/pnas.1010529108; PMID: 21282636
   PubMed Web of Science ®Google Scholar
• Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 2011; 141:599 - 609; http://dx.doi.org/10.1053/j.gastro.2011.04.052; PMID: 21683077
   PubMed Web of Science ®Google Scholar
• Collins S. Intestinal microbiota and the brain-gut axis. in Finlay, B (ed), Microbiota: Agents for Health and Disease, The Biomedical & Life Sciences Collection. London: Henry Stewart Talks Ltd, 2011.
   Google Scholar
• Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A, et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 2011; 105:755 - 64; http://dx.doi.org/10.1017/S0007114510004319; PMID: 20974015
   PubMed Web of Science ®Google Scholar
• Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 2011; 108:16050 - 5; http://dx.doi.org/10.1073/pnas.1102999108; PMID: 21876150
   PubMed Web of Science ®Google Scholar
• Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, et al. Bacterial infection causes stress-induced memory dysfunction in mice. Gut 2011; 60:307 - 17; http://dx.doi.org/10.1136/gut.2009.202515; PMID: 20966022
   PubMed Web of Science ®Google Scholar
• Tannock GW, Savage DC. Influences of dietary and environmental stress on microbial populations in the murine gastrointestinal tract. Infect Immun 1974; 9:591 - 8; PMID: 4593471
   PubMed Web of Science ®Google Scholar
• Suzuki K, Harasawa R, Yoshitake Y, Mitsuoka T. Effects of crowding and heat stress on intestinal flora, body weight gain, and feed efficiency of growing rats and chicks. Nihon Juigaku Zasshi 1983; 45:331 - 8; http://dx.doi.org/10.1292/jvms1939.45.331; PMID: 6632469
   PubMedGoogle Scholar
• Holdeman LV, Good IJ, Moore WEC. Human fecal flora: variation in bacterial composition within individuals and a possible effect of emotional stress. Appl Environ Microbiol 1976; 31:359 - 75; PMID: 938032
   PubMed Web of Science ®Google Scholar
• Bailey MT, Coe CL. Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Dev Psychobiol 1999; 35:146 - 55; http://dx.doi.org/10.1002/(SICI)1098-2302(199909)35:2<146::AID-DEV7>3.0.CO;2-G; PMID: 10461128
   PubMed Web of Science ®Google Scholar
• Demaude J, Salvador-Cartier C, Fioramonti J, Ferrier L, Bueno L. Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction. Gut 2006; 55:655 - 61; http://dx.doi.org/10.1136/gut.2005.078675; PMID: 16299034
   PubMed Web of Science ®Google Scholar
• Freestone PP, Williams PH, Haigh RD, Maggs AF, Neal CP, Lyte M. Growth stimulation of intestinal commensal Escherichia coli by catecholamines: a possible contributory factor in trauma-induced sepsis. Shock 2002; 18:465 - 70; http://dx.doi.org/10.1097/00024382-200211000-00014; PMID: 12412628
   PubMed Web of Science ®Google Scholar
• Freestone PP, Haigh RD, Williams PH, Lyte M. Involvement of enterobactin in norepinephrine-mediated iron supply from transferrin to enterohaemorrhagic Escherichia coli. FEMS Microbiol Lett 2003; 222:39 - 43; http://dx.doi.org/10.1016/S0378-1097(03)00243-X; PMID: 12757944
   PubMed Web of Science ®Google Scholar
• Rubio CA, Huang CB. Quantification of the sulphomucin-producing cell population of the colonic mucosa during protracted stress in rats. In Vivo 1992; 6:81 - 4; PMID: 1627747
   PubMedGoogle Scholar
• Collins SM, Bercik P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 2009; 136:2003 - 14; http://dx.doi.org/10.1053/j.gastro.2009.01.075; PMID: 19457424
   PubMed Web of Science ®Google Scholar
• Barker DJP. Maternal nutrition, fetal nutrition, and disease in later life. Nutrition 1997; 13:807 - 13; http://dx.doi.org/10.1016/S0899-9007(97)00193-7; PMID: 9290095
   PubMed Web of Science ®Google Scholar
• Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, et al. Early life programming and neurodevelopmental disorders. Biol Psychiatry 2010; 68:314 - 9; http://dx.doi.org/10.1016/j.biopsych.2010.05.028; PMID: 20674602
   PubMed Web of Science ®Google Scholar
• Finegold SM, Molitoris D, Song Y, Liu C, Vaisanen ML, Bolte E, et al. Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis 2002; 35:Suppl 1 S6 - 16; http://dx.doi.org/10.1086/341914; PMID: 12173102
   PubMed Web of Science ®Google Scholar
• Mittal VA, Ellman LM, Cannon TD. Gene-environment interaction and covariation in schizophrenia: the role of obstetric complications. Schizophr Bull 2008; 34:1083 - 94; http://dx.doi.org/10.1093/schbul/sbn080; PMID: 18635675
   PubMed Web of Science ®Google Scholar
• Goehler LE, Park SM, Opitz N, Lyte M, Gaykema RP. Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior. Brain Behav Immun 2008; 22:354 - 66; http://dx.doi.org/10.1016/j.bbi.2007.08.009; PMID: 17920243
   PubMed Web of Science ®Google Scholar
• Bilbo SD, Levkoff LH, Mahoney JH, Watkins LR, Rudy JW, Maier SF. Neonatal infection induces memory impairments following an immune challenge in adulthood. Behav Neurosci 2005; 119:293 - 301; http://dx.doi.org/10.1037/0735-7044.119.1.293; PMID: 15727533
   PubMed Web of Science ®Google Scholar
• Sullivan R, Wilson DA, Feldon J, Yee BK, Meyer U, Richter-Levin G, et al. The International Society for Developmental Psychobiology annual meeting symposium: Impact of early life experiences on brain and behavioral development. Dev Psychobiol 2006; 48:583 - 602; http://dx.doi.org/10.1002/dev.20170; PMID: 17016842
   PubMed Web of Science ®Google Scholar
• Jiménez E, Fernández L, Marín ML, Martín R, Odriozola JM, Nueno-Palop C, et al. Isolation of commensal bacteria from umbilical cord blood of healthy neonates born by cesarean section. Curr Microbiol 2005; 51:270 - 4; http://dx.doi.org/10.1007/s00284-005-0020-3; PMID: 16187156
   PubMed Web of Science ®Google Scholar
• Jiménez E, Marín ML, Martín R, Odriozola JM, Olivares M, Xaus J, et al. Is meconium from healthy newborns actually sterile?. Res Microbiol 2008; 159:187 - 93; http://dx.doi.org/10.1016/j.resmic.2007.12.007; PMID: 18281199
   PubMed Web of Science ®Google Scholar
• Satokari R, Grönroos T, Laitinen K, Salminen S, Isolauri E. Bifidobacterium and Lactobacillus DNA in the human placenta. Lett Appl Microbiol 2009; 48:8 - 12; http://dx.doi.org/10.1111/j.1472-765X.2008.02475.x; PMID: 19018955
   PubMed Web of Science ®Google Scholar
• Steel JH, Malatos S, Kennea N, Edwards AD, Miles L, Duggan P, et al. Bacteria and inflammatory cells in fetal membranes do not always cause preterm labor. Pediatr Res 2005; 57:404 - 11; http://dx.doi.org/10.1203/01.PDR.0000153869.96337.90; PMID: 15659699
   PubMed Web of Science ®Google Scholar
• Dancis J. The Role of the Placenta in Fetal Survival. Pediatr Clin North Am 1965; 12:477 - 92; PMID: 14312821
   PubMed Web of Science ®Google Scholar
• Kalb C. Fetal armor. Sci Am 2012; 306:72 - 3; http://dx.doi.org/10.1038/scientificamerican0212-72; PMID: 22295682
   PubMedGoogle Scholar
• Broad KD, Keverne EB. Placental protection of the fetal brain during short-term food deprivation. Proc Natl Acad Sci USA 2011; 108:15237 - 41; http://dx.doi.org/10.1073/pnas.1106022108; PMID: 21810990
   PubMed Web of Science ®Google Scholar
• Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, et al. A transient placental source of serotonin for the fetal forebrain. Nature 2011; 472:347 - 50; http://dx.doi.org/10.1038/nature09972; PMID: 21512572
   PubMed Web of Science ®Google Scholar
• Henry C, Kabbaj M, Simon H, Le Moal M, Maccari S. Prenatal stress increases the hypothalamo-pituitary-adrenal axis response in young and adult rats. J Neuroendocrinol 1994; 6:341 - 5; http://dx.doi.org/10.1111/j.1365-2826.1994.tb00591.x; PMID: 7920600
   PubMed Web of Science ®Google Scholar
• McCormick CM, Smythe JW, Sharma S, Meaney MJ. Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats. Brain Res Dev Brain Res 1995; 84:55 - 61; http://dx.doi.org/10.1016/0165-3806(94)00153-Q; PMID: 7720217
   PubMedGoogle Scholar
• Alonso J, Castellano MA, Rodriguez M. Behavioral lateralization in rats: prenatal stress effects on sex differences. Brain Res 1991; 539:45 - 50; http://dx.doi.org/10.1016/0006-8993(91)90684-N; PMID: 2015502
   PubMed Web of Science ®Google Scholar
• Vallée M, Mayo W, Dellu F, Le Moal M, Simon H, Maccari S. Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: correlation with stress-induced corticosterone secretion. J Neurosci 1997; 17:2626 - 36; PMID: 9065522
   PubMed Web of Science ®Google Scholar
• Caldji C, Tannenbaum B, Sharma S, Francis D, Plotsky PM, Meaney MJ. Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proc Natl Acad Sci USA 1998; 95:5335 - 40; http://dx.doi.org/10.1073/pnas.95.9.5335; PMID: 9560276
   PubMed Web of Science ®Google Scholar
• Maccari S, Piazza PV, Kabbaj M, Barbazanges A, Simon H, Le Moal M. Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress. J Neurosci 1995; 15:110 - 6; PMID: 7823121
   PubMed Web of Science ®Google Scholar
• Vallée M, MacCari S, Dellu F, Simon H, Le Moal M, Mayo W. Long-term effects of prenatal stress and postnatal handling on age-related glucocorticoid secretion and cognitive performance: a longitudinal study in the rat. Eur J Neurosci 1999; 11:2906 - 16; http://dx.doi.org/10.1046/j.1460-9568.1999.00705.x; PMID: 10457187
   PubMed Web of Science ®Google Scholar
• Barouei J, Hodgson DM. Prophylactic Potential of Maternal Probiotic Supplementation Against Intestinal Dysfunctions Induced by Early Life Stress. J Dev Orig Health Dis 2011; 2:S77 - S
   Google Scholar
• Noback CRSNL, Demarest RJ. The Human Nervous System. Philadelphia: Williams and Wilkins, 1995.
   Google Scholar
• Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 2010; 107:11971 - 5; http://dx.doi.org/10.1073/pnas.1002601107; PMID: 20566857
   PubMed Web of Science ®Google Scholar
• Pop M. We are what we eat: how the diet of infants affects their gut microbiome. Genome Biol 2012; 13:152; http://dx.doi.org/10.1186/gb-2012-13-4-152; PMID: 22546514
   PubMed Web of Science ®Google Scholar
• Kramer MS, Aboud F, Mironova E, Vanilovich I, Platt RW, Matush L, et al, Promotion of Breastfeeding Intervention Trial (PROBIT) Study Group. Breastfeeding and child cognitive development: new evidence from a large randomized trial. Arch Gen Psychiatry 2008; 65:578 - 84; http://dx.doi.org/10.1001/archpsyc.65.5.578; PMID: 18458209
   PubMed Web of Science ®Google Scholar
• Guxens M, Mendez MA, Moltó-Puigmartí C, Julvez J, García-Esteban R, Forns J, et al. Breastfeeding, long-chain polyunsaturated fatty acids in colostrum, and infant mental development. Pediatrics 2011; 128:e880 - 9; http://dx.doi.org/10.1542/peds.2010-1633; PMID: 21930546
   PubMedGoogle Scholar
• Schwartz S, Friedberg I, Ivanov IV, Davidson LA, Goldsby JS, Dahl DB, et al. A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response. Genome Biol 2012; 13:r32; http://dx.doi.org/10.1186/gb-2012-13-4-r32; PMID: 22546241
   PubMed Web of Science ®Google Scholar
• Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. Development of the human infant intestinal microbiota. PLoS Biol 2007; 5:e177; http://dx.doi.org/10.1371/journal.pbio.0050177; PMID: 17594176
   PubMed Web of Science ®Google Scholar
• Adlerberth I, Wold AE. Establishment of the gut microbiota in Western infants. Acta Paediatr 2009; 98:229 - 38; http://dx.doi.org/10.1111/j.1651-2227.2008.01060.x; PMID: 19143664
   PubMed Web of Science ®Google Scholar
• Shkoporov AN, Khokhlova EV, Kulagina EV, Smeianov VV, Kafarskaia LI, Efimov BA. Application of several molecular techniques to study numerically predominant Bifidobacterium spp. and Bacteroidales order strains in the feces of healthy children. Biosci Biotechnol Biochem 2008; 72:742 - 8; http://dx.doi.org/10.1271/bbb.70628; PMID: 18323636
   PubMed Web of Science ®Google Scholar
• Wall R, Marques TM, O’Sullivan O, Ross RP, Shanahan F, Quigley EM, et al. Contrasting effects of Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 on the composition of murine brain fatty acids and gut microbiota. Am J Clin Nutr 2012; 95:1278 - 87; http://dx.doi.org/10.3945/ajcn.111.026435; PMID: 22492373
   PubMed Web of Science ®Google Scholar
• Santos F, Wegkamp A, de Vos WM, Smid EJ, Hugenholtz J. High-Level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112. Appl Environ Microbiol 2008; 74:3291 - 4; http://dx.doi.org/10.1128/AEM.02719-07; PMID: 18344331
   PubMed Web of Science ®Google Scholar
• Marques TM, Wall R, Ross RP, Fitzgerald GF, Ryan CA, Stanton C. Programming infant gut microbiota: influence of dietary and environmental factors. Curr Opin Biotechnol 2010; 21:149 - 56; http://dx.doi.org/10.1016/j.copbio.2010.03.020; PMID: 20434324
   PubMed Web of Science ®Google Scholar
• Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 2008; 66:250 - 5; http://dx.doi.org/10.1111/j.1753-4887.2008.00031.x; PMID: 18454811
   PubMed Web of Science ®Google Scholar
• Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 2012; http://dx.doi.org/10.1038/mp.2012.77; PMID: 22688187
   PubMed Web of Science ®Google Scholar
• Noverr MC, Huffnagle GB. The ‘microflora hypothesis’ of allergic diseases. Clin Exp Allergy 2005; 35:1511 - 20; http://dx.doi.org/10.1111/j.1365-2222.2005.02379.x; PMID: 16393316
   PubMed Web of Science ®Google Scholar
• Becker KG. Autism, asthma, inflammation, and the hygiene hypothesis. Med Hypotheses 2007; 69:731 - 40; http://dx.doi.org/10.1016/j.mehy.2007.02.019; PMID: 17412520
   PubMed Web of Science ®Google Scholar
• Sandler RH, Finegold SM, Bolte ER, Buchanan CP, Maxwell AP, Väisänen ML, et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol 2000; 15:429 - 35; http://dx.doi.org/10.1177/088307380001500701; PMID: 10921511
   PubMed Web of Science ®Google Scholar
• Song Y, Liu C, Finegold SM. Real-time PCR quantitation of clostridia in feces of autistic children. Appl Environ Microbiol 2004; 70:6459 - 65; http://dx.doi.org/10.1128/AEM.70.11.6459-6465.2004; PMID: 15528506
   PubMed Web of Science ®Google Scholar
• Finegold SM. Therapy and epidemiology of autism--clostridial spores as key elements. Med Hypotheses 2008; 70:508 - 11; http://dx.doi.org/10.1016/j.mehy.2007.07.019; PMID: 17904761
   PubMed Web of Science ®Google Scholar
• Roy CC, Kien CL, Bouthillier L, Levy E. Short-chain fatty acids: ready for prime time?. Nutr Clin Pract 2006; 21:351 - 66; http://dx.doi.org/10.1177/0115426506021004351; PMID: 16870803
   PubMedGoogle Scholar
• Sleeth ML, Thompson EL, Ford HE, Zac-Varghese SE, Frost G. Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation. Nutr Res Rev 2010; 23:135 - 45; http://dx.doi.org/10.1017/S0954422410000089; PMID: 20482937
   PubMed Web of Science ®Google Scholar
• Tang Y, Chen Y, Jiang H, Robbins GT, Nie D. G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer. Int J Cancer 2011; 128:847 - 56; http://dx.doi.org/10.1002/ijc.25638; PMID: 20979106
   PubMed Web of Science ®Google Scholar
• Wolever TMS, Spadafora P, Eshuis H. Interaction between colonic acetate and propionate in humans. Am J Clin Nutr 1991; 53:681 - 7; PMID: 2000822
   PubMed Web of Science ®Google Scholar
• Scheppach W. Effects of short chain fatty acids on gut morphology and function. Gut 1994; 35:Suppl S35 - 8; http://dx.doi.org/10.1136/gut.35.1_Suppl.S35; PMID: 8125387
   PubMed Web of Science ®Google Scholar
• Waldecker M, Kautenburger T, Daumann H, Busch C, Schrenk D. Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. J Nutr Biochem 2008; 19:587 - 93; http://dx.doi.org/10.1016/j.jnutbio.2007.08.002; PMID: 18061431
   PubMed Web of Science ®Google Scholar
• Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009; 461:1282 - 6; http://dx.doi.org/10.1038/nature08530; PMID: 19865172
   PubMed Web of Science ®Google Scholar
• Vieira EL, Leonel AJ, Sad AP, Beltrao NR, Costa TF, Ferreira TM, et al. Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis. J Nutr Biochem 2011; PMID: 21658926
   PubMed Web of Science ®Google Scholar
• Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, et al. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci USA 2011; 108:8030 - 5; http://dx.doi.org/10.1073/pnas.1016088108; PMID: 21518883
   PubMed Web of Science ®Google Scholar
• Vecsey CG, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner MA, et al. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci 2007; 27:6128 - 40; http://dx.doi.org/10.1523/JNEUROSCI.0296-07.2007; PMID: 17553985
   PubMed Web of Science ®Google Scholar
• Stefanko DP, Barrett RM, Ly AR, Reolon GK, Wood MA. Modulation of long-term memory for object recognition via HDAC inhibition. Proc Natl Acad Sci USA 2009; 106:9447 - 52; http://dx.doi.org/10.1073/pnas.0903964106; PMID: 19470462
   PubMed Web of Science ®Google Scholar
• Schroeder FA, Lin CL, Crusio WE, Akbarian S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry 2007; 62:55 - 64; http://dx.doi.org/10.1016/j.biopsych.2006.06.036; PMID: 16945350
   PubMed Web of Science ®Google Scholar
• MacFabe DF, Cain DP, Rodriguez-Capote K, Franklin AE, Hoffman JE, Boon F, et al. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav Brain Res 2007; 176:149 - 69; http://dx.doi.org/10.1016/j.bbr.2006.07.025; PMID: 16950524
   PubMed Web of Science ®Google Scholar
• MacFabe DF, Cain NE, Boon F, Ossenkopp KP, Cain DP. Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder. Behav Brain Res 2011; 217:47 - 54; http://dx.doi.org/10.1016/j.bbr.2010.10.005; PMID: 20937326
   PubMed Web of Science ®Google Scholar
• Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci USA 2009; 106:3698 - 703; http://dx.doi.org/10.1073/pnas.0812874106; PMID: 19234110
   PubMed Web of Science ®Google Scholar
• Fetissov SO, Déchelotte P. The new link between gut-brain axis and neuropsychiatric disorders. Curr Opin Clin Nutr Metab Care 2011; 14:477 - 82; http://dx.doi.org/10.1097/MCO.0b013e32834936e7; PMID: 21832903
   PubMed Web of Science ®Google Scholar
• Borovikova LV, Ivanova S, Zhang MH, Yang H, Botchkina GI, Watkins LR, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405:458 - 62; http://dx.doi.org/10.1038/35013070; PMID: 10839541
   PubMed Web of Science ®Google Scholar
• Wang X, Wang BR, Zhang XJ, Xu Z, Ding YQ, Ju G. Evidences for vagus nerve in maintenance of immune balance and transmission of immune information from gut to brain in STM-infected rats. World J Gastroenterol 2002; 8:540 - 5; PMID: 12046088
   PubMed Web of Science ®Google Scholar
• Kunze WA, Mao YK, Wang B, Huizinga JD, Ma X, Forsythe P, et al. Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening. J Cell Mol Med 2009; 13:8B 2261 - 70; http://dx.doi.org/10.1111/j.1582-4934.2009.00686.x; PMID: 19210574
   PubMed Web of Science ®Google Scholar
• Bercik P, Verdu EF, Foster JA, Macri J, Potter M, Huang XX, et al. Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. . Gastroenterology 2010; 139:2102 - 12; http://dx.doi.org/10.1053/j.gastro.2010.06.063; PMID: 20600016
   PubMed Web of Science ®Google Scholar
• Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008; 4:337 - 49; http://dx.doi.org/10.1016/j.chom.2008.09.009; PMID: 18854238
   PubMed Web of Science ®Google Scholar
• Gaboriau-Routhiau V, Rakotobe S, Lécuyer E, Mulder I, Lan A, Bridonneau C, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 2009; 31:677 - 89; http://dx.doi.org/10.1016/j.immuni.2009.08.020; PMID: 19833089
   PubMed Web of Science ®Google Scholar
• Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139:485 - 98; http://dx.doi.org/10.1016/j.cell.2009.09.033; PMID: 19836068
   PubMed Web of Science ®Google Scholar
• Hall JA, Bouladoux N, Sun CM, Wohlfert EA, Blank RB, Zhu Q, et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 2008; 29:637 - 49; http://dx.doi.org/10.1016/j.immuni.2008.08.009; PMID: 18835196
   PubMed Web of Science ®Google Scholar
• Diamond B, Huerta PT, Tracey K, Volpe BT. It takes guts to grow a brain: Increasing evidence of the important role of the intestinal microflora in neuro- and immune-modulatory functions during development and adulthood. Bioessays 2011; 33:588 - 91; http://dx.doi.org/10.1002/bies.201100042; PMID: 21681774
   PubMed Web of Science ®Google Scholar
• Uribe A, Alam M, Johansson O, Midtvedt T, Theodorsson E. Microflora modulates endocrine cells in the gastrointestinal mucosa of the rat. Gastroenterology 1994; 107:1259 - 69; PMID: 7926490
   PubMed Web of Science ®Google Scholar
• Bates JM, Mittge E, Kuhlman J, Baden KN, Cheesman SE, Guillemin K. Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation. Dev Biol 2006; 297:374 - 86; http://dx.doi.org/10.1016/j.ydbio.2006.05.006; PMID: 16781702
   PubMed Web of Science ®Google Scholar
• Reinhardt C, Reigstad CS, Bäckhed F. Intestinal microbiota during infancy and its implications for obesity. J Pediatr Gastroenterol Nutr 2009; 48:249 - 56; http://dx.doi.org/10.1097/MPG.0b013e318183187c; PMID: 19271298
   PubMed Web of Science ®Google Scholar
• Drucker DJ. Glucagon-like Peptide 2. Trends Endocrinol Metab 1999; 10:153 - 6; http://dx.doi.org/10.1016/S1043-2760(98)00136-2; PMID: 10322410
   PubMed Web of Science ®Google Scholar
• Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009; 58:1091 - 103; http://dx.doi.org/10.1136/gut.2008.165886; PMID: 19240062
   PubMed Web of Science ®Google Scholar
• Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, Yu Y, et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci USA 2009; 106:2365 - 70; http://dx.doi.org/10.1073/pnas.0812600106; PMID: 19164560
   PubMed Web of Science ®Google Scholar
• le Roux CW, Welbourn R, Werling M, Osborne A, Kokkinos A, Laurenius A, et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg 2007; 246:780 - 5; http://dx.doi.org/10.1097/SLA.0b013e3180caa3e3; PMID: 17968169
   PubMed Web of Science ®Google Scholar
• Korner J, Inabnet W, Febres G, Conwell IM, McMahon DJ, Salas R, et al. Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass. Int J Obes (Lond) 2009; 33:786 - 95; http://dx.doi.org/10.1038/ijo.2009.79; PMID: 19417773
   PubMed Web of Science ®Google Scholar
• Woodard GA, Encarnacion B, Downey JR, Peraza J, Chong K, Hernandez-Boussard T, et al. Probiotics improve outcomes after Roux-en-Y gastric bypass surgery: a prospective randomized trial. J Gastrointest Surg 2009; 13:1198 - 204; http://dx.doi.org/10.1007/s11605-009-0891-x; PMID: 19381735
   PubMed Web of Science ®Google Scholar