The influence of commensal bacteria-derived signals on basophil-associated allergic inflammation

References

• Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006; 355:2226 - 35; http://dx.doi.org/10.1056/NEJMra054308; PMID: 17124020
   PubMed Web of Science ®Google Scholar
• Bahadori K, Doyle-Waters MM, Marra C, Lynd L, Alasaly K, Swiston J, et al. Economic burden of asthma: a systematic review. BMC Pulm Med 2009; 9:24; http://dx.doi.org/10.1186/1471-2466-9-24; PMID: 19454036
   PubMedGoogle Scholar
• Mowen KA, Glimcher LH. Signaling pathways in Th2 development. Immunol Rev 2004; 202:203 - 22; http://dx.doi.org/10.1111/j.0105-2896.2004.00209.x; PMID: 15546395
   PubMed Web of Science ®Google Scholar
• Holgate ST. Pathogenesis of asthma. Clin Exp Allergy 2008; 38:872 - 97; http://dx.doi.org/10.1111/j.1365-2222.2008.02971.x; PMID: 18498538
   PubMed Web of Science ®Google Scholar
• Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008; 8:169 - 82; http://dx.doi.org/10.1038/nri2257; PMID: 18301422
   PubMed Web of Science ®Google Scholar
• Zeiger RS. Food allergen avoidance in the prevention of food allergy in infants and children. Pediatrics 2003; 111:1662 - 71; PMID: 12777607
   PubMed Web of Science ®Google Scholar
• Gilliland FD. Outdoor air pollution, genetic susceptibility, and asthma management: opportunities for intervention to reduce the burden of asthma. Pediatrics 2009; 123:Suppl 3 S168 - 73; http://dx.doi.org/10.1542/peds.2008-2233G; PMID: 19221160
   PubMedGoogle Scholar
• Ege MJ, Mayer M, Normand AC, Genuneit J, Cookson WO, Braun-Fahrländer C, et al, GABRIELA Transregio 22 Study Group. Exposure to environmental microorganisms and childhood asthma. N Engl J Med 2011; 364:701 - 9; http://dx.doi.org/10.1056/NEJMoa1007302; PMID: 21345099
   PubMed Web of Science ®Google Scholar
• Eckburg PB, Lepp PW, Relman DA. Archaea and their potential role in human disease. Infect Immun 2003; 71:591 - 6; http://dx.doi.org/10.1128/IAI.71.2.591-596.2003; PMID: 12540534
   PubMed Web of Science ®Google Scholar
• Hill DA, Artis D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol 2010; 28:623 - 67; http://dx.doi.org/10.1146/annurev-immunol-030409-101330; PMID: 20192812
   PubMed Web of Science ®Google Scholar
• Whitman WB, Coleman DC, Wiebe WJ. Prokaryotes: the unseen majority. Proc Natl Acad Sci U S A 1998; 95:6578 - 83; http://dx.doi.org/10.1073/pnas.95.12.6578; PMID: 9618454
   PubMed Web of Science ®Google Scholar
• Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 2006; 124:837 - 48; http://dx.doi.org/10.1016/j.cell.2006.02.017; PMID: 16497592
   PubMed Web of Science ®Google Scholar
• Kalliomäki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 2001; 107:129 - 34; http://dx.doi.org/10.1067/mai.2001.111237; PMID: 11150002
   PubMed Web of Science ®Google Scholar
• Kummeling I, Stelma FF, Dagnelie PC, Snijders BE, Penders J, Huber M, et al. Early life exposure to antibiotics and the subsequent development of eczema, wheeze, and allergic sensitization in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics 2007; 119:e225 - 31; http://dx.doi.org/10.1542/peds.2006-0896; PMID: 17200248
   PubMed Web of Science ®Google Scholar
• Marra F, Marra CA, Richardson K, Lynd LD, Kozyrskyj A, Patrick DM, et al. Antibiotic use in children is associated with increased risk of asthma. Pediatrics 2009; 123:1003 - 10; http://dx.doi.org/10.1542/peds.2008-1146; PMID: 19255032
   PubMed Web of Science ®Google Scholar
• Lambrecht BN, Hammad H. The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. Lancet 2010; 376:835 - 43; http://dx.doi.org/10.1016/S0140-6736(10)61226-3; PMID: 20816550
   PubMed Web of Science ®Google Scholar
• Paul WE, Zhu J. How are T(H)2-type immune responses initiated and amplified?. Nat Rev Immunol 2010; 10:225 - 35; http://dx.doi.org/10.1038/nri2735; PMID: 20336151
   PubMed Web of Science ®Google Scholar
• Herbst T, Sichelstiel A, Schär C, Yadava K, Bürki K, Cahenzli J, et al. Dysregulation of allergic airway inflammation in the absence of microbial colonization. Am J Respir Crit Care Med 2011; 184:198 - 205; http://dx.doi.org/10.1164/rccm.201010-1574OC; PMID: 21471101
   PubMed Web of Science ®Google Scholar
• Morin S, Bernard H, Przybylski-Nicaise L, Corthier G, Rabot S, Wal JM, et al. Allergenic and immunogenic potential of cow’s milk β-lactoglobulin and caseins evidenced without adjuvant in germ-free mice. Mol Nutr Food Res 2011; 55:1700 - 7; http://dx.doi.org/10.1002/mnfr.201100024; PMID: 22045656
   PubMed Web of Science ®Google Scholar
• Rodriguez B, Prioult G, Hacini-Rachinel F, Moine D, Bruttin A, Ngom-Bru C, et al. Infant gut microbiota is protective against cow’s milk allergy in mice despite immature ileal T-cell response. FEMS Microbiol Ecol 2012; 79:192 - 202; http://dx.doi.org/10.1111/j.1574-6941.2011.01207.x; PMID: 22029421
   PubMed Web of Science ®Google Scholar
• Noverr MC, Falkowski NR, McDonald RA, McKenzie AN, Huffnagle GB. Development of allergic airway disease in mice following antibiotic therapy and fungal microbiota increase: role of host genetics, antigen, and interleukin-13. Infect Immun 2005; 73:30 - 8; http://dx.doi.org/10.1128/IAI.73.1.30-38.2005; PMID: 15618138
   PubMed Web of Science ®Google Scholar
• Noverr MC, Noggle RM, Toews GB, Huffnagle GB. Role of antibiotics and fungal microbiota in driving pulmonary allergic responses. Infect Immun 2004; 72:4996 - 5003; http://dx.doi.org/10.1128/IAI.72.9.4996-5003.2004; PMID: 15321991
   PubMed Web of Science ®Google Scholar
• Bashir ME, Louie S, Shi HN, Nagler-Anderson C. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J Immunol 2004; 172:6978 - 87; PMID: 15153518
   PubMed Web of Science ®Google Scholar
• Hill DA, Hoffmann C, Abt MC, Du Y, Kobuley D, Kirn TJ, et al. Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis. Mucosal Immunol 2010; 3:148 - 58; http://dx.doi.org/10.1038/mi.2009.132; PMID: 19940845
   PubMed Web of Science ®Google Scholar
• Russell SL, Gold MJ, Hartmann M, Willing BP, Thorson L, Wlodarska M, et al. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep 2012; 13:440 - 7; http://dx.doi.org/10.1038/embor.2012.32; PMID: 22422004
   PubMed Web of Science ®Google Scholar
• Tulic MK, Hodder M, Forsberg A, McCarthy S, Richman T, D’Vaz N, et al. Differences in innate immune function between allergic and nonallergic children: new insights into immune ontogeny. J Allergy Clin Immunol 2011; 127:470 - 8.e1; http://dx.doi.org/10.1016/j.jaci.2010.09.020; PMID: 21093030
   PubMed Web of Science ®Google Scholar
• Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012; 336:489 - 93; http://dx.doi.org/10.1126/science.1219328; PMID: 22442383
   PubMed Web of Science ®Google Scholar
• Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart MA, Kool M, et al. Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med 2010; 207:2097 - 111; http://dx.doi.org/10.1084/jem.20101563; PMID: 20819925
   PubMed Web of Science ®Google Scholar
• Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2008; 9:310 - 8; http://dx.doi.org/10.1038/ni1558; PMID: 18300366
   PubMed Web of Science ®Google Scholar
• Skokos D, Botros HG, Demeure C, Morin J, Peronet R, Birkenmeier G, et al. Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J Immunol 2003; 170:3037 - 45; PMID: 12626558
   PubMed Web of Science ®Google Scholar
• Padigel UM, Hess JA, Lee JJ, Lok JB, Nolan TJ, Schad GA, et al. Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice. J Infect Dis 2007; 196:1844 - 51; http://dx.doi.org/10.1086/522968; PMID: 18190266
   PubMed Web of Science ®Google Scholar
• Charles N, Hardwick D, Daugas E, Illei GG, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med 2010; 16:701 - 7; http://dx.doi.org/10.1038/nm.2159; PMID: 20512127
   PubMed Web of Science ®Google Scholar
• Gessner A, Mohrs K, Mohrs M. Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J Immunol 2005; 174:1063 - 72; PMID: 15634931
   PubMed Web of Science ®Google Scholar
• Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity 2005; 23:419 - 29; http://dx.doi.org/10.1016/j.immuni.2005.09.006; PMID: 16226507
   PubMed Web of Science ®Google Scholar
• Min B, Prout M, Hu-Li J, Zhu J, Jankovic D, Morgan ES, et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med 2004; 200:507 - 17; http://dx.doi.org/10.1084/jem.20040590; PMID: 15314076
   PubMed Web of Science ®Google Scholar
• Durkin HG, Bazin H, Waksman BH. Origin and fate of IgE-bearing lymphocytes. I. Peyer’s patches as differentiation site of cells. Simultaneously bearing IgA and IgE. J Exp Med 1981; 154:640 - 8; http://dx.doi.org/10.1084/jem.154.3.640; PMID: 6974216
   PubMed Web of Science ®Google Scholar
• McCoy KD, Harris NL, Diener P, Hatak S, Odermatt B, Hangartner L, et al. Natural IgE production in the absence of MHC Class II cognate help. Immunity 2006; 24:329 - 39; http://dx.doi.org/10.1016/j.immuni.2006.01.013; PMID: 16546101
   PubMed Web of Science ®Google Scholar
• Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell CA, et al. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol 2005; 174:4495 - 504; PMID: 15814670
   PubMed Web of Science ®Google Scholar
• Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M. Mast cells as “tunable” effector and immunoregulatory cells: recent advances. Annu Rev Immunol 2005; 23:749 - 86; http://dx.doi.org/10.1146/annurev.immunol.21.120601.141025; PMID: 15771585
   PubMed Web of Science ®Google Scholar
• Xiang Z, Möller C, Nilsson G. IgE-receptor activation induces survival and Bfl-1 expression in human mast cells but not basophils. Allergy 2006; 61:1040 - 6; http://dx.doi.org/10.1111/j.1398-9995.2006.01024.x; PMID: 16918505
   PubMed Web of Science ®Google Scholar
• Smith K, McCoy KD, Macpherson AJ. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin Immunol 2007; 19:59 - 69; http://dx.doi.org/10.1016/j.smim.2006.10.002; PMID: 17118672
   PubMed Web of Science ®Google Scholar
• Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, et al. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol 2009; 10:697 - 705; http://dx.doi.org/10.1038/ni.1740; PMID: 19465906
   PubMed Web of Science ®Google Scholar
• Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y, et al. Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat Immunol 2009; 10:706 - 12; http://dx.doi.org/10.1038/ni.1737; PMID: 19465908
   PubMed Web of Science ®Google Scholar
• Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, et al. Genetic analysis of basophil function in vivo. Nat Immunol 2011; 12:527 - 35; http://dx.doi.org/10.1038/ni.2036; PMID: 21552267
   PubMed Web of Science ®Google Scholar
• Ohnmacht C, Schwartz C, Panzer M, Schiedewitz I, Naumann R, Voehringer D. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 2010; 33:364 - 74; http://dx.doi.org/10.1016/j.immuni.2010.08.011; PMID: 20817571
   PubMed Web of Science ®Google Scholar
• Kim S, Prout M, Ramshaw H, Lopez AF, LeGros G, Min B. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J Immunol 2010; 184:1143 - 7; http://dx.doi.org/10.4049/jimmunol.0902447; PMID: 20038645
   PubMed Web of Science ®Google Scholar
• Ohnmacht C, Voehringer D. Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells. J Immunol 2010; 184:344 - 50; http://dx.doi.org/10.4049/jimmunol.0901841; PMID: 19955520
   PubMed Web of Science ®Google Scholar
• Nakanishi K. Basophils are potent antigen-presenting cells that selectively induce Th2 cells. Eur J Immunol 2010; 40:1836 - 42; http://dx.doi.org/10.1002/eji.201040588; PMID: 20518033
   PubMed Web of Science ®Google Scholar
• Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 2009; 10:713 - 20; http://dx.doi.org/10.1038/ni.1738; PMID: 19465907
   PubMed Web of Science ®Google Scholar
• Torrero MN, Hübner MP, Larson D, Karasuyama H, Mitre E. Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis. J Immunol 2010; 185:7426 - 34; http://dx.doi.org/10.4049/jimmunol.0903864; PMID: 21057084
   PubMed Web of Science ®Google Scholar
• Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature 2011; 477:229 - 33; http://dx.doi.org/10.1038/nature10329; PMID: 21841801
   PubMed Web of Science ®Google Scholar
• Fink LN, Metzdorff SB, Zeuthen LH, Nellemann C, Kristensen MB, Licht TR, et al. Establishment of tolerance to commensal bacteria requires a complex microbiota and is accompanied by decreased intestinal chemokine expression. Am J Physiol Gastrointest Liver Physiol 2012; 302:G55 - 65; http://dx.doi.org/10.1152/ajpgi.00428.2010; PMID: 21960522
   PubMedGoogle Scholar
• Redhu NS, Saleh A, Lee HC, Halayko AJ, Ziegler SF, Gounni AS. IgE induces transcriptional regulation of thymic stromal lymphopoietin in human airway smooth muscle cells. J Allergy Clin Immunol 2011; 128:892 - 6.e2; http://dx.doi.org/10.1016/j.jaci.2011.06.045; PMID: 21835441
   PubMed Web of Science ®Google Scholar
• Maurer D, Fiebiger S, Ebner C, Reininger B, Fischer GF, Wichlas S, et al. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol 1996; 157:607 - 16; PMID: 8752908
   PubMed Web of Science ®Google Scholar
• Tunon-De-Lara JM, Redington AE, Bradding P, Church MK, Hartley JA, Semper AE, et al. Dendritic cells in normal and asthmatic airways: expression of the alpha subunit of the high affinity immunoglobulin E receptor (Fc epsilon RI -alpha). Clin Exp Allergy 1996; 26:648 - 55; http://dx.doi.org/10.1111/j.1365-2222.1996.tb00591.x; PMID: 8809422
   PubMed Web of Science ®Google Scholar
• Ekman AK, Erjefält JS, Jansson L, Cardell LO. Allergen-induced accumulation of CD68-,CD123+ dendritic cells in the nasal mucosa. Int Arch Allergy Immunol 2011; 155:234 - 42; http://dx.doi.org/10.1159/000320480; PMID: 21282962
   PubMed Web of Science ®Google Scholar
• Afifi SS, Helal AM. CD11c+ and CD123+ dendritic cell subsets in peripheral blood of lung cancer patients. Egypt J Immunol 2009; 16:9 - 15; PMID: 22059349
   PubMedGoogle Scholar
• Rajakulasingam K, Durham SR, O’Brien F, Humbert M, Barata LT, Reece L, et al. Enhanced expression of high-affinity IgE receptor (Fc epsilon RI) alpha chain in human allergen-induced rhinitis with co-localization to mast cells, macrophages, eosinophils, and dendritic cells. J Allergy Clin Immunol 1997; 100:78 - 86; http://dx.doi.org/10.1016/S0091-6749(97)70198-2; PMID: 9257791
   PubMed Web of Science ®Google Scholar
• Bouskra D, Brézillon C, Bérard M, Werts C, Varona R, Boneca IG, et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 2008; 456:507 - 10; http://dx.doi.org/10.1038/nature07450; PMID: 18987631
   PubMed Web of Science ®Google Scholar
• Umesaki Y, Setoyama H, Matsumoto S, Okada Y. Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus. Immunology 1993; 79:32 - 7; PMID: 8509140
   PubMed Web of Science ®Google Scholar
• Macpherson AJ. IgA adaptation to the presence of commensal bacteria in the intestine. Curr Top Microbiol Immunol 2006; 308:117 - 36; http://dx.doi.org/10.1007/3-540-30657-9_5; PMID: 16922088
   PubMed Web of Science ®Google Scholar
• Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011; 331:337 - 41; http://dx.doi.org/10.1126/science.1198469; PMID: 21205640
   PubMed Web of Science ®Google Scholar
• Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139:485 - 98; http://dx.doi.org/10.1016/j.cell.2009.09.033; PMID: 19836068
   PubMed Web of Science ®Google Scholar
• Liu N, Ohnishi N, Ni L, Akira S, Bacon KB. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat Immunol 2003; 4:687 - 93; http://dx.doi.org/10.1038/ni941; PMID: 12766768
   PubMed Web of Science ®Google Scholar
• Macpherson AJ, Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 2004; 303:1662 - 5; http://dx.doi.org/10.1126/science.1091334; PMID: 15016999
   PubMed Web of Science ®Google Scholar
• Saenz SA, Noti M, Artis D. Innate immune cell populations function as initiators and effectors in Th2 cytokine responses. Trends Immunol 2010; 31:407 - 13; http://dx.doi.org/10.1016/j.it.2010.09.001; PMID: 20951092
   PubMed Web of Science ®Google Scholar
• Saenz SA, Siracusa MC, Perrigoue JG, Spencer SP, Urban JF Jr., Tocker JE, et al. IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature 2010; 464:1362 - 6; http://dx.doi.org/10.1038/nature08901; PMID: 20200520
   PubMed Web of Science ®Google Scholar
• Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, et al. ATP drives lamina propria T(H)17 cell differentiation. Nature 2008; 455:808 - 12; http://dx.doi.org/10.1038/nature07240; PMID: 18716618
   PubMed Web of Science ®Google Scholar
• Zaph C, Du Y, Saenz SA, Nair MG, Perrigoue JG, Taylor BC, et al. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J Exp Med 2008; 205:2191 - 8; http://dx.doi.org/10.1084/jem.20080720; PMID: 18762568
   PubMed Web of Science ®Google Scholar
• Engelhardt KR, McGhee S, Winkler S, Sassi A, Woellner C, Lopez-Herrera G, et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol 2009; 124:1289 - 302.e4; http://dx.doi.org/10.1016/j.jaci.2009.10.038; PMID: 20004785
   PubMed Web of Science ®Google Scholar
• Zhang Q, Davis JC, Lamborn IT, Freeman AF, Jing H, Favreau AJ, et al. Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med 2009; 361:2046 - 55; http://dx.doi.org/10.1056/NEJMoa0905506; PMID: 19776401
   PubMed Web of Science ®Google Scholar
• Grimbacher B, Holland SM, Puck JM. Hyper-IgE syndromes. Immunol Rev 2005; 203:244 - 50; http://dx.doi.org/10.1111/j.0105-2896.2005.00228.x; PMID: 15661034
   PubMed Web of Science ®Google Scholar
• Herbst T, Esser J, Prati M, Kulagin M, Stettler R, Zaiss MM, et al. Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci U S A 2012; 109:14954 - 9; http://dx.doi.org/10.1073/pnas.1117584109; PMID: 22930820
   PubMed Web of Science ®Google Scholar
• Holgate S, Buhl R, Bousquet J, Smith N, Panahloo Z, Jimenez P. The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update. Respir Med 2009; 103:1098 - 113; http://dx.doi.org/10.1016/j.rmed.2009.03.008; PMID: 19362459
   PubMed Web of Science ®Google Scholar
• Pace E, Ferraro M, Bruno A, Chiappara G, Bousquet J, Gjomarkaj M. Clinical benefits of 7 years of treatment with omalizumab in severe uncontrolled asthmatics. J Asthma 2011; 48:387 - 92; http://dx.doi.org/10.3109/02770903.2011.561512; PMID: 21391878
   PubMed Web of Science ®Google Scholar
• Saini SS, MacGlashan DW Jr.. Assessing basophil functional measures during monoclonal anti-IgE therapy. J Immunol Methods 2012; 383:60 - 4; http://dx.doi.org/10.1016/j.jim.2012.05.016; PMID: 22664098
   PubMed Web of Science ®Google Scholar
• Hill DA, Siracusa MC, Abt MC, Kim BS, Kobuley D, Kubo M, et al. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat Med 2012; 18:538 - 46; http://dx.doi.org/10.1038/nm.2657; PMID: 22447074
   PubMed Web of Science ®Google Scholar