Influenza virus-specific TCR-transduced T cells as a model for adoptive immunotherapy

References

• Doubrovina E, Oflaz-Sozmen B, Prockop SE, Kernan NA, Abramson S, Teruya-Feldstein J, et al. Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation. Blood 2012; 119:2644 - 56; http://dx.doi.org/10.1182/blood-2011-08-371971; PMID: 22138512
   PubMed Web of Science ®Google Scholar
• Peggs KS, Verfuerth S, Pizzey A, Khan N, Guiver M, Moss PA, et al. Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines. Lancet 2003; 362:1375 - 7; http://dx.doi.org/10.1016/S0140-6736(03)14634-X; PMID: 14585640
   PubMed Web of Science ®Google Scholar
• Gustafsson Å, Levitsky V, Zou JZ, Frisan T, Dalianis T, Ljungman P, et al. Epstein-Barr virus (EBV) load in bone marrow transplant recipients at risk to develop posttransplant lymphoproliferative disease: prophylactic infusion of EBV-specific cytotoxic T cells. Blood 2000; 95:807 - 14; PMID: 10648390
   PubMed Web of Science ®Google Scholar
• Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, Sherry RM, et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 2006; 314:126 - 9; http://dx.doi.org/10.1126/science.1129003; PMID: 16946036
   PubMed Web of Science ®Google Scholar
• Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer 2008; 8:299 - 308; http://dx.doi.org/10.1038/nrc2355; PMID: 18354418
   PubMed Web of Science ®Google Scholar
• Rosenberg SA. Raising the bar: the curative potential of human cancer immunotherapy. Sci Transl Med 2012; 4:ps8; http://dx.doi.org/10.1126/scitranslmed.3003634; PMID: 22461638
   PubMed Web of Science ®Google Scholar
• Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol 2011; 29:917 - 24; http://dx.doi.org/10.1200/JCO.2010.32.2537; PMID: 21282551
   PubMed Web of Science ®Google Scholar
• Dudley ME, Wunderlich JR, Yang JC, Sherry RM, Topalian SL, Restifo NP, et al. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol 2005; 23:2346 - 57; http://dx.doi.org/10.1200/JCO.2005.00.240; PMID: 15800326
   PubMed Web of Science ®Google Scholar
• Bobisse S, Zanovello P, Rosato A. T-cell receptor gene transfer by lentiviral vectors in adoptive cell therapy. Expert Opin Biol Ther 2007; 7:893 - 906; http://dx.doi.org/10.1517/14712598.7.6.893; PMID: 17555374
   PubMed Web of Science ®Google Scholar
• Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 2001; 7:33 - 40; http://dx.doi.org/10.1038/83324; PMID: 11135613
   PubMed Web of Science ®Google Scholar
• Stripecke R, Kasahara N.. Lentiviral and Retroviral Vector Systems. Cancer Drug Discovery: Gene Therapy for Cancer 2009; 39 - 71
   Google Scholar
• Schambach A, Swaney WP, van der Loo JCM. Design and production of retro- and lentiviral vectors for gene expression in hematopoietic cells. Methods Mol Biol 2009; 506:191 - 205; http://dx.doi.org/10.1007/978-1-59745-409-4_14; PMID: 19110628
   PubMedGoogle Scholar
• Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC, Hughes MS, et al. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood 2009; 114:535 - 46; http://dx.doi.org/10.1182/blood-2009-03-211714; PMID: 19451549
   PubMed Web of Science ®Google Scholar
• Naumov YN, Naumova EN, Yassai MB, Kota K, Welsh RM, Selin LK. Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus. J Immunol 2008; 181:7407 - 19; PMID: 18981164
   PubMed Web of Science ®Google Scholar
• Weber K, Bartsch U, Stocking C, Fehse B. A multicolor panel of novel lentiviral “gene ontology” (LeGO) vectors for functional gene analysis. Mol Ther 2008; 16:698 - 706; http://dx.doi.org/10.1038/mt.2008.6; PMID: 18362927
   PubMed Web of Science ®Google Scholar
• Newrzela S, Cornils K, Li Z, Baum C, Brugman MH, Hartmann M, et al. Resistance of mature T cells to oncogene transformation. Blood 2008; 112:2278 - 86; http://dx.doi.org/10.1182/blood-2007-12-128751; PMID: 18566328
   PubMed Web of Science ®Google Scholar
• Sommermeyer D, Neudorfer J, Weinhold M, Leisegang M, Engels B, Noessner E, et al. Designer T cells by T cell receptor replacement. Eur J Immunol 2006; 36:3052 - 9; http://dx.doi.org/10.1002/eji.200636539; PMID: 17051621
   PubMed Web of Science ®Google Scholar
• Bunnell BA, Muul LM, Donahue RE, Blaese RM, Morgan RA. High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes. Proc Natl Acad Sci U S A 1995; 92:7739 - 43; http://dx.doi.org/10.1073/pnas.92.17.7739; PMID: 7644487
   PubMed Web of Science ®Google Scholar
• Lam JS, Reeves ME, Cowherd R, Rosenberg SA, Hwu P. Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope. Hum Gene Ther 1996; 7:1415 - 22; http://dx.doi.org/10.1089/hum.1996.7.12-1415; PMID: 8844200
   PubMed Web of Science ®Google Scholar
• Ayuk F, Li Z, Kühlcke K, Lindemann C, Schade U, Eckert HG, et al. Establishment of an optimised gene transfer protocol for human primary T lymphocytes according to clinical requirements. Gene Ther 1999; 6:1788 - 92; http://dx.doi.org/10.1038/sj.gt.3300999; PMID: 10516731
   PubMed Web of Science ®Google Scholar
• Atanackovic D, Matsuo M, Ritter E, Mazzara G, Ritter G, Jäger E, et al. Monitoring CD4+ T cell responses against viral and tumor antigens using T cells as novel target APC. J Immunol Methods 2003; 278:57 - 66; http://dx.doi.org/10.1016/S0022-1759(03)00209-6; PMID: 12957396
   PubMed Web of Science ®Google Scholar
• Sommermeyer D, Uckert W. Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells. J Immunol 2010; 184:6223 - 31; http://dx.doi.org/10.4049/jimmunol.0902055; PMID: 20483785
   PubMed Web of Science ®Google Scholar
• Schub A, Schuster IG, Hammerschmidt W, Moosmann A. CMV-specific TCR-transgenic T cells for immunotherapy. J Immunol 2009; 183:6819 - 30; http://dx.doi.org/10.4049/jimmunol.0902233; PMID: 19864595
   PubMed Web of Science ®Google Scholar
• Cohen CJ, Li YF, El-Gamil M, Robbins PF, Rosenberg SA, Morgan RA. Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond. Cancer Res 2007; 67:3898 - 903; http://dx.doi.org/10.1158/0008-5472.CAN-06-3986; PMID: 17440104
   PubMed Web of Science ®Google Scholar
• Thomas S, Stauss HJ, Morris EC. Molecular immunology lessons from therapeutic T-cell receptor gene transfer. Immunology 2010; 129:170 - 7; http://dx.doi.org/10.1111/j.1365-2567.2009.03227.x; PMID: 20561357
   PubMed Web of Science ®Google Scholar
• Bendle GM, Linnemann C, Hooijkaas AI, Bies L, de Witte MA, Jorritsma A, et al. Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nat Med 2010; 16:565 - 70, 1p, 570; http://dx.doi.org/10.1038/nm.2128; PMID: 20400962
   PubMed Web of Science ®Google Scholar
• Ahmadi M, King JW, Xue S-A, Voisine C, Holler A, Wright GP, et al. CD3 limits the efficacy of TCR gene therapy in vivo. Blood 2011; 118:3528 - 37; http://dx.doi.org/10.1182/blood-2011-04-346338; PMID: 21750319
   PubMed Web of Science ®Google Scholar
• Govers C, Sebestyén Z, Coccoris M, Willemsen RA, Debets R. T cell receptor gene therapy: strategies for optimizing transgenic TCR pairing. Trends Mol Med 2010; 16:77 - 87; http://dx.doi.org/10.1016/j.molmed.2009.12.004; PMID: 20122868
   PubMed Web of Science ®Google Scholar
• Kuball J, Dossett ML, Wolfl M, Ho WY, Voss R-H, Fowler C, et al. Facilitating matched pairing and expression of TCR chains introduced into human T cells. Blood 2007; 109:2331 - 8; http://dx.doi.org/10.1182/blood-2006-05-023069; PMID: 17082316
   PubMed Web of Science ®Google Scholar
• Cohen CJ, Zhao Y, Zheng Z, Rosenberg SA, Morgan RA. Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability. Cancer Res 2006; 66:8878 - 86; http://dx.doi.org/10.1158/0008-5472.CAN-06-1450; PMID: 16951205
   PubMed Web of Science ®Google Scholar
• Bialer G, Horovitz-Fried M, Ya’acobi S, Morgan RA, Cohen CJ. Selected murine residues endow human TCR with enhanced tumor recognition. J Immunol 2010; 184:6232 - 41; http://dx.doi.org/10.4049/jimmunol.0902047; PMID: 20427762
   PubMed Web of Science ®Google Scholar
• Heemskerk MHM, Hagedoorn RS, van der Hoorn MAWG, van der Veken LT, Hoogeboom M, Kester MGD, et al. Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex. Blood 2007; 109:235 - 43; http://dx.doi.org/10.1182/blood-2006-03-013318; PMID: 16968899
   PubMed Web of Science ®Google Scholar
• Walther W, Stein U. Viral vectors for gene transfer: a review of their use in the treatment of human diseases. Drugs 2000; 60:249 - 71; http://dx.doi.org/10.2165/00003495-200060020-00002; PMID: 10983732
   PubMed Web of Science ®Google Scholar
• Bobisse S, Rondina M, Merlo A, Tisato V, Mandruzzato S, Amendola M, et al. Reprogramming T lymphocytes for melanoma adoptive immunotherapy by T-cell receptor gene transfer with lentiviral vectors. Cancer Res 2009; 69:9385 - 94; http://dx.doi.org/10.1158/0008-5472.CAN-09-0494; PMID: 19996290
   PubMed Web of Science ®Google Scholar
• Newrzela S, Cornils K, Heinrich T, Schläger J, Yi J-H, Lysenko O, et al. Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes. Mol Med 2011; 17:1223 - 32; http://dx.doi.org/10.2119/molmed.2010.00193; PMID: 21826372
   PubMed Web of Science ®Google Scholar
• Engels B, Cam H, Schüler T, Indraccolo S, Gladow M, Baum C, et al. Retroviral vectors for high-level transgene expression in T lymphocytes. Hum Gene Ther 2003; 14:1155 - 68; http://dx.doi.org/10.1089/104303403322167993; PMID: 12908967
   PubMed Web of Science ®Google Scholar
• Leisegang M, Engels B, Meyerhuber P, Kieback E, Sommermeyer D, Xue S-A, et al. Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette. J Mol Med (Berl) 2008; 86:573 - 83; http://dx.doi.org/10.1007/s00109-008-0317-3; PMID: 18335188
   PubMed Web of Science ®Google Scholar
• Thomas S, Xue SA, Cesco-Gaspere M, San José E, Hart DP, Wong V, et al. Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells. J Immunol 2007; 179:5803 - 10; PMID: 17947653
   PubMed Web of Science ®Google Scholar
• Engels B, Noessner E, Frankenberger B, Blankenstein T, Schendel DJ, Uckert W. Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes. Hum Gene Ther 2005; 16:799 - 810; http://dx.doi.org/10.1089/hum.2005.16.799; PMID: 16000062
   PubMed Web of Science ®Google Scholar
• Hacein-Bey-Abina S, Garrigue A, Wang GP, Soulier J, Lim A, Morillon E, et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest 2008; 118:3132 - 42; http://dx.doi.org/10.1172/JCI35700; PMID: 18688285
   PubMed Web of Science ®Google Scholar
• Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H, et al. Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest 2008; 118:3143 - 50; http://dx.doi.org/10.1172/JCI35798; PMID: 18688286
   PubMed Web of Science ®Google Scholar
• Holst J, Szymczak-Workman AL, Vignali KM, Burton AR, Workman CJ, Vignali DAA. Generation of T-cell receptor retrogenic mice. Nat Protoc 2006; 1:406 - 17; http://dx.doi.org/10.1038/nprot.2006.61; PMID: 17406263
   PubMed Web of Science ®Google Scholar
• Baum C, Hegewisch-Becker S, Eckert HG, Stocking C, Ostertag W. Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells. J Virol 1995; 69:7541 - 7; PMID: 7494260
   PubMed Web of Science ®Google Scholar
• Hildinger M, Abel KL, Ostertag W, Baum C. Design of 5′ untranslated sequences in retroviral vectors developed for medical use. J Virol 1999; 73:4083 - 9; PMID: 10196304
   PubMed Web of Science ®Google Scholar
• Weber K, Thomaschewski M, Benten D, Fehse B. RGB marking with lentiviral vectors for multicolor clonal cell tracking. Nat Protoc 2012; 7:839 - 49; http://dx.doi.org/10.1038/nprot.2012.026; PMID: 22481527
   PubMed Web of Science ®Google Scholar
• Fehse B, Schade UM, Li Z, Uhde A, Koch S, Goller B, et al. Highly-efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin. Br J Haematol 1998; 102:566 - 74; http://dx.doi.org/10.1046/j.1365-2141.1998.00785.x; PMID: 9695974
   PubMed Web of Science ®Google Scholar