Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines

References

• Cohen J, Nussenzweig V, Nussenzweig R, Vekemans J, Leach A. From the circumsporozoite protein to the RTS, S/AS candidate vaccine. Hum Vaccin 2010; 6:90 - 6; http://dx.doi.org/10.4161/hv.6.1.9677; PMID: 19806009
   PubMed Web of Science ®Google Scholar
• WHO Malaria Policy Advisory Committee and Secretariat. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of September 2012 meeting. Malar J 2012; 11:424; http://dx.doi.org/10.1186/1475-2875-11-424; PMID: 23253143
   PubMed Web of Science ®Google Scholar
• Regules JA, Cummings JF, Ockenhouse CF. The RTS,S vaccine candidate for malaria. Expert Rev Vaccines 2011; 10:589 - 99; http://dx.doi.org/10.1586/erv.11.57; PMID: 21604980
   PubMed Web of Science ®Google Scholar
• Garçon N, Van Mechelen M. Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems. Expert Rev Vaccines 2011; 10:471 - 86; http://dx.doi.org/10.1586/erv.11.29; PMID: 21506645
   PubMed Web of Science ®Google Scholar
• White MT, Bejon P, Olotu A, Griffin JT, Riley EM, Kester KE, Ockenhouse CF, Ghani AC. The relationship between RTS,S vaccine-induced antibodies, CD4⁺ T cell responses and protection against Plasmodium falciparum infection. PLoS One 2013; 8:e61395; http://dx.doi.org/10.1371/journal.pone.0061395; PMID: 23613845
   PubMed Web of Science ®Google Scholar
• Ndungu FM, Mwacharo J, Kimani D, Kai O, Moris P, Jongert E, Vekemans J, Olotu A, Bejon P. A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E. PLoS One 2012; 7:e52870; http://dx.doi.org/10.1371/journal.pone.0052870; PMID: 23300801
   PubMed Web of Science ®Google Scholar
• Lumsden JM, Schwenk RJ, Rein LE, Moris P, Janssens M, Ofori-Anyinam O, Cohen J, Kester KE, Heppner DG, Krzych U. Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells. PLoS One 2011; 6:e20775; http://dx.doi.org/10.1371/journal.pone.0020775; PMID: 21779319
   PubMed Web of Science ®Google Scholar
• Ansong D, Asante KP, Vekemans J, Owusu SK, Owusu R, Brobby NA, Dosoo D, Osei-Akoto A, Osei-Kwakye K, Asafo-Adjei E, et al. T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children. PLoS One 2011; 6:e18891; http://dx.doi.org/10.1371/journal.pone.0018891; PMID: 21556142
   PubMed Web of Science ®Google Scholar
• Agnandji ST, Fendel R, Mestré M, Janssens M, Vekemans J, Held J, Gnansounou F, Haertle S, von Glasenapp I, Oyakhirome S, et al. Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D). PLoS One 2011; 6:e18559; http://dx.doi.org/10.1371/journal.pone.0018559; PMID: 21494604
   PubMed Web of Science ®Google Scholar
• Olotu A, Moris P, Mwacharo J, Vekemans J, Kimani D, Janssens M, Kai O, Jongert E, Lievens M, Leach A, et al. Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria. PLoS One 2011; 6:e25786; http://dx.doi.org/10.1371/journal.pone.0025786; PMID: 21998698
   PubMed Web of Science ®Google Scholar
• Kester KE, Cummings JF, Ofori-Anyinam O, Ockenhouse CF, Krzych U, Moris P, Schwenk R, Nielsen RA, Debebe Z, Pinelis E, et al, RTS,S Vaccine Evaluation Group. Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection. J Infect Dis 2009; 200:337 - 46; http://dx.doi.org/10.1086/600120; PMID: 19569965
   PubMed Web of Science ®Google Scholar
• Polhemus ME, Remich SA, Ogutu BR, Waitumbi JN, Otieno L, Apollo S, Cummings JF, Kester KE, Ockenhouse CF, Stewart A, et al. Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area. PLoS One 2009; 4:e6465; http://dx.doi.org/10.1371/journal.pone.0006465; PMID: 19649245
   PubMed Web of Science ®Google Scholar
• Owusu-Agyei S, Ansong D, Asante K, Kwarteng Owusu S, Owusu R, Wireko Brobby NA, Dosoo D, Osei Akoto A, Osei-Kwakye K, Adjei EA, et al. Randomized controlled trial of RTS,S/AS02D and RTS,S/AS01E malaria candidate vaccines given according to different schedules in Ghanaian children. PLoS One 2009; 4:e7302; http://dx.doi.org/10.1371/journal.pone.0007302; PMID: 19806184
   PubMed Web of Science ®Google Scholar
• Lell B, Agnandji S, von Glasenapp I, Haertle S, Oyakhiromen S, Issifou S, Vekemans J, Leach A, Lievens M, Dubois MC, et al. A randomized trial assessing the safety and immunogenicity of AS01 and AS02 adjuvanted RTS,S malaria vaccine candidates in children in Gabon. PLoS One 2009; 4:e7611; http://dx.doi.org/10.1371/journal.pone.0007611; PMID: 19859560
   PubMed Web of Science ®Google Scholar
• RTS,S Clinical Trials Partnership, Agnandji ST, Lell B, Soulanoudjingar SS, Fernandes JF, Abossolo BP, Conzelmann C, Methogo BG, Doucka Y, Flamen A, Mordmüller B, et al. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med 2011; 365:1863 - 75; http://dx.doi.org/10.1056/NEJMoa1102287; PMID: 22007715
   PubMed Web of Science ®Google Scholar
• RTS,S Clinical Trials Partnership, Agnandji ST, Lell B, Fernandes JF, Abossolo BP, Methogo BG, Kabwende AL, Adegnika AA, Mordmüller B, Issifou S, Kremsner PG, et al. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N Engl J Med 2012; 367:2284 - 95; http://dx.doi.org/10.1056/NEJMoa1208394; PMID: 23136909
   PubMed Web of Science ®Google Scholar
• Committee for Medicinal Products for Human Use (CHMP). Guideline on adjuvants in vaccines for human use. The European Medicines Agency; 2005. Report No.: EMEA/CHMP/VEG/134716/2004.
   Google Scholar
• Ma DY, Clark EA. The role of CD40 and CD154/CD40L in dendritic cells. Semin Immunol 2009; 21:265 - 72; http://dx.doi.org/10.1016/j.smim.2009.05.010; PMID: 19524453
   PubMed Web of Science ®Google Scholar
• Cerutti A, Puga I, Cols M. Innate control of B cell responses. Trends Immunol 2011; 32:202 - 11; http://dx.doi.org/10.1016/j.it.2011.02.004; PMID: 21419699
   PubMed Web of Science ®Google Scholar
• Liao W, Lin JX, Leonard WJ. IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol 2011; 23:598 - 604; http://dx.doi.org/10.1016/j.coi.2011.08.003; PMID: 21889323
   PubMed Web of Science ®Google Scholar
• Reece WH, Pinder M, Gothard PK, Milligan P, Bojang K, Doherty T, Plebanski M, Akinwunmi P, Everaere S, Watkins KR, et al. A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease. Nat Med 2004; 10:406 - 10; http://dx.doi.org/10.1038/nm1009; PMID: 15034567
   PubMed Web of Science ®Google Scholar
• Pinder M, Reece WH, Plebanski M, Akinwunmi P, Flanagan KL, Lee EA, Doherty T, Milligan P, Jaye A, Tornieporth N, et al. Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS,S/AS02, in semi-immune adults in The Gambia. Clin Exp Immunol 2004; 135:286 - 93; http://dx.doi.org/10.1111/j.1365-2249.2004.02371.x; PMID: 14738458
   PubMed Web of Science ®Google Scholar
• Barbosa A, Naniche D, Aponte JJ, Manaca MN, Mandomando I, Aide P, Sacarlal J, Renom M, Lafuente S, Ballou WR, et al. Plasmodium falciparum-specific cellular immune responses after immunization with the RTS,S/AS02D candidate malaria vaccine in infants living in an area of high endemicity in Mozambique. Infect Immun 2009; 77:4502 - 9; http://dx.doi.org/10.1128/IAI.00442-09; PMID: 19651872
   PubMed Web of Science ®Google Scholar
• Stoute JA, Kester KE, Krzych U, Wellde BT, Hall T, White K, Glenn G, Ockenhouse CF, Garcon N, Schwenk R, et al. Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine. J Infect Dis 1998; 178:1139 - 44; http://dx.doi.org/10.1086/515657; PMID: 9806046
   PubMed Web of Science ®Google Scholar
• Lalvani A, Moris P, Voss G, Pathan AA, Kester KE, Brookes R, Lee E, Koutsoukos M, Plebanski M, Delchambre M, et al. Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine. J Infect Dis 1999; 180:1656 - 64; http://dx.doi.org/10.1086/315074; PMID: 10515829
   PubMed Web of Science ®Google Scholar
• Macdonald RA, Hosking CS, Jones CL. The measurement of relative antibody affinity by ELISA using thiocyanate elution. J Immunol Methods 1988; 106:191 - 4; http://dx.doi.org/10.1016/0022-1759(88)90196-2; PMID: 3339255
   PubMed Web of Science ®Google Scholar
• Garçon N, Leroux-Roels G, Cheng W-F. Vaccine adjuvants. In: Garçon N, Stern PL, Cunningham AL, Stanberry LR, editors. Understanding Modern Vaccines: Perspectives in Vaccinology. Elsevier B.V.; 2011. 89-113.
   Google Scholar
• Clement F, Dewar V, Van Braeckel E, Desombere I, Dewerchin M, Swysen C, Demoitié MA, Jongert E, Cohen J, Leroux-Roels G, et al. Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum. Malar J 2012; 11:384; http://dx.doi.org/10.1186/1475-2875-11-384; PMID: 23173602
   PubMed Web of Science ®Google Scholar
• Leroux-Roels I, Leroux-Roels G, Ofori-Anyinam O, Moris P, De Kock E, Clement F, Dubois MC, Koutsoukos M, Demoitié MA, Cohen J, et al. Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02(A) candidate tuberculosis vaccine in purified protein derivative-negative adults. Clin Vaccine Immunol 2010; 17:1763 - 71; http://dx.doi.org/10.1128/CVI.00133-10; PMID: 20861328
   PubMed Web of Science ®Google Scholar
• Moris P, van der Most R, Leroux-Roels I, Clement F, Dramé M, Hanon E, Leroux-Roels GG, Van Mechelen M. H5N1 influenza vaccine formulated with AS03 A induces strong cross-reactive and polyfunctional CD4 T-cell responses. J Clin Immunol 2011; 31:443 - 54; http://dx.doi.org/10.1007/s10875-010-9490-6; PMID: 21174144
   PubMed Web of Science ®Google Scholar