In vivo dynamics of innate immune sentinels in the CNS

References

• Ransohoff RM, Cardona AE. The myeloid cells of the central nervous system parenchyma. Nature 2010; 468:253 - 62; http://dx.doi.org/10.1038/nature09615; PMID: 21068834
   PubMed Web of Science ®Google Scholar
• Prinz M, Priller J, Sisodia SS, Ransohoff RM. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci 2011; 14:1227 - 35; http://dx.doi.org/10.1038/nn.2923; PMID: 21952260
   PubMed Web of Science ®Google Scholar
• Ransohoff RM, Engelhardt B. The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol 2012; 12:623 - 35; http://dx.doi.org/10.1038/nri3265; PMID: 22903150
   PubMed Web of Science ®Google Scholar
• Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010; 330:841 - 5; http://dx.doi.org/10.1126/science.1194637; PMID: 20966214
   PubMed Web of Science ®Google Scholar
• Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308:1314 - 8; http://dx.doi.org/10.1126/science.1110647; PMID: 15831717
   PubMed Web of Science ®Google Scholar
• Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 2000; 20:4106 - 14; http://dx.doi.org/10.1128/MCB.20.11.4106-4114.2000; PMID: 10805752
   PubMed Web of Science ®Google Scholar
• Faust N, Varas F, Kelly LM, Heck S, Graf T. Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages. Blood 2000; 96:719 - 26; PMID: 10887140
   PubMed Web of Science ®Google Scholar
• Lauterbach H, Zuniga EI, Truong P, Oldstone MB, McGavern DB. Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. J Exp Med 2006; 203:1963 - 75; http://dx.doi.org/10.1084/jem.20060039; PMID: 16847068
   PubMed Web of Science ®Google Scholar
• D’Agostino PM, Kwak C, Vecchiarelli HA, Toth JG, Miller JM, Masheeb Z, et al. Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb. Proc Natl Acad Sci U S A 2012; 109:6175 - 80; http://dx.doi.org/10.1073/pnas.1203941109; PMID: 22474352
   PubMed Web of Science ®Google Scholar
• Anandasabapathy N, Victora GD, Meredith M, Feder R, Dong B, Kluger C, et al. Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med 2011; 208:1695 - 705; http://dx.doi.org/10.1084/jem.20102657; PMID: 21788405
   PubMed Web of Science ®Google Scholar
• Lindquist RL, Shakhar G, Dudziak D, Wardemann H, Eisenreich T, Dustin ML, et al. Visualizing dendritic cell networks in vivo. Nat Immunol 2004; 5:1243 - 50; http://dx.doi.org/10.1038/ni1139; PMID: 15543150
   PubMed Web of Science ®Google Scholar
• Bulloch K, Miller MM, Gal-Toth J, Milner TA, Gottfried-Blackmore A, Waters EM, et al. CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain. J Comp Neurol 2008; 508:687 - 710; http://dx.doi.org/10.1002/cne.21668; PMID: 18386786
   PubMed Web of Science ®Google Scholar
• Prodinger C, Bunse J, Krüger M, Schiefenhövel F, Brandt C, Laman JD, et al. CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system. Acta Neuropathol 2011; 121:445 - 58; http://dx.doi.org/10.1007/s00401-010-0774-y; PMID: 21076838
   PubMed Web of Science ®Google Scholar
• Santambrogio L, Belyanskaya SL, Fischer FR, Cipriani B, Brosnan CF, Ricciardi-Castagnoli P, et al. Developmental plasticity of CNS microglia. Proc Natl Acad Sci U S A 2001; 98:6295 - 300; http://dx.doi.org/10.1073/pnas.111152498; PMID: 11371643
   PubMed Web of Science ®Google Scholar
• D’Agostino PM, Gottfried-Blackmore A, Anandasabapathy N, Bulloch K. Brain dendritic cells: biology and pathology. Acta Neuropathol 2012; 124:599 - 614; http://dx.doi.org/10.1007/s00401-012-1018-0; PMID: 22825593
   PubMed Web of Science ®Google Scholar
• McGavern DB, Kang SS. Illuminating viral infections in the nervous system. Nat Rev Immunol 2011; 11:318 - 29; http://dx.doi.org/10.1038/nri2971; PMID: 21508982
   PubMed Web of Science ®Google Scholar
• Herz J, Zinselmeyer BH, McGavern DB. Two-photon imaging of microbial immunity in living tissues. Microsc Microanal 2012; 18:730 - 41; http://dx.doi.org/10.1017/S1431927612000281; PMID: 22846498
   PubMed Web of Science ®Google Scholar
• Denk W, Strickler JH, Webb WW. Two-photon laser scanning fluorescence microscopy. Science 1990; 248:73 - 6; http://dx.doi.org/10.1126/science.2321027; PMID: 2321027
   PubMed Web of Science ®Google Scholar
• Yuste R, Denk W. Dendritic spines as basic functional units of neuronal integration. Nature 1995; 375:682 - 4; http://dx.doi.org/10.1038/375682a0; PMID: 7791901
   PubMed Web of Science ®Google Scholar
• Kleinfeld D, Mitra PP, Helmchen F, Denk W. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc Natl Acad Sci U S A 1998; 95:15741 - 6; http://dx.doi.org/10.1073/pnas.95.26.15741; PMID: 9861040
   PubMed Web of Science ®Google Scholar
• Schiller J, Schiller Y, Clapham DE. NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. Nat Neurosci 1998; 1:114 - 8; http://dx.doi.org/10.1038/363; PMID: 10195125
   PubMed Web of Science ®Google Scholar
• Lendvai B, Stern EA, Chen B, Svoboda K. Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo. Nature 2000; 404:876 - 81; http://dx.doi.org/10.1038/35009107; PMID: 10786794
   PubMed Web of Science ®Google Scholar
• Chaigneau E, Oheim M, Audinat E, Charpak S. Two-photon imaging of capillary blood flow in olfactory bulb glomeruli. Proc Natl Acad Sci U S A 2003; 100:13081 - 6; http://dx.doi.org/10.1073/pnas.2133652100; PMID: 14569029
   PubMed Web of Science ®Google Scholar
• Ohki K, Chung S, Ch’ng YH, Kara P, Reid RC. Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex. Nature 2005; 433:597 - 603; http://dx.doi.org/10.1038/nature03274; PMID: 15660108
   PubMed Web of Science ®Google Scholar
• Wang KH, Majewska A, Schummers J, Farley B, Hu C, Sur M, et al. In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex. Cell 2006; 126:389 - 402; http://dx.doi.org/10.1016/j.cell.2006.06.038; PMID: 16873068
   PubMed Web of Science ®Google Scholar
• Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature 2009; 457:191 - 5; http://dx.doi.org/10.1038/nature07591; PMID: 19011611
   PubMed Web of Science ®Google Scholar
• Bartholomäus I, Kawakami N, Odoardi F, Schläger C, Miljkovic D, Ellwart JW, et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 2009; 462:94 - 8; http://dx.doi.org/10.1038/nature08478; PMID: 19829296
   PubMed Web of Science ®Google Scholar
• Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schläger C, Lodygin D, et al. T cells become licensed in the lung to enter the central nervous system. Nature 2012; 488:675 - 9; http://dx.doi.org/10.1038/nature11337; PMID: 22914092
   PubMed Web of Science ®Google Scholar
• Denk W, Sugimori M, Llinás R. Two types of calcium response limited to single spines in cerebellar Purkinje cells. Proc Natl Acad Sci U S A 1995; 92:8279 - 82; http://dx.doi.org/10.1073/pnas.92.18.8279; PMID: 7667282
   PubMed Web of Science ®Google Scholar
• Denk W, Holt JR, Shepherd GMG, Corey DP. Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links. Neuron 1995; 15:1311 - 21; http://dx.doi.org/10.1016/0896-6273(95)90010-1; PMID: 8845155
   PubMed Web of Science ®Google Scholar
• Potter SM, Wang C-M, Garrity PA, Fraser SE. Intravital imaging of green fluorescent protein using two-photon laser-scanning microscopy. Gene 1996; 173:1 Spec No 25 - 31; http://dx.doi.org/10.1016/0378-1119(95)00681-8; PMID: 8707052
   PubMedGoogle Scholar
• Shaner NC, Steinbach PA, Tsien RY. A guide to choosing fluorescent proteins. Nat Methods 2005; 2:905 - 9; http://dx.doi.org/10.1038/nmeth819; PMID: 16299475
   PubMed Web of Science ®Google Scholar
• Mainen ZF, Maletic-Savatic M, Shi SH, Hayashi Y, Malinow R, Svoboda K. Two-photon imaging in living brain slices. Methods 1999; 18:231 - 9, 181; http://dx.doi.org/10.1006/meth.1999.0776; PMID: 10356355
   PubMed Web of Science ®Google Scholar
• Kleinfeld D, Mitra PP, Helmchen F, Denk W. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc Natl Acad Sci U S A 1998; 95:15741 - 6; http://dx.doi.org/10.1073/pnas.95.26.15741; PMID: 9861040
   PubMed Web of Science ®Google Scholar
• Svoboda K, Denk W, Kleinfeld D, Tank DW. In vivo dendritic calcium dynamics in neocortical pyramidal neurons. Nature 1997; 385:161 - 5; http://dx.doi.org/10.1038/385161a0; PMID: 8990119
   PubMed Web of Science ®Google Scholar
• Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW, et al. Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science 2003; 300:1434 - 6; http://dx.doi.org/10.1126/science.1083780; PMID: 12775841
   PubMed Web of Science ®Google Scholar
• Nimmerjahn A, Kirchhoff F, Kerr JND, Helmchen F. Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nat Methods 2004; 1:31 - 7; http://dx.doi.org/10.1038/nmeth706; PMID: 15782150
   PubMed Web of Science ®Google Scholar
• Appaix F, Girod S, Boisseau S, Römer J, Vial JC, Albrieux M, et al. Specific in vivo staining of astrocytes in the whole brain after intravenous injection of sulforhodamine dyes. PLoS One 2012; 7:e35169; http://dx.doi.org/10.1371/journal.pone.0035169; PMID: 22509398
   PubMedGoogle Scholar
• Zipfel WR, Williams RM, Christie R, Nikitin AY, Hyman BT, Webb WW. Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation. Proc Natl Acad Sci U S A 2003; 100:7075 - 80; http://dx.doi.org/10.1073/pnas.0832308100; PMID: 12756303
   PubMed Web of Science ®Google Scholar
• Witte S, Negrean A, Lodder JC, de Kock CP, Testa Silva G, Mansvelder HD, et al. Label-free live brain imaging and targeted patching with third-harmonic generation microscopy. Proc Natl Acad Sci U S A 2011; 108:5970 - 5; http://dx.doi.org/10.1073/pnas.1018743108; PMID: 21444784
   PubMed Web of Science ®Google Scholar
• Del Rio-Hortega P. Microglia. In: Penfield W, ed. Cytology and Cellular Pathology of the Nervous System. New York: P.B. Hoeber, inc, 1937:481–534.
   Google Scholar
• Kettenmann H, Hanisch UK, Noda M, Verkhratsky A. Physiology of microglia. Physiol Rev 2011; 91:461 - 553; http://dx.doi.org/10.1152/physrev.00011.2010; PMID: 21527731
   PubMed Web of Science ®Google Scholar
• Booth PL, Thomas WE. Evidence for motility and pinocytosis in ramified microglia in tissue culture. Brain Res 1991; 548:163 - 71; http://dx.doi.org/10.1016/0006-8993(91)91118-K; PMID: 1868330
   PubMed Web of Science ®Google Scholar
• Ward SA, Ransom PA, Booth PL, Thomas WE. Characterization of ramified microglia in tissue culture: pinocytosis and motility. J Neurosci Res 1991; 29:13 - 28; http://dx.doi.org/10.1002/jnr.490290103; PMID: 1886165
   PubMed Web of Science ®Google Scholar
• Brockhaus J, Möller T, Kettenmann H. Phagocytozing ameboid microglial cells studied in a mouse corpus callosum slice preparation. Glia 1996; 16:81 - 90; http://dx.doi.org/10.1002/(SICI)1098-1136(199601)16:1<81::AID-GLIA9>3.0.CO;2-E; PMID: 8787776
   PubMed Web of Science ®Google Scholar
• Dailey ME, Waite M. Confocal imaging of microglial cell dynamics in hippocampal slice cultures. Methods 1999; 18:222 - 30, 177; http://dx.doi.org/10.1006/meth.1999.0775; PMID: 10356354
   PubMed Web of Science ®Google Scholar
• Stence N, Waite M, Dailey ME. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 2001; 33:256 - 66; http://dx.doi.org/10.1002/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J; PMID: 11241743
   PubMed Web of Science ®Google Scholar
• Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005; 8:752 - 8; http://dx.doi.org/10.1038/nn1472; PMID: 15895084
   PubMed Web of Science ®Google Scholar
• Junger WG. Immune cell regulation by autocrine purinergic signalling. Nat Rev Immunol 2011; 11:201 - 12; http://dx.doi.org/10.1038/nri2938; PMID: 21331080
   PubMed Web of Science ®Google Scholar
• Damani MR, Zhao L, Fontainhas AM, Amaral J, Fariss RN, Wong WT. Age-related alterations in the dynamic behavior of microglia. Aging Cell 2011; 10:263 - 76; http://dx.doi.org/10.1111/j.1474-9726.2010.00660.x; PMID: 21108733
   PubMed Web of Science ®Google Scholar
• Eichhoff G, Brawek B, Garaschuk O. Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo. Biochim Biophys Acta 2011; 1813:1014 - 24; http://dx.doi.org/10.1016/j.bbamcr.2010.10.018; PMID: 21056596
   PubMed Web of Science ®Google Scholar
• Xu HT, Pan F, Yang G, Gan WB. Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat Neurosci 2007; 10:549 - 51; http://dx.doi.org/10.1038/nn1883; PMID: 17417634
   PubMed Web of Science ®Google Scholar
• Yang G, Pan F, Parkhurst CN, Grutzendler J, Gan WB. Thinned-skull cranial window technique for long-term imaging of the cortex in live mice. Nat Protoc 2010; 5:201 - 8; http://dx.doi.org/10.1038/nprot.2009.222; PMID: 20134419
   PubMed Web of Science ®Google Scholar
• Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, et al. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer’s disease. Nature 2008; 451:720 - 4; http://dx.doi.org/10.1038/nature06616; PMID: 18256671
   PubMed Web of Science ®Google Scholar
• Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, et al. Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 2009; 12:1361 - 3; http://dx.doi.org/10.1038/nn.2432; PMID: 19838177
   PubMed Web of Science ®Google Scholar
• Fuhrmann M, Bittner T, Jung CKE, Burgold S, Page RM, Mitteregger G, et al. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer’s disease. Nat Neurosci 2010; 13:411 - 3; http://dx.doi.org/10.1038/nn.2511; PMID: 20305648
   PubMed Web of Science ®Google Scholar
• Liu Z, Condello C, Schain A, Harb R, Grutzendler J. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. J Neurosci 2010; 30:17091 - 101; http://dx.doi.org/10.1523/JNEUROSCI.4403-10.2010; PMID: 21159979
   PubMed Web of Science ®Google Scholar
• Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, et al. Locus ceruleus controls Alzheimer’s disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A 2010; 107:6058 - 63; http://dx.doi.org/10.1073/pnas.0909586107; PMID: 20231476
   PubMed Web of Science ®Google Scholar
• Simard AR, Soulet D, Gowing G, Julien J-P, Rivest S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease. Neuron 2006; 49:489 - 502; http://dx.doi.org/10.1016/j.neuron.2006.01.022; PMID: 16476660
   PubMed Web of Science ®Google Scholar
• Rosidi NL, Zhou J, Pattanaik S, Wang P, Jin W, Brophy M, et al. Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration. PLoS One 2011; 6:e26612; http://dx.doi.org/10.1371/journal.pone.0026612; PMID: 22028924
   PubMedGoogle Scholar
• Masuda T, Croom D, Hida H, Kirov SA. Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions. Glia 2011; 59:1744 - 53; http://dx.doi.org/10.1002/glia.21220; PMID: 21800362
   PubMed Web of Science ®Google Scholar
• Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 2009; 29:3974 - 80; http://dx.doi.org/10.1523/JNEUROSCI.4363-08.2009; PMID: 19339593
   PubMed Web of Science ®Google Scholar
• Tremblay ME, Lowery RL, Majewska AK. Microglial interactions with synapses are modulated by visual experience. PLoS Biol 2010; 8:e1000527; http://dx.doi.org/10.1371/journal.pbio.1000527; PMID: 21072242
   PubMed Web of Science ®Google Scholar
• Shapiro EM, Sharer K, Skrtic S, Koretsky AP. In vivo detection of single cells by MRI. Magn Reson Med 2006; 55:242 - 9; http://dx.doi.org/10.1002/mrm.20718; PMID: 16416426
   PubMed Web of Science ®Google Scholar
• Pappata S, Levasseur M, Gunn RN, Myers R, Crouzel C, Syrota A, et al. Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195. Neurology 2000; 55:1052 - 4; http://dx.doi.org/10.1212/WNL.55.7.1052; PMID: 11061271
   PubMed Web of Science ®Google Scholar
• Gerhard A, Neumaier B, Elitok E, Glatting G, Ries V, Tomczak R, et al. In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke. Neuroreport 2000; 11:2957 - 60; http://dx.doi.org/10.1097/00001756-200009110-00025; PMID: 11006973
   PubMed Web of Science ®Google Scholar
• Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, et al. In-vivo measurement of activated microglia in dementia. Lancet 2001; 358:461 - 7; http://dx.doi.org/10.1016/S0140-6736(01)05625-2; PMID: 11513911
   PubMed Web of Science ®Google Scholar
• Edison P, Archer HA, Gerhard A, Hinz R, Pavese N, Turkheimer FE, et al. Microglia, amyloid, and cognition in Alzheimer’s disease: An [11C](R)PK11195-PET and [11C]PIB-PET study. Neurobiol Dis 2008; 32:412 - 9; http://dx.doi.org/10.1016/j.nbd.2008.08.001; PMID: 18786637
   PubMed Web of Science ®Google Scholar
• Gehrmann J, Matsumoto Y, Kreutzberg GW. Microglia: intrinsic immuneffector cell of the brain. Brain Res Brain Res Rev 1995; 20:269 - 87; http://dx.doi.org/10.1016/0165-0173(94)00015-H; PMID: 7550361
   PubMed Web of Science ®Google Scholar
• Grossmann R, Stence N, Carr J, Fuller L, Waite M, Dailey ME. Juxtavascular microglia migrate along brain microvessels following activation during early postnatal development. Glia 2002; 37:229 - 40; http://dx.doi.org/10.1002/glia.10031; PMID: 11857681
   PubMed Web of Science ®Google Scholar
• Mathiisen TM, Lehre KP, Danbolt NC, Ottersen OP. The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction. Glia 2010; 58:1094 - 103; http://dx.doi.org/10.1002/glia.20990; PMID: 20468051
   PubMed Web of Science ®Google Scholar
• Lassmann H, Zimprich F, Vass K, Hickey WF. Microglial cells are a component of the perivascular glia limitans. J Neurosci Res 1991; 28:236 - 43; http://dx.doi.org/10.1002/jnr.490280211; PMID: 2033652
   PubMed Web of Science ®Google Scholar
• Mander TH, Morris JF. Immunophenotypic evidence for distinct populations of microglia in the rat hypothalamo-neurohypophysial system. Cell Tissue Res 1995; 280:665 - 73; http://dx.doi.org/10.1007/BF00318369; PMID: 7606773
   PubMed Web of Science ®Google Scholar
• Hickey WF, Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 1988; 239:290 - 2; http://dx.doi.org/10.1126/science.3276004; PMID: 3276004
   PubMed Web of Science ®Google Scholar
• Bechmann I, Priller J, Kovac A, Böntert M, Wehner T, Klett FF, et al. Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages. Eur J Neurosci 2001; 14:1651 - 8; http://dx.doi.org/10.1046/j.0953-816x.2001.01793.x; PMID: 11860459
   PubMed Web of Science ®Google Scholar
• Lewis CA, Solomon JN, Rossi FM, Krieger C. Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1. Glia 2009; 57:1410 - 9; http://dx.doi.org/10.1002/glia.20859; PMID: 19243075
   PubMed Web of Science ®Google Scholar
• Elmquist JK, Breder CD, Sherin JE, Scammell TE, Hickey WF, Dewitt D, et al. Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J Comp Neurol 1997; 381:119 - 29; http://dx.doi.org/10.1002/(SICI)1096-9861(19970505)381:2<119::AID-CNE1>3.0.CO;2-6; PMID: 9130663
   PubMed Web of Science ®Google Scholar
• Van Dam AM, Bauer J, Tilders FJH, Berkenbosch F. Endotoxin-induced appearance of immunoreactive interleukin-1 β in ramified microglia in rat brain: a light and electron microscopic study. Neuroscience 1995; 65:815 - 26; http://dx.doi.org/10.1016/0306-4522(94)00549-K; PMID: 7609880
   PubMed Web of Science ®Google Scholar
• Mato M, Ookawara S, Sakamoto A, Aikawa E, Ogawa T, Mitsuhashi U, et al. Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex. Proc Natl Acad Sci U S A 1996; 93:3269 - 74; http://dx.doi.org/10.1073/pnas.93.8.3269; PMID: 8622926
   PubMed Web of Science ®Google Scholar
• Claudio L, Martiney JA, Brosnan CF. Ultrastructural studies of the blood-retina barrier after exposure to interleukin-1 beta or tumor necrosis factor-alpha. Lab Invest 1994; 70:850 - 61; PMID: 8015289
   PubMed Web of Science ®Google Scholar
• Linehan SA, Martínez-Pomares L, Stahl PD, Gordon S. Mannose receptor and its putative ligands in normal murine lymphoid and nonlymphoid organs: In situ expression of mannose receptor by selected macrophages, endothelial cells, perivascular microglia, and mesangial cells, but not dendritic cells. J Exp Med 1999; 189:1961 - 72; http://dx.doi.org/10.1084/jem.189.12.1961; PMID: 10377192
   PubMed Web of Science ®Google Scholar
• Galea I, Palin K, Newman TA, Van Rooijen N, Perry VH, Boche D. Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain. Glia 2005; 49:375 - 84; http://dx.doi.org/10.1002/glia.20124; PMID: 15538754
   PubMed Web of Science ®Google Scholar
• Williams K, Alvarez X, Lackner AA. Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system. Glia 2001; 36:156 - 64; http://dx.doi.org/10.1002/glia.1105; PMID: 11596124
   PubMed Web of Science ®Google Scholar
• Aguirre K, Miller S. MHC class II-positive perivascular microglial cells mediate resistance to Cryptococcus neoformans brain infection. Glia 2002; 39:184 - 8; http://dx.doi.org/10.1002/glia.10093; PMID: 12112369
   PubMed Web of Science ®Google Scholar
• Thompson KA, Cherry CL, Bell JE, McLean CA. Brain cell reservoirs of latent virus in presymptomatic HIV-infected individuals. Am J Pathol 2011; 179:1623 - 9; http://dx.doi.org/10.1016/j.ajpath.2011.06.039; PMID: 21871429
   PubMed Web of Science ®Google Scholar
• Williams KC, Hickey WF. Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annu Rev Neurosci 2002; 25:537 - 62; http://dx.doi.org/10.1146/annurev.neuro.25.112701.142822; PMID: 12052920
   PubMed Web of Science ®Google Scholar
• Bechmann I, Galea I, Perry VH. What is the blood-brain barrier (not)?. Trends Immunol 2007; 28:5 - 11; http://dx.doi.org/10.1016/j.it.2006.11.007; PMID: 17140851
   PubMed Web of Science ®Google Scholar
• Gottfried-Blackmore A, Kaunzner UW, Idoyaga J, Felger JC, McEwen BS, Bulloch K. Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells. Proc Natl Acad Sci U S A 2009; 106:20918 - 23; http://dx.doi.org/10.1073/pnas.0911509106; PMID: 19906988
   PubMed Web of Science ®Google Scholar
• John B, Ricart B, Tait Wojno ED, Harris TH, Randall LM, Christian DA, et al. Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis. PLoS Pathog 2011; 7:e1002246; http://dx.doi.org/10.1371/journal.ppat.1002246; PMID: 21949652
   PubMedGoogle Scholar
• Kang SS, Herz J, Kim JV, Nayak D, Stewart-Hutchinson P, Dustin ML, et al. Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection. J Exp Med 2011; 208:747 - 59; http://dx.doi.org/10.1084/jem.20101295; PMID: 21464219
   PubMed Web of Science ®Google Scholar
• Felger JC, Abe T, Kaunzner UW, Gottfried-Blackmore A, Gal-Toth J, McEwen BS, et al. Brain dendritic cells in ischemic stroke: time course, activation state, and origin. Brain Behav Immun 2010; 24:724 - 37; http://dx.doi.org/10.1016/j.bbi.2009.11.002; PMID: 19914372
   PubMed Web of Science ®Google Scholar
• Greter M, Heppner FL, Lemos MP, Odermatt BM, Goebels N, Laufer T, et al. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat Med 2005; 11:328 - 34; http://dx.doi.org/10.1038/nm1197; PMID: 15735653
   PubMed Web of Science ®Google Scholar
• McMahon EJ, Bailey SL, Castenada CV, Waldner H, Miller SD. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat Med 2005; 11:335 - 9; http://dx.doi.org/10.1038/nm1202; PMID: 15735651
   PubMed Web of Science ®Google Scholar
• Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, et al. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med 2005; 11:146 - 52; http://dx.doi.org/10.1038/nm1177; PMID: 15665833
   PubMed Web of Science ®Google Scholar
• Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 2009; 10:514 - 23; http://dx.doi.org/10.1038/ni.1716; PMID: 19305396
   PubMed Web of Science ®Google Scholar
• King IL, Dickendesher TL, Segal BM. Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease. Blood 2009; 113:3190 - 7; http://dx.doi.org/10.1182/blood-2008-07-168575; PMID: 19196868
   PubMed Web of Science ®Google Scholar
• Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 2003; 19:71 - 82; http://dx.doi.org/10.1016/S1074-7613(03)00174-2; PMID: 12871640
   PubMed Web of Science ®Google Scholar
• Mildner A, Mack M, Schmidt H, Brück W, Djukic M, Zabel MD, et al. CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 2009; 132:2487 - 500; http://dx.doi.org/10.1093/brain/awp144; PMID: 19531531
   PubMed Web of Science ®Google Scholar
• Kaminski M, Bechmann I, Pohland M, Kiwit J, Nitsch R, Glumm J. Migration of monocytes after intracerebral injection at entorhinal cortex lesion site. J Leuko Biol 2012.
   Google Scholar
• Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FMV. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 2011; 14:1142 - 9; http://dx.doi.org/10.1038/nn.2887; PMID: 21804537
   PubMed Web of Science ®Google Scholar
• Priller J, Flügel A, Wehner T, Boentert M, Haas CA, Prinz M, et al. Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat Med 2001; 7:1356 - 61; http://dx.doi.org/10.1038/nm1201-1356; PMID: 11726978
   PubMed Web of Science ®Google Scholar
• Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch U-K, Mack M, et al. Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci 2007; 10:1544 - 53; http://dx.doi.org/10.1038/nn2015; PMID: 18026096
   PubMed Web of Science ®Google Scholar
• Auffray C, Fogg D, Garfa M, Elain G, Join-Lambert O, Kayal S, et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science 2007; 317:666 - 70; http://dx.doi.org/10.1126/science.1142883; PMID: 17673663
   PubMed Web of Science ®Google Scholar
• Audoy-Rémus J, Richard JF, Soulet D, Zhou H, Kubes P, Vallières L. Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2. J Neurosci 2008; 28:10187 - 99; http://dx.doi.org/10.1523/JNEUROSCI.3510-08.2008; PMID: 18842879
   PubMed Web of Science ®Google Scholar