Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells

References

• Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996; 39:1005 - 29; http://dx.doi.org/10.1007/BF00400649; PMID: 8877284
   PubMed Web of Science ®Google Scholar
• Eizirik DL, Mandrup-Poulsen T. A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001; 44:2115 - 33; http://dx.doi.org/10.1007/s001250100021; PMID: 11793013
   PubMed Web of Science ®Google Scholar
• Rapoport MJ, Mor A, Vardi P, Ramot Y, Winker R, Hindi A, et al. Decreased secretion of Th2 cytokines precedes Up-regulated and delayed secretion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin-dependent diabetes mellitus. J Autoimmun 1998; 11:635 - 42; http://dx.doi.org/10.1006/jaut.1998.0240; PMID: 9878085
   PubMed Web of Science ®Google Scholar
• Berman MA, Sandborg CI, Wang Z, Imfeld KL, Zaldivar F Jr., Dadufalza V, et al. Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus. J Immunol 1996; 157:4690 - 6; PMID: 8906850
   PubMed Web of Science ®Google Scholar
• Marselli L, Dotta F, Piro S, Santangelo C, Masini M, Lupi R, et al. Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines. J Clin Endocrinol Metab 2001; 86:4974 - 8; http://dx.doi.org/10.1210/jc.86.10.4974; PMID: 11600573
   PubMed Web of Science ®Google Scholar
• Kaminski A, Kaminski ER, Morgan NG. Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines. Clin Exp Immunol 2007; 148:583 - 8; http://dx.doi.org/10.1111/j.1365-2249.2007.03375.x; PMID: 17403060
   PubMed Web of Science ®Google Scholar
• Souza KL, Gurgul-Convey E, Elsner M, Lenzen S. Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells. J Endocrinol 2008; 197:139 - 50; http://dx.doi.org/10.1677/JOE-07-0638; PMID: 18372240
   PubMed Web of Science ®Google Scholar
• Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system?. Diabetologia 1998; 41:1241 - 8; http://dx.doi.org/10.1007/s001250051058; PMID: 9794114
   PubMed Web of Science ®Google Scholar
• Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011; 11:98 - 107; http://dx.doi.org/10.1038/nri2925; PMID: 21233852
   PubMed Web of Science ®Google Scholar
• Campbell IL, Cutri A, Wilson A, Harrison LC. Evidence for IL-6 production by and effects on the pancreatic beta-cell. J Immunol 1989; 143:1188 - 91; PMID: 2501390
   PubMed Web of Science ®Google Scholar
• Donath MY, Böni-Schnetzler M, Ellingsgaard H, Halban PA, Ehses JA. Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endocrinol Metab 2010; 21:261 - 7; http://dx.doi.org/10.1016/j.tem.2009.12.010; PMID: 20096598
   PubMed Web of Science ®Google Scholar
• Olsson A, Johansson U, Korsgren O, Frisk G. Inflammatory gene expression in Coxsackievirus B-4-infected human islets of Langerhans. Biochem Biophys Res Commun 2005; 330:571 - 6; http://dx.doi.org/10.1016/j.bbrc.2005.03.016; PMID: 15796921
   PubMed Web of Science ®Google Scholar
• Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG. The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 2009; 52:1143 - 51; http://dx.doi.org/10.1007/s00125-009-1276-0; PMID: 19266182
   PubMed Web of Science ®Google Scholar
• Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK. Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol 2011; 33:9 - 21; http://dx.doi.org/10.1007/s00281-010-0205-0; PMID: 20424842
   PubMed Web of Science ®Google Scholar
• Roy B, Bhattacharjee A, Xu B, Ford D, Maizel AL, Cathcart MK. IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats. J Leukoc Biol 2002; 72:580 - 9; PMID: 12223527
   PubMed Web of Science ®Google Scholar
• Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen PJ, Julkunen I. Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells. Blood 1999; 93:1980 - 91; PMID: 10068671
   PubMed Web of Science ®Google Scholar
• Kaminski A, Welters HJ, Kaminski ER, Morgan NG. Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep 2010; 30:169 - 75; http://dx.doi.org/10.1042/BSR20090021; PMID: 19531027
   PubMed Web of Science ®Google Scholar
• Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 2002; 8:240 - 6; http://dx.doi.org/10.1038/nm0302-240; PMID: 11875494
   PubMed Web of Science ®Google Scholar
• Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, et al. Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc Natl Acad Sci U S A 2008; 105:13163 - 8; http://dx.doi.org/10.1073/pnas.0801059105; PMID: 18719127
   PubMed Web of Science ®Google Scholar
• Villanueva EC, Myers MG Jr.. Leptin receptor signaling and the regulation of mammalian physiology. Int J Obes (Lond) 2008; 32:Suppl 7 S8 - 12; http://dx.doi.org/10.1038/ijo.2008.232; PMID: 19136996
   PubMedGoogle Scholar
• Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner KU, et al. Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. Mol Endocrinol 2007; 21:2218 - 32; http://dx.doi.org/10.1210/me.2007-0173; PMID: 17550976
   PubMed Web of Science ®Google Scholar
• Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD. Interleukin-4 and interleukin-13 signaling connections maps. Science 2003; 300:1527 - 8; http://dx.doi.org/10.1126/science.1085458; PMID: 12791978
   PubMed Web of Science ®Google Scholar
• Hershey GK. IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 2003; 111:677 - 90, quiz 691; http://dx.doi.org/10.1067/mai.2003.1333; PMID: 12704343
   PubMed Web of Science ®Google Scholar
• Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003; 374:1 - 20; http://dx.doi.org/10.1042/BJ20030407; PMID: 12773095
   PubMed Web of Science ®Google Scholar
• Andrews RP, Ericksen MB, Cunningham CM, Daines MO, Hershey GK. Analysis of the life cycle of stat6. Continuous cycling of STAT6 is required for IL-4 signaling. J Biol Chem 2002; 277:36563 - 9; http://dx.doi.org/10.1074/jbc.M200986200; PMID: 12121972
   PubMed Web of Science ®Google Scholar
• Carey GB, Semenova E, Qi X, Keegan AD. IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway. Cell Res 2007; 17:942 - 55; http://dx.doi.org/10.1038/sj.cr.2007.90; PMID: 17968425
   PubMed Web of Science ®Google Scholar
• Yang L, Wang L, Lin HK, Kan PY, Xie S, Tsai MY, et al. Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells. Biochem Biophys Res Commun 2003; 305:462 - 9; http://dx.doi.org/10.1016/S0006-291X(03)00792-7; PMID: 12763015
   PubMed Web of Science ®Google Scholar
• Lust JA, Donovan KA, Kline MP, Greipp PR, Kyle RA, Maihle NJ. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 1992; 4:96 - 100; http://dx.doi.org/10.1016/1043-4666(92)90043-Q; PMID: 1633265
   PubMed Web of Science ®Google Scholar
• Nishimura Y, Nitto T, Inoue T, Node K. IL-13 attenuates vascular tube formation via JAK2-STAT6 pathway. Circ J 2008; 72:469 - 75; http://dx.doi.org/10.1253/circj.72.469; PMID: 18296848
   PubMed Web of Science ®Google Scholar
• Pedranzini L, Dechow T, Berishaj M, Comenzo R, Zhou P, Azare J, et al. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res 2006; 66:9714 - 21; http://dx.doi.org/10.1158/0008-5472.CAN-05-4280; PMID: 17018630
   PubMed Web of Science ®Google Scholar
• Donath MY, Böni-Schnetzler M, Ellingsgaard H, Ehses JA. Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes. Physiology (Bethesda) 2009; 24:325 - 31; http://dx.doi.org/10.1152/physiol.00032.2009; PMID: 19996363
   PubMed Web of Science ®Google Scholar
• Zaccone P, Phillips J, Conget I, Gomis R, Haskins K, Minty A, et al. Interleukin-13 prevents autoimmune diabetes in NOD mice. Diabetes 1999; 48:1522 - 8; http://dx.doi.org/10.2337/diabetes.48.8.1522; PMID: 10426368
   PubMed Web of Science ®Google Scholar
• Pennline KJ, Roque-Gaffney E, Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol 1994; 71:169 - 75; http://dx.doi.org/10.1006/clin.1994.1068; PMID: 8181185
   PubMedGoogle Scholar
• Rapoport MJ, Jaramillo A, Zipris D, Lazarus AH, Serreze DV, Leiter EH, et al. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med 1993; 178:87 - 99; http://dx.doi.org/10.1084/jem.178.1.87; PMID: 8315397
   PubMed Web of Science ®Google Scholar
• Gaddy DF, Riedel MJ, Bertera S, Kieffer TJ, Robbins PD. dsAAV8-mediated gene transfer and β-cell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice. Gene Ther 2011; 19:791 - 9; http://dx.doi.org/10.1038/gt.2011.181; PMID: 22089495
   PubMed Web of Science ®Google Scholar
• Rehman KK, Trucco M, Wang Z, Xiao X, Robbins PD. AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther 2008; 16:1409 - 16; http://dx.doi.org/10.1038/mt.2008.116; PMID: 18560422
   PubMed Web of Science ®Google Scholar
• Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 2011; 1813:878 - 88; http://dx.doi.org/10.1016/j.bbamcr.2011.01.034; PMID: 21296109
   PubMed Web of Science ®Google Scholar
• Drucker C, Gewiese J, Malchow S, Scheller J, Rose-John S. Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration. J Autoimmun 2010; 34:29 - 37; http://dx.doi.org/10.1016/j.jaut.2009.08.003; PMID: 19717281
   PubMed Web of Science ®Google Scholar
• Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, et al. The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest 2005; 115:313 - 25; PMID: 15668741
   PubMed Web of Science ®Google Scholar
• Hebenstreit D, Wirnsberger G, Horejs-Hoeck J, Duschl A. Signaling mechanisms, interaction partners, and target genes of STAT6. Cytokine Growth Factor Rev 2006; 17:173 - 88; http://dx.doi.org/10.1016/j.cytogfr.2006.01.004; PMID: 16540365
   PubMed Web of Science ®Google Scholar
• Wadt KA, Larsen CM, Andersen HU, Nielsen K, Karlsen AE, Mandrup-Poulsen T. Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase. Diabetes 1998; 47:1602 - 8; http://dx.doi.org/10.2337/diabetes.47.10.1602; PMID: 9753298
   PubMed Web of Science ®Google Scholar
• Oh YS, Lee YJ, Park EY, Jun HS. Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production. Diabetes Metab Res Rev 2011; 27:813 - 9; http://dx.doi.org/10.1002/dmrr.1233; PMID: 22069265
   PubMed Web of Science ®Google Scholar
• Kolios G, Wright KL, Linehan JD, Robertson DA, Westwick J. Interleukin-13 inhibits nitric oxide production in human colonic mucosa. Hepatogastroenterology 2000; 47:714 - 7; PMID: 10919016
   PubMed Web of Science ®Google Scholar
• Bogdan C, Thüring H, Dlaska M, Röllinghoff M, Weiss G. Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population. J Immunol 1997; 159:4506 - 13; PMID: 9379051
   PubMed Web of Science ®Google Scholar
• Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 1992; 130:167 - 78; http://dx.doi.org/10.1210/en.130.1.167; PMID: 1370150
   PubMed Web of Science ®Google Scholar
• McCluskey JT, Hamid M, Guo-Parke H, McClenaghan NH, Gomis R, Flatt PR. Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion. J Biol Chem 2011; 286:21982 - 92; http://dx.doi.org/10.1074/jbc.M111.226795; PMID: 21515691
   PubMed Web of Science ®Google Scholar
• Kissler HJ, Niland JC, Olack B, Ricordi C, Hering BJ, Naji A, et al. Validation of methodologies for quantifying isolated human islets: an Islet Cell Resources study. Clin Transplant 2010; 24:236 - 42; http://dx.doi.org/10.1111/j.1399-0012.2009.01052.x; PMID: 19719726
   PubMed Web of Science ®Google Scholar
• Morgan NG, Diakogiannaki E, Russell MA. The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines. Methods Mol Biol 2009; 560:53 - 64; http://dx.doi.org/10.1007/978-1-59745-448-3_5; PMID: 19504243
   PubMedGoogle Scholar
• Welters HJ, Oknianska A, Erdmann KS, Ryffel GU, Morgan NG. The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway. J Endocrinol 2008; 197:543 - 52; http://dx.doi.org/10.1677/JOE-07-0262; PMID: 18413347
   PubMed Web of Science ®Google Scholar