2,905
Views
47
CrossRef citations to date
0
Altmetric
Research Paper

Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2

, , , &
Article: e28095 | Received 09 Dec 2013, Accepted 03 Feb 2014, Published online: 18 Feb 2014

References

  • Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, Nagaraj V, Reinbothe TM, Tuncel J, Eliasson L, et al. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science 2010; 327:217 - 20
  • Reinbothe TM, Alkayyali S, Ahlqvist E, Tuomi T, Isomaa B, Lyssenko V, Renström E. The human L-type calcium channel Cav1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes. Diabetologia 2013; 56:340 - 9; http://dx.doi.org/10.1007/s00125-012-2758-z; PMID: 23229155
  • Rorsman P, Braun M, Zhang Q. Regulation of calcium in pancreatic α- and β-cells in health and disease. Cell Calcium 2012; 51:300 - 8; http://dx.doi.org/10.1016/j.ceca.2011.11.006; PMID: 22177710
  • Hauge-Evans AC, King AJ, Carmignac D, Richardson CC, Robinson IC, Low MJ, Christie MR, Persaud SJ, Jones PM. Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes 2009; 58:403 - 11; http://dx.doi.org/10.2337/db08-0792; PMID: 18984743
  • Kieffer TJ, Heller RS, Unson CG, Weir GC, Habener JF. Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets. Endocrinology 1996; 137:5119 - 25; PMID: 8895386
  • Jaques F, Jousset H, Tomas A, Prost AL, Wollheim CB, Irminger JC, Demaurex N, Halban PA. Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion. Endocrinology 2008; 149:2494 - 505; http://dx.doi.org/10.1210/en.2007-0974; PMID: 18218692
  • Göpel S, Zhang Q, Eliasson L, Ma XS, Galvanovskis J, Kanno T, Salehi A, Rorsman P. Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. J Physiol 2004; 556:711 - 26; http://dx.doi.org/10.1113/jphysiol.2003.059675; PMID: 14966302
  • Deisseroth K. Optogenetics. Nat Methods 2011; 8:26 - 9; PMID: 21191368
  • Nagel G, Szellas T, Huhn W, Kateriya S, Adeishvili N, Berthold P, Ollig D, Hegemann P, Bamberg E. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc Natl Acad Sci U S A 2003; 100:13940 - 5; http://dx.doi.org/10.1073/pnas.1936192100; PMID: 14615590
  • Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YW, Garcia AJ 3rd, Gu X, Zanella S, et al. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci 2012; 15:793 - 802; http://dx.doi.org/10.1038/nn.3078; PMID: 22446880
  • Kalis M, Bolmeson C, Esguerra JL, Gupta S, Edlund A, Tormo-Badia N, Speidel D, Holmberg D, Mayans S, Khoo NK, et al. Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. PLoS One 2011; 6:e29166; http://dx.doi.org/10.1371/journal.pone.0029166; PMID: 22216196
  • Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260:3440 - 50; PMID: 3838314
  • Buda P, Reinbothe T, Nagaraj V, Mahdi T, Luan C, Tang Y, Axelsson AS, Li D, Rosengren AH, Renström E, et al. Eukaryotic translation initiation factor 3 subunit e controls intracellular calcium homeostasis by regulation of cav1.2 surface expression. PLoS One 2013; 8:e64462; http://dx.doi.org/10.1371/journal.pone.0064462; PMID: 23737983
  • Reinbothe TM, Ivarsson R, Li DQ, Niazi O, Jing X, Zhang E, Stenson L, Bryborn U, Renstrom E. Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion. Molecular endocrinology (Baltimore, Md 2009; 23:893-900.
  • Wollheim CB, Sharp GW. Regulation of insulin release by calcium. Physiol Rev 1981; 61:914 - 73; PMID: 6117094
  • Zhang F, Wang LP, Brauner M, Liewald JF, Kay K, Watzke N, Wood PG, Bamberg E, Nagel G, Gottschalk A, et al. Multimodal fast optical interrogation of neural circuitry. Nature 2007; 446:633 - 9; http://dx.doi.org/10.1038/nature05744; PMID: 17410168
  • Jing X, Li DQ, Olofsson CS, Salehi A, Surve VV, Caballero J, Ivarsson R, Lundquist I, Pereverzev A, Schneider T, et al. CaV2.3 calcium channels control second-phase insulin release. J Clin Invest 2005; 115:146 - 54; http://dx.doi.org/10.1172/JCI200522518; PMID: 15630454
  • Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, et al. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J 2003; 22:3844 - 54; http://dx.doi.org/10.1093/emboj/cdg389; PMID: 12881419
  • Lin JY. A user’s guide to channelrhodopsin variants: features, limitations and future developments. Exp Physiol 2011; 96:19 - 25; http://dx.doi.org/10.1113/expphysiol.2009.051961; PMID: 20621963
  • Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB. Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 2005; 54:1808 - 15; http://dx.doi.org/10.2337/diabetes.54.6.1808; PMID: 15919803
  • Olsen HL, Theander S, Bokvist K, Buschard K, Wollheim CB, Gromada J. Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology 2005; 146:4861 - 70; http://dx.doi.org/10.1210/en.2005-0800; PMID: 16081632
  • Jones CN, Pei D, Staris P, Polonsky KS, Chen YD, Reaven GM. Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals. J Clin Endocrinol Metab 1997; 82:1834 - 8; http://dx.doi.org/10.1210/jcem.82.6.3979; PMID: 9177392
  • Reimer MK, Ahrén B. Altered beta-cell distribution of pdx-1 and GLUT-2 after a short-term challenge with a high-fat diet in C57BL/6J mice. Diabetes 2002; 51:Suppl 1 S138 - 43; http://dx.doi.org/10.2337/diabetes.51.2007.S138; PMID: 11815473
  • Peyot ML, Pepin E, Lamontagne J, Latour MG, Zarrouki B, Lussier R, Pineda M, Jetton TL, Madiraju SR, Joly E, et al. Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass. Diabetes 2010; 59:2178 - 87; http://dx.doi.org/10.2337/db09-1452; PMID: 20547980
  • Gonzalez A, Merino B, Marroquí L, Ñeco P, Alonso-Magdalena P, Caballero-Garrido E, Vieira E, Soriano S, Gomis R, Nadal A, et al. Insulin hypersecretion in islets from diet-induced hyperinsulinemic obese female mice is associated with several functional adaptations in individual β-cells. Endocrinology 2013; 154:3515 - 24; http://dx.doi.org/10.1210/en.2013-1424; PMID: 23867214
  • Remizov O, Jakubov R, Düfer M, Krippeit Drews P, Drews G, Waring M, Brabant G, Wienbergen A, Rustenbeck I, Schöfl C. Palmitate-induced Ca2+-signaling in pancreatic beta-cells. Mol Cell Endocrinol 2003; 212:1 - 9; http://dx.doi.org/10.1016/j.mce.2003.09.026; PMID: 14654245
  • Olofsson CS, Salehi A, Holm C, Rorsman P. Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. J Physiol 2004; 557:935 - 48; http://dx.doi.org/10.1113/jphysiol.2004.066258; PMID: 15090611
  • Rosengren AH, Braun M, Mahdi T, Andersson SA, Travers ME, Shigeto M, Zhang E, Almgren P, Ladenvall C, Axelsson AS, et al. Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes 2012; 61:1726 - 33; http://dx.doi.org/10.2337/db11-1516; PMID: 22492527
  • Zhang F, Gradinaru V, Adamantidis AR, Durand R, Airan RD, de Lecea L, Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc 2010; 5:439 - 56; http://dx.doi.org/10.1038/nprot.2009.226; PMID: 20203662