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mAbs Volume 5, 2013 - Issue 5
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Developability studies before initiation of process development

Improving manufacturability of monoclonal antibodies

Xiaoyu Yang BioProcess Development; Merck Research Laboratories; Union, NJ USA
,
Wei Xu BioProcess Development; Merck Research Laboratories; Union, NJ USA
,
Svetlana Dukleska BioProcess Development; Merck Research Laboratories; Union, NJ USA
,
Sabrina Benchaar Discovery Biologics; Merck Research Laboratories PaloAlto; Palo Alto, CA USA
,
Selina Mengisen BioProcess Development; Merck Research Laboratories; Union, NJ USA
,
Valentyn Antochshuk BioProcess Development; Merck Research Laboratories; Summit, NJ USA
,
Jason Cheung BioProcess Development; Merck Research Laboratories; Summit, NJ USA
,
Leslie Mann BioProcess Development; Merck Research Laboratories; Union, NJ USA
,
Zulfia Babadjanova BioProcess Development; Merck Research Laboratories; Union, NJ USA
,
Jason Rowand BioProcess Development; Merck Research Laboratories; Union, NJ USA
,
Rico Gunawan BioProcess Development; Merck Research Laboratories; Union, NJ USA
,
Alexander McCampbell Molecular biomarkers; Merck Research Laboratories; West Point, PA USA
,
Maribel Beaumont Discovery Biologics; Merck Research Laboratories PaloAlto; Palo Alto, CA USA
,
David Meininger Discovery Biologics; Merck Research Laboratories PaloAlto; Palo Alto, CA USA
,
Daisy Richardson BioProcess Development; Merck Research Laboratories; Union, NJ USA
&
Alexandre Ambrogelly BioProcess Development; Merck Research Laboratories; Union, NJ USACorrespondence[email protected]
 show all
Pages 787-794 | Received 28 Apr 2013, Accepted 03 Jun 2013, Published online: 07 Jun 2013

References

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  • Robinson NE, Robinson AB. Molecular Clocks: Deamidation of Asparaginyl and Glutaminyl Residues in Peptides and Proteins. 2004 Althouse Press, Cave Junction, OR.
  • Du Y, Walsh A, Ehrick R, Xu W, May K, Liu H. Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies. MAbs 2012; 4:578 - 85; http://dx.doi.org/10.4161/mabs.21328; PMID: 22820257
  • Wypych J, Li M, Guo A, Zhang Z, Martinez T, Allen MJ, et al. Human IgG2 antibodies display disulfide-mediated structural isoforms. J Biol Chem 2008; 283:16194 - 205; http://dx.doi.org/10.1074/jbc.M709987200; PMID: 18339624

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