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Purification of monoclonal antibodies by hydrophobic interaction chromatography under no-salt conditions

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Pages 795-800 | Received 21 May 2013, Accepted 25 Jun 2013, Published online: 26 Jun 2013

References

  • Shukla AA, Thömmes J. Recent advances in large-scale production of monoclonal antibodies and related proteins. Trends Biotechnol 2010; 28:253 - 61; http://dx.doi.org/10.1016/j.tibtech.2010.02.001; PMID: 20304511
  • Cramer SM, Holstein MA. Downstream bioprocessing: recent advances and future promise. Curr Opin Chem Eng 2011; 1:27 - 37; http://dx.doi.org/10.1016/j.coche.2011.08.008
  • McCue JT, Engel P, Ng A, Macniven R, Thömmes J. Modeling of protein monomer/aggregate purification and separation using hydrophobic interaction chromatography. Bioprocess Biosyst Eng 2008; 31:261 - 75; http://dx.doi.org/10.1007/s00449-008-0200-1; PMID: 18205016
  • Shukla AA, Hubbard B, Tressel T, Guhan S, Low D. Downstream processing of monoclonal antibodies--application of platform approaches. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 848:28 - 39; http://dx.doi.org/10.1016/j.jchromb.2006.09.026; PMID: 17046339
  • Jiang C, Flansburg L, Ghose S, Jorjorian P, Shukla AA. Defining process design space for a hydrophobic interaction chromatography (HIC) purification step: application of quality by design (QbD) principles. Biotechnol Bioeng 2010; 107:985 - 97; http://dx.doi.org/10.1002/bit.22894; PMID: 20683852
  • Lu Y, Williamson B, Gillespie R. Recent advancement in application of hydrophobic interaction chromatography for aggregate removal in industrial purification process. Curr Pharm Biotechnol 2009; 10:427 - 33; http://dx.doi.org/10.2174/138920109788488897; PMID: 19519419
  • Nagrath D, Xia F, Cramer SM. Characterization and modeling of nonlinear hydrophobic interaction chromatographic systems. J Chromatogr A 2011; 1218:1219 - 26; http://dx.doi.org/10.1016/j.chroma.2010.12.111; PMID: 21255785
  • Melander WR, Corradini D, Horváth CS. Salt-mediated retention of proteins in hydrophobic-interaction chromatography. Application of solvophobic theory. J Chromatogr 1984; 317:67 - 85; http://dx.doi.org/10.1016/S0021-9673(01)91648-6; PMID: 6530455
  • Liu HF, Ma J, Winter C, Bayer R. Recovery and purification process development for monoclonal antibody production. MAbs 2010; 2:480 - 99; http://dx.doi.org/10.4161/mabs.2.5.12645; PMID: 20647768
  • Senczuk AM, Klinke R, Arakawa T, Vedantham G, Yigzaw Y. Hydrophobic interaction chromatography in dual salt system increases protein binding capacity. Biotechnol Bioeng 2009; 103:930 - 5; http://dx.doi.org/10.1002/bit.22313; PMID: 19382248
  • Urmann M, Graalfs H, Joehnck M, Jacob LR, Frech C. Cation-exchange chromatography of monoclonal antibodies: Characterization of a novel stationary phase designed for production-scale purification. MAbs 2010; 2:395 - 404; PMID: 20559022
  • Roemling R, Jungbauer A. Meeting report: 8th HIC/RPC bioseparation conference. Biotechnol J 2013; Apr 26. doi: http://dx.doi.org/10.1002/biot.201300123. [Epub ahead of print].
  • Chen J, Tetrault J, Ley A. Comparison of standard and new generation hydrophobic interaction chromatography resins in the monoclonal antibody purification process. J Chromatogr A 2008; 1177:272 - 81; http://dx.doi.org/10.1016/j.chroma.2007.07.083; PMID: 17709111
  • Ghose S, Jin M, Liu J, Hickey J. Integrated polishing steps for monoclonal antibody purification. In: Gottschalk U, ed. Process Scale Purification of Antibodies. New York: John Wiley & Sons, 2009:145-167.
  • Gagnon P. Polishing methods for monoclonal IgG purification. In: Shukla AA, Etzel MR, Gadam S, ed. Process Scale Bioseparations for the Biopharmaceutical Industry. New York: Taylor & Francis, 2006: 491-505.
  • Arakawa T, Tsumoto K, Nagase K, Ejima D. The effects of arginine on protein binding and elution in hydrophobic interaction and ion-exchange chromatography. Protein Expr Purif 2007; 54:110 - 6; http://dx.doi.org/10.1016/j.pep.2007.02.010; PMID: 17408966
  • Tsumoto K, Ejima D, Nagase K, Arakawa T. Arginine improves protein elution in hydrophobic interaction chromatography. The cases of human interleukin-6 and activin-A. J Chromatogr A 2007; 1154:81 - 6; http://dx.doi.org/10.1016/j.chroma.2007.02.061; PMID: 17449045
  • Gagnon P. Technology trends in antibody purification. J Chromatogr A 2012; 1221:57 - 70; http://dx.doi.org/10.1016/j.chroma.2011.10.034; PMID: 22071423
  • Kato Y, Nakamura K, Kitamura T, Hasegawa M, Sasaki H. Hydrophobic interaction chromatography at low salt concentration for the capture of monoclonal antibodies. J Chromatogr A 2004; 1036:45 - 50; http://dx.doi.org/10.1016/j.chroma.2004.02.009; PMID: 15139412
  • Shukla AA, Yigzaw Y. Modes of Preparative Chromatography. In: Shukla AA, Etzel MR, Gadam S, ed. Process Scale Bioseparations for the Biopharmaceutical Industry. New York: Taylor & Francis, 2006: 491-505.