1,370
Views
30
CrossRef citations to date
0
Altmetric
Report

Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design

, , , , , , , , , & show all
Pages 487-494 | Received 03 May 2011, Accepted 15 Jun 2011, Published online: 01 Sep 2011

References

  • Enever C, Batuwangala T, Plummer C, Sepp A. Next generation immunotherapeutics—honing the magic bullet. Curr Opin Biotechnol 2009; 20:405 - 411
  • Uno T, Takeda K, Kojima Y, Yoshizawa H, Akiba H, Mittler RS, et al. Eradication of established tumors in mice by a combination antibody-based therapy. Nat Med 2006; 12:693 - 698
  • Wu C, Ying H, Grinnell C, Bryant S, Miller R, Clabbers A, et al. Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin. Nat Biotechnol 2007; 25:1290 - 1297
  • Wu C, Ying H, Bose S, Miller R, Medina L, Santora L, et al. Molecular construction and optimization of anti-human IL-1alpha/beta dual variable domain immunoglobulin (DVD-Ig) molecules. mAbs 2009; 1:339 - 347
  • Wu C, Ghayur T, Salfeld J. Generation and Characterization of a Dual Variable Domain Immunoglobulin (DVD-Ig™) Molecule in Kontermann R, Dübel S, Eds. Antibody Engineering 2010; 2:239 - 250
  • Andrew SM, Titus JA. Fragmentation of immunoglobulin G. Curr Protoc Cell Biol 2003; 16:4; PMID: 18228421
  • Goding JW. Purification, fragmentation and isotopic labeling of monoclonal antibodies. Monoclonal Antibodies: Principles and Practice 1996; third edition San Diego CA Academic Press 192 - 233
  • Parham P. On the fragmentation of monoclonal IgG1, IgG2a and IgG2b from BALB/c mice. J Immunol 1983; 131:2895 - 2902
  • Myszka DG. Improving biosensor analysis. J Mol Recognit 1999; 12:279 - 284
  • Sandin S, Ofverstedt LG, Wikström AC, Wrange O, Skoglund U. Structure and flexibility of individual immunoglobulin G molecules in solution. Structure 2004; 12:409 - 415
  • Evans EJ, Esnouf RM, Manso-Sancho R, Gilbert RJ, James JR, Yu C, et al. Crystal structure of a soluble CD28-Fab complex. Nat Immunol 2005; 6:271 - 279

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.