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Review

Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies

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Pages 431-439 | Received 20 Jun 2011, Accepted 12 Jul 2011, Published online: 01 Sep 2011

References

  • Brambell FWR, Halliday R, Morris IG. Interference by human and bovine serum and serum protein fractions with the absorption of antibodies by suckling rats and mice. Proc R Soc B 1958; 149:1
  • Brambell FWR, Hemmings WA, Morris IG. A theoretical model of gammaglobulin catabolism. Nature 1964; 203:1352 - 1355
  • Spiegelberg HL, Weigle WO. The catabolism of homologous and heterologous 7s gamma globulin fragments. J Exp Med 1965; 121:323 - 338
  • Kraehenbuhl JP, Campiche MA. Early stages of intestinal absorption of specific antibiodies in the newborn. An ultrastructural, cytochemical and immunological study in the pig, rat and rabbit. J Cell Biol 1969; 42:345 - 365
  • Butler JE. Hasegawa T, Hayashi M, Ebling FJG, Henderson IW. Transmission of immunity from mother to young. Fertility and Sterility 1971; Amsterdam Excerpta Medica 92 - 98
  • Jones EA, Waldmann TA. The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. J Clin Invest 1972; 51:2916 - 2927
  • Rodewald R, Kraehenbuhl JP. Receptor-mediated transport of IgG. J Cell Biol 1984; 99:159 - 164
  • Simister NE, Rees AR. Isolation and characterization of an Fc receptor from neonatal rat small intestine. Eur J Immunol 1985; 15:733 - 738
  • Simister NE, Mostov KE. An Fc receptor structurally related to MHC class I antigens. Nature 1989; 337:184 - 187
  • Roopenian DC, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 2007; 7:715 - 725
  • Ward ES, Ober RJ. Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn. Adv Immunol 2009; 103:77 - 115
  • Roopenian DC, Sun VZ. Clinical ramifications of the MHC family Fc receptor FcRn. J Clin Immunol 2010; 30:790 - 797
  • Kuo TT, Baker K, Yoshida M, Qiao SW, Aveson VG, Lencer WI, et al. Neonatal Fc receptor: from immunity to therapeutics. J Clin Immunol 2010; 30:777 - 789
  • Vidarsson G, Stemerding AM, Stapleton NM, Spliethoff SE, Janssen H, Rebers FE, et al. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood 2006; 108:3573 - 3579
  • Qiao SW, Kobayashi K, Johansen FE, Sollid LM, Andersen JT, Milford E, et al. Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci USA 2008; 105:9337 - 9342
  • Mi W, Wanjie S, Lo ST, Gan Z, Pickl-Herk B, Ober RJ, et al. Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments. J Immunol 2008; 181:7550 - 7561
  • Liu X, Lu L, Yang Z, Palaniyandi S, Zeng R, Gao LY, et al. The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells. J Immunol 2011; 186:4674 - 4686
  • Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, et al. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci USA 2011; 108:9927 - 9932
  • Lu W, Zhao Z, Zhao Y, Yu S, Zhao Y, Fan B, et al. Overexpression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice. Immunology 2007; 122:401 - 408
  • Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, et al. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 2006; 18:1759 - 1769
  • Bender B, Bodrogi L, Mayer B, Schneider Z, Zhao Y, Hammarstrom L, et al. Position independent and copy-number-related expression of the bovine neonatal Fc receptor alpha-chain in transgenic mice carrying a 102 kb BAC genomic fragment. Transgenic Res 2007; 16:613 - 627
  • Vegh A, Cervenak J, Jankovics I, Kacskovics I. FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen. mAbs 2011; 3:173 - 180
  • Schneider Z, Cervenak J, Baranyi M, Papp K, Prechl J, Laszlo G, et al. Transgenic expression of bovine neonatal Fc receptor in mice boosts immune response and improves hybridoma production efficiency without any sign of autoimmunity. Immunol Lett 2011; 137:62 - 69
  • Cervenak J, Bender B, Schneider Z, Magna M, Carstea BV, Liliom K, et al. Neonatal FcR overexpression boosts humoral immune response in transgenic mice. J Immunol 2011; 186:959 - 968
  • Collarini EJ, Lee FE, Foord O, Park M, Sperinde G, Wu H, et al. Potent high-affinity antibodies for treatment and prophylaxis of respiratory syncytial virus derived from B cells of infected patients. J Immunol 2009; 183:6338 - 6345
  • Bosze Z, Hiripi L, Hoffmann O, Kerekes A, Bender B, Kacskovics I. Bosze Z, Fan J, Duranthon V. IgG binding FcRn transgenic rabbits created through BAC transgensis. 4th International Rabbit Biotechnology Meeting 2011; Budapest, Hungary
  • Humphrey JH, Fahey JL. The metabolism of normal plasma proteins and gamma-myeloma protein in mice bearing plasma-cell tumors. J Clin Invest 1961; 40:1696 - 1705
  • Fahey JL, Robinson AG. Factors controlling serum gamma-globulin concentration. J Exp Med 1963; 118:845 - 868
  • Sell S, Fahey JL. Relationship between gamma-globulin metabolism and low serum gamma-globulin in germfree mice. J Imunol 1964; 93:81 - 87
  • Junghans RP, Anderson CL. The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor. Proc Natl Acad Sci USA 1996; 93:5512 - 5516
  • Waldmann TA, Strober W. Metabolism of immunoglobulins. Prog Allergy 1969; 13:1 - 110
  • Bleeker WK, Teeling JL, Hack CE. Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect. Blood 2001; 98:3136 - 3142
  • Andersen SB, Bjorneboe M. Gamma globulin turnover in rabbits before and during hyperimmunization. J Exp Med 1964; 119:537 - 546
  • Jin F, Tayab ZR, Balthasar JP. Pharmacokinetic and pharmacodynamic effects of high-dose monoclonal antibody therapy in a rat model of immune thrombocytopenia. Aaps J 2005; 7:895 - 902
  • Roopenian DC, Christianson GJ, Sproule TJ, Brown AC, Akilesh S, Jung N, et al. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis and fate of IgG-Fc-coupled drugs. J Immunol 2003; 170:3528 - 3533
  • Kacskovics I, Wu Z, Simister NE, Frenyo LV, Hammarstrom L. Cloning and characterization of the bovine MHC class I-like Fc receptor. J Immunol 2000; 164:1889 - 1897
  • Mayer B, Zolnai A, Frenyo LV, Jancsik V, Szentirmay Z, Hammarstrom L, et al. Redistribution of the sheep neonatal Fc receptor in the mammary gland around the time of parturition in ewes and its localization in the small intestine of neonatal lambs. Immunology 2002; 107:288 - 296
  • Mayer B, Kis Z, Kajan G, Frenyo LV, Hammarstrom L, Kacskovics I. The neonatal Fc receptor (FcRn) is expressed in the bovine lung. Vet Immunol Immunopathol 2004; 98:85 - 89
  • Kacskovics I, Kis Z, Mayer B, West AP Jr, Tiangco NE, Tilahun M, et al. FcRn mediates elongated serum half-life of human IgG in cattle. Int Immunol 2006; 18:525 - 536
  • Kuroiwa Y, Kasinathan P, Choi YJ, Naeem R, Tomizuka K, Sullivan EJ, et al. Cloned transchromosomic calves producing human immunoglobulin. Nat Biotechnol 2002; 20:889 - 894
  • Cianga P, Medesan C, Richardson JA, Ghetie V, Ward ES. Identification and function of neonatal Fc receptor in mammary gland of lactating mice. Eur J Immunol 1999; 29:2515 - 2523
  • Keler T, Guyre PM, Vitale LA, Sundarapandiyan K, van De Winkel JG, Deo YM, et al. Targeting weak antigens to CD64 elicits potent humoral responses in human CD64 transgenic mice. J Immunol 2000; 165:6738 - 6742
  • Keler T, He L, Graziano RF. Development of antibody-targeted vaccines. Curr Opin Mol Ther 2005; 7:157 - 163
  • Goins CL, Chappell CP, Shashidharamurthy R, Selvaraj P, Jacob J. Immune complex-mediated enhancement of secondary antibody responses. J Immunol 2010; 184:6293 - 6298
  • Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, et al. Antibody recognition of a highly conserved influenza virus epitope. Science 2009; 324:246 - 251
  • Sui J, Hwang WC, Perez S, Wei G, Aird D, Chen LM, et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat Struct Mol Biol 2009; 16:265 - 273
  • Throsby M, van den Brink E, Jongeneelen M, Poon LL, Alard P, Cornelissen L, et al. Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS One 2008; 3:3942
  • Onisk D, Brown M, Keter D, Chambers R, Fancy D, Kacskovics I, et al. DNA immunization in bFcRn transgenic mice results in enhanced immunogenic response. IMPULSE: IMmune-related Pathologies: Understanding Leukocyte Signaling and Emerging therapies 2011; Visegrad, Hungary
  • Bradbury AR, Sidhu S, Dubel S, McCafferty J. Beyond natural antibodies: the power of in vitro display technologies. Nat Biotechnol 2011; 29:245 - 254
  • Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356:314 - 317
  • Knott CL, Reed JC, Bodrug S, Saedi MS, Kumar A, Kuus-Reichel K. Evaluation of Bcl-2/B cell transgenic mice (B6) for hybridoma production. Hybridoma 1996; 15:365 - 371
  • Takai T, Ono M, Hikida M, Ohmori H, Ravetch JV. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 1996; 379:346 - 349
  • Takahashi N, Kakinuma H, Hamada K, Shimazaki K, Yamasaki Y, Matsushita H, et al. Improved generation of catalytic antibodies by MRL/MPJ-lpr/lpr autoimmune mice. J Immunol Methods 2000; 235:113 - 120
  • Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S, Wilson CB, McConahey PJ, et al. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 1978; 148:1198 - 1215
  • Vyse TJ, Kotzin BL. Genetic susceptibility to systemic lupus erythematosus. Annu Rev Immunol 1998; 16:261 - 292
  • Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S, et al. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 1991; 88:8661 - 8665
  • Bolland S, Yim YS, Tus K, Wakeland EK, Ravetch JV. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 2002; 195:1167 - 1174
  • Tiller T, Kofer J, Kreschel C, Busse CE, Riebel S, Wickert S, et al. Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc{gamma}RIIB-deficient mice. J Exp Med 2010; 207:2767 - 2778
  • Papp K, Vegh P, Tchorbanov A, Vassilev T, Erdei A, Prechl J. Progression of lupus-like disease drives the appearance of complement-activating IgG antibodies in MRL/lpr mice. Rheumatology (Oxford) 2010; 49:2273 - 2280
  • Kunkl A, Klaus GG. The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response. Immunology 1981; 43:371 - 378
  • Laissue J, Cottier H, Hess MW, Stoner RD. Early and enhanced germinal center formation and antibody responses in mice after primary stimulation with antigen-isologous antibody complexes as compared with antigen alone. J Immunol 1971; 107:822 - 831
  • Coulie PG, Van Snick J. Enhancement of IgG anti-carrier responses by IgG2 anti-hapten antibodies in mice. Eur J Immunol 1985; 15:793 - 798
  • Getahun A, Heyman B. How antibodies act as natural adjuvants. Immunol Lett 2006; 104:38 - 45
  • Chappell CP, Jacob J. Identification of memory B cells using a novel transgenic mouse model. J Immunol 2006; 176:4706 - 4715
  • Maletto BA, Ropolo AS, Alignani DO, Liscovsky MV, Ranocchia RP, Moron VG, et al. Presence of neutrophil-bearing antigen in lymphoid organs of immune mice. Blood 2006; 108:3094 - 3102
  • Calabro S, Tortoli M, Baudner BC, Pacitto A, Cortese M, O'Hagan DT, et al. Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes. Vaccine 2011; 29:1812 - 1823
  • Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry ML, et al. CCR7 is involved in the migration of neutrophils to lymph nodes. Blood 2011; 117:1196 - 1204
  • Soehnlein O. An elegant defense: how neutrophils shape the immune response. Trends Immunol 2009; 30:511 - 512
  • Israel EJ, Patel VK, Taylor SF, Marshak-Rothstein A, Simister NE. Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J Immunol 1995; 154:6246 - 6251
  • Ghetie V, Hubbard JG, Kim JK, Tsen MF, Lee Y, Ward ES. Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol 1996; 26:690 - 696
  • Christianson GJ, Brooks W, Vekasi S, Manolfi EA, Niles J, Roopenian SL, et al. Beta2-microglobulin-deficient mice are protected from hypergamma-globulinemia and have defective antibody responses because of increased IgG catabolism. J Immunol 1997; 159:4781 - 4792
  • Lehmann-Grube F, Lohler J, Utermohlen O, Gegin C. Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta2-microglobulin gene. J Virol 1993; 67:332 - 339
  • Noble A, Zhao ZS, Cantor H. Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses. J Immunol 1998; 160:566 - 571
  • Zhu X, Meng G, Dickinson BL, Li X, Mizoguchi E, Miao L, et al. MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages and dendritic cells. J Immunol 2001; 166:3266 - 3276
  • Liu X, Ye L, Christianson GJ, Yang JQ, Roopenian DC, Zhu X. NF-{kappa}B Signaling Regulates Functional Expression of the MHC Class I-Related Neonatal Fc Receptor for IgG via Intronic Binding Sequences. J Immunol 2007; 179:2999 - 3011
  • Ye L, Liu X, Rout SN, Li Z, Yan Y, Lu L, et al. The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments. J Immunol 2008; 181:2572 - 2585
  • Love JC, Ronan JL, Grotenbreg GM, van der Veen AG, Ploegh HL. A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nat Biotechnol 2006; 24:703 - 707
  • Jin A, Ozawa T, Tajiri K, Obata T, Kondo S, Kinoshita K, et al. A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood. Nat Med 2009; 15:1088 - 1092
  • Reddy ST, Ge X, Miklos AE, Hughes RA, Kang SH, Hoi KH, et al. Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nat Biotechnol 2010; 28:965 - 969
  • Wang TT, Tan GS, Hai R, Pica N, Petersen E, Moran TM, et al. Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS Pathog 2010; 6:1000796
  • Carter PJ. Potent antibody therapeutics by design. Nat Rev Immunol 2006; 6:343 - 357