2,540
Views
25
CrossRef citations to date
0
Altmetric
Research Paper

Nesprin-1 role in DNA damage response

, &
Pages 173-191 | Received 29 Nov 2013, Accepted 25 Apr 2014, Published online: 29 Apr 2014

References

  • Shimi T, Butin-Israeli V, Goldman RD. The functions of the nuclear envelope in mediating the molecular crosstalk between the nucleus and the cytoplasm. Curr Opin Cell Biol 2012; 24:71 - 8; http://dx.doi.org/10.1016/j.ceb.2011.11.007; PMID: 22192274
  • Maraldi NM, Lattanzi G, Cenni V, Bavelloni A, Marmiroli S, Manzoli FA. Laminopathies and A-type lamin-associated signalling pathways. Adv Enzyme Regul 2010; 50:248 - 61; http://dx.doi.org/10.1016/j.advenzreg.2009.10.019; PMID: 19917303
  • Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L. Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science 2003; 301:1380 - 2; http://dx.doi.org/10.1126/science.1088176; PMID: 12958361
  • Therizols P, Fairhead C, Cabal GG, Genovesio A, Olivo-Marin JC, Dujon B, Fabre E. Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J Cell Biol 2006; 172:189 - 99; http://dx.doi.org/10.1083/jcb.200505159; PMID: 16418532
  • Chow KH, Factor RE, Ullman KS. The nuclear envelope environment and its cancer connections. Nat Rev Cancer 2012; 12:196 - 209; PMID: 22337151
  • Padmakumar VC, Libotte T, Lu W, Zaim H, Abraham S, Noegel AA, Gotzmann J, Foisner R, Karakesisoglou I. The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. J Cell Sci 2005; 118:3419 - 30; http://dx.doi.org/10.1242/jcs.02471; PMID: 16079285
  • Zhang Q, Bethmann C, Worth NF, Davies JD, Wasner C, Feuer A, Ragnauth CD, Yi Q, Mellad JA, Warren DT, et al. Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. Hum Mol Genet 2007; 16:2816 - 33; http://dx.doi.org/10.1093/hmg/ddm238; PMID: 17761684
  • Gros-Louis F, Dupré N, Dion P, Fox MA, Laurent S, Verreault S, Sanes JR, Bouchard JP, Rouleau GA. Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia. Nat Genet 2007; 39:80 - 5; http://dx.doi.org/10.1038/ng1927; PMID: 17159980
  • Attali R, Warwar N, Israel A, Gurt I, McNally E, Puckelwartz M, Glick B, Nevo Y, Ben-Neriah Z, Melki J. Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis. Hum Mol Genet 2009; 18:3462 - 9; http://dx.doi.org/10.1093/hmg/ddp290; PMID: 19542096
  • Grady RM, Starr DA, Ackerman GL, Sanes JR, Han M. Syne proteins anchor muscle nuclei at the neuromuscular junction. Proc Natl Acad Sci U S A 2005; 102:4359 - 64; http://dx.doi.org/10.1073/pnas.0500711102; PMID: 15749817
  • Banerjee I, Zhang J, Moore-Morris T, Pfeiffer E, Buchholz KS, Liu A, Ouyang K, Stroud MJ, Gerace L, Evans SM, et al. Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response. PLoS Genet 2014; 10:e1004114; http://dx.doi.org/10.1371/journal.pgen.1004114; PMID: 24586179
  • Puckelwartz MJ, Kessler E, Zhang Y, Hodzic D, Randles KN, Morris G, Earley JU, Hadhazy M, Holaska JM, Mewborn SK, et al. Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Hum Mol Genet 2009; 18:607 - 20; http://dx.doi.org/10.1093/hmg/ddn386; PMID: 19008300
  • Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, et al. Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet 2010; 19:329 - 41; http://dx.doi.org/10.1093/hmg/ddp499; PMID: 19864491
  • Chancellor TJ, Lee J, Thodeti CK, Lele T. Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation. Biophys J 2010; 99:115 - 23; http://dx.doi.org/10.1016/j.bpj.2010.04.011; PMID: 20655839
  • Marmé A, Zimmermann HP, Moldenhauer G, Schorpp-Kistner M, Müller C, Keberlein O, Giersch A, Kretschmer J, Seib B, Spiess E, et al. Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas. Int J Cancer 2008; 123:2048 - 56; http://dx.doi.org/10.1002/ijc.23763; PMID: 18709643
  • Doherty JA, Rossing MA, Cushing-Haugen KL, Chen C, Van Den Berg DJ, Wu AH, Pike MC, Ness RB, Moysich K, Chenevix-Trench G, et al, Australian Ovarian Cancer Study Management Group, Australian Cancer Study (Ovarian Cancer), Ovarian Cancer Association Consortium (OCAC). ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study. Cancer Epidemiol Biomarkers Prev 2010; 19:245 - 50; http://dx.doi.org/10.1158/1055-9965.EPI-09-0729; PMID: 20056644
  • Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006; 314:268 - 74; http://dx.doi.org/10.1126/science.1133427; PMID: 16959974
  • Tessema M, Willink R, Do K, Yu YY, Yu W, Machida EO, Brock M, Van Neste L, Stidley CA, Baylin SB, et al. Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. Cancer Res 2008; 68:1707 - 14; http://dx.doi.org/10.1158/0008-5472.CAN-07-6325; PMID: 18339850
  • Schuebel KE, Chen W, Cope L, Glöckner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, et al. Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet 2007; 3:1709 - 23; http://dx.doi.org/10.1371/journal.pgen.0030157; PMID: 17892325
  • Masica DL, Karchin R. Correlation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival. Cancer Res 2011; 71:4550 - 61; http://dx.doi.org/10.1158/0008-5472.CAN-11-0180; PMID: 21555372
  • Rajgor D, Mellad JA, Autore F, Zhang Q, Shanahan CM. Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds. PLoS One 2012; 7:e40098; http://dx.doi.org/10.1371/journal.pone.0040098; PMID: 22768332
  • Taranum S, Sur I, Müller R, Lu W, Rashmi RN, Munck M, Neumann S, Karakesisoglou I, Noegel AA. Cytoskeletal interactions at the nuclear envelope mediated by nesprins. Int J Cell Biol 2012; 2012:736524; http://dx.doi.org/10.1155/2012/736524; PMID: 22518138
  • Taranum S, Vaylann E, Meinke P, Abraham S, Yang L, Neumann S, Karakesisoglou I, Wehnert M, Noegel AA. LINC complex alterations in DMD and EDMD/CMT fibroblasts. Eur J Cell Biol 2012; 91:614 - 28; http://dx.doi.org/10.1016/j.ejcb.2012.03.003; PMID: 22555292
  • Dechat T, Gajewski A, Korbei B, Gerlich D, Daigle N, Haraguchi T, Furukawa K, Ellenberg J, Foisner R. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. J Cell Sci 2004; 117:6117 - 28; http://dx.doi.org/10.1242/jcs.01529; PMID: 15546916
  • Dorner D, Vlcek S, Foeger N, Gajewski A, Makolm C, Gotzmann J, Hutchison CJ, Foisner R. Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. J Cell Biol 2006; 173:83 - 93; http://dx.doi.org/10.1083/jcb.200511149; PMID: 16606692
  • Strambio-De-Castillia C, Niepel M, Rout MP. The nuclear pore complex: bridging nuclear transport and gene regulation. Nat Rev Mol Cell Biol 2010; 11:490 - 501; http://dx.doi.org/10.1038/nrm2928; PMID: 20571586
  • Chatel G, Fahrenkrog B. Dynamics and diverse functions of nuclear pore complex proteins. Nucleus 2012; 3:162 - 71; http://dx.doi.org/10.4161/nucl.19674; PMID: 22555605
  • Martínez N, Alonso A, Moragues MD, Pontón J, Schneider J. The nuclear pore complex protein Nup88 is overexpressed in tumor cells. Cancer Res 1999; 59:5408 - 11; PMID: 10554006
  • Agudo D, Gómez-Esquer F, Martínez-Arribas F, Núñez-Villar MJ, Pollán M, Schneider J. Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer. Int J Cancer 2004; 109:717 - 20; http://dx.doi.org/10.1002/ijc.20034; PMID: 14999780
  • Zhang ZY, Zhao ZR, Jiang L, Li JC, Gao YM, Cui DS, Wang CJ, Schneider J, Wang MW, Sun XF. Nup88 expression in normal mucosa, adenoma, primary adenocarcinoma and lymph node metastasis in the colorectum. Tumour Biol 2007; 28:93 - 9; http://dx.doi.org/10.1159/000099154; PMID: 17264541
  • Brustmann H, Hager M. Nucleoporin 88 expression in normal and neoplastic squamous epithelia of the uterine cervix. Ann Diagn Pathol 2009; 13:303 - 7; http://dx.doi.org/10.1016/j.anndiagpath.2009.05.005; PMID: 19751906
  • Schneider J, Martínez-Arribas F, Torrejón R. Nup88 expression is associated with myometrial invasion in endometrial carcinoma. Int J Gynecol Cancer 2010; 20:804 - 8; http://dx.doi.org/10.1111/IGC.0b013e3181dfaa6b; PMID: 20973273
  • Emterling A, Skoglund J, Arbman G, Schneider J, Evertsson S, Carstensen J, Zhang H, Sun XF. Clinicopathological significance of Nup88 expression in patients with colorectal cancer. Oncology 2003; 64:361 - 9; http://dx.doi.org/10.1159/000070294; PMID: 12759533
  • Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS. Structure of the human MutSalpha DNA lesion recognition complex. Mol Cell 2007; 26:579 - 92; http://dx.doi.org/10.1016/j.molcel.2007.04.018; PMID: 17531815
  • Li F, Mao G, Tong D, Huang J, Gu L, Yang W, Li GM. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell 2013; 153:590 - 600; http://dx.doi.org/10.1016/j.cell.2013.03.025; PMID: 23622243
  • Jacob S, Aguado M, Fallik D, Praz F. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Res 2001; 61:6555 - 62; PMID: 11522654
  • Aebi S, Fink D, Gordon R, Kim HK, Zheng H, Fink JL, Howell SB. Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells. Clin Cancer Res 1997; 3:1763 - 7; PMID: 9815561
  • de las Alas MM, Aebi S, Fink D, Howell SB, Los G. Loss of DNA mismatch repair: effects on the rate of mutation to drug resistance. J Natl Cancer Inst 1997; 89:1537 - 41; http://dx.doi.org/10.1093/jnci/89.20.1537; PMID: 9337351
  • Shahi A, Lee JH, Kang Y, Lee SH, Hyun JW, Chang IY, Jun JY, You HJ. Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair. Nucleic Acids Res 2011; 39:2130 - 43; http://dx.doi.org/10.1093/nar/gkq1095; PMID: 21075794
  • Villemure JF, Abaji C, Cousineau I, Belmaaza A. MSH2-deficient human cells exhibit a defect in the accurate termination of homology-directed repair of DNA double-strand breaks. Cancer Res 2003; 63:3334 - 9; PMID: 12810667
  • Marti TM, Hefner E, Feeney L, Natale V, Cleaver JE. H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc Natl Acad Sci U S A 2006; 103:9891 - 6; http://dx.doi.org/10.1073/pnas.0603779103; PMID: 16788066
  • Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000; 14:1448 - 59; PMID: 10859164
  • Kastan MB, Lim DS. The many substrates and functions of ATM. Nat Rev Mol Cell Biol 2000; 1:179 - 86; http://dx.doi.org/10.1038/35043058; PMID: 11252893
  • Sun J, Lee KJ, Davis AJ, Chen DJ. Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. J Biol Chem 2012; 287:4936 - 45; http://dx.doi.org/10.1074/jbc.M111.306167; PMID: 22179609
  • Liang F, Jasin M. Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA. J Biol Chem 1996; 271:14405 - 11; http://dx.doi.org/10.1074/jbc.271.24.14405; PMID: 8662903
  • Downs JA, Jackson SP. A means to a DNA end: the many roles of Ku. Nat Rev Mol Cell Biol 2004; 5:367 - 78; http://dx.doi.org/10.1038/nrm1367; PMID: 15122350
  • Capo-chichi CD, Cai KQ, Testa JR, Godwin AK, Xu XX. Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer. Mol Cell Biol 2009; 29:4766 - 77; http://dx.doi.org/10.1128/MCB.00087-09; PMID: 19581290
  • Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, et al. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A 2004; 101:8963 - 8; http://dx.doi.org/10.1073/pnas.0402943101; PMID: 15184648
  • Cao K, Capell BC, Erdos MR, Djabali K, Collins FS. A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc Natl Acad Sci U S A 2007; 104:4949 - 54; http://dx.doi.org/10.1073/pnas.0611640104; PMID: 17360355
  • Chen CY, Chi YH, Mutalif RA, Starost MF, Myers TG, Anderson SA, Stewart CL, Jeang KT. Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell 2012; 149:565 - 77; http://dx.doi.org/10.1016/j.cell.2012.01.059; PMID: 22541428
  • Sherr CJ. Principles of tumor suppression. Cell 2004; 116:235 - 46; http://dx.doi.org/10.1016/S0092-8674(03)01075-4; PMID: 14744434
  • Clifford B, Beljin M, Stark GR, Taylor WR. G2 arrest in response to topoisomerase II inhibitors: the role of p53. Cancer Res 2003; 63:4074 - 81; PMID: 12874009
  • Lei K, Zhu X, Xu R, Shao C, Xu T, Zhuang Y, Han M. Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. Curr Biol 2012; 22:1609 - 15; http://dx.doi.org/10.1016/j.cub.2012.06.043; PMID: 22863315
  • Pena-Diaz J, Bregenhorn S, Ghodgaonkar M, Follonier C, Artola-Boran M, Castor D, et al. Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells. Mol Cell 2012; 47:669-80. http://dx.doi.org/10.1016/S0091-679X(01)67022-5; PMID: 11550478
  • Young LC, Hays JB, Tron VA, Andrew SE. DNA mismatch repair proteins: potential guardians against genomic instability and tumorigenesis induced by ultraviolet photoproducts. J Invest Dermatol 2003; 121:435 - 40; http://dx.doi.org/10.1046/j.1523-1747.2003.12450.x; PMID: 12925197
  • Schofield MJ, Hsieh P. DNA mismatch repair: molecular mechanisms and biological function. Annu Rev Microbiol 2003; 57:579 - 608; http://dx.doi.org/10.1146/annurev.micro.57.030502.090847; PMID: 14527292
  • di Pietro M, Sabates Bellver J, Menigatti M, Bannwart F, Schnider A, Russell A, Truninger K, Jiricny J, Marra G. Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers. Gastroenterology 2005; 129:1047 - 59; http://dx.doi.org/10.1053/j.gastro.2005.06.028; PMID: 16143142
  • Peters AC, Young LC, Maeda T, Tron VA, Andrew SE. Mammalian DNA mismatch repair protects cells from UVB-induced DNA damage by facilitating apoptosis and p53 activation. DNA Repair (Amst) 2003; 2:427 - 35; http://dx.doi.org/10.1016/S1568-7864(03)00003-X; PMID: 12606123
  • Oza P, Jaspersen SL, Miele A, Dekker J, Peterson CL. Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery. Genes Dev 2009; 23:912 - 27; http://dx.doi.org/10.1101/gad.1782209; PMID: 19390086
  • Buurman R, Gürlevik E, Schäffer V, Eilers M, Sandbothe M, Kreipe H, Wilkens L, Schlegelberger B, Kühnel F, Skawran B. Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. Gastroenterology 2012; 143:811 - , e1-15; http://dx.doi.org/10.1053/j.gastro.2012.05.033; PMID: 22641068
  • Paddison PJ, Caudy AA, Bernstein E, Hannon GJ, Conklin DS. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev 2002; 16:948 - 58; http://dx.doi.org/10.1101/gad.981002; PMID: 11959843
  • Wheeler MA, Davies JD, Zhang Q, Emerson LJ, Hunt J, Shanahan CM, Ellis JA. Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy. Exp Cell Res 2007; 313:2845 - 57; http://dx.doi.org/10.1016/j.yexcr.2007.03.025; PMID: 17462627
  • Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross A, Korsmeyer SJ. A role for proapoptotic BID in the DNA-damage response. Cell 2005; 122:579 - 91; http://dx.doi.org/10.1016/j.cell.2005.06.022; PMID: 16122425