525
Views
4
CrossRef citations to date
0
Altmetric
Author's View

Opposing effects of androgen ablation on immune function in prostate cancer

&
Pages 1220-1221 | Received 18 Apr 2012, Accepted 20 Apr 2012, Published online: 01 Oct 2012

References

  • Mercader M, Bodner BK, Moser MT, Kwon PS, Park ES, Manecke RG, et al. T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer. Proc Natl Acad Sci U S A 2001; 98:14565 - 70; http://dx.doi.org/10.1073/pnas.251140998; PMID: 11734652
  • Drake CG, Doody AD, Mihalyo MA, Huang CT, Kelleher E, Ravi S, et al. Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell 2005; 7:239 - 49; http://dx.doi.org/10.1016/j.ccr.2005.01.027; PMID: 15766662
  • Aragon-Ching JB, Williams KM, Gulley JL. Impact of androgen-deprivation therapy on the immune system: implications for combination therapy of prostate cancer. Front Biosci 2007; 12:4957 - 71; http://dx.doi.org/10.2741/2441; PMID: 17569623
  • Ansar Ahmed S, Penhale WJ, Talal N. Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am J Pathol 1985; 121:531 - 51; PMID: 3907369
  • Akins EJ, Moore ML, Tang S, Willingham MC, Tooze JA, Dubey P. In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice. Cancer Res 2010; 70:3473 - 82; http://dx.doi.org/10.1158/0008-5472.CAN-09-2490; PMID: 20406970
  • Tang S, Moore ML, Grayson JM, Dubey P. Increased CD8+ T-cell Function following Castration and Immunization Is Countered by Parallel Expansion of Regulatory T Cells. Cancer Res 2012; 72:1975 - 85; http://dx.doi.org/10.1158/0008-5472.CAN-11-2499; PMID: 22374980
  • Malek TR, Castro I. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity 2010; 33:153 - 65; http://dx.doi.org/10.1016/j.immuni.2010.08.004; PMID: 20732639
  • McNally A, Hill GR, Sparwasser T, Thomas R, Steptoe RJ. CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proc Natl Acad Sci U S A 2011; 108:7529 - 34; http://dx.doi.org/10.1073/pnas.1103782108; PMID: 21502514
  • Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch DH, Belkaid Y, et al. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol 2011; 187:3186 - 97; http://dx.doi.org/10.4049/jimmunol.1101649; PMID: 21849683
  • Dannull J, Su Z, Rizzieri D, Yang BK, Coleman D, Yancey D, et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest 2005; 115:3623 - 33; http://dx.doi.org/10.1172/JCI25947; PMID: 16308572