Advanced search
Publication Cover
OncoImmunology Volume 2, 2013 - Issue 8
Submit an article Journal homepage
427
Views
6
CrossRef citations to date
0
Altmetric
Author's View

Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation

Shigeo Koido Division of Gastroenterology and Hepatology; Department of Internal Medicine; The Jikei University School of Medicine; Tokyo, Japan; Institute of Clinical Medicine and Research; The Jikei University School of Medicine; Tokyo, Japan; Department of Oncology; Institute of DNA Medicine; The Jikei University School of Medicine; Tokyo, JapanCorrespondence[email protected]
,
Sadamu Homma Department of Oncology; Institute of DNA Medicine; The Jikei University School of Medicine; Tokyo, Japan
,
Masato Okamoto Division of Cellular Signaling; Institute for Advanced Medical Research; Keio University School of Medicine; Tokyo, Japan
,
Yoshihisa Namiki Institute of Clinical Medicine and Research; The Jikei University School of Medicine; Tokyo, Japan
,
Shin Kan Department of Oncology; Institute of DNA Medicine; The Jikei University School of Medicine; Tokyo, Japan
,
Kazuki Takakura Division of Gastroenterology and Hepatology; Department of Internal Medicine; The Jikei University School of Medicine; Tokyo, Japan
,
Mikio Kajihara Division of Gastroenterology and Hepatology; Department of Internal Medicine; The Jikei University School of Medicine; Tokyo, Japan
,
Kan Uchiyama Division of Gastroenterology and Hepatology; Department of Internal Medicine; The Jikei University School of Medicine; Tokyo, Japan
,
Eiich Hara Institute for Clinical Oncology; Saitama Cancer Center Research; Saitama, Japan
,
Toshifumi Ohkusa Division of Gastroenterology and Hepatology; Department of Internal Medicine; The Jikei University School of Medicine; Tokyo, Japan
,
Jianlin Gong Department of Medicine; Boston University School of Medicine; Boston, MA USA
&
Hisao Tajiri Division of Gastroenterology and Hepatology; Department of Internal Medicine; The Jikei University School of Medicine; Tokyo, Japan
 show all
Article: e25375 | Received 08 Jun 2013, Accepted 12 Jun 2013, Published online: 01 Jul 2013

References

  • Gong J, Chen D, Kashiwaba M, Kufe D. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Nat Med 1997; 3:558 - 61; http://dx.doi.org/10.1038/nm0597-558; PMID: 9142127
  • Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, et al. Fusions between dendritic cells and whole tumor cells as anticancer vaccines. Oncoimmunology 2013; 2:e24437; http://dx.doi.org/10.4161/onci.24437; PMID: 23762810
  • Koido S, Hara E, Homma S, Namiki Y, Ohkusa T, Gong J, et al. Cancer vaccine by fusions of dendritic and cancer cells. Clin Dev Immunol 2009; 2009:657369; http://dx.doi.org/10.1155/2009/657369; PMID: 20182533
  • Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, et al. Combined TLR2/4-activated dendritic/tumor cell fusions induce augmented cytotoxic T lymphocytes. PLoS One 2013; 8:e59280; http://dx.doi.org/10.1371/journal.pone.0059280; PMID: 23555011
  • Terabe M, Ambrosino E, Takaku S, O’Konek JJ, Venzon D, Lonning S, et al. Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody. Clin Cancer Res 2009; 15:6560 - 9; http://dx.doi.org/10.1158/1078-0432.CCR-09-1066; PMID: 19861451
  • Ueda R, Fujita M, Zhu X, Sasaki K, Kastenhuber ER, Kohanbash G, et al. Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines. Clin Cancer Res 2009; 15:6551 - 9; http://dx.doi.org/10.1158/1078-0432.CCR-09-1067; PMID: 19861464
  • Conroy H, Galvin KC, Higgins SC, Mills KHG. Gene silencing of TGF-β1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells. Cancer Immunol Immunother 2012; 61:425 - 31; http://dx.doi.org/10.1007/s00262-011-1188-y; PMID: 22193988
  • Zhang M, Berndt BE, Chen JJ, Kao JY. Expression of a soluble TGF-beta receptor by tumor cells enhances dendritic cell/tumor fusion vaccine efficacy. J Immunol 2008; 181:3690 - 7; PMID: 18714045
  • Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, et al. Augmentation of Antitumor Immunity by Fusions of Ethanol-Treated Tumor Cells and Dendritic Cells Stimulated via Dual TLRs through TGF-β1 Blockade and IL-12p70 Production. PLoS One 2013; 8:e63498; http://dx.doi.org/10.1371/journal.pone.0063498; PMID: 23717436
  • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252 - 64; http://dx.doi.org/10.1038/nrc3239; PMID: 22437870

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.