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OncoImmunology Volume 2, 2013 - Issue 8
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Microsatellite instability in hematological malignancies

Hypermutation vs. immune control—who is challenging who?

Claudia Maletzki Molecular Oncology and Immunotherapy; Department of General Surgery; University of Rostock; Rostock, Germany
,
Saskia Stier Molecular Oncology and Immunotherapy; Department of General Surgery; University of Rostock; Rostock, Germany
&
Michael Linnebacher Molecular Oncology and Immunotherapy; Department of General Surgery; University of Rostock; Rostock, GermanyCorrespondence[email protected]
Article: e25419 | Received 01 Jun 2013, Accepted 14 Jun 2013, Published online: 01 Jul 2013

References

  • Sellick GS, Lubbe SJ, Matutes E, Catovsky D, Houlston RS. Microsatellite instability indicative of defects in the major mismatch repair genes is rare in patients with B-cell chronic lymphocytic leukemia: Evaluation with disease stage and family history. Leuk Lymphoma 2007; 48:1320 - 2; http://dx.doi.org/10.1080/10428190701361844; PMID: 17613760
  • Casorelli I, Bossa C, Bignami M. DNA damage and repair in human cancer: molecular mechanisms and contribution to therapy-related leukemias. Int J Environ Res Public Health 2012; 9:2636 - 57; http://dx.doi.org/10.3390/ijerph9082636; PMID: 23066388
  • Offman J, Opelz G, Doehler B, Cummins D, Halil O, Banner NR, et al. Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation. Blood 2004; 104:822 - 8; http://dx.doi.org/10.1182/blood-2003-11-3938; PMID: 15090454
  • Karran P. Thiopurines, DNA damage, DNA repair and therapy-related cancer. Br Med Bull 2006; 79-80:153 - 70; http://dx.doi.org/10.1093/bmb/ldl020; PMID: 17277075
  • Garbe Y, Maletzki C, Linnebacher M. An MSI tumor specific frameshift mutation in a coding microsatellite of MSH3 encodes for HLA-A0201-restricted CD8+ cytotoxic T cell epitopes. PLoS One 2011; 6:e26517; http://dx.doi.org/10.1371/journal.pone.0026517; PMID: 22110587
  • Schwitalle Y, Kloor M, Eiermann S, Linnebacher M, Kienle P, Knaebel HP, et al. Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers. Gastroenterology 2008; 134:988 - 97; http://dx.doi.org/10.1053/j.gastro.2008.01.015; PMID: 18395080
  • Schwitalle Y, Linnebacher M, Ripberger E, Gebert J, von Knebel Doeberitz M. Immunogenic peptides generated by frameshift mutations in DNA mismatch repair-deficient cancer cells. Cancer Immun 2004; 4:14; PMID: 15563124
  • Maletzki C, Schmidt F, Dirks WG, Schmitt M, Linnebacher M. Frameshift-derived neoantigens constitute immunotherapeutic targets for patients with microsatellite-instable haematological malignancies: Frameshift peptides for treating MSI(+) blood cancers. Eur J Cancer 2013; In press http://dx.doi.org/10.1016/j.ejca.2013.02.035; PMID: 23561850
  • Buckowitz A, Knaebel HP, Benner A, Bläker H, Gebert J, Kienle P, et al. Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases. Br J Cancer 2005; 92:1746 - 53; http://dx.doi.org/10.1038/sj.bjc.6602534; PMID: 15856045

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