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OncoImmunology Volume 2, 2013 - Issue 9
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Regulation of NKG2D signaling during the epithelial-to-mesenchymal transition

Alejandro López-Soto Departamento de Biología Funcional; IUOPA; Universidad de Oviedo; Oviedo, Spain
,
Leticia Huergo Zapico Departamento de Biología Funcional; IUOPA; Universidad de Oviedo; Oviedo, Spain
,
Andrea Acebes-Huerta Departamento de Biología Funcional; IUOPA; Universidad de Oviedo; Oviedo, Spain
,
Luis Rodrigo Hospital Universitario Central de Asturias; Oviedo, Spain
&
Segundo Gonzalez Departamento de Biología Funcional; IUOPA; Universidad de Oviedo; Oviedo, SpainCorrespondence[email protected]
Article: e25820 | Received 19 Jul 2013, Accepted 20 Jul 2013, Published online: 29 Jul 2013

References

  • López-Larrea C, Suárez-Alvarez B, López-Soto A, López-Vázquez A, Gonzalez S. The NKG2D receptor: sensing stressed cells. Trends Mol Med 2008; 14:179 - 89; http://dx.doi.org/10.1016/j.molmed.2008.02.004; PMID: 18353724
  • González S, López-Soto A, Suarez-Alvarez B, López-Vázquez A, López-Larrea C. NKG2D ligands: key targets of the immune response. Trends Immunol 2008; 29:397 - 403; http://dx.doi.org/10.1016/j.it.2008.04.007; PMID: 18602338
  • López-Soto A, Huergo-Zapico L, Galván JA, Rodrigo L, de Herreros AG, Astudillo A, et al. Epithelial-mesenchymal transition induces an antitumor immune response mediated by NKG2D receptor. J Immunol 2013; 190:4408 - 19; http://dx.doi.org/10.4049/jimmunol.1202950; PMID: 23509364
  • López-Soto A, Folgueras AR, Seto E, Gonzalez S. HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer. Oncogene 2009; 28:2370 - 82; http://dx.doi.org/10.1038/onc.2009.117; PMID: 19430493
  • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9:265 - 73; http://dx.doi.org/10.1038/nrc2620; PMID: 19262571
  • López-Soto A, Quiñones-Lombraña A, López-Arbesú R, López-Larrea C, González S. Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor. J Biol Chem 2006; 281:30419 - 30; http://dx.doi.org/10.1074/jbc.M604868200; PMID: 16901903
  • Rodríguez-Rodero S, González S, Rodrigo L, Fernández-Morera JL, Martínez-Borra J, López-Vázquez A, et al. Transcriptional regulation of MICA and MICB: a novel polymorphism in MICB promoter alters transcriptional regulation by Sp1. Eur J Immunol 2007; 37:1938 - 53; http://dx.doi.org/10.1002/eji.200737031; PMID: 17557375
  • Kmieciak M, Knutson KL, Dumur CI, Manjili MH. HER-2/neu antigen loss and relapse of mammary carcinoma are actively induced by T cell-mediated anti-tumor immune responses. Eur J Immunol 2007; 37:675 - 85; http://dx.doi.org/10.1002/eji.200636639; PMID: 17304628
  • Kaiser BK, Yim D, Chow IT, Gonzalez S, Dai Z, Mann HH, et al. Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands. Nature 2007; 447:482 - 6; http://dx.doi.org/10.1038/nature05768; PMID: 17495932
  • Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N. Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. J Exp Med 2006; 203:289 - 95; http://dx.doi.org/10.1084/jem.20051986; PMID: 16461340

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