1,195
Views
31
CrossRef citations to date
0
Altmetric
Author's View

EGFR-mediated tumor immunoescape

The imbalance between phosphorylated STAT1 and phosphorylated STAT3

, , &
Article: e27215 | Received 03 Nov 2013, Accepted 14 Nov 2013, Published online: 05 Dec 2013

References

  • Leibowitz MS, Andrade Filho PA, Ferrone S, Ferris RL. Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes. Cancer Immunol Immunother 2011; 60:525 - 35; http://dx.doi.org/10.1007/s00262-010-0961-7; PMID: 21207025
  • Meissner M, Reichert TE, Kunkel M, Gooding W, Whiteside TL, Ferrone S, Seliger B. Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome. Clin Cancer Res 2005; 11:2552 - 60; http://dx.doi.org/10.1158/1078-0432.CCR-04-2146; PMID: 15814633
  • Ferris RL, Whiteside TL, Ferrone S. Immune escape associated with functional defects in antigen-processing machinery in head and neck cancer. Clin Cancer Res 2006; 12:3890 - 5; http://dx.doi.org/10.1158/1078-0432.CCR-05-2750; PMID: 16818683
  • López-Albaitero A, Nayak JV, Ogino T, Machandia A, Gooding W, DeLeo AB, Ferrone S, Ferris RL. Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTL. J Immunol 2006; 176:3402 - 9; PMID: 16517708
  • Leibowitz MS, Srivastava RM, Andrade Filho PA, Egloff AM, Wang L, Seethala RR, Ferrone S, Ferris RL. SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells. Clin Cancer Res 2013; 19:798 - 808; http://dx.doi.org/10.1158/1078-0432.CCR-12-1517; PMID: 23363816
  • Agazie YM, Hayman MJ. Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol Cell Biol 2003; 23:7875 - 86; http://dx.doi.org/10.1128/MCB.23.21.7875-7886.2003; PMID: 14560030
  • Sapkota B, Hill CE, Pollack BP. Vemurafenib enhances MHC induction in BRAF(V600E) homozygous melanoma cells. Oncoimmunology 2013; 2:e22890; http://dx.doi.org/10.4161/onci.22890; PMID: 23483066
  • Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, Tweardy DJ. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest 1998; 102:1385 - 92; http://dx.doi.org/10.1172/JCI3785; PMID: 9769331
  • Grandis JR, Drenning SD, Zeng Q, Watkins SC, Melhem MF, Endo S, Johnson DE, Huang L, He Y, Kim JD. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A 2000; 97:4227 - 32; http://dx.doi.org/10.1073/pnas.97.8.4227; PMID: 10760290
  • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007; 7:41 - 51; http://dx.doi.org/10.1038/nri1995; PMID: 17186030
  • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mulé J, Kerr WG, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005; 11:1314 - 21; http://dx.doi.org/10.1038/nm1325; PMID: 16288283
  • Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D, et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 2004; 10:48 - 54; http://dx.doi.org/10.1038/nm976; PMID: 14702634
  • Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind JS. Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res 2003; 63:2948 - 56; PMID: 12782602