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OncoImmunology Volume 3, 2014 - Issue 4
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Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide

Xin Chen Basic Science Program; Leidos Biomedical Research, Inc.; Frederick National Laboratory for Cancer Research; Frederick, MD USA; Laboratory of Molecular Immunoregulation; Cancer Inflammation Program; Center for Cancer Research; National Cancer Institute; Frederick, MD USACorrespondence[email protected] [email protected]
,
Lalage M Wakefield Laboratory of Cancer Biology and Genetics; Center for Cancer Research; National Cancer Institute; Frederick, MD USA
&
Joost J Oppenheim Laboratory of Molecular Immunoregulation; Cancer Inflammation Program; Center for Cancer Research; National Cancer Institute; Frederick, MD USACorrespondence[email protected] [email protected]
Article: e28247 | Received 12 Feb 2014, Accepted 15 Feb 2014, Published online: 16 Apr 2014

References

  • Kyi C, Postow MA. Checkpoint blocking antibodies in cancer immunotherapy. FEBS Lett 2014; 588:368 - 76; http://dx.doi.org/10.1016/j.febslet.2013.10.015; PMID: 24161671
  • Nishikawa H, Sakaguchi S. Regulatory T cells in cancer immunotherapy. Curr Opin Immunol 2014; 27C:1 - 7; http://dx.doi.org/10.1016/j.coi.2013.12.005; PMID: 24413387
  • Chen X, Yang Y, Zhou Q, Weiss JM, Howard OZ, McPherson JM, Wakefield LM, Oppenheim JJ. Effective chemoimmunotherapy with anti-TGFβ antibody and cyclophosphamide in a mouse model of breast cancer. PLoS One 2014; 9:e85398; http://dx.doi.org/10.1371/journal.pone.0085398; PMID: 24416401
  • Fox FE, Ford HC, Douglas R, Cherian S, Nowell PC. Evidence that TGF-beta can inhibit human T-lymphocyte proliferation through paracrine and autocrine mechanisms. Cell Immunol 1993; 150:45 - 58; http://dx.doi.org/10.1006/cimm.1993.1177; PMID: 8393732
  • van der Most RG, Currie AJ, Mahendran S, Prosser A, Darabi A, Robinson BW, Nowak AK, Lake RA. Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy. Cancer Immunol Immunother 2009; 58:1219 - 28; http://dx.doi.org/10.1007/s00262-008-0628-9; PMID: 19052741
  • Zhou Q, Hu Y, Howard OM, Oppenheim JJ, Chen X. In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo. Cytokine 2014; 65:56 - 64; http://dx.doi.org/10.1016/j.cyto.2013.09.008; PMID: 24080164
  • Muranski P, Borman ZA, Kerkar SP, Klebanoff CA, Ji Y, Sanchez-Perez L, Sukumar M, Reger RN, Yu Z, Kern SJ, et al. Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity 2011; 35:972 - 85; http://dx.doi.org/10.1016/j.immuni.2011.09.019; PMID: 22177921
  • Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 2013; 342:971 - 6; http://dx.doi.org/10.1126/science.1240537; PMID: 24264990
  • Chen G, Emens LA. Chemoimmunotherapy: reengineering tumor immunity. Cancer Immunol Immunother 2013; 62:203 - 16; http://dx.doi.org/10.1007/s00262-012-1388-0; PMID: 23389507
  • Pickup M, Novitskiy S, Moses HL. The roles of TGFβ in the tumour microenvironment. Nat Rev Cancer 2013; 13:788 - 99; http://dx.doi.org/10.1038/nrc3603; PMID: 24132110

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