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The hedgehog’s trick for escaping immunosurveillance

The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors

Article: e29180 | Received 06 May 2014, Accepted 09 May 2014, Published online: 05 Jun 2014

References

  • Ostrand-Rosenberg S, Sinha P, Beury DW, Clements VK. Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression. Semin Cancer Biol 2012; 22:275 - 81; http://dx.doi.org/10.1016/j.semcancer.2012.01.011; PMID: 22313874
  • Talmadge JE, Gabrilovich DI. History of myeloid-derived suppressor cells. Nat Rev Cancer 2013; 13:739 - 52; http://dx.doi.org/10.1038/nrc3581; PMID: 24060865
  • Sonda N, Chioda M, Zilio S, Simonato F, Bronte V. Transcription factors in myeloid-derived suppressor cell recruitment and function. Curr Opin Immunol 2011; 23:279 - 85; http://dx.doi.org/10.1016/j.coi.2010.12.006; PMID: 21227670
  • Ortiz ML, Lu L, Ramachandran I, Gabrilovich DI. Myeloid-derived suppressor cells in the development of lung cancer. Cancer Immunol Res 2014; 2:50 - 8; http://dx.doi.org/10.1158/2326-6066.CIR-13-0129; PMID: 24778162
  • Fan Q, Gu D, Liu H, Yang L, Zhang X, Yoder MC, Kaplan MH, Xie J. Defective TGF-β signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors. Cancer Res 2014; 74:471 - 83; http://dx.doi.org/10.1158/0008-5472.CAN-13-2134-T; PMID: 24282281
  • Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP. A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res 2006; 66:10171 - 8; http://dx.doi.org/10.1158/0008-5472.CAN-06-0657; PMID: 17047082
  • Fan Q, He M, Sheng T, Zhang X, Sinha M, Luxon B, Zhao X, Xie J. Requirement of TGFbeta signaling for SMO-mediated carcinogenesis. J Biol Chem 2010; 285:36570 - 6; http://dx.doi.org/10.1074/jbc.C110.164442; PMID: 20858897
  • Pang Y, Gara SK, Achyut BR, Li Z, Yan HH, Day CP, Weiss JM, Trinchieri G, Morris JC, Yang L. TGF-β signaling in myeloid cells is required for tumor metastasis. Cancer Discov 2013; 3:936 - 51; http://dx.doi.org/10.1158/2159-8290.CD-12-0527; PMID: 23661553
  • Novitskiy SV, Pickup MW, Chytil A, Polosukhina D, Owens P, Moses HL. Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties. J Leukoc Biol 2012; 92:641 - 51; http://dx.doi.org/10.1189/jlb.1211639; PMID: 22685318

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