794
Views
15
CrossRef citations to date
0
Altmetric
Author's View

Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis

<span lang="EN-US">Glycans make the difference</span>

&
Article: e29380 | Received 24 May 2014, Accepted 27 May 2014, Published online: 25 Jun 2014

References

  • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285:1182 - 6; http://dx.doi.org/10.1056/NEJM197111182852108; PMID: 4938153
  • Kowanetz M, Ferrara N. Vascular endothelial growth factor signaling pathways: therapeutic perspective. Clin Cancer Res 2006; 12:5018 - 22; http://dx.doi.org/10.1158/1078-0432.CCR-06-1520; PMID: 16951216
  • Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011; 473:298 - 307; http://dx.doi.org/10.1038/nature10144; PMID: 21593862
  • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008; 8:592 - 603; http://dx.doi.org/10.1038/nrc2442; PMID: 18650835
  • Chung AS, Wu X, Zhuang G, Ngu H, Kasman I, Zhang J, Vernes JM, Jiang Z, Meng YG, Peale FV, et al. An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy. Nat Med 2013; 19:1114 - 23; http://dx.doi.org/10.1038/nm.3291; PMID: 23913124
  • Rabinovich GA, Croci DO. Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer. Immunity 2012; 36:322 - 35; http://dx.doi.org/10.1016/j.immuni.2012.03.004; PMID: 22444630
  • Dennis JW, Nabi IR, Demetriou M. Metabolism, cell surface organization, and disease. Cell 2009; 139:1229 - 41; http://dx.doi.org/10.1016/j.cell.2009.12.008; PMID: 20064370
  • Thijssen VL, Rabinovich GA, Griffioen AW. Vascular galectins: regulators of tumor progression and targets for cancer therapy. Cytokine Growth Factor Rev 2013; 24:547 - 58; http://dx.doi.org/10.1016/j.cytogfr.2013.07.003; PMID: 23942184
  • Croci DO, Salatino M, Rubinstein N, Cerliani JP, Cavallin LE, Leung HJ, Ouyang J, Ilarregui JM, Toscano MA, Domaica CI, et al. Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma. J Exp Med 2012; 209:1985 - 2000; http://dx.doi.org/10.1084/jem.20111665; PMID: 23027923
  • Croci DO, Cerliani JP, Dalotto-Moreno T, Méndez-Huergo SP, Mascanfroni ID, Dergan-Dylon S, Toscano MA, Caramelo JJ, García-Vallejo JJ, Ouyang J, et al. Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell 2014; 156:744 - 58; http://dx.doi.org/10.1016/j.cell.2014.01.043; PMID: 24529377