In vitro reconstitution of pancreatic islets

References

• Vardanyan M, Parkin E, Gruessner C, Rodriguez Rilo HL. Pancreas vs. islet transplantation: a call on the future. Curr Opin Organ Transplant 2010; 15:124 - 30; http://dx.doi.org/10.1097/MOT.0b013e32833553f8; PMID: 20009930
   PubMed Web of Science ®Google Scholar
• Ludwig B, Ludwig S, Steffen A, Saeger HD, Bornstein SR. Islet versus pancreas transplantation in type 1 diabetes: competitive or complementary?. Curr Diab Rep 2010; 10:506 - 11; http://dx.doi.org/10.1007/s11892-010-0146-y; PMID: 20830612
   PubMed Web of Science ®Google Scholar
• Ricordi C, Strom TB. Clinical islet transplantation: advances and immunological challenges. Nat Rev Immunol 2004; 4:259 - 68; http://dx.doi.org/10.1038/nri1332; PMID: 15057784
   PubMed Web of Science ®Google Scholar
• Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343:230 - 8; http://dx.doi.org/10.1056/NEJM200007273430401; PMID: 10911004
   PubMed Web of Science ®Google Scholar
• Ryan EA, Lakey JR, Rajotte RV, Korbutt GS, Kin T, Imes S, Rabinovitch A, Elliott JF, Bigam D, Kneteman NM, et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001; 50:710 - 9; http://dx.doi.org/10.2337/diabetes.50.4.710; PMID: 11289033
   PubMed Web of Science ®Google Scholar
• Kizilel S, Garfinkel M, Opara E. The bioartificial pancreas: progress and challenges. Diabetes Technol Ther 2005; 7:968 - 85; http://dx.doi.org/10.1089/dia.2005.7.968; PMID: 16386103
   PubMedGoogle Scholar
• Narang AS, Mahato RI. Biological and biomaterial approaches for improved islet transplantation. Pharmacol Rev 2006; 58:194 - 243; http://dx.doi.org/10.1124/pr.58.2.6; PMID: 16714486
   PubMed Web of Science ®Google Scholar
• Wilson JT, Chaikof EL. Challenges and emerging technologies in the immunoisolation of cells and tissues. Adv Drug Deliv Rev 2008; 60:124 - 45; http://dx.doi.org/10.1016/j.addr.2007.08.034; PMID: 18022728
   PubMed Web of Science ®Google Scholar
• Scharp DW, Downing R, Merrell RC, Greider M. Isolating the elusive islet. Diabetes 1980; 29:Suppl 1 19 - 30; http://dx.doi.org/10.2337/diab.29.1.S19; PMID: 6243591
   PubMedGoogle Scholar
• Britt LD, Stojeba PC, Scharp CR, Greider MH, Scharp DW. Neonatal pig pseudo-islets. A product of selective aggregation. Diabetes 1981; 30:580 - 3; http://dx.doi.org/10.2337/diab.30.7.580; PMID: 7018963
   PubMed Web of Science ®Google Scholar
• Halban PA, Wollheim CB, Blondel B, Meda P, Niesor EN, Mintz DH. The possible importance of contact between pancreatic islet cells for the control of insulin release. Endocrinology 1982; 111:86 - 94; http://dx.doi.org/10.1210/endo-111-1-86; PMID: 6123433
   PubMed Web of Science ®Google Scholar
• Tze WJ, Tai J. Preparation of pseudoislets for morphological and functional studies. Transplantation 1982; 34:228 - 31; http://dx.doi.org/10.1097/00007890-198210000-00019; PMID: 6815845
   PubMed Web of Science ®Google Scholar
• Hopcroft DW, Mason DR, Scott RS. Insulin secretion from perifused rat pancreatic pseudoislets. In Vitro Cell Dev Biol 1985; 21:421 - 7; http://dx.doi.org/10.1007/BF02620828; PMID: 3897182
   PubMed Web of Science ®Google Scholar
• Halban PA, Powers SL, George KL, Bonner-Weir S. Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes 1987; 36:783 - 90; http://dx.doi.org/10.2337/diab.36.7.783; PMID: 3556277
   PubMed Web of Science ®Google Scholar
• Montesano R, Mouron P, Amherdt M, Orci L. Collagen matrix promotes reorganization of pancreatic endocrine cell monolayers into islet-like organoids. J Cell Biol 1983; 97:935 - 9; http://dx.doi.org/10.1083/jcb.97.3.935; PMID: 6350323
   PubMed Web of Science ®Google Scholar
• Schröder D, Wegner U, Hehmke B, Besch W, Zühlke H. Pancreatic islet cell suspensions of newborn rats and the formation of pseudo-islets in culture. Acta Biol Med Ger 1982; 41:1145 - 50; PMID: 6201029
   PubMedGoogle Scholar
• Schröder D, Wegner U, Besch W, Zühlke H. Characterization of pseudo-islets formed from pancreatic islet cell suspensions of neonatal rats. Mol Cell Endocrinol 1983; 32:179 - 93; http://dx.doi.org/10.1016/0303-7207(83)90081-3; PMID: 6357894
   PubMed Web of Science ®Google Scholar
• Kuo CY, Herrod HG, Burghen GA. Formation of pseudoislets from human pancreatic cultures. Pancreas 1992; 7:320 - 5; http://dx.doi.org/10.1097/00006676-199205000-00008; PMID: 1375749
   PubMed Web of Science ®Google Scholar
• Farkas G, Joó F. Simple and reliable conditions for routine, long-term culturing of fetal human pancreatic tissue fragments. Diabetes 1984; 33:1165 - 8; http://dx.doi.org/10.2337/diab.33.12.1165; PMID: 6389232
   PubMed Web of Science ®Google Scholar
• Halban PA, Powers SL, George KL, Bonner-Weir S. Altered differentiated cell surface properties of transformed (RINm5F) compared with native adult rat pancreatic B cells. Endocrinology 1988; 123:113 - 9; http://dx.doi.org/10.1210/endo-123-1-113; PMID: 3289893
   PubMed Web of Science ®Google Scholar
• Rouiller DG, Cirulli V, Halban PA. Uvomorulin mediates calcium-dependent aggregation of islet cells, whereas calcium-independent cell adhesion molecules distinguish between islet cell types. Dev Biol 1991; 148:233 - 42; http://dx.doi.org/10.1016/0012-1606(91)90332-W; PMID: 1936561
   PubMed Web of Science ®Google Scholar
• Cirulli V, Halban PA, Rouiller DG. Tumor necrosis factor-alpha modifies adhesion properties of rat islet B cells. J Clin Invest 1993; 91:1868 - 76; http://dx.doi.org/10.1172/JCI116403; PMID: 8098044
   PubMed Web of Science ®Google Scholar
• Cirulli V, Baetens D, Rutishauser U, Halban PA, Orci L, Rouiller DG. Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation. J Cell Sci 1994; 107:1429 - 36; PMID: 7962186
   PubMed Web of Science ®Google Scholar
• Orci L, Malaisse-Lagae F, Ravazzola M, Rouiller D, Renold AE, Perrelet A, Unger R. A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas. J Clin Invest 1975; 56:1066 - 70; http://dx.doi.org/10.1172/JCI108154; PMID: 1099118
   PubMed Web of Science ®Google Scholar
• Orci L, Unger RH. Functional subdivision of islets of Langerhans and possible role of D cells. Lancet 1975; 2:1243 - 4; http://dx.doi.org/10.1016/S0140-6736(75)92078-4; PMID: 53729
   PubMed Web of Science ®Google Scholar
• Unger RH, Dobbs RE, Orci L. Insulin, glucagon, and somatostatin secretion in the regulation of metabolism. Annu Rev Physiol 1978; 40:307 - 43; http://dx.doi.org/10.1146/annurev.ph.40.030178.001515; PMID: 205166
   PubMed Web of Science ®Google Scholar
• Orci L. Macro- and micro-domains in the endocrine pancreas. Diabetes 1982; 31:538 - 65; http://dx.doi.org/10.2337/diab.31.6.538; PMID: 6759269
   PubMed Web of Science ®Google Scholar
• Weir GC, Bonner-Weir S. Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes. J Clin Invest 1990; 85:983 - 7; http://dx.doi.org/10.1172/JCI114574; PMID: 1969425
   PubMed Web of Science ®Google Scholar
• Hopcroft DW, Mason DR, Scott RS. Structure-function relationships in pancreatic islets: support for intraislet modulation of insulin secretion. Endocrinology 1985; 117:2073 - 80; http://dx.doi.org/10.1210/endo-117-5-2073; PMID: 2864239
   PubMed Web of Science ®Google Scholar
• Hauge-Evans AC, Squires PE, Persaud SJ, Jones PM. Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 1999; 48:1402 - 8; http://dx.doi.org/10.2337/diabetes.48.7.1402; PMID: 10389845
   PubMed Web of Science ®Google Scholar
• Squires PE, Hauge-Evans AC, Persaud SJ, Jones PM. Synchronization of Ca(2+)-signals within insulin-secreting pseudoislets: effects of gap-junctional uncouplers. Cell Calcium 2000; 27:287 - 96; http://dx.doi.org/10.1054/ceca.2000.0117; PMID: 10859595
   PubMed Web of Science ®Google Scholar
• Hauge-Evans AC, Squires PE, Belin VD, Roderigo-Milne H, Ramracheya RD, Persaud SJ, Jones PM. Role of adenine nucleotides in insulin secretion from MIN6 pseudoislets. Mol Cell Endocrinol 2002; 191:167 - 76; http://dx.doi.org/10.1016/S0303-7207(02)00051-5; PMID: 12062900
   PubMed Web of Science ®Google Scholar
• Luther MJ, Davies E, Muller D, Harrison M, Bone AJ, Persaud SJ, Jones PM. Cell-to-cell contact influences proliferative marker expression and apoptosis in MIN6 cells grown in islet-like structures. Am J Physiol Endocrinol Metab 2005; 288:E502 - 9; http://dx.doi.org/10.1152/ajpendo.00424.2004; PMID: 15479950
   PubMed Web of Science ®Google Scholar
• Luther MJ, Hauge-Evans A, Souza KL, Jörns A, Lenzen S, Persaud SJ, Jones PM. MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients. Biochem Biophys Res Commun 2006; 343:99 - 104; http://dx.doi.org/10.1016/j.bbrc.2006.02.003; PMID: 16529716
   PubMed Web of Science ®Google Scholar
• Brereton HC, Carvell MJ, Asare-Anane H, Roberts G, Christie MR, Persaud SJ, Jones PM. Homotypic cell contact enhances insulin but not glucagon secretion. Biochem Biophys Res Commun 2006; 344:995 - 1000; http://dx.doi.org/10.1016/j.bbrc.2006.03.214; PMID: 16643853
   PubMed Web of Science ®Google Scholar
• Carvell MJ, Marsh PJ, Persaud SJ, Jones PM. E-cadherin interactions regulate beta-cell proliferation in islet-like structures. Cell Physiol Biochem 2007; 20:617 - 26; http://dx.doi.org/10.1159/000107545; PMID: 17762188
   PubMed Web of Science ®Google Scholar
• Kitsou-Mylona I, Burns CJ, Squires PE, Persaud SJ, Jones PM. A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of langerhans. Cell Physiol Biochem 2008; 22:557 - 66; http://dx.doi.org/10.1159/000185540; PMID: 19088438
   PubMed Web of Science ®Google Scholar
• Reers C, Hauge-Evans AC, Morgan NG, Wilcox A, Persaud SJ, Jones PM. Down-regulation of proliferation does not affect the secretory function of transformed β-cell lines regardless of their anatomical configuration. Islets 2011; 3:80 - 8; http://dx.doi.org/10.4161/isl.3.3.15428; PMID: 21505275
   PubMed Web of Science ®Google Scholar
• Josefsen K, Stenvang JP, Kindmark H, Berggren PO, Horn T, Kjaer T, Buschard K. Fluorescence-activated cell sorted rat islet cells and studies of the insulin secretory process. J Endocrinol 1996; 149:145 - 54; http://dx.doi.org/10.1677/joe.0.1490145; PMID: 8676047
   PubMed Web of Science ®Google Scholar
• Hamaguchi K, Utsunomiya N, Takaki R, Yoshimatsu H, Sakata T. Cellular interaction between mouse pancreatic alpha-cell and beta-cell lines: possible contact-dependent inhibition of insulin secretion. Exp Biol Med (Maywood) 2003; 228:1227 - 33; PMID: 14610265
   PubMed Web of Science ®Google Scholar
• Brereton H, Carvell MJ, Persaud SJ, Jones PM. Islet alpha-cells do not influence insulin secretion from beta-cells through cell-cell contact. Endocrine 2007; 31:61 - 5; http://dx.doi.org/10.1007/s12020-007-0004-0; PMID: 17709899
   PubMed Web of Science ®Google Scholar
• Kojima N, Takeuchi S, Sakai Y. Engineering of Pseudoislets: Effect on Insulin Secretion Activity by Cell Number, Cell Population, and Microchannel Networks. Transplant Proc 2013; Forthcoming
   Web of Science ®Google Scholar
• Brissova M, Fowler MJ, Nicholson WE, Chu A, Hirshberg B, Harlan DM, Powers AC. Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem 2005; 53:1087 - 97; http://dx.doi.org/10.1369/jhc.5C6684.2005; PMID: 15923354
   PubMed Web of Science ®Google Scholar
• Kim A, Miller K, Jo J, Kilimnik G, Wojcik P, Hara M. Islet architecture: A comparative study. Islets 2009; 1:129 - 36; http://dx.doi.org/10.4161/isl.1.2.9480; PMID: 20606719
   PubMed Web of Science ®Google Scholar
• Matta SG, Wobken JD, Williams FG, Bauer GE. Pancreatic islet cell reaggregation systems: efficiency of cell reassociation and endocrine cell topography of rat islet-like aggregates. Pancreas 1994; 9:439 - 49; http://dx.doi.org/10.1097/00006676-199407000-00005; PMID: 7937692
   PubMed Web of Science ®Google Scholar
• Lee DY, Park SJ, Nam JH, Byun Y. Optimal aggregation of dissociated islet cells for functional islet-like cluster. J Biomater Sci Polym Ed 2008; 19:441 - 52; http://dx.doi.org/10.1163/156856208783719527; PMID: 18318957
   PubMed Web of Science ®Google Scholar
• Ohgawara H, Mochizuki N, Karibe S, Omori Y. Survival and B-cell function of neonatal pig pancreatic islet-like cell clusters in an extracellular matrix. Pancreas 1991; 6:625 - 30; http://dx.doi.org/10.1097/00006676-199111000-00002; PMID: 1723523
   PubMed Web of Science ®Google Scholar
• Otonkoski T, Beattie GM, Mally MI, Ricordi C, Hayek A. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest 1993; 92:1459 - 66; http://dx.doi.org/10.1172/JCI116723; PMID: 8104197
   PubMed Web of Science ®Google Scholar
• Beattie GM, Rubin JS, Mally MI, Otonkoski T, Hayek A. Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact. Diabetes 1996; 45:1223 - 8; http://dx.doi.org/10.2337/diab.45.9.1223; PMID: 8772726
   PubMed Web of Science ®Google Scholar
• Caton D, Calabrese A, Mas C, Serre-Beinier V, Charollais A, Caille D, Zufferey R, Trono D, Meda P. Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreatic beta-cells. J Cell Sci 2003; 116:2285 - 94; http://dx.doi.org/10.1242/jcs.00442; PMID: 12697840
   PubMed Web of Science ®Google Scholar
• Yang XD, Li HM, Chen M, Zou XH, Zhu LY, Wei CJ, Chen GQ. Enhanced insulin production from murine islet beta cells incubated on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). J Biomed Mater Res A 2010; 92:548 - 55; PMID: 19235213
   PubMed Web of Science ®Google Scholar
• Pethig R, Menachery A, Heart E, Sanger RH, Smith PJ. Dielectrophoretic assembly of insulinoma cells and fluorescent nanosensors into three-dimensional pseudo-islet constructs. IET Nanobiotechnol 2008; 2:31; http://dx.doi.org/10.1049/iet-nbt:20070027; PMID: 18500910
   PubMed Web of Science ®Google Scholar
• Tsang WG, Zheng T, Wang Y, Tang J, Rind HB, Francki A, Bufius N. Generation of functional islet-like clusters after monolayer culture and intracapsular aggregation of adult human pancreatic islet tissue. Transplantation 2007; 83:685 - 93; http://dx.doi.org/10.1097/01.tp.0000256178.57359.4f; PMID: 17414699
   PubMed Web of Science ®Google Scholar
• Tze WJ, Tai J. Allotransplantation and xenotransplantation of pseudoislets in diabetic rats and mice. Transplantation 1984; 38:438 - 40; http://dx.doi.org/10.1097/00007890-198410000-00026; PMID: 6437026
   PubMed Web of Science ®Google Scholar
• Wolf-Jochim M, Wöhrle M, Federlin K, Bretzel RG. Comparison of the survival of fresh or cultured pancreatic islets, pseudoislets and single cells following allotransplantation beneath the kidney capsule in non-immunosuppressed diabetic rats. Exp Clin Endocrinol Diabetes 1995; 103:Suppl 2 118 - 22; http://dx.doi.org/10.1055/s-0029-1211407; PMID: 8839267
   PubMedGoogle Scholar
• Beger C, Cirulli V, Vajkoczy P, Halban PA, Menger MD. Vascularization of purified pancreatic islet-like cell aggregates (pseudoislets) after syngeneic transplantation. Diabetes 1998; 47:559 - 65; http://dx.doi.org/10.2337/diabetes.47.4.559; PMID: 9568687
   PubMed Web of Science ®Google Scholar
• Penko D, Mohanasundaram D, Sen S, Drogemuller C, Mee C, Bonder CS, Coates PT, Jessup CF. Incorporation of endothelial progenitor cells into mosaic pseudoislets. Islets 2011; 3:73 - 9; http://dx.doi.org/10.4161/isl.3.3.15392; PMID: 21478677
   PubMed Web of Science ®Google Scholar
• Teramura Y, Iwata H. Bioartificial pancreas microencapsulation and conformal coating of islet of Langerhans. Adv Drug Deliv Rev 2010; 62:827 - 40; http://dx.doi.org/10.1016/j.addr.2010.01.005; PMID: 20138097
   PubMed Web of Science ®Google Scholar
• Ohgawara H, Miyazaki J, Karibe S, Tashiro F, Akaike T, Hashimoto Y. Embedded-culture of pancreatic beta-cells derived from transgenic mouse insulinoma as a potential source for xenotransplantation using a diffusion chamber. Cell Transplant 1995; 4:307 - 13; http://dx.doi.org/10.1016/0963-6897(95)00001-E; PMID: 7640870
   PubMed Web of Science ®Google Scholar
• Sakai S, Inagaki H, Inamoto K, Taya M. Wrapping tissues with a pre-established cage-like layer composed of living cells. Biomaterials 2012; 33:6721 - 7; http://dx.doi.org/10.1016/j.biomaterials.2012.06.027; PMID: 22770525
   PubMed Web of Science ®Google Scholar
• Onoe H, Okitsu T, Itou A, Kato-Negishi M, Gojo R, Kiriya D, Sato K, Miura S, Iwanaga S, Kuribayashi-Shigetomi K, et al. Metre-long cell-laden microfibres exhibit tissue morphologies and functions. Nat Mater 2013; 12:584 - 90; http://dx.doi.org/10.1038/nmat3606; PMID: 23542870
   PubMed Web of Science ®Google Scholar
• Mason MN, Mahoney MJ. Selective beta-cell differentiation of dissociated embryonic pancreatic precursor cells cultured in synthetic polyethylene glycol hydrogels. Tissue Eng Part A 2009; 15:1343 - 52; http://dx.doi.org/10.1089/ten.tea.2008.0290; PMID: 19072086
   PubMed Web of Science ®Google Scholar
• Mason MN, Arnold CA, Mahoney MJ. Entrapped collagen type 1 promotes differentiation of embryonic pancreatic precursor cells into glucose-responsive beta-cells when cultured in three-dimensional PEG hydrogels. Tissue Eng Part A 2009; 15:3799 - 808; http://dx.doi.org/10.1089/ten.tea.2009.0148; PMID: 19537960
   PubMed Web of Science ®Google Scholar
• Mason MN, Mahoney MJ. Inhibition of gamma-secretase activity promotes differentiation of embryonic pancreatic precursor cells into functional islet-like clusters in poly(ethylene glycol) hydrogel culture. Tissue Eng Part A 2010; 16:2593 - 603; http://dx.doi.org/10.1089/ten.tea.2010.0015; PMID: 20236034
   PubMed Web of Science ®Google Scholar
• Datar SP, Bhonde RR. Islet-derived stellate-like cells as a novel source for islet neogenesis in chicks. Poult Sci 2009; 88:654 - 60; http://dx.doi.org/10.3382/ps.2007-00440; PMID: 19211538
   PubMed Web of Science ®Google Scholar
• Todorov I, Omori K, Pascual M, Rawson J, Nair I, Valiente L, Vuong T, Matsuda T, Orr C, Ferreri K, et al. Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation. Pancreas 2006; 32:130 - 8; http://dx.doi.org/10.1097/01.mpa.0000202945.78331.93; PMID: 16552331
   PubMed Web of Science ®Google Scholar
• Zanini C, Bruno S, Mandili G, Baci D, Cerutti F, Cenacchi G, Izzi L, Camussi G, Forni M. Differentiation of mesenchymal stem cells derived from pancreatic islets and bone marrow into islet-like cell phenotype. PLoS One 2011; 6:e28175; http://dx.doi.org/10.1371/journal.pone.0028175; PMID: 22194812
   PubMed Web of Science ®Google Scholar
• Koblas T, Pektorova L, Zacharovova K, Berkova Z, Girman P, Dovolilova E, Karasova L, Saudek F. Differentiation of CD133-positive pancreatic cells into insulin-producing islet-like cell clusters. Transplant Proc 2008; 40:415 - 8; http://dx.doi.org/10.1016/j.transproceed.2008.02.017; PMID: 18374086
   PubMed Web of Science ®Google Scholar
• Tang DQ, Cao LZ, Burkhardt BR, Xia CQ, Litherland SA, Atkinson MA, Yang LJ. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004; 53:1721 - 32; http://dx.doi.org/10.2337/diabetes.53.7.1721; PMID: 15220196
   PubMed Web of Science ®Google Scholar
• Thatava T, Ma B, Rohde M, Mayer H. Chromatin-remodeling factors allow differentiation of bone marrow cells into insulin-producing cells. Stem Cells 2006; 24:2858 - 67; http://dx.doi.org/10.1634/stemcells.2006-0109; PMID: 16990588
   PubMed Web of Science ®Google Scholar
• Oh SH, Muzzonigro TM, Bae SH, LaPlante JM, Hatch HM, Petersen BE. Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes. Lab Invest 2004; 84:607 - 17; http://dx.doi.org/10.1038/labinvest.3700074; PMID: 15034596
   PubMed Web of Science ®Google Scholar
• Li L, Li F, Qi H, Feng G, Yuan K, Deng H, Zhou H. Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids. Stem Cells Dev 2008; 17:815 - 23; http://dx.doi.org/10.1089/scd.2008.0060; PMID: 18439098
   PubMed Web of Science ®Google Scholar
• Xie QP, Huang H, Xu B, Dong X, Gao SL, Zhang B, Wu YL. Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation 2009; 77:483 - 91; http://dx.doi.org/10.1016/j.diff.2009.01.001; PMID: 19505629
   PubMed Web of Science ®Google Scholar
• Chandra V, G S, Phadnis S, Nair PD, Bhonde RR. Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells. Stem Cells 2009; 27:1941 - 53; http://dx.doi.org/10.1002/stem.117; PMID: 19544426
   PubMed Web of Science ®Google Scholar
• Okura H, Komoda H, Fumimoto Y, Lee CM, Nishida T, Sawa Y, Matsuyama A. Transdifferentiation of human adipose tissue-derived stromal cells into insulin-producing clusters. J Artif Organs 2009; 12:123 - 30; http://dx.doi.org/10.1007/s10047-009-0455-6; PMID: 19536630
   PubMed Web of Science ®Google Scholar
• Chandra V, Swetha G, Muthyala S, Jaiswal AK, Bellare JR, Nair PD, Bhonde RR. Islet-like cell aggregates generated from human adipose tissue derived stem cells ameliorate experimental diabetes in mice. PLoS One 2011; 6:e20615; http://dx.doi.org/10.1371/journal.pone.0020615; PMID: 21687731
   PubMed Web of Science ®Google Scholar
• Ruhnke M, Ungefroren H, Nussler A, Martin F, Brulport M, Schormann W, Hengstler JG, Klapper W, Ulrichs K, Hutchinson JA, et al. Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology 2005; 128:1774 - 86; http://dx.doi.org/10.1053/j.gastro.2005.03.029; PMID: 15940611
   PubMed Web of Science ®Google Scholar
• Sun B, Roh KH, Lee SR, Lee YS, Kang KS. Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure. Biochem Biophys Res Commun 2007; 354:919 - 23; http://dx.doi.org/10.1016/j.bbrc.2007.01.069; PMID: 17274951
   PubMed Web of Science ®Google Scholar
• Tateishi K, He J, Taranova O, Liang G, D’Alessio AC, Zhang Y. Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J Biol Chem 2008; 283:31601 - 7; http://dx.doi.org/10.1074/jbc.M806597200; PMID: 18782754
   PubMed Web of Science ®Google Scholar
• Kadam SS, Bhonde RR. Islet neogenesis from the constitutively nestin expressing human umbilical cord matrix derived mesenchymal stem cells. Islets 2010; 2:112 - 20; http://dx.doi.org/10.4161/isl.2.2.11280; PMID: 21099303
   PubMed Web of Science ®Google Scholar
• Kadam S, Muthyala S, Nair P, Bhonde R. Human placenta-derived mesenchymal stem cells and islet-like cell clusters generated from these cells as a novel source for stem cell therapy in diabetes. Rev Diabet Stud 2010; 7:168 - 82; http://dx.doi.org/10.1900/RDS.2010.7.168; PMID: 21060975
   PubMedGoogle Scholar
• Kadam SS, Sudhakar M, Nair PD, Bhonde RR. Reversal of experimental diabetes in mice by transplantation of neo-islets generated from human amnion-derived mesenchymal stromal cells using immuno-isolatory macrocapsules. Cytotherapy 2010; 12:982 - 91; http://dx.doi.org/10.3109/14653249.2010.509546; PMID: 20807019
   PubMed Web of Science ®Google Scholar
• Bi D, Chen FG, Zhang WJ, Zhou GD, Cui L, Liu W, Cao Y. Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters. BMC Cell Biol 2010; 11:46; http://dx.doi.org/10.1186/1471-2121-11-46; PMID: 20579360
   PubMed Web of Science ®Google Scholar
• Chiou SH, Chen SJ, Chang YL, Chen YC, Li HY, Chen DT, Wang HH, Chang CM, Chen YJ, Ku HH. MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin+ cells. J Cell Mol Med 2011; 15:612 - 24; http://dx.doi.org/10.1111/j.1582-4934.2010.01034.x; PMID: 20158571
   PubMed Web of Science ®Google Scholar
• Govindasamy V, Ronald VS, Abdullah AN, Nathan KR, Ab Aziz ZA, Abdullah M, Musa S, Kasim NH, Bhonde RR. Differentiation of dental pulp stem cells into islet-like aggregates. J Dent Res 2011; 90:646 - 52; http://dx.doi.org/10.1177/0022034510396879; PMID: 21335539
   PubMed Web of Science ®Google Scholar
• Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A 2002; 99:16105 - 10; http://dx.doi.org/10.1073/pnas.252618999; PMID: 12441403
   PubMed Web of Science ®Google Scholar
• Schroeder IS, Rolletschek A, Blyszczuk P, Kania G, Wobus AM. Differentiation of mouse embryonic stem cells to insulin-producing cells. Nat Protoc 2006; 1:495 - 507; http://dx.doi.org/10.1038/nprot.2006.71; PMID: 17406275
   PubMed Web of Science ®Google Scholar
• Wang X, Ye K. Three-dimensional differentiation of embryonic stem cells into islet-like insulin-producing clusters. Tissue Eng Part A 2009; 15:1941 - 52; http://dx.doi.org/10.1089/ten.tea.2008.0181; PMID: 19196138
   PubMed Web of Science ®Google Scholar
• Kubo A, Stull R, Takeuchi M, Bonham K, Gouon-Evans V, Sho M, Iwano M, Saito Y, Keller G, Snodgrass R. Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population. PLoS One 2011; 6:e24058; http://dx.doi.org/10.1371/journal.pone.0024058; PMID: 21931641
   PubMedGoogle Scholar
• Yue F, Cui L, Johkura K, Ogiwara N, Sasaki K. Glucagon-like peptide-1 differentiation of primate embryonic stem cells into insulin-producing cells. Tissue Eng 2006; 12:2105 - 16; http://dx.doi.org/10.1089/ten.2006.12.2105; PMID: 16968152
   PubMedGoogle Scholar
• Segev H, Fishman B, Ziskind A, Shulman M, Itskovitz-Eldor J. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 2004; 22:265 - 74; http://dx.doi.org/10.1634/stemcells.22-3-265; PMID: 15153604
   PubMed Web of Science ®Google Scholar
• Jiang J, Au M, Lu K, Eshpeter A, Korbutt G, Fisk G, Majumdar AS. Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 2007; 25:1940 - 53; http://dx.doi.org/10.1634/stemcells.2006-0761; PMID: 17510217
   PubMed Web of Science ®Google Scholar
• Mao GH, Chen GA, Bai HY, Song TR, Wang YX. The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells. Biomaterials 2009; 30:1706 - 14; http://dx.doi.org/10.1016/j.biomaterials.2008.12.030; PMID: 19135250
   PubMed Web of Science ®Google Scholar
• Schulz TC, Young HY, Agulnick AD, Babin MJ, Baetge EE, Bang AG, Bhoumik A, Cepa I, Cesario RM, Haakmeester C, et al. A scalable system for production of functional pancreatic progenitors from human embryonic stem cells. PLoS One 2012; 7:e37004; http://dx.doi.org/10.1371/journal.pone.0037004; PMID: 22623968
   PubMed Web of Science ®Google Scholar
• Saito H, Takeuchi M, Chida K, Miyajima A. Generation of glucose-responsive functional islets with a three-dimensional structure from mouse fetal pancreatic cells and iPS cells in vitro. PLoS One 2011; 6:e28209; http://dx.doi.org/10.1371/journal.pone.0028209; PMID: 22145030
   PubMedGoogle Scholar
• Thatava T, Nelson TJ, Edukulla R, Sakuma T, Ohmine S, Tonne JM, Yamada S, Kudva Y, Terzic A, Ikeda Y. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther 2011; 18:283 - 93; http://dx.doi.org/10.1038/gt.2010.145; PMID: 21048796
   PubMed Web of Science ®Google Scholar
• Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg LA, et al. Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proc Natl Acad Sci U S A 2013; 110:4557 - 62; http://dx.doi.org/10.1073/pnas.1222902110; PMID: 23431169
   PubMed Web of Science ®Google Scholar