Epithelial-mesenchymal co-culture model for studying alveolar morphogenesis

References

• Morrisey EE, Hogan BL. Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell 2010; 18:8-23; PMID:20152174; http://dx.doi.org/10.1016/j.devcel.2009.12.010
   PubMed Web of Science ®Google Scholar
• Warburton D, El-Hashash A, Carraro G, Tiozzo C, Sala F, Rogers O, De Langhe S, Kemp PJ, Riccardi D, Torday J, et al. Lung organogenesis. Curr Top Dev Biol 2010; 90:73-158; PMID:20691848; http://dx.doi.org/10.1016/S0070-2153(10)90003-3
   PubMed Web of Science ®Google Scholar
• Kresch MJ, Christian C, Wu F, Hussain N. Ontogeny of apoptosis during lung development. Pediatr Res 1998; 43:426-31; PMID:9505285; http://dx.doi.org/10.1203/00006450-199803000-00020
   PubMedGoogle Scholar
• Collet AJ, Des Biens G. Evolution of mesenchymal cells in fetal rat lung. Anat Embryol (Berl) 1975; 147:273-92; PMID:1211654; http://dx.doi.org/10.1007/BF00315076
   PubMedGoogle Scholar
• Roth-Kleiner M, Post M. Similarities and dissimilarities of branching and septation during lung development. Pediatr Pulmonol 2005; 40:113-34; PMID:15965895; http://dx.doi.org/10.1002/ppul.20252
   PubMed Web of Science ®Google Scholar
• Burri PH. Structural aspects of postnatal lung development - alveolar formation and growth. Biol Neonate 2006; 89:313-22; PMID:16770071; http://dx.doi.org/10.1159/000092868
   PubMedGoogle Scholar
• Hislop A, Reid L. Development of the acinus in the human lung. Thorax 1974; 29:90-4; PMID:4825556; http://dx.doi.org/10.1136/thx.29.1.90
   PubMed Web of Science ®Google Scholar
• Hislop AA, Wigglesworth JS, Desai R. Alveolar development in the human fetus and infant. Early Hum Dev 1986; 13:1-11; PMID:3956418; http://dx.doi.org/10.1016/0378-3782(86)90092-7
   PubMed Web of Science ®Google Scholar
• Bellusci S, Grindley J, Emoto H, Itoh N, Hogan BL. Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 1997; 124:4867-78; PMID:9428423
   PubMed Web of Science ®Google Scholar
• Park WY, Miranda B, Lebeche D, Hashimoto G, Cardoso WV. FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Dev Biol 1998; 201:125-34; PMID:9740653; http://dx.doi.org/10.1006/dbio.1998.8994
   PubMedGoogle Scholar
• Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK. Keratinocyte growth factor and its receptor are involved in regulating early lung branching. Development 1996; 122:3107-15; PMID:8898224
   PubMed Web of Science ®Google Scholar
• Bellusci S, Furuta Y, Rush MG, Henderson R, Winnier G, Hogan BL. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 1997; 124:53-63; PMID:9006067
   PubMed Web of Science ®Google Scholar
• Shannon JM, Hyatt BA. Epithelial-mesenchymal interactions in the developing lung. Annu Rev Physiol 2004; 66:625-45; PMID:14977416; http://dx.doi.org/10.1146/annurev.physiol.66.032102.135749
   PubMed Web of Science ®Google Scholar
• Del Moral PM, Sala FG, Tefft D, Shi W, Keshet E, Bellusci S, Warburton D. VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol 2006; 290:177-88; PMID:16375885; http://dx.doi.org/10.1016/j.ydbio.2005.11.022
   PubMedGoogle Scholar
• Weaver M, Dunn NR, Hogan BL. Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. Development 2000; 127:2695-704; PMID:10821767
   PubMed Web of Science ®Google Scholar
• Shi W, Zhao J, Anderson KD, Warburton D. Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis. Am J Physiol Lung Cell Mol Physiol 2001; 280:L1030-9; PMID:11290528
   PubMed Web of Science ®Google Scholar
• Blanco LN. A model of postnatal formation of alveoli in rat lung. J Theor Biol 1992; 157:427-46; PMID:1460874; http://dx.doi.org/10.1016/S0022-5193(05)80662-9
   PubMedGoogle Scholar
• Boström H, Willetts K, Pekny M, Levéen P, Lindahl P, Hedstrand H, Pekna M, Hellström M, Gebre-Medhin S, Schalling M, et al. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 1996; 85:863-73; PMID:8681381; http://dx.doi.org/10.1016/S0092-8674(00)81270-2
   PubMed Web of Science ®Google Scholar
• Delisser HM, Helmke BP, Cao G, Egan PM, Taichman D, Fehrenbach M, Zaman A, Cui Z, Mohan GS, Baldwin HS, et al. Loss of PECAM-1 function Impairs alveolarization. J Biol Chem 2006; 281:8724-31; PMID:16377626
   PubMed Web of Science ®Google Scholar
• Wert SE, Dey CR, Blair PA, Kimura S, Whitsett JA. Increased expression of thyroid transcription factor-1 (TTF-1) in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammation. Dev Biol 2002; 242:75-87; PMID:11820807; http://dx.doi.org/10.1006/dbio.2001.0540
   PubMedGoogle Scholar
• Taylor BK, Stoops TD, Everett AD. Protein phosphatase inhibitors arrest cell cycle and reduce branching morphogenesis in fetal rat lung cultures. Am J Physiol Lung Cell Mol Physiol 2000; 278:L1062-70; PMID:10781439
   PubMed Web of Science ®Google Scholar
• Prince LS, Dieperink HI, Okoh VO, Fierro-Perez GA, Lallone RL. Toll-like receptor signaling inhibits structural development of the distal fetal mouse lung. Dev Dyn 2005; 233:553-61; PMID:15830384; http://dx.doi.org/10.1002/dvdy.20362
   PubMed Web of Science ®Google Scholar
• Benjamin JT, Gaston DC, Halloran BA, Schnapp LM, Zent R, Prince LS. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev Biol 2009; 335:407-17; PMID:19769957; http://dx.doi.org/10.1016/j.ydbio.2009.09.021
   PubMed Web of Science ®Google Scholar
• Souza P, Sedlackova L, Kuliszewski M, Wang J, Liu J, Tseu I, Liu M, Tanswell AK, Post M. Antisense oligodeoxynucleotides targeting PDGF-B mRNA inhibit cell proliferation during embryonic rat lung development. Development 1994; 120:2163-73; PMID:7925018
   PubMed Web of Science ®Google Scholar
• Smith BT. Cell line A549: a model system for the study of alveolar type II cell function. Am Rev Respir Dis 1977; 115:285-93; PMID:842942
   PubMed Web of Science ®Google Scholar
• Balis JU, Bumgarner SD, Paciga JE, Paterson JF, Shelley SA. Synthesis of lung surfactant-associated glycoproteins by A549 cells: description of an in vitro model for human type II cell dysfunction. Exp Lung Res 1984; 6:197-213; PMID:6092046; http://dx.doi.org/10.3109/01902148409109248
   PubMed Web of Science ®Google Scholar
• Greco E, Santucci MB, Sali M, De Angelis FR, Papi M, De Spirito M, Delogu G, Colizzi V, Fraziano M. Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells. Immunology 2010; 129:125-32; PMID:19878354; http://dx.doi.org/10.1111/j.1365-2567.2009.03145.x
   PubMed Web of Science ®Google Scholar
• Benjamin JT, Smith RJ, Halloran BA, Day TJ, Kelly DR, Prince LS. FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. Am J Physiol Lung Cell Mol Physiol 2007; 292:L550-8; PMID:17071719; http://dx.doi.org/10.1152/ajplung.00329.2006
   PubMedGoogle Scholar
• Benjamin JT, Carver BJ, Plosa EJ, Yamamoto Y, Miller JD, Liu JH, van der Meer R, Blackwell TS, Prince LS. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol 2010; 185:4896-903; PMID:20861353; http://dx.doi.org/10.4049/jimmunol.1001857
   PubMed Web of Science ®Google Scholar
• Kumar PA, Hu Y, Yamamoto Y, Hoe NB, Wei TS, Mu D, Sun Y, Joo LS, Dagher R, Zielonka EM, et al. Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell 2011; 147:525-38; PMID:22036562; http://dx.doi.org/10.1016/j.cell.2011.10.001
   PubMed Web of Science ®Google Scholar
• Ding BS, Nolan DJ, Guo P, Babazadeh AO, Cao Z, Rosenwaks Z, Crystal RG, Simons M, Sato TN, Worgall S, et al. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 2011; 147:539-53; PMID:22036563; http://dx.doi.org/10.1016/j.cell.2011.10.003
   PubMed Web of Science ®Google Scholar
• Fujita J, Ohtsuki Y, Bandoh S, Ueda Y, Kubo A, Tojo Y, Yamaji Y, Ishida T. Expression of thyroid transcription factor-1 in 16 human lung cancer cell lines. Lung Cancer 2003; 39:31-6; PMID:12499091; http://dx.doi.org/10.1016/S0169-5002(02)00390-2
   PubMedGoogle Scholar
• Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem 1994; 269:6271-4; PMID:8119973
   PubMed Web of Science ®Google Scholar
• Suzuki H, Aoshiba K, Yokohori N, Nagai A. Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis. Cancer Res 2003; 63:5054-9; PMID:12941834
   PubMed Web of Science ®Google Scholar
• Liu J, Xu K, Chase M, Ji Y, Logan JK, Buchsbaum RJ. Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells. J Cell Sci 2012; 125:376-86; PMID:22302986; http://dx.doi.org/10.1242/jcs.089466
   PubMed Web of Science ®Google Scholar
• Andl CD, McCowan KM, Allison GL, Rustgi AK. Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner. Neoplasia 2010; 12:485-98; PMID:20563251
   PubMed Web of Science ®Google Scholar
• Kodithuwakku SP, Pang RT, Ng EH, Cheung AN, Horne AW, Ho PC, Yeung WS, Lee KF. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy. Lab Invest 2012; 92:256-64; PMID:21968811; http://dx.doi.org/10.1038/labinvest.2011.148
   PubMedGoogle Scholar
• Mailleux AA, Overholtzer M, Brugge JS. Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle 2008; 7:57-62; PMID:18196964; http://dx.doi.org/10.4161/cc.7.1.5150
   PubMed Web of Science ®Google Scholar
• Curchoe CL, Russo J, Terskikh AV. hESC derived neuro-epithelial rosettes recapitulate early mammalian neurulation events; an in vitro model. Stem Cell Res 2012; 8:239-46; PMID:22265743; http://dx.doi.org/10.1016/j.scr.2011.11.003
   PubMedGoogle Scholar
• Boström H, Gritli-Linde A, Betsholtz C. PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev Dyn 2002; 223:155-62; PMID:11803579; http://dx.doi.org/10.1002/dvdy.1225
   PubMedGoogle Scholar
• McGowan SE, McCoy DM. Fibroblasts expressing PDGF-receptor-alpha diminish during alveolar septal thinning in mice. Pediatr Res 2011; 70:44-9; PMID:21659960; http://dx.doi.org/10.1203/PDR.0b013e31821cfb5a
   PubMedGoogle Scholar
• Nicola T, Hagood JS, James ML, Macewen MW, Williams TA, Hewitt MM, Schwiebert L, Bulger A, Oparil S, Chen YF, et al. Loss of Thy-1 inhibits alveolar development in the newborn mouse lung. Am J Physiol Lung Cell Mol Physiol 2009; 296:L738-50; PMID:19270178; http://dx.doi.org/10.1152/ajplung.90603.2008
   PubMedGoogle Scholar
• Ambalavanan N, Nicola T, Hagood J, Bulger A, Serra R, Murphy-Ullrich J, Oparil S, Chen YF. Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung. Am J Physiol Lung Cell Mol Physiol 2008; 295:L86-95; PMID:18487357; http://dx.doi.org/10.1152/ajplung.00534.2007
   PubMedGoogle Scholar
• Dabovic B, Chen Y, Choi J, Davis EC, Sakai LY, Todorovic V, Vassallo M, Zilberberg L, Singh A, Rifkin DB. Control of lung development by latent TGF-β binding proteins. J Cell Physiol 2011; 226:1499-509; PMID:20945348; http://dx.doi.org/10.1002/jcp.22479
   PubMedGoogle Scholar
• Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000; 106:1311-9; PMID:11104784; http://dx.doi.org/10.1172/JCI10259
   PubMed Web of Science ®Google Scholar
• Kunig AM, Balasubramaniam V, Markham NE, Morgan D, Montgomery G, Grover TR, Abman SH. Recombinant human VEGF treatment enhances alveolarization after hyperoxic lung injury in neonatal rats. Am J Physiol Lung Cell Mol Physiol 2005; 289:L529-35; PMID:15908474; http://dx.doi.org/10.1152/ajplung.00336.2004
   PubMed Web of Science ®Google Scholar
• Franco-Montoya ML, Boucherat O, Thibault C, Chailley-Heu B, Incitti R, Delacourt C, Bourbon JR. Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development. Physiol Genomics 2011; 43:1226-40; PMID:21878612; http://dx.doi.org/10.1152/physiolgenomics.00034.2011
   PubMedGoogle Scholar
• Perl AK, Gale E. FGF signaling is required for myofibroblast differentiation during alveolar regeneration. Am J Physiol Lung Cell Mol Physiol 2009; 297:L299-308; PMID:19502291; http://dx.doi.org/10.1152/ajplung.00008.2009
   PubMedGoogle Scholar
• Ahlfeld SK, Conway SJ. Aberrant signaling pathways of the lung mesenchyme and their contributions to the pathogenesis of bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol 2012; 94:3-15; PMID:22125178; http://dx.doi.org/10.1002/bdra.22869
   PubMed Web of Science ®Google Scholar
• Bourbon JR, Boucherat O, Boczkowski J, Crestani B, Delacourt C. Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets. Trends Mol Med 2009; 15:169-79; PMID:19303361; http://dx.doi.org/10.1016/j.molmed.2009.02.003
   PubMed Web of Science ®Google Scholar
• Wright CJ, Kirpalani H. Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies? Pediatrics 2011; 128:111-26; PMID:21646264; http://dx.doi.org/10.1542/peds.2010-3875
   PubMed Web of Science ®Google Scholar
• Stichel H, Bäckström E, Hafström O, Nilsson S, Lappalainen U, Bry K. Inflammatory cytokines in gastric fluid at birth and the development of bronchopulmonary dysplasia. Acta Paediatr 2011; 100:1206-12; PMID:21438921; http://dx.doi.org/10.1111/j.1651-2227.2011.02286.x
   PubMedGoogle Scholar
• Blackwell TS, Hipps AN, Yamamoto Y, Han W, Barham WJ, Ostrowski MC, Yull FE, Prince LSNF. NF-κB signaling in fetal lung macrophages disrupts airway morphogenesis. J Immunol 2011; 187:2740-7; PMID:21775686; http://dx.doi.org/10.4049/jimmunol.1101495
   PubMed Web of Science ®Google Scholar
• Moss TJ, Newnham JP, Willett KE, Kramer BW, Jobe AH, Ikegami M. Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry. Am J Respir Crit Care Med 2002; 165:805-11; PMID:11897648; http://dx.doi.org/10.1164/ajrccm.165.6.2108053
   PubMed Web of Science ®Google Scholar
• Thébaud B. Angiogenesis in lung development, injury and repair: implications for chronic lung disease of prematurity. Neonatology 2007; 91:291-7; PMID:17575472; http://dx.doi.org/10.1159/000101344
   PubMed Web of Science ®Google Scholar
• Yamamoto Y, Baldwin HS, Prince LS. Endothelial differentiation by multipotent fetal mouse lung mesenchymal cells. Stem Cells Dev 2012; 21:1455-65; PMID:22008017; http://dx.doi.org/10.1089/scd.2011.0219
   PubMed Web of Science ®Google Scholar
• Dieperink HI, Blackwell TS, Prince LS. Hyperoxia and apoptosis in developing mouse lung mesenchyme. Pediatr Res 2006; 59:185-90; PMID:16439576; http://dx.doi.org/10.1203/01.pdr.0000196371.85945.3a
   PubMed Web of Science ®Google Scholar