Aerosols

References

• Aguzzi A, Calella AM. Prions: protein aggregation and infectious diseases. Physiol Rev 2009; 89:1105 - 1152
   PubMed Web of Science ®Google Scholar
• Brown P, Gajdusek DC, Gibbs CJ Jr, Asher DM. Potential epidemic of Creutzfeldt-Jakob disease from human growth hormone therapy. N Engl J Med 1985; 313:728 - 731
   PubMed Web of Science ®Google Scholar
• Kimberlin RH, Walker CA. Pathogenesis of mouse scrapie: dynamics of agent replication in spleen, spinal cord and brain after infection by different routes. J Comp Pathol 1979; 89:551 - 562
   PubMed Web of Science ®Google Scholar
• Petsch B, Müller-Schiffmann A, Lehle A, Zirdum E, Prikulis I, Kuhn F, et al. Biological effects and use of PrPSc- and PrP-specific antibodies generated by immunizing with purified full length native mouse prions. J Virol 2011; 85:4538 - 4546; PMID: 21345946
   PubMed Web of Science ®Google Scholar
• Mulcahy ER, Bartz JC, Kincaid AE, Bessen RA. Prion infection of skeletal muscle cells and papillae in the tongue. J Virol 2004; 78:6792 - 6798
   PubMed Web of Science ®Google Scholar
• Glatzel M, Aguzzi A. PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion. J Gen Virol 2000; 81:2813 - 2821
   PubMed Web of Science ®Google Scholar
• Scott JR, Foster JD, Fraser H. Conjunctival instillation of scrapie in mice can produce disease. Vet Microbiol 1993; 34:305 - 309
   PubMed Web of Science ®Google Scholar
• Kincade AE, Bartz JC. The nasal cavity is a route for prion infection in hamsters. J Virol 2007; 81:4482 - 4491
   PubMed Web of Science ®Google Scholar
• Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, et al. A crucial role for B cells in neuroinvasive scrapie. Nature 1997; 390:687 - 690
   PubMed Web of Science ®Google Scholar
• Klein MA, Kaeser PS, Schwarz P, Weyd H, Xenarios I, Zinkernagel RM, et al. Complement facilitates early prion pathogenesis. Nat Med 2001; 7:488 - 492
   PubMed Web of Science ®Google Scholar
• Blättler T, Brandner S, Raeber AJ, Klein MA, Voigtländer T, Weissmann C, et al. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 1997; 389:69 - 73
   PubMed Web of Science ®Google Scholar
• Raeber AJ, Sailer A, Hegyi I, et al. Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication. PNAS 1999; 96:3987 - 3992
   PubMed Web of Science ®Google Scholar
• Klein MA, Frigg R, Raeber AJ, Flechsig E, Hegyi I, Zinkernagel RM, et al. PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat Med 1998; 4:1429 - 1433
   PubMedGoogle Scholar
• Raeber AJ, Klein MA, Frigg R, Flechsig E, Aguzzi A, Weissmann C, et al. PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice. EMBO J 1999; 18:2702 - 2706
   PubMed Web of Science ®Google Scholar
• Montrasio F, Cozzio A, Flechsig E, Rossi D, Klein MA, Rülicke T, et al. B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice. Proc Natl Acad Sci USA 2001; 98:4034 - 4037
   PubMed Web of Science ®Google Scholar
• Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, et al. A crucial role for B cells in neuroinvasive scrapie. Nature 1997; 390:687 - 690
   PubMed Web of Science ®Google Scholar
• Prinz M, Huber G, Macpherson AJ, Heppner FL, Glatzel M, Eugster HP, et al. Oral Prion Infection Requires Normal Numbers of Peyer's Patches but Not of Enteric Lymphocytes. Am J Pathol 2003; 162:1103 - 1111
   PubMed Web of Science ®Google Scholar
• Prinz M, Montrasio F, Klein MA, Schwarz P, Priller J, Odermatt B, et al. Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. Proc Natl Acad Sci USA 2002; 99:919 - 924
   PubMed Web of Science ®Google Scholar
• Klein MA, Kaeser PS, Schwarz P, Weyd H, Xenarios I, Zinkernagel RM, et al. Complement facilitates early prion pathogenesis. Nat Med 2001; 7:488 - 492
   PubMed Web of Science ®Google Scholar
• Zabel MD, Heikenwalder M, Prinz M, Arrighi I, Schwarz P, Kranich J, et al. Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. J Immunol 2007; 179:6144 - 6152
   Google Scholar
• Brown P, Gibbs CJ, Rodgers-Johnson P, Asher DM, Sulima MP, Bacote A, et al. Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease. Ann Neurol 1994; 35:513 - 529
   PubMed Web of Science ®Google Scholar
• Clarke MC, Haig DA. Presence of the transmissible agent of scrapie in the serum of affected mice and rats. Vet Rec 1967; 80:504
   PubMed Web of Science ®Google Scholar
• Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, et al. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science 2006; 314:133 - 136
   PubMed Web of Science ®Google Scholar
• Lacroux C, Simon S, Benestad SL, Maillet S, Mathey J, Lugan S, et al. Prions in milk from ewes incubating natural scrapie. PLoS Pathog 2008; 4:1000238
   PubMed Web of Science ®Google Scholar
• Seeger H, Heikenwalder M, Zeller N, Kranich J, Schwarz P, Gaspert A, et al. Coincident scrapie infection and nephritis lead to urinary prion excretion. Science 2005; 310:324 - 326
   PubMed Web of Science ®Google Scholar
• Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, et al. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity 2008; 29:998 - 1008
   Google Scholar
• Heikenwalder M, Zeller N, Seeger H, Prinz M, Klöhn PC, Schwarz P, et al. Chronic lymphocytic inflammation specifies the organ tropism of prions. Science 2005; 307:1107 - 1110
   PubMed Web of Science ®Google Scholar
• Raabe OG, Yeh HC, Newton GJ, Phalen RF, Velasquez DJ. Deposition of inhaled monodisperse aerosols in small rodents. Inhaled Part 1975; 41:3 - 21
   Google Scholar
• Raabe OG, Al-Bayati MA, Teague SV, Rasolt A. Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Ann Occup Hyg 1988; 32:53 - 63
   Google Scholar
• Haybaeck J, Heikenwalder M, Klevenz B, Schwarz P, Margalith I, Bridel C, et al. Aerosols transmit prions to immunocompetent and immunodeficient mice. PLoS Pathog 2011; 7:1001257
   PubMed Web of Science ®Google Scholar
• Hainfellner JA, Jellinger K, Budka H. Testing for prion protein does not confirm previously reported conjugal CJD. Lancet 1996; 347:616 - 617
   PubMed Web of Science ®Google Scholar
• Ligios C, Sigurdson CJ, Santucciu C, Carcassola G, Manco G, Basagni M, et al. PrP(Sc) in mammary glands of sheep affected by scrapie and mastitis. Nat Med 2005; 11:1137 - 1138
   PubMed Web of Science ®Google Scholar
• Denkers ND, Seelig DM, Telling GC, Hoover EA. Aerosol and nasal transmission of chronic wasting disease in cervidized mice. J Gen Virol 2010; 91:1651 - 1658
   PubMed Web of Science ®Google Scholar
• Nichols TA, Pulford B, Wyckoff AC, Meyerett C, Michel B, Gertig K, et al. Detection of protease-resistant cervid prion protein in water from a CWD-endemic area. Prion 2009; 3:171 - 183
   PubMed Web of Science ®Google Scholar
• Llewelyn CA, Hewitt PE, Knight RS, Amar K, Cousens S, Mackenzie J, et al. Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet 2004; 363:417 - 421
   PubMed Web of Science ®Google Scholar
• Peden AH, Head MW, Ritchie DL, Bell JE, Ironside JW. Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet 2004; 364:527 - 529
   PubMed Web of Science ®Google Scholar
• Adjemian JZ, Howell J, Holzbauer S, Harris J, Recuenco S, McQuiston J, et al. A clustering of immune-mediated polyradiculoneuropathy among swine abattoir workers exposed to aerosolized porcine brains, Indiana, United States. Int J Occup Environ Health 2009; 15:331 - 338
   PubMed Web of Science ®Google Scholar
• Agrawal A, Singh SK, Singh VP, Murphy E, Parikh I. Partitioning of asal and pulmonary resistance changes during noninvasive plethysmography in mice. J Appl Physiol 2008; 105:1975 - 1979
   PubMed Web of Science ®Google Scholar
• Bates JH, Irvin CG. Measuring lung function in mice: the phenotyping uncertainty principle. J Appl Physiol 2003; 94:1297 - 1306
   PubMed Web of Science ®Google Scholar
• Zanusso G, Ferrari S, Cardone F, Zampieri P, Gelati M, Fiorini M, et al. Detection of pathologic prion protein in the olfactory epithelium in sporadic Creutzfeldt-Jakob disease. N Engl J Med 2003; 348:711 - 719
   PubMed Web of Science ®Google Scholar
• Tabaton M, Monaco S, Cordone MP, Colucci M, Giaccone G, Tagliavini F, et al. Prion deposition in olfactory biopsy of sporadic Creutzfeldt-Jakob disease. Ann Neurol 2004; 55:294 - 296
   PubMed Web of Science ®Google Scholar