MicroRNAs, wild-type and mutant p53: More questions than answers

References

• Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391:806 - 11; http://dx.doi.org/10.1038/35888; PMID: 9486653
   PubMed Web of Science ®Google Scholar
• Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75:843 - 54; http://dx.doi.org/10.1016/0092-8674(93)90529-Y; PMID: 8252621
   PubMed Web of Science ®Google Scholar
• Ghildiyal M, Zamore PD. Small silencing RNAs: an expanding universe. Nat Rev Genet 2009; 10:94 - 108; http://dx.doi.org/10.1038/nrg2504; PMID: 19148191
   PubMed Web of Science ®Google Scholar
• He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5:522 - 31; http://dx.doi.org/10.1038/nrg1379; PMID: 15211354
   PubMed Web of Science ®Google Scholar
• Mendell JT. MicroRNAs: critical regulators of development, cellular physiology and malignancy. Cell Cycle 2005; 4:1179 - 84; http://dx.doi.org/10.4161/cc.4.9.2032; PMID: 16096373
   PubMed Web of Science ®Google Scholar
• Bushati N, Cohen SM. microRNA functions. Annu Rev Cell Dev Biol 2007; 23:175 - 205; http://dx.doi.org/10.1146/annurev.cellbio.23.090506.123406; PMID: 17506695
   PubMed Web of Science ®Google Scholar
• Ambros V. The functions of animal microRNAs. Nature 2004; 431:350 - 5; http://dx.doi.org/10.1038/nature02871; PMID: 15372042
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281 - 97; http://dx.doi.org/10.1016/S0092-8674(04)00045-5; PMID: 14744438
   PubMed Web of Science ®Google Scholar
• Berezikov E. Evolution of microRNA diversity and regulation in animals. Nat Rev Genet 2011; 12:846 - 60; http://dx.doi.org/10.1038/nrg3079; PMID: 22094948
   PubMed Web of Science ®Google Scholar
• Rigoutsos I. Short RNAs: how big is this iceberg? Current biology: CB 2010; 20:R110-3.
   Google Scholar
• Kim VN, Han J, Siomi MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 2009; 10:126 - 39; http://dx.doi.org/10.1038/nrm2632; PMID: 19165215
   PubMed Web of Science ®Google Scholar
• Baek D, Villén J, Shin C, Camargo FD, Gygi SP, Bartel DP. The impact of microRNAs on protein output. Nature 2008; 455:64 - 71; http://dx.doi.org/10.1038/nature07242; PMID: 18668037
   PubMed Web of Science ®Google Scholar
• Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19:92 - 105; http://dx.doi.org/10.1101/gr.082701.108; PMID: 18955434
   PubMed Web of Science ®Google Scholar
• Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120:15 - 20; http://dx.doi.org/10.1016/j.cell.2004.12.035; PMID: 15652477
   PubMed Web of Science ®Google Scholar
• Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N. Widespread changes in protein synthesis induced by microRNAs. Nature 2008; 455:58 - 63; http://dx.doi.org/10.1038/nature07228; PMID: 18668040
   PubMed Web of Science ®Google Scholar
• Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, et al. Combinatorial microRNA target predictions. Nat Genet 2005; 37:495 - 500; http://dx.doi.org/10.1038/ng1536; PMID: 15806104
   PubMed Web of Science ®Google Scholar
• Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004; 432:307 - 15; http://dx.doi.org/10.1038/nature03098; PMID: 15549092
   PubMed Web of Science ®Google Scholar
• Bode AM, Dong Z. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 2004; 4:793 - 805; http://dx.doi.org/10.1038/nrc1455; PMID: 15510160
   PubMed Web of Science ®Google Scholar
• Braithwaite AW, Prives CL. p53: more research and more questions. Cell Death Differ 2006; 13:877 - 80; http://dx.doi.org/10.1038/sj.cdd.4401938; PMID: 16708075
   PubMed Web of Science ®Google Scholar
• Junttila MR, Evan GI. p53--a Jack of all trades but master of none. Nat Rev Cancer 2009; 9:821 - 9; http://dx.doi.org/10.1038/nrc2728; PMID: 19776747
   PubMed Web of Science ®Google Scholar
• Meek DW. Tumour suppression by p53: a role for the DNA damage response?. Nat Rev Cancer 2009; 9:714 - 23; PMID: 19730431
   PubMed Web of Science ®Google Scholar
• Vousden KH, Lu X. Live or let die: the cell’s response to p53. Nat Rev Cancer 2002; 2:594 - 604; http://dx.doi.org/10.1038/nrc864; PMID: 12154352
   PubMed Web of Science ®Google Scholar
• Menendez D, Inga A, Resnick MA. The expanding universe of p53 targets. Nat Rev Cancer 2009; 9:724 - 37; http://dx.doi.org/10.1038/nrc2730; PMID: 19776742
   PubMed Web of Science ®Google Scholar
• Riley T, Sontag E, Chen P, Levine A. Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 2008; 9:402 - 12; http://dx.doi.org/10.1038/nrm2395; PMID: 18431400
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307 - 10; http://dx.doi.org/10.1038/35042675; PMID: 11099028
   PubMed Web of Science ®Google Scholar
• Vousden KH, Lane DP. p53 in health and disease. Nat Rev Mol Cell Biol 2007; 8:275 - 83; http://dx.doi.org/10.1038/nrm2147; PMID: 17380161
   PubMed Web of Science ®Google Scholar
• Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell 2009; 137:413 - 31; http://dx.doi.org/10.1016/j.cell.2009.04.037; PMID: 19410540
   PubMed Web of Science ®Google Scholar
• McKenzie L, King S, Marcar L, Nicol S, Dias SS, Schumm K, et al. p53-dependent repression of polo-like kinase-1 (PLK1). Cell Cycle 2010; 9:4200 - 12; http://dx.doi.org/10.4161/cc.9.20.13532; PMID: 20962589
   PubMed Web of Science ®Google Scholar
• Spurgers KB, Gold DL, Coombes KR, Bohnenstiehl NL, Mullins B, Meyn RE, et al. Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression. J Biol Chem 2006; 281:25134 - 42; http://dx.doi.org/10.1074/jbc.M513901200; PMID: 16798743
   PubMed Web of Science ®Google Scholar
• Murphy M, Ahn J, Walker KK, Hoffman WH, Evans RM, Levine AJ, et al. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev 1999; 13:2490 - 501; http://dx.doi.org/10.1101/gad.13.19.2490; PMID: 10521394
   PubMed Web of Science ®Google Scholar
• Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005; 6:376 - 85; http://dx.doi.org/10.1038/nrm1644; PMID: 15852042
   PubMed Web of Science ®Google Scholar
• Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res 2004; 14:10A 1902 - 10; http://dx.doi.org/10.1101/gr.2722704; PMID: 15364901
   PubMed Web of Science ®Google Scholar
• Lee Y, Jeon K, Lee JT, Kim S, Kim VN. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J 2002; 21:4663 - 70; http://dx.doi.org/10.1093/emboj/cdf476; PMID: 12198168
   PubMed Web of Science ®Google Scholar
• Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 2006; 125:887 - 901; http://dx.doi.org/10.1016/j.cell.2006.03.043; PMID: 16751099
   PubMed Web of Science ®Google Scholar
• Czech B, Hannon GJ. Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet 2011; 12:19 - 31; http://dx.doi.org/10.1038/nrg2916; PMID: 21116305
   PubMed Web of Science ®Google Scholar
• Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell 2003; 115:209 - 16; http://dx.doi.org/10.1016/S0092-8674(03)00801-8; PMID: 14567918
   PubMed Web of Science ®Google Scholar
• Brodersen P, Voinnet O. Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol 2009; 10:141 - 8; http://dx.doi.org/10.1038/nrm2619; PMID: 19145236
   PubMed Web of Science ®Google Scholar
• Djuranovic S, Nahvi A, Green R. A parsimonious model for gene regulation by miRNAs. Science 2011; 331:550 - 3; http://dx.doi.org/10.1126/science.1191138; PMID: 21292970
   PubMed Web of Science ®Google Scholar
• Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O’Day E, et al. miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to “seedless” 3’UTR microRNA recognition elements. Mol Cell 2009; 35:610 - 25; http://dx.doi.org/10.1016/j.molcel.2009.08.020; PMID: 19748357
   PubMed Web of Science ®Google Scholar
• Shin C, Nam JW, Farh KK, Chiang HR, Shkumatava A, Bartel DP. Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell 2010; 38:789 - 802; http://dx.doi.org/10.1016/j.molcel.2010.06.005; PMID: 20620952
   PubMed Web of Science ®Google Scholar
• Chi SW, Hannon GJ, Darnell RB. An alternative mode of microRNA target recognition. Nat Struct Mol Biol 2012; 19:321 - 7; http://dx.doi.org/10.1038/nsmb.2230; PMID: 22343717
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215 - 33; http://dx.doi.org/10.1016/j.cell.2009.01.002; PMID: 19167326
   PubMed Web of Science ®Google Scholar
• Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009; 136:642 - 55; http://dx.doi.org/10.1016/j.cell.2009.01.035; PMID: 19239886
   PubMed Web of Science ®Google Scholar
• Thomas M, Lieberman J, Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol 2010; 17:1169 - 74; http://dx.doi.org/10.1038/nsmb.1921; PMID: 20924405
   PubMed Web of Science ®Google Scholar
• Chi SW, Zang JB, Mele A, Darnell RB. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 2009; 460:479 - 86; PMID: 19536157
   PubMed Web of Science ®Google Scholar
• Forman JJ, Coller HA. The code within the code: microRNAs target coding regions. Cell Cycle 2010; 9:1533 - 41; http://dx.doi.org/10.4161/cc.9.8.11202; PMID: 20372064
   PubMed Web of Science ®Google Scholar
• Forman JJ, Legesse-Miller A, Coller HA. A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc Natl Acad Sci U S A 2008; 105:14879 - 84; http://dx.doi.org/10.1073/pnas.0803230105; PMID: 18812516
   PubMed Web of Science ®Google Scholar
• Lee EK, Gorospe M. Coding region: the neglected post-transcriptional code. RNA Biol 2011; 8:44 - 8; http://dx.doi.org/10.4161/rna.8.1.13863; PMID: 21289484
   PubMed Web of Science ®Google Scholar
• Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 2008; 455:1124 - 8; http://dx.doi.org/10.1038/nature07299; PMID: 18806776
   PubMed Web of Science ®Google Scholar
• Guo H, Ingolia NT, Weissman JS, Bartel DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010; 466:835 - 40; http://dx.doi.org/10.1038/nature09267; PMID: 20703300
   PubMed Web of Science ®Google Scholar
• Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 2010; 79:351 - 79; http://dx.doi.org/10.1146/annurev-biochem-060308-103103; PMID: 20533884
   PubMed Web of Science ®Google Scholar
• Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009; 10:704 - 14; http://dx.doi.org/10.1038/nrg2634; PMID: 19763153
   PubMed Web of Science ®Google Scholar
• Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259 - 69; http://dx.doi.org/10.1038/nrc1840; PMID: 16557279
   PubMed Web of Science ®Google Scholar
• Esteller M. Non-coding RNAs in human disease. Nat Rev Genet 2011; 12:861 - 74; http://dx.doi.org/10.1038/nrg3074; PMID: 22094949
   PubMed Web of Science ®Google Scholar
• Hammond SM. MicroRNAs as tumor suppressors. Nat Genet 2007; 39:582 - 3; http://dx.doi.org/10.1038/ng0507-582; PMID: 17460676
   PubMed Web of Science ®Google Scholar
• Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007; 449:682 - 8; http://dx.doi.org/10.1038/nature06174; PMID: 17898713
   PubMed Web of Science ®Google Scholar
• Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, et al. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010; 12:247 - 56; PMID: 20173740
   PubMed Web of Science ®Google Scholar
• Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA. MicroRNAs--the micro steering wheel of tumour metastases. Nat Rev Cancer 2009; 9:293 - 302; http://dx.doi.org/10.1038/nrc2619; PMID: 19262572
   PubMed Web of Science ®Google Scholar
• Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008; 451:147 - 52; http://dx.doi.org/10.1038/nature06487; PMID: 18185580
   PubMed Web of Science ®Google Scholar
• Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szász AM, Wang ZC, et al. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 2009; 137:1032 - 46; http://dx.doi.org/10.1016/j.cell.2009.03.047; PMID: 19524507
   PubMed Web of Science ®Google Scholar
• Ventura A, Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell 2009; 136:586 - 91; http://dx.doi.org/10.1016/j.cell.2009.02.005; PMID: 19239879
   PubMed Web of Science ®Google Scholar
• Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002; 99:15524 - 9; http://dx.doi.org/10.1073/pnas.242606799; PMID: 12434020
   PubMed Web of Science ®Google Scholar
• Klein U, Lia M, Crespo M, Siegel R, Shen Q, Mo T, et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 2010; 17:28 - 40; http://dx.doi.org/10.1016/j.ccr.2009.11.019; PMID: 20060366
   PubMed Web of Science ®Google Scholar
• Calin GA, Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD, et al. MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci U S A 2004; 101:11755 - 60; http://dx.doi.org/10.1073/pnas.0404432101; PMID: 15284443
   PubMed Web of Science ®Google Scholar
• Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6:857 - 66; http://dx.doi.org/10.1038/nrc1997; PMID: 17060945
   PubMed Web of Science ®Google Scholar
• Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435:834 - 8; http://dx.doi.org/10.1038/nature03702; PMID: 15944708
   PubMed Web of Science ®Google Scholar
• Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet 2009; 41:365 - 70; http://dx.doi.org/10.1038/ng.317; PMID: 19219043
   PubMed Web of Science ®Google Scholar
• Hill DA, Ivanovich J, Priest JR, Gurnett CA, Dehner LP, Desruisseau D, et al. DICER1 mutations in familial pleuropulmonary blastoma. Science 2009; 325:965; http://dx.doi.org/10.1126/science.1174334; PMID: 19556464
   PubMed Web of Science ®Google Scholar
• Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, et al. A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 2010; 18:303 - 15; http://dx.doi.org/10.1016/j.ccr.2010.09.007; PMID: 20951941
   PubMed Web of Science ®Google Scholar
• West JA, Viswanathan SR, Yabuuchi A, Cunniff K, Takeuchi A, Park IH, et al. A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 2009; 460:909 - 13; PMID: 19578360
   PubMed Web of Science ®Google Scholar
• Davalos V, Moutinho C, Villanueva A, Boque R, Silva P, Carneiro F, et al. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene 2012; 31:2062 - 74; PMID: 21874049
   PubMed Web of Science ®Google Scholar
• Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006; 9:435 - 43; http://dx.doi.org/10.1016/j.ccr.2006.04.020; PMID: 16766263
   PubMed Web of Science ®Google Scholar
• Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, et al. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet 2008; 40:43 - 50; http://dx.doi.org/10.1038/ng.2007.30; PMID: 18066065
   PubMed Web of Science ®Google Scholar
• O’Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005; 435:839 - 43; http://dx.doi.org/10.1038/nature03677; PMID: 15944709
   PubMed Web of Science ®Google Scholar
• Chang TC, Zeitels LR, Hwang HW, Chivukula RR, Wentzel EA, Dews M, et al. Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A 2009; 106:3384 - 9; http://dx.doi.org/10.1073/pnas.0808300106; PMID: 19211792
   PubMed Web of Science ®Google Scholar
• Bui TV, Mendell JT. Myc: Maestro of MicroRNAs. Genes & cancer 2010; 1:568-75.
   Google Scholar
• Emmrich S, Pützer BM. Checks and balances: E2F-microRNA crosstalk in cancer control. Cell Cycle 2010; 9:2555 - 67; http://dx.doi.org/10.4161/cc.9.13.12061; PMID: 20581444
   PubMed Web of Science ®Google Scholar
• Woods K, Thomson JM, Hammond SM. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem 2007; 282:2130 - 4; http://dx.doi.org/10.1074/jbc.C600252200; PMID: 17135268
   PubMed Web of Science ®Google Scholar
• Brabletz S, Brabletz T. The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?. EMBO Rep 2010; 11:670 - 7; http://dx.doi.org/10.1038/embor.2010.117; PMID: 20706219
   PubMed Web of Science ®Google Scholar
• Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 2009; 11:1487 - 95; http://dx.doi.org/10.1038/ncb1998; PMID: 19935649
   PubMed Web of Science ®Google Scholar
• Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Current biology 2007; 17:1298 - 307
   PubMed Web of Science ®Google Scholar
• Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007; 26:745 - 52; http://dx.doi.org/10.1016/j.molcel.2007.05.010; PMID: 17540599
   PubMed Web of Science ®Google Scholar
• He L, He X, Lowe SW, Hannon GJ. microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer 2007; 7:819 - 22; http://dx.doi.org/10.1038/nrc2232; PMID: 17914404
   PubMed Web of Science ®Google Scholar
• Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, Moskovits N, et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 2007; 26:731 - 43; http://dx.doi.org/10.1016/j.molcel.2007.05.017; PMID: 17540598
   PubMed Web of Science ®Google Scholar
• Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, et al. Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell 2010; 18:367 - 81; http://dx.doi.org/10.1016/j.ccr.2010.09.005; PMID: 20951946
   PubMed Web of Science ®Google Scholar
• Xiao J, Lin H, Luo X, Luo X, Wang Z. miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. EMBO J 2011; 30:524 - 32; http://dx.doi.org/10.1038/emboj.2010.347; PMID: 21217645
   PubMed Web of Science ®Google Scholar
• Yamakuchi M, Ferlito M, Lowenstein CJ. miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A 2008; 105:13421 - 6; http://dx.doi.org/10.1073/pnas.0801613105; PMID: 18755897
   PubMed Web of Science ®Google Scholar
• Hermeking H. p53 enters the microRNA world. Cancer Cell 2007; 12:414 - 8; http://dx.doi.org/10.1016/j.ccr.2007.10.028; PMID: 17996645
   PubMed Web of Science ®Google Scholar
• Hermeking H. MiR-34a and p53. Cell Cycle 2009; 8:1308; http://dx.doi.org/10.4161/cc.8.9.8511; PMID: 19342875
   PubMed Web of Science ®Google Scholar
• Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, et al. A global map of p53 transcription-factor binding sites in the human genome. Cell 2006; 124:207 - 19; http://dx.doi.org/10.1016/j.cell.2005.10.043; PMID: 16413492
   PubMed Web of Science ®Google Scholar
• Giono LE, Manfredi JJ. The p53 tumor suppressor participates in multiple cell cycle checkpoints. J Cell Physiol 2006; 209:13 - 20; http://dx.doi.org/10.1002/jcp.20689; PMID: 16741928
   PubMed Web of Science ®Google Scholar
• Lal A, Thomas MP, Altschuler G, Navarro F, O’Day E, Li XL, et al. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet 2011; 7:e1002363; http://dx.doi.org/10.1371/journal.pgen.1002363; PMID: 22102825
   PubMed Web of Science ®Google Scholar
• Kim NH, Kim HS, Li XY, Lee I, Choi HS, Kang SE, et al. A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol 2011; 195:417 - 33; http://dx.doi.org/10.1083/jcb.201103097; PMID: 22024162
   PubMed Web of Science ®Google Scholar
• Navarro F, Gutman D, Meire E, Cáceres M, Rigoutsos I, Bentwich Z, et al. miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood 2009; 114:2181 - 92; http://dx.doi.org/10.1182/blood-2009-02-205062; PMID: 19584398
   PubMed Web of Science ®Google Scholar
• Sotillo E, Laver T, Mellert H, Schelter JM, Cleary MA, McMahon S, et al. Myc overexpression brings out unexpected antiapoptotic effects of miR-34a. Oncogene 2011; 30:2587 - 94; http://dx.doi.org/10.1038/onc.2010.634; PMID: 21297663
   PubMed Web of Science ®Google Scholar
• Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008; 22:894 - 907; http://dx.doi.org/10.1101/gad.1640608; PMID: 18381893
   PubMed Web of Science ®Google Scholar
• Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10:593 - 601; http://dx.doi.org/10.1038/ncb1722; PMID: 18376396
   PubMed Web of Science ®Google Scholar
• Korpal M, Kang Y. The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol 2008; 5:115 - 9; http://dx.doi.org/10.4161/rna.5.3.6558; PMID: 19182522
   PubMed Web of Science ®Google Scholar
• Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, et al. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol 2011; 13:317 - 23; http://dx.doi.org/10.1038/ncb2173; PMID: 21336307
   PubMed Web of Science ®Google Scholar
• Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, Volinia S, et al. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med 2011; 208:875 - 83; http://dx.doi.org/10.1084/jem.20110235; PMID: 21518799
   PubMed Web of Science ®Google Scholar
• Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celià-Terrassa T, et al. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med 2011; 17:1101 - 8; http://dx.doi.org/10.1038/nm.2401; PMID: 21822286
   PubMed Web of Science ®Google Scholar
• Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, et al. miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One 2009; 4:e7181; http://dx.doi.org/10.1371/journal.pone.0007181; PMID: 19787069
   PubMed Web of Science ®Google Scholar
• Braun CJ, Zhang X, Savelyeva I, Wolff S, Moll UM, Schepeler T, et al. p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest. Cancer Res 2008; 68:10094 - 104; http://dx.doi.org/10.1158/0008-5472.CAN-08-1569; PMID: 19074875
   PubMed Web of Science ®Google Scholar
• Böhlig L, Friedrich M, Engeland K. p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins. Nucleic Acids Res 2011; 39:440 - 53; http://dx.doi.org/10.1093/nar/gkq796; PMID: 20833636
   PubMed Web of Science ®Google Scholar
• Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT, et al. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci U S A 2010; 107:6334 - 9; http://dx.doi.org/10.1073/pnas.0911082107; PMID: 20308559
   PubMed Web of Science ®Google Scholar
• Huppi K, Volfovsky N, Runfola T, Jones TL, Mackiewicz M, Martin SE, et al. The identification of microRNAs in a genomically unstable region of human chromosome 8q24. Mol Cancer Res 2008; 6:212 - 21; http://dx.doi.org/10.1158/1541-7786.MCR-07-0105; PMID: 18314482
   PubMed Web of Science ®Google Scholar
• Barsotti AM, Beckerman R, Laptenko O, Huppi K, Caplen NJ, Prives C. p53-Dependent induction of PVT1 and miR-1204. J Biol Chem 2012; 287:2509 - 19; http://dx.doi.org/10.1074/jbc.M111.322875; PMID: 22110125
   PubMed Web of Science ®Google Scholar
• Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 2006; 103:2257 - 61; http://dx.doi.org/10.1073/pnas.0510565103; PMID: 16461460
   PubMed Web of Science ®Google Scholar
• Chen L, Li C, Zhang R, Gao X, Qu X, Zhao M, et al. miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. Cancer Lett 2011; 309:62 - 70; http://dx.doi.org/10.1016/j.canlet.2011.05.017; PMID: 21664042
   PubMed Web of Science ®Google Scholar
• Yan HL, Xue G, Mei Q, Wang YZ, Ding FX, Liu MF, et al. Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis. EMBO J 2009; 28:2719 - 32; http://dx.doi.org/10.1038/emboj.2009.214; PMID: 19696742
   PubMed Web of Science ®Google Scholar
• Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 2007; 67:7713 - 22; http://dx.doi.org/10.1158/0008-5472.CAN-07-1083; PMID: 17699775
   PubMed Web of Science ®Google Scholar
• Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007; 131:1109 - 23; http://dx.doi.org/10.1016/j.cell.2007.10.054; PMID: 18083101
   PubMed Web of Science ®Google Scholar
• Weidhaas JB, Babar I, Nallur SM, Trang P, Roush S, Boehm M, et al. MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res 2007; 67:11111 - 6; http://dx.doi.org/10.1158/0008-5472.CAN-07-2858; PMID: 18056433
   PubMed Web of Science ®Google Scholar
• Saleh AD, Savage JE, Cao L, Soule BP, Ly D, DeGraff W, et al. Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53. PLoS One 2011; 6:e24429; http://dx.doi.org/10.1371/journal.pone.0024429; PMID: 22022355
   PubMed Web of Science ®Google Scholar
• Sengupta S, Harris CC. p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol 2005; 6:44 - 55; http://dx.doi.org/10.1038/nrm1546; PMID: 15688066
   PubMed Web of Science ®Google Scholar
• Riley KJ, Maher LJ 3rd. p53 RNA interactions: new clues in an old mystery. RNA 2007; 13:1825 - 33; http://dx.doi.org/10.1261/rna.673407; PMID: 17804642
   PubMed Web of Science ®Google Scholar
• Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K. Modulation of microRNA processing by p53. Nature 2009; 460:529 - 33; http://dx.doi.org/10.1038/nature08199; PMID: 19626115
   PubMed Web of Science ®Google Scholar
• Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009; 137:647 - 58; http://dx.doi.org/10.1016/j.cell.2009.02.038; PMID: 19409607
   PubMed Web of Science ®Google Scholar
• Borralho PM, Kren BT, Castro RE, da Silva IB, Steer CJ, Rodrigues CM. MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells. FEBS J 2009; 276:6689 - 700; http://dx.doi.org/10.1111/j.1742-4658.2009.07383.x; PMID: 19843160
   PubMed Web of Science ®Google Scholar
• Bourguignon LY, Spevak CC, Wong G, Xia W, Gilad E. Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J Biol Chem 2009; 284:26533 - 46; http://dx.doi.org/10.1074/jbc.M109.027466; PMID: 19633292
   PubMed Web of Science ®Google Scholar
• Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008; 454:56 - 61; http://dx.doi.org/10.1038/nature07086; PMID: 18548003
   PubMed Web of Science ®Google Scholar
• Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, et al. Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell 2009; 36:340 - 7; http://dx.doi.org/10.1016/j.molcel.2009.08.017; PMID: 19854141
   PubMed Web of Science ®Google Scholar
• Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, et al. MicroRNA-125b is a novel negative regulator of p53. Genes Dev 2009; 23:862 - 76; http://dx.doi.org/10.1101/gad.1767609; PMID: 19293287
   PubMed Web of Science ®Google Scholar
• Le MT, Shyh-Chang N, Khaw SL, Chin L, Teh C, Tay J, et al. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet 2011; 7:e1002242; http://dx.doi.org/10.1371/journal.pgen.1002242; PMID: 21935352
   PubMed Web of Science ®Google Scholar
• Hu W, Chan CS, Wu R, Zhang C, Sun Y, Song JS, et al. Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell 2010; 38:689 - 99; http://dx.doi.org/10.1016/j.molcel.2010.05.027; PMID: 20542001
   PubMed Web of Science ®Google Scholar
• Kumar M, Lu Z, Takwi AA, Chen W, Callander NS, Ramos KS, et al. Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene 2011; 30:843 - 53; http://dx.doi.org/10.1038/onc.2010.457; PMID: 20935678
   PubMed Web of Science ®Google Scholar
• Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res 2006; 34:Database issue D140 - 4; http://dx.doi.org/10.1093/nar/gkj112; PMID: 16381832
   PubMed Web of Science ®Google Scholar
• Chen QR, Yu LR, Tsang P, Wei JS, Song YK, Cheuk A, et al. Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a. J Proteome Res 2011; 10:479 - 87; http://dx.doi.org/10.1021/pr1006697; PMID: 21182263
   PubMed Web of Science ®Google Scholar
• Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001; 107:137 - 48; http://dx.doi.org/10.1016/S0092-8674(01)00524-4; PMID: 11672522
   PubMed Web of Science ®Google Scholar
• Sui G, Affar el B, Shi Y, Brignone C, Wall NR, Yin P, et al. Yin Yang 1 is a negative regulator of p53. Cell 2004; 117:859 - 72; http://dx.doi.org/10.1016/j.cell.2004.06.004; PMID: 15210108
   PubMed Web of Science ®Google Scholar
• Choi J, Nannenga B, Demidov ON, Bulavin DV, Cooney A, Brayton C, et al. Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Mol Cell Biol 2002; 22:1094 - 105; http://dx.doi.org/10.1128/MCB.22.4.1094-1105.2002; PMID: 11809801
   PubMed Web of Science ®Google Scholar
• Zhang X, Wan G, Mlotshwa S, Vance V, Berger FG, Chen H, et al. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res 2010; 70:7176 - 86; http://dx.doi.org/10.1158/0008-5472.CAN-10-0697; PMID: 20668064
   PubMed Web of Science ®Google Scholar
• Park SY, Lee JH, Ha M, Nam JW, Kim VN. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol 2009; 16:23 - 9; http://dx.doi.org/10.1038/nsmb.1533; PMID: 19079265
   PubMed Web of Science ®Google Scholar
• Fornari F, Gramantieri L, Giovannini C, Veronese A, Ferracin M, Sabbioni S, et al. MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res 2009; 69:5761 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-08-4797; PMID: 19584283
   PubMed Web of Science ®Google Scholar
• Burns DM, D’Ambrogio A, Nottrott S, Richter JD. CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation. Nature 2011; 473:105 - 8; http://dx.doi.org/10.1038/nature09908; PMID: 21478871
   PubMed Web of Science ®Google Scholar
• Muller PA, Vousden KH, Norman JC. p53 and its mutants in tumor cell migration and invasion. J Cell Biol 2011; 192:209 - 18; http://dx.doi.org/10.1083/jcb.201009059; PMID: 21263025
   PubMed Web of Science ®Google Scholar
• Liu Y, Bodmer WF. Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines. Proc Natl Acad Sci U S A 2006; 103:976 - 81; http://dx.doi.org/10.1073/pnas.0510146103; PMID: 16418264
   PubMed Web of Science ®Google Scholar
• Brosh R, Rotter V. When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer 2009; 9:701 - 13; PMID: 19693097
   PubMed Web of Science ®Google Scholar
• Oren M, Rotter V. Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol 2010; 2:a001107; http://dx.doi.org/10.1101/cshperspect.a001107; PMID: 20182618
   PubMed Web of Science ®Google Scholar
• Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, et al. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell 2006; 10:437 - 49; http://dx.doi.org/10.1016/j.ccr.2006.09.013; PMID: 17097565
   PubMed Web of Science ®Google Scholar
• Fontemaggi G, Dell’Orso S, Trisciuoglio D, Shay T, Melucci E, Fazi F, et al. The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis. Nat Struct Mol Biol 2009; 16:1086 - 93; http://dx.doi.org/10.1038/nsmb.1669; PMID: 19783986
   PubMed Web of Science ®Google Scholar
• Stambolsky P, Tabach Y, Fontemaggi G, Weisz L, Maor-Aloni R, Siegfried Z, et al. Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell 2010; 17:273 - 85; http://dx.doi.org/10.1016/j.ccr.2009.11.025; PMID: 20227041
   PubMed Web of Science ®Google Scholar
• Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, Sacchi A, et al. Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell 2006; 10:191 - 202; http://dx.doi.org/10.1016/j.ccr.2006.08.013; PMID: 16959611
   PubMed Web of Science ®Google Scholar
• Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol 2001; 21:1874 - 87; http://dx.doi.org/10.1128/MCB.21.5.1874-1887.2001; PMID: 11238924
   PubMed Web of Science ®Google Scholar
• Li Y, Prives C. Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?. Oncogene 2007; 26:2220 - 5; http://dx.doi.org/10.1038/sj.onc.1210311; PMID: 17401431
   PubMed Web of Science ®Google Scholar
• Matas D, Sigal A, Stambolsky P, Milyavsky M, Weisz L, Schwartz D, et al. Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis. EMBO J 2001; 20:4163 - 72; http://dx.doi.org/10.1093/emboj/20.15.4163; PMID: 11483519
   PubMed Web of Science ®Google Scholar
• Weisz L, Zalcenstein A, Stambolsky P, Cohen Y, Goldfinger N, Oren M, et al. Transactivation of the EGR1 gene contributes to mutant p53 gain of function. Cancer Res 2004; 64:8318 - 27; http://dx.doi.org/10.1158/0008-5472.CAN-04-1145; PMID: 15548700
   PubMed Web of Science ®Google Scholar
• Göhler T, Jäger S, Warnecke G, Yasuda H, Kim E, Deppert W. Mutant p53 proteins bind DNA in a DNA structure-selective mode. Nucleic Acids Res 2005; 33:1087 - 100; http://dx.doi.org/10.1093/nar/gki252; PMID: 15722483
   PubMed Web of Science ®Google Scholar
• Donzelli S, Fontemaggi G, Fazi F, Di Agostino S, Padula F, Biagioni F, et al. MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function. Cell Death Differ 2012; 19:1038 - 48; PMID: 22193543
   PubMed Web of Science ®Google Scholar
• Su X, Chakravarti D, Cho MS, Liu L, Gi YJ, Lin YL, et al. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature 2010; 467:986 - 90; http://dx.doi.org/10.1038/nature09459; PMID: 20962848
   PubMed Web of Science ®Google Scholar
• Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A. MicroRNAs can generate thresholds in target gene expression. Nat Genet 2011; 43:854 - 9; http://dx.doi.org/10.1038/ng.905; PMID: 21857679
   PubMed Web of Science ®Google Scholar
• Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, et al. The microRNAs of Caenorhabditis elegans. Genes Dev 2003; 17:991 - 1008; http://dx.doi.org/10.1101/gad.1074403; PMID: 12672692
   PubMed Web of Science ®Google Scholar
• Leung AK, Sharp PA. MicroRNA functions in stress responses. Mol Cell 2010; 40:205 - 15; http://dx.doi.org/10.1016/j.molcel.2010.09.027; PMID: 20965416
   PubMed Web of Science ®Google Scholar
• Li X, Cassidy JJ, Reinke CA, Fischboeck S, Carthew RW. A microRNA imparts robustness against environmental fluctuation during development. Cell 2009; 137:273 - 82; http://dx.doi.org/10.1016/j.cell.2009.01.058; PMID: 19379693
   PubMed Web of Science ®Google Scholar
• Xu P, Vernooy SY, Guo M, Hay BA. The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Current biology: CB 2003; 13:790-5.
   Google Scholar
• Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009; 136:823 - 37; http://dx.doi.org/10.1016/j.cell.2009.02.024; PMID: 19269363
   PubMed Web of Science ®Google Scholar