Tyrosine-1 and threonine-4 phosphorylation marks complete the RNA polymerase II CTD phospho-code

Martin Heidemann Department of Molecular Epigenetics; Helmholtz Zentrum München and Center for Integrated Protein Science Munich (CIPSM); Munich, Germany

Dirk Eick Department of Molecular Epigenetics; Helmholtz Zentrum München and Center for Integrated Protein Science Munich (CIPSM); Munich, GermanyCorrespondence[email protected]

Pages 1144-1146 | Published online: 01 Sep 2012

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https://doi.org/10.4161/rna.21726

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Cramer P, Armache KJ, Baumli S, Benkert S, Brueckner F, Buchen C, et al. Structure of eukaryotic RNA polymerases. Annu Rev Biophys 2008; 37:337 - 52; http://dx.doi.org/10.1146/annurev.biophys.37.032807.130008; PMID: 18573085
PubMed Web of Science ®Google Scholar
Chapman RD, Heidemann M, Hintermair C, Eick D. Molecular evolution of the RNA polymerase II CTD. Trends Genet 2008; 24:289 - 96; http://dx.doi.org/10.1016/j.tig.2008.03.010; PMID: 18472177
PubMed Web of Science ®Google Scholar
Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA. Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J Biol Chem 2012; 287:23549 - 61; http://dx.doi.org/10.1074/jbc.M111.330910; PMID: 22605332
PubMed Web of Science ®Google Scholar
Li H, Zhang Z, Wang B, Zhang J, Zhao Y, Jin Y. Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells. Mol Cell Biol 2007; 27:5296 - 305; http://dx.doi.org/10.1128/MCB.01667-06; PMID: 17526739
PubMed Web of Science ®Google Scholar
Sims RJ 3rd, Rojas LA, Beck D, Bonasio R, Schüller R, Drury WJ 3rd, et al. The C-terminal domain of RNA polymerase II is modified by site-specific methylation. Science 2011; 332:99 - 103; http://dx.doi.org/10.1126/science.1202663; PMID: 21454787
PubMed Web of Science ®Google Scholar
Buratowski S. Progression through the RNA polymerase II CTD cycle. Mol Cell 2009; 36:541 - 6; http://dx.doi.org/10.1016/j.molcel.2009.10.019; PMID: 19941815
PubMed Web of Science ®Google Scholar
Egloff S, Dienstbier M, Murphy S. Updating the RNA polymerase CTD code: adding gene-specific layers. Trends Genet 2012; a 28:333 - 41; http://dx.doi.org/10.1016/j.tig.2012.03.007; PMID: 22622228
PubMed Web of Science ®Google Scholar
Hengartner CJ, Myer VE, Liao SM, Wilson CJ, Koh SS, Young RA. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol Cell 1998; 2:43 - 53; http://dx.doi.org/10.1016/S1097-2765(00)80112-4; PMID: 9702190
PubMed Web of Science ®Google Scholar
Akhtar MS, Heidemann M, Tietjen JR, Zhang DW, Chapman RD, Eick D, et al. TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II. Mol Cell 2009; 34:387 - 93; http://dx.doi.org/10.1016/j.molcel.2009.04.016; PMID: 19450536
PubMed Web of Science ®Google Scholar
Egloff S, Zaborowska J, Laitem C, Kiss T, Murphy S. Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes. Mol Cell 2012; b 45:111 - 22; http://dx.doi.org/10.1016/j.molcel.2011.11.006; PMID: 22137580
PubMed Web of Science ®Google Scholar
Hintermair C, Heidemann M, Koch F, Descostes N, Gut M, Gut I, et al. Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation. EMBO J 2012; 31:2784 - 97; http://dx.doi.org/10.1038/emboj.2012.123; PMID: 22549466
PubMed Web of Science ®Google Scholar
Hsin J-P, Sheth A, Manley JL. RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3′ end processing. Science 2011; 334:683 - 6; http://dx.doi.org/10.1126/science.1206034; PMID: 22053051
PubMed Web of Science ®Google Scholar
Mayer A, Heidemann M, Lidschreiber M, Schreieck A, Sun M, Hintermair C, et al. CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II. Science 2012; 336:1723 - 5; http://dx.doi.org/10.1126/science.1219651; PMID: 22745433
PubMed Web of Science ®Google Scholar
Stiller JW, McConaughy BL, Hall BD. Evolutionary complementation for polymerase II CTD function. Yeast 2000; 16:57 - 64; http://dx.doi.org/10.1002/(SICI)1097-0061(20000115)16:1<57::AID-YEA509>3.0.CO;2-E; PMID: 10620775
PubMed Web of Science ®Google Scholar
Schwer B, Shuman S. Deciphering the RNA polymerase II CTD code in fission yeast. Mol Cell 2011; 43:311 - 8; http://dx.doi.org/10.1016/j.molcel.2011.05.024; PMID: 21684186
PubMed Web of Science ®Google Scholar
Meinhart A, Cramer P. Recognition of RNA polymerase II carboxy-terminal domain by 3′-RNA-processing factors. Nature 2004; 430:223 - 6; http://dx.doi.org/10.1038/nature02679; PMID: 15241417
PubMed Web of Science ®Google Scholar
Svejstrup JQ. Transcription: another mark in the tail. EMBO J 2012; 31:2753 - 4; http://dx.doi.org/10.1038/emboj.2012.154; PMID: 22617426
PubMed Web of Science ®Google Scholar
Baskaran R, Dahmus ME, Wang JY. Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain. Proc Natl Acad Sci U S A 1993; 90:11167 - 71; http://dx.doi.org/10.1073/pnas.90.23.11167; PMID: 7504297
PubMed Web of Science ®Google Scholar
Buratowski S. The CTD code. Nat Struct Biol 2003; 10:679 - 80; http://dx.doi.org/10.1038/nsb0903-679; PMID: 12942140
PubMedGoogle Scholar
Corden JL. Transcription. Seven ups the code. Science 2007; 318:1735 - 6; http://dx.doi.org/10.1126/science.1152624; PMID: 18079391
PubMed Web of Science ®Google Scholar

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