Assembly, disassembly and recycling

References

• Dreyfuss G, Matunis MJ, Piñol-Roma S, Burd CG. hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 1993; 62:289 - 321
   PubMed Web of Science ®Google Scholar
• Moore MJ. From birth to death: the complex lives of eukaryotic mRNAs. Science 2005; 309:1514 - 1518
   PubMed Web of Science ®Google Scholar
• Le Hir H, Izaurralde E, Maquat LE, Moore MJ. The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon-exon junctions. EMBO J 2000; 19:6860 - 6869
   PubMed Web of Science ®Google Scholar
• Tange TØ, Nott A, Moore MJ. The ever-increasing complexities of the exon junction complex. Curr Opin Cell Biol 2004; 16:279 - 284
   PubMed Web of Science ®Google Scholar
• Kim VN, Yong J, Kataoka N, Abel L, Diem MD, Dreyfuss G. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions. The EMBO J 2001; 20:2062 - 2068
   PubMed Web of Science ®Google Scholar
• Le Hir H, Gatfield D, Braun IC, Forler D, Izaurralde E. The protein Mago provides a link between splicing and mRNA localization. EMBO Rep 2001; 2:1119 - 1124
   PubMed Web of Science ®Google Scholar
• Chan CC, Dostie J, Diem MD, Feng W, Mann M, Rappsilber J, et al. eIF4A3 is a novel component of the exon junction complex. RNA 2004; 10:200 - 209
   PubMed Web of Science ®Google Scholar
• Degot S, Le Hir H, Alpy F, Kedinger V, Stoll I, Wendling C, et al. Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. J Biol Chem 2004; 279:33702 - 33715
   PubMed Web of Science ®Google Scholar
• Ferraiuolo MA, Lee CS, Ler LW, Hsu JL, Costa-Mattioli M, Luo MJ, et al. A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci USA 2004; 101:4118 - 4123
   PubMed Web of Science ®Google Scholar
• Palacios IM, Gatfield D, St. Johnston D, Izaurralde E. An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature 2004; 427:753 - 757
   PubMed Web of Science ®Google Scholar
• Shibuya T, Tange TØ, Sonenberg N, Moore MJ. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol 2004; 11:346 - 351
   PubMed Web of Science ®Google Scholar
• Ballut L, Marchadier B, Baguet A, Tomasetto C, Séraphin B, Le Hir H. The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. Nat Struct Mol Biol 2005; 12:861 - 869
   PubMed Web of Science ®Google Scholar
• Tange TØ, Shibuya T, Jurica MS, Moore MJ. Biochemical analysis of the E°C reveals two new factors and a stable tetrameric protein core. RNA 2005; 11:1869 - 1883
   PubMed Web of Science ®Google Scholar
• Conti E, Izaurralde E. Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species. Curr Opin Cell Biol 2005; 17:316 - 325
   PubMedGoogle Scholar
• Chang YF, Imam JS, Wilkinson MF. The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 2007; 76:51 - 74
   PubMed Web of Science ®Google Scholar
• Newmark PA, Boswell RE. The mago nashi locus encodes an essential product required for germ plasm assembly in Drosophila. Development 1994; 120:1303 - 1313
   PubMed Web of Science ®Google Scholar
• Micklem DR, Dasgupta R, Elliott H, Gergely F, Davidson C, Brand A, et al. The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila. Curr Biol 1997; 7:468 - 478
   PubMed Web of Science ®Google Scholar
• Hachet O, Ephrussi A. Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport. Curr Biol 2001; 11:1666 - 1674
   PubMed Web of Science ®Google Scholar
• Mohr SE, Dillon ST, Boswell RE. The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis. Genes Dev 2001; 15:2886 - 2899
   PubMed Web of Science ®Google Scholar
• van Eeden FJ, Palacios IM, Petronczki M, Weston MJ, St. Johnston D. Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole.. J Cell Biol 2001; 154:511 - 523
   PubMed Web of Science ®Google Scholar
• Hachet O, Ephrussi A. Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Nature 2004; 428:959 - 963
   PubMed Web of Science ®Google Scholar
• Gatfield D, Unterholzner L, Ciccarelli FD, Bork P, Izaurralde E. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J 2003; 22:3960 - 3970
   PubMed Web of Science ®Google Scholar
• Wiegand HL, Lu S, Cullen BR. Exon junction complexes mediate the enhancing effect of splicing on mRNA expression. Proc Natl Acad Sci USA 2003; 100:11327 - 11332
   PubMed Web of Science ®Google Scholar
• Nott A, Le Hir H, Moore MJ. Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. Genes Dev 2004; 18:210 - 222
   PubMed Web of Science ®Google Scholar
• Gudikote JP, Imam JS, Garcia RF, Wilkinson MF. RNA splicing promotes translation and RNA surveillance. Nat Struct Mol Biol 2005; 12:801 - 809
   PubMed Web of Science ®Google Scholar
• Diem MD, Chan CC, Younis I, Dreyfuss G. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. Nat Struct Mol Biol 2007; 14:1173 - 1179
   PubMed Web of Science ®Google Scholar
• Ma XM, Yoon SO, Richardson CJ, Jülich K, Blenis J. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 2008; 133:303 - 313
   PubMed Web of Science ®Google Scholar
• Le Hir H, Nott A, Moore MJ. How introns influence and enhance eukaryotic gene expression. Trends Biochem Sci 2003; 28:215 - 220
   PubMed Web of Science ®Google Scholar
• Giorgi C, Moore MJ. The nuclear nurture and cytoplasmic nature of localized mRNPs. Semin Cell Dev Biol 2007; 18:186 - 193
   PubMedGoogle Scholar
• Ideue, Sasaki, Hagiwara, Hirose. Introns play an essential role in splicing-dependent formation of the exon junction complex. Genes Dev 2007; 21:1993 - 1998
   PubMedGoogle Scholar
• Bessonov S, Anokhina M, Will CL, Urlaub H, Lührmann R. Isolation of an active step I spliceosome and composition of its RNP core. Nature 2008; 452:846 - 850
   PubMed Web of Science ®Google Scholar
• Mishler DM, Christ AB, Steitz JA. Flexibility in the site of exon junction complex deposition revealed by functional group and RNA secondary structure alterations in the splicing substrate. RNA 2008; 14:2657 - 2670
   PubMed Web of Science ®Google Scholar
• Gehring NH, Lamprinaki S, Hentze MW, Kulozik AE. The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay. PLoS Biol 2009; 7:1000120
   PubMed Web of Science ®Google Scholar
• Deckert J, Hartmuth K, Boehringer D, Behzadnia N, Will CL, Kastner B, et al. Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Mol Cell Biol 2006; 26:5528 - 5543
   PubMed Web of Science ®Google Scholar
• Macchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B, Ambrosino C, et al. Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. J Neurosci 2003; 23:5778 - 5788
   PubMed Web of Science ®Google Scholar
• Herold N, Will CL, Wolf E, Kastner B, Urlaub H, Lührmann R. Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol Cell Biol 2009; 29:281 - 301
   PubMed Web of Science ®Google Scholar
• Merz C, Urlaub H, Will CL, Lührmann R. Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment. RNA 2007; 13:116 - 128
   PubMed Web of Science ®Google Scholar
• Zhang Z, Krainer AR. Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components. Proc Natl Acad Sci USA 2007; 104:11574 - 11579
   PubMed Web of Science ®Google Scholar
• Andersen CBF, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CLP, et al. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science 2006; 313:1968 - 1972
   PubMed Web of Science ®Google Scholar
• Bono F, Ebert J, Lorentzen E, Conti E. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. Cell 2006; 126:713 - 725
   PubMed Web of Science ®Google Scholar
• Cordin O, Banroques J, Tanner NK, Linder P. The DEAD-box protein family of RNA helicases. Gene 2006; 367:17 - 37
   PubMed Web of Science ®Google Scholar
• Hilbert M, Karow AR, Klostermeier D. The mechanism of ATP-dependent RNA unwinding by DEAD box proteins. Biol Chem 2009; 390:1237 - 1250
   PubMed Web of Science ®Google Scholar
• Noble CG, Song H. MLN51 stimulates the RNA-helicase activity of eIF4AIII. PLoS ONE 2007; 2:303
   PubMed Web of Science ®Google Scholar
• Nielsen KH, Chamieh H, Andersen CBF, Fredslund F, Hamborg K, Le Hir H, et al. Mechanism of ATP turnover inhibition in the EJC. RNA 2009; 15:67 - 75
   PubMed Web of Science ®Google Scholar
• Gehring NH, Neu-Yilik G, Schell T, Hentze MW, Kulozik AE. Y14 and hUpf3b form an NMD-activating complex. Mol Cell 2003; 11:939 - 949
   PubMed Web of Science ®Google Scholar
• Chamieh H, Ballut L, Bonneau F, Le Hir H. NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat Struct Mol Biol 2008; 15:85 - 93
   PubMedGoogle Scholar
• Buchwald G, Ebert J, Basquin C, Sauliere J, Jayachandran U, Bono F, et al. Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex. Proc Natl Acad Sci USA 2010; 107:10050 - 10055
   PubMed Web of Science ®Google Scholar
• Dostie J, Dreyfuss G. Translation is required to remove Y14 from mRNAs in the cytoplasm. Curr Biol 2002; 12:1060 - 1067
   PubMedGoogle Scholar
• Lejeune F, Ishigaki Y, Li X, Maquat LE. The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO 2002; 21:3536 - 3545
   PubMed Web of Science ®Google Scholar
• Fribourg S, Gatfield D, Izaurralde E, Conti E. A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol 2003; 10:433 - 439
   PubMedGoogle Scholar
• Lau C-K, Diem MD, Dreyfuss G, Van Duyne GD. Structure of the Y14-Magoh core of the exon junction complex. Curr Biol 2003; 13:933 - 941
   PubMed Web of Science ®Google Scholar
• Shi H, Xu RM. Crystal structure of the Drosophila Mago nashi-Y14 complex. Genes Dev 2003; 17:971 - 976
   PubMed Web of Science ®Google Scholar
• Forler D, Köcher T, Rode M, Gentzel M, Izaurralde E, Wilm M. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nat Biotechnol 2003; 21:89 - 92
   PubMed Web of Science ®Google Scholar
• Bono F, Ebert J, Unterholzner L, Güttler T, Izaurralde E, Conti E. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. EMBO Rep 2004; 5:304 - 310
   PubMed Web of Science ®Google Scholar
• Gehring NH, Lamprinaki S, Kulozik AE, Hentze MW. Disassembly of exon junction complexes by PYM. Cell 2009; 137:536 - 548
   PubMed Web of Science ®Google Scholar
• Cook A, Bono F, Jinek M, Conti E. Structural biology of nucleocytoplasmic transport. Annu Rev Biochem 2007; 76:647 - 671
   PubMed Web of Science ®Google Scholar
• Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D. Importin 13: a novel mediator of nuclear import and export. EMBO J 2001; 20:3685 - 3694
   PubMed Web of Science ®Google Scholar
• Bono F, Cook AG, Grunwald M, Ebert J, Conti E. Nuclear Import Mechanism of the EJC Component Mago-Y14 Revealed by Structural Studies of Importin 13. Mol Cell 2010; 37:211 - 222
   PubMed Web of Science ®Google Scholar