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Commentary

Rictor encounters RhoGDI2

The second pilot is taking a lead

, &
Pages 102-105 | Received 01 Oct 2012, Accepted 19 Dec 2012, Published online: 25 Jan 2013

References

  • Lauffenburger DA, Horwitz AF. Cell migration: a physically integrated molecular process. Cell 1996; 84:359 - 69; http://dx.doi.org/10.1016/S0092-8674(00)81280-5; PMID: 8608589
  • Dovas A, Couchman JR. RhoGDI: multiple functions in the regulation of Rho family GTPase activities. Biochem J 2005; 390:1 - 9; http://dx.doi.org/10.1042/BJ20050104; PMID: 16083425
  • Nomanbhoy TK, Cerione R. Characterization of the interaction between RhoGDI and Cdc42Hs using fluorescence spectroscopy. J Biol Chem 1996; 271:10004 - 9; http://dx.doi.org/10.1074/jbc.271.17.10004; PMID: 8626553
  • Titus B, Frierson HF Jr., Conaway M, Ching K, Guise T, Chirgwin J, et al. Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res 2005; 65:7320 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-05-1403; PMID: 16103083
  • Theodorescu D, Sapinoso LM, Conaway MR, Oxford G, Hampton GM, Frierson HF Jr.. Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. Clin Cancer Res 2004; 10:3800 - 6; http://dx.doi.org/10.1158/1078-0432.CCR-03-0653; PMID: 15173088
  • Hu LD, Zou HF, Zhan SX, Cao KM. Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis. Oncol Rep 2007; 17:1383 - 9; PMID: 17487395
  • Gildea JJ, Seraj MJ, Oxford G, Harding MA, Hampton GM, Moskaluk CA, et al. RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Cancer Res 2002; 62:6418 - 23; PMID: 12438227
  • Abiatari I, DeOliveira T, Kerkadze V, Schwager C, Esposito I, Giese NA, et al. Consensus transcriptome signature of perineural invasion in pancreatic carcinoma. Mol Cancer Ther 2009; 8:1494 - 504; http://dx.doi.org/10.1158/1535-7163.MCT-08-0755; PMID: 19509238
  • Jiang WG, Watkins G, Lane J, Cunnick GH, Douglas-Jones A, Mokbel K, et al. Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res 2003; 9:6432 - 40; PMID: 14695145
  • Ma L, Xu G, Sotnikova A, Szczepanowski M, Giefing M, Krause K, et al. Loss of expression of LyGDI (ARHGDIB), a rho GDP-dissociation inhibitor, in Hodgkin lymphoma. Br J Haematol 2007; 139:217 - 23; http://dx.doi.org/10.1111/j.1365-2141.2007.06782.x; PMID: 17897297
  • Dransart E, Morin A, Cherfils J, Olofsson B. RhoGDI-3, a promising system to investigate the regulatory function of rhoGDIs: uncoupling of inhibitory and shuttling functions of rhoGDIs. Biochem Soc Trans 2005; 33:623 - 6; http://dx.doi.org/10.1042/BST0330623; PMID: 16042558
  • Garcia-Mata R, Boulter E, Burridge K. The ‘invisible hand’: regulation of RHO GTPases by RHOGDIs. Nat Rev Mol Cell Biol 2011; 12:493 - 504; http://dx.doi.org/10.1038/nrm3153; PMID: 21779026
  • Longenecker K, Read P, Derewenda U, Dauter Z, Liu X, Garrard S, et al. How RhoGDI binds Rho. Acta Crystallogr D Biol Crystallogr 1999; 55:1503 - 15; http://dx.doi.org/10.1107/S090744499900801X; PMID: 10489445
  • Scheffzek K, Stephan I, Jensen ON, Illenberger D, Gierschik P. The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nat Struct Biol 2000; 7:122 - 6; http://dx.doi.org/10.1038/72392; PMID: 10655614
  • Tnimov Z, Guo Z, Gambin Y, Nguyen UT, Wu YW, Abankwa D, et al. Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. J Biol Chem 2012; 287:26549 - 62; http://dx.doi.org/10.1074/jbc.M112.371294; PMID: 22628549
  • Agarwal NK, Chen CH, Cho H, Boulbès DR, Spooner E, Sarbassov DD. Rictor regulates cell migration by suppressing RhoGDI2. Oncogene 2012; In press http://dx.doi.org/10.1038/onc.2012.287; PMID: 22777355
  • Chen MY, Long Y, Devreotes PN. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev 1997; 11:3218 - 31; http://dx.doi.org/10.1101/gad.11.23.3218; PMID: 9389653
  • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14:1296 - 302; http://dx.doi.org/10.1016/j.cub.2004.06.054; PMID: 15268862
  • Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004; 6:1122 - 8; http://dx.doi.org/10.1038/ncb1183; PMID: 15467718
  • Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol 2005; 17:596 - 603; http://dx.doi.org/10.1016/j.ceb.2005.09.009; PMID: 16226444
  • Schmidt A, Bickle M, Beck T, Hall MN. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 1997; 88:531 - 42; http://dx.doi.org/10.1016/S0092-8674(00)81893-0; PMID: 9038344
  • Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MPA. A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol 2008; 28:4215 - 26; http://dx.doi.org/10.1128/MCB.00867-07; PMID: 18426911
  • McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, et al. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res 2008; 68:1618 - 24; http://dx.doi.org/10.1158/0008-5472.CAN-07-5869; PMID: 18339839
  • Gunst SJ, Zhang W. Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction. Am J Physiol Cell Physiol 2008; 295:C576 - 87; http://dx.doi.org/10.1152/ajpcell.00253.2008; PMID: 18596210
  • Golovanov AP, Chuang TH, DerMardirossian C, Barsukov I, Hawkins D, Badii R, et al. Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI. J Mol Biol 2001; 305:121 - 35; http://dx.doi.org/10.1006/jmbi.2000.4262; PMID: 11114252
  • DerMardirossian C, Rocklin G, Seo JY, Bokoch GM. Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling. Mol Biol Cell 2006; 17:4760 - 8; http://dx.doi.org/10.1091/mbc.E06-06-0533; PMID: 16943322
  • Wu Y, Moissoglu K, Wang H, Wang X, Frierson HF, Schwartz MA, et al. Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. Proc Natl Acad Sci U S A 2009; 106:5807 - 12; http://dx.doi.org/10.1073/pnas.0810094106; PMID: 19321744
  • Dovas A, Choi Y, Yoneda A, Multhaupt HA, Kwon SH, Kang D, et al. Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. J Biol Chem 2010; 285:23296 - 308; http://dx.doi.org/10.1074/jbc.M109.098129; PMID: 20472934
  • Griner EM, Churchill ME, Brautigan DL, Theodorescu D. PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity. Oncogene 2012; In press http://dx.doi.org/10.1038/onc.2012.124; PMID: 22469974
  • DerMardirossian C, Schnelzer A, Bokoch GM. Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. Mol Cell 2004; 15:117 - 27; http://dx.doi.org/10.1016/j.molcel.2004.05.019; PMID: 15225553
  • Yu J, Zhang D, Liu J, Li J, Yu Y, Wu XR, et al. RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility. J Biol Chem 2012; 287:13752 - 60; http://dx.doi.org/10.1074/jbc.M111.337469; PMID: 22393046

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