Adjudin disrupts spermatogenesis via the action of some unlikely partners

References

• Silvestrini B, Palazzo G, De Gregorio M. Lonidamine and related compounds. Prog Med Chem 1984; 21:110 - 35; PMID: 6400133
   PubMedGoogle Scholar
• Corsi G, Palazzo G, Germani C, Scorza Barcellona P, Silvestrini B. 1-Halobenzyl-1H-indazole-3-carboxylic acids. A new class of antispermatogenic agents. J Med Chem 1976; 19:778 - 83; http://dx.doi.org/10.1021/jm00228a008; PMID: 950645
   PubMed Web of Science ®Google Scholar
• Pelicano H, Martin DS, Xu RH, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006; 25:4633 - 46; http://dx.doi.org/10.1038/sj.onc.1209597; PMID: 16892078
   PubMed Web of Science ®Google Scholar
• Prabhakara S, Kalia VK. Optimizing radiotherapy of brain tumours by a combination of temozolomide and lonidamine. Indian J Med Res 2008; 128:140 - 8; PMID: 19001677
   PubMed Web of Science ®Google Scholar
• Silvestrini B. Basic and applied research in the study of indazole carboxylic acids. Chemotherapy 1981; 27:Suppl 2 9 - 20; http://dx.doi.org/10.1159/000238040; PMID: 6793319
   PubMed Web of Science ®Google Scholar
• Lobl TJ, Bardin CW, Gunsalus GL, Musto NA. Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 1981; 27:Suppl 2 61 - 76; http://dx.doi.org/10.1159/000238046; PMID: 6793318
   PubMedGoogle Scholar
• Lobl TJ. 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid (DICA), an exfoliative antispermatogenic angent in the rat. Arch Androl 1979; 2:353 - 63; http://dx.doi.org/10.3109/01485017908987337; PMID: 496513
   PubMed Web of Science ®Google Scholar
• Traina ME, Guarino M, Urbani E, Saso L, Eleuteri P, Cordelli E, et al. Lonidamine transiently affects spermatogenesis in pubertal CD1 mice. Contraception 2005; 72:262 - 7; http://dx.doi.org/10.1016/j.contraception.2005.04.008; PMID: 16181969
   PubMed Web of Science ®Google Scholar
• Maranghi F, Mantovani A, Macri C, Romeo A, Eleuteri P, Leter G, et al. Long-term effects of lonidamine on mouse testes. Contraception 2005; 72:268 - 72; http://dx.doi.org/10.1016/j.contraception.2005.05.019; PMID: 16181970
   PubMed Web of Science ®Google Scholar
• De Martino C, Malcorni W, Bellocci M, Floridi A, Marcante M. Effects of AF1312 TS and lonidamine on mammalian testis. A morphological study. Chemotherapy 1981; 27:Suppl 2 27 - 42; http://dx.doi.org/10.1159/000238043; PMID: 7285636
   PubMedGoogle Scholar
• Malorni W, Meschini S, Matarrese P, Arancia G. The cytoskeleton as a subcellular target of the antineoplastic drug lonidamine. Anticancer Res 1992; 12:2037 - 45; PMID: 1295447
   PubMed Web of Science ®Google Scholar
• Mruk DD, Silvestrini B, Cheng CY. Anchoring junctions as drug targets: Role in contraceptive development. Pharmacol Rev 2008; 60:146 - 80; http://dx.doi.org/10.1124/pr.107.07105; PMID: 18483144
   PubMed Web of Science ®Google Scholar
• Berruti A, Bitossi R, Gorzegno G, Bottini A, Alquati P, De Matteis A, et al. Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of phase III study with a factorial design. J Clin Oncol 2002; 20:4150 - 9; http://dx.doi.org/10.1200/JCO.2002.08.012; PMID: 12377958
   PubMed Web of Science ®Google Scholar
• Papaldo P, Lopez M, Cortesi E, Cammilluzzi E, Antimi M, Terzoli E, et al. Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide. J Clin Oncol 2003; 21:3462 - 8; http://dx.doi.org/10.1200/JCO.2003.03.034; PMID: 12972521
   PubMed Web of Science ®Google Scholar
• Milane L, Duan Z, Amiji M. Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer. PLoS ONE 2011; 6:e24075; http://dx.doi.org/10.1371/journal.pone.0024075; PMID: 21931642
   PubMed Web of Science ®Google Scholar
• Calviño E, Estañ MC, Simon GP, Sancho P, Boyano-Adanez MD, de Blas E, et al. Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, AktmTOR) modulation. Biochem Pharmacol 2011; In press PMID: 21889928
   PubMed Web of Science ®Google Scholar
• Brawer MK. Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders. Rev Urol 2005; 7:Suppl 7 S21 - 6; PMID: 16986057
   PubMedGoogle Scholar
• De Marinis F, Rinaldi M, Ardizzoni A, Bruzzi P, Pennucci MC, Portalone L, et al. The role of vindesine and lonidamine in the treatment of elderly patients with advanced non-small cell lung cancer: a phase III randomized FONICAP trial. Italian Lung Cancer Task Force. Tumori 1999; 85:177 - 82; PMID: 10426128
   PubMed Web of Science ®Google Scholar
• Amadori D, Frassineti GL, De Matteis A, Mustacchi G, Santoro A, Cariello S, et al. Modulating effect of lonidamine on response to doxorubicin in metastatic breast cancer patients: rsults from a multicenter prospective randomized trial. Breast Cancer Res Treat 1998; 49:209 - 17; http://dx.doi.org/10.1023/A:1006063412726; PMID: 9776504
   PubMed Web of Science ®Google Scholar
• Dogliotti L, Danese S, Berutti A, Zola P, Buniva T, Bottini A, et al. Ciplatin, epirubicin, and lonidamine combination regimen as first-line chemotheraphy for metastatic breast cancer: a pilot study. Cancer Chemother Pharmacol 1998; 41:333 - 8; http://dx.doi.org/10.1007/s002800050747; PMID: 9488603
   PubMed Web of Science ®Google Scholar
• Mruk DD, Cheng CY. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev 2004; 25:747 - 806; http://dx.doi.org/10.1210/er.2003-0022; PMID: 15466940
   PubMed Web of Science ®Google Scholar
• Cheng CY, Silvestrini B, Grima J, Mo MY, Zhu LJ, Johansson E, et al. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biol Reprod 2001; 65:449 - 61; http://dx.doi.org/10.1095/biolreprod65.2.449; PMID: 11466213
   PubMed Web of Science ®Google Scholar
• Mruk DD, Cheng CY. Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis. Spermatogenesis 2011; 1:137 - 146; http://dx.doi.org/10.4161/spmg.1.2.16449
   PubMedGoogle Scholar
• Cheng CY, Mruk D, Silvestrini B, Bonanomi M, Wong CH, Siu MK, et al. AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: A review of recent data. Contraception 2005; 72:251 - 61; http://dx.doi.org/10.1016/j.contraception.2005.03.008; PMID: 16181968
   PubMed Web of Science ®Google Scholar
• Mok KW, Lie PPY, Mruk DD, Mannu J, Mathur PP, Silverstini B, Cheng CY. . The apical ectoplasmic specialization-blood-testis barrier functional axis is a novel target for male contraception. Biology and Regulation of Blood-Tissue Barriers2011;http://www.landesbioscience.com/curie/chapter/5148/.
   Google Scholar
• Mok KW, Mruk DD, Lie PPY, Lui WY, Cheng CY. Adjudin, a potential male contraceptive, exerts its effects locally in the seminifeorus epithelium of mammalian testes. Reproduction 2011; 141:571 - 80; http://dx.doi.org/10.1530/REP-10-0464; PMID: 21307270
   PubMed Web of Science ®Google Scholar
• Cheng CY, Mruk DD. New frontiers in non-hormonal male contraception. Contraception 2010; 82:476 - 82; http://dx.doi.org/10.1016/j.contraception.2010.03.017; PMID: 20933122
   PubMed Web of Science ®Google Scholar
• Yan HHN, Mruk DD, Lee WM, Cheng CY. Ectoplasmic specialization: a friend or a foe of spermatogenesis?. Bioessays 2007; 29:36 - 48; http://dx.doi.org/10.1002/bies.20513; PMID: 17187371
   PubMed Web of Science ®Google Scholar
• Siu MKY, Cheng CY. Dynamic cross-talk between cells and the extracellular matrix in the testis. Bioessays 2004; 26:978 - 92; http://dx.doi.org/10.1002/bies.20099; PMID: 15351968
   PubMed Web of Science ®Google Scholar
• Mok KW, Mruk DD, Lee WM, Cheng CY. Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility. Int J Androl 2011; In press http://dx.doi.org/10.1111/j.1365-2605.2011.01183.x; PMID: 21696392
   PubMed Web of Science ®Google Scholar
• Mruk DD, Wong CH, Silvestrini B, Cheng CY. A male contraceptive targeting germ cell adhesion. Nat Med 2006; 12:1323 - 8; http://dx.doi.org/10.1038/nm1420; PMID: 17072312
   PubMed Web of Science ®Google Scholar
• Lie PPY, Mruk DD, Lee WM, Cheng CY. Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium. FASEB J 2009; 23:2555 - 67; http://dx.doi.org/10.1096/fj.06-070573; PMID: 19293393
   PubMed Web of Science ®Google Scholar
• Lie PPY, Chan AYN, Mruk DD, Lee WM, Cheng CY. Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis. Proc Natl Acad Sci USA 2010; 107:11411 - 6; http://dx.doi.org/10.1073/pnas.1001823107; PMID: 20534520
   PubMed Web of Science ®Google Scholar
• Li MWM, Xiao X, Mruk D, Lam YL, Lee WM, Lui WY, et al. Actin binding protein drebrin E is involved in junction dynamics during spermatogenesis. Spermatogenesis 2011; 1:123 - 36; http://dx.doi.org/10.4161/spmg.1.2.16393
   PubMedGoogle Scholar
• Wong EWP, Mruk DD, Lee WM, Cheng CY. Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis. Proc Natl Acad Sci USA 2008; 105:9657 - 62; http://dx.doi.org/10.1073/pnas.0801527105; PMID: 18621709
   PubMed Web of Science ®Google Scholar
• Wong EWP, Sun S, Li MWM, Lee WM, Cheng CY. 14-3-3 protein regulates cell adhesion in the seminiferous epithelium of rat testes. Endocrinology 2009; 150:4713 - 23; http://dx.doi.org/10.1210/en.2009-0427; PMID: 19608648
   PubMed Web of Science ®Google Scholar
• Grima J, Silvestrini B, Cheng CY. Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide. Biol Reprod 2001; 64:1500 - 8; http://dx.doi.org/10.1095/biolreprod64.5.1500; PMID: 11319158
   PubMed Web of Science ®Google Scholar
• Cheng CY, Mruk DD. The blood-testis barrier and its implication in male contraception. Pharmacol Rev 2011; In press
   Web of Science ®Google Scholar
• Vogl AW, Vaid KS, Guttman JA. The Setoli cell cytoskeleton. Adv Exp Med Biol 2008; 636:186 - 211; http://dx.doi.org/10.1007/978-0-387-09597-4_11; PMID: 19856169
   PubMed Web of Science ®Google Scholar
• Cheng CY, Mruk DD. A local autocrine axis in the testes that regulates spermatogenesis. Nature Rev Endocrinol 2010; 6:380 - 95; http://dx.doi.org/10.1038/nrendo.2010.71; PMID: 20571538
   PubMed Web of Science ®Google Scholar
• Cheng CY, Mruk DD. An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: a biochemical and molecular perspective. Crit Rev Biochem Mol Biol 2009; 44:245 - 63; http://dx.doi.org/10.1080/10409230903061207; PMID: 19622063
   PubMed Web of Science ®Google Scholar
• Wolski KM, Perrault C, Tran-Son-Tay R, Cameron DF. Strength measurement of the Sertoli-spermatid junctional complex. J Androl 2005; 26:354 - 9; http://dx.doi.org/10.2164/jandrol.04142; PMID: 15867003
   PubMed Web of Science ®Google Scholar
• Green KJ, Simpson CL. Desmosomes: New perspectives on a classic. J Invest Dermatol 2007; 127:2499 - 515; http://dx.doi.org/10.1038/sj.jid.5701015; PMID: 17934502
   PubMed Web of Science ®Google Scholar
• Green KJ, Getsios S, Troyanovsky S, Godsel LM. Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harb Perspect Biol 2010; 2:a000125; http://dx.doi.org/10.1101/cshperspect.a000125; PMID: 20182611
   PubMed Web of Science ®Google Scholar
• Wolski KM, Mruk DD, Cameron DF. The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin. J Androl 2006; 27:790 - 4; http://dx.doi.org/10.2164/jandrol.106.000422; PMID: 16809272
   PubMed Web of Science ®Google Scholar
• Su L, Cheng CY, Mruk DD. Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo.. Int J Biochem Cell Biol 2010; 42:1864 - 75; http://dx.doi.org/10.1016/j.biocel.2010.08.004; PMID: 20713173
   PubMed Web of Science ®Google Scholar
• Cheng CY, Mruk DD. Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: novel insights from studies on Eps8 and Arp3. Biochem J 2011; 435:553 - 62; http://dx.doi.org/10.1042/BJ20102121; PMID: 21486226
   PubMed Web of Science ®Google Scholar
• Lie PPY, Mruk DD, Lee WM, Cheng CY. Cytoskeletal dynamics and spermatogenesis. Philos Trans R Soc Lond B Biol Sci 2010; 365:1581 - 92; http://dx.doi.org/10.1098/rstb.2009.0261; PMID: 20403871
   PubMed Web of Science ®Google Scholar
• Cheng CY, Mruk DD. Actin binding proteins and spermatogenesis. Some unexpected findings. Spermatogenesis 2011; 1:99 - 104; http://dx.doi.org/10.4161/spmg.1.2.16913
   PubMedGoogle Scholar
• Young JS, Guttman JA, Vaid KS, Vogl AW. Tubulobulbar complexes are intercellular podosome-like structures that internalize intact intercellular junctions during epithelial remodeling events in the rat testis. Biol Reprod 2009; 80:162 - 74; http://dx.doi.org/10.1095/biolreprod.108.070623; PMID: 18799754
   PubMed Web of Science ®Google Scholar
• Young JS, Guttman JA, Vaid KS, Vogl AW. Cortactin (CTTN), N-WASP (WASL), and clathrin (CLTC) are present at podosome-like tubulobulbar complexes in the rat testis. Biol Reprod 2009; 80:153 - 61; http://dx.doi.org/10.1095/biolreprod.108.070615; PMID: 18799755
   PubMed Web of Science ®Google Scholar
• Wong EWP, Cheng CY. Polarity proteins and cell-cell interactions in the testis. Int Rev Cell Mol Biol 2009; 278:309 - 53; http://dx.doi.org/10.1016/S1937-6448(09)78007-4; PMID: 19815182
   PubMed Web of Science ®Google Scholar
• Assémat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D. Polarity complex proteins. Biochim Biophys Acta 2008; 1778:614 - 30; http://dx.doi.org/10.1016/j.bbamem.2007.08.029; PMID: 18005931
   PubMed Web of Science ®Google Scholar
• Cheng CY, Wong EWP, Lie PPY, Li MWM, Mruk DD, Yan HHN, et al. Regulation of blood-testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: An unexpected turn of events. Spermatogenesis 2011; 1:105 - 15; http://dx.doi.org/10.4161/spmg.1.2.15745
   PubMedGoogle Scholar
• Sun S, Wong EWP, Li MWM, Lee WM, Cheng CY. 14-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis. J Endocrinol 2009; 202:327 - 36; http://dx.doi.org/10.1677/JOE-09-0041; PMID: 19366886
   PubMed Web of Science ®Google Scholar
• Lie PPY, Cheng CY, Mruk DD. The biology of the desmosome-like junction: A versatile anchoring junction and signal transducer in the seminiferous epithelium. Int Rev Cell Mol Biol 2011; 286:223 - 69; http://dx.doi.org/10.1016/B978-0-12-385859-7.00005-7; PMID: 21199783
   PubMed Web of Science ®Google Scholar
• O'Donnell L, Nicholls PK, O'Bryan MK, McLachlan RI, Stanton PG. Spermiation: the process of sperm release. Spermatogenesis 2011; 1:14 - 35; http://dx.doi.org/10.4161/spmg.1.1.14525; PMID: 21866274
   PubMedGoogle Scholar