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Research Paper

Glucuronoxylomannan, galactoxylomannan, and mannoprotein occupy spatially separate and discrete regions in the capsule of Cryptococcus neoformans

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Pages 500-508 | Received 14 Jul 2010, Accepted 27 Aug 2010, Published online: 01 Nov 2010

References

  • Yauch LE, Mansour MK, Levitz SM. Receptor-mediated clearance of Cryptococcus neoformans capsular polysaccharide in vivo. Infect Immun 2005; 73:8429 - 8432
  • Mitchell TG, Perfect JR. Cryptococcosis in the era of AIDS—100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev 1995; 8:515 - 548
  • Rivera J, Mukherjee J, Weiss LM, Casadevall A. Antibody efficacy in murine pulmonary Cryptococcus neoformans infection: a role for nitric oxide. J Immunol 2002; 168:3419 - 3427
  • Schop J. Protective immunity against Cryptococcus neoformans infection. Mcgill J Med 2007; 10:35 - 43
  • Mukherjee J, Casadevall A, Scharff MD. Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization. J Exp Med 1993; 177:1105 - 1116
  • McFadden D, Zaragoza O, Casadevall A. The capsular dynamics of Cryptococcus neoformans. Trends Microbiol 2006; 14:497 - 505
  • Vaishnav VV, Bacon BE, O'Neill M, Cherniak R. Structural characterization of the galactoxylomannan of Cryptococcus neoformans Cap67. Carbohydr Res 1998; 306:315 - 330
  • Levitz SM, Specht CA. The molecular basis for the immunogenicity of Cryptococcus neoformans mannoproteins. FEMS Yeast Res 2006; 6:513 - 524
  • Heiss C, Klutts JS, Wang Z, Doering TL, Azadi P. The structure of Cryptococcus neoformans galactoxylomannan contains beta-D-glucuronic acid. Carbohydr Res 2009; 344:915 - 920
  • De Jesus M, Chow SK, Cordero RJ, Frases S, Casadevall A. Galactoxylomannans from Cryptococcus neoformans varieties neoformans and grubii are structurally and antigenically variable. Eukaryot Cell 9:1018 - 1028
  • Frases S, Nimrichter L, Viana NB, Nakouzi A, Casadevall A. Cryptococcus neoformans capsular polysaccharide and exopolysaccharide fractions manifest physical, chemical and antigenic differences. Eukaryot Cell 2008; 7:319 - 327
  • James PG, Cherniak R, Jones RG, Stortz CA, Reiss E. Cell-wall glucans of Cryptococcus neoformans Cap 67. Carbohydr Res 1990; 198:23 - 38
  • Vartivarian SE, Reyes GH, Jacobson ES, James PG, Cherniak R, Mumaw VR, Tingler MJ. Localization of mannoprotein in Cryptococcus neoformans. J Bacteriol 1989; 171:6850 - 6852
  • Murphy JW. Influence of cryptococcal antigens on cellmediated immunity. Rev Infect Dis 1988; 10:432 - 435
  • Reiss E, Huppert M, Cherniak R. Characterization of protein and mannan polysaccharide antigens of yeasts, moulds and actinomycetes. Curr Top Med Mycol 1985; 1:172 - 207
  • Eigenheer RA, Jin Lee Y, Blumwald E, Phinney BS, Gelli A. Extracellular glycosylphosphatidylinositol-anchored mannoproteins and proteases of Cryptococcus neoformans. FEMS Yeast Res 2007; 7:499 - 510
  • Specht CA, Nong S, Dan JM, Lee CK, Levitz SM. Contribution of glycosylation to T cell responses stimulated by recombinant Cryptococcus neoformans mannoprotein. J Infect Dis 2007; 196:796 - 800
  • Chaka W, Verheul AF, Vaishnav VV, Cherniak R, Scharringa J, Verhoef J, et al. Induction of TNFalpha in human peripheral blood mononuclear cells by the mannoprotein of Cryptococcus neoformans involves human mannose binding protein. J Immunol 1997; 159:2979 - 2985
  • Murphy JW, Mosley RL, Cherniak R, Reyes GH, Kozel TR, Reiss E. Serological, electrophoretic and biological properties of Cryptococcus neoformans antigens. Infect Immun 1988; 56:424 - 431
  • Delfino D, Cianci L, Lupis E, Celeste A, Petrelli ML, Curro F, et al. Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components. Infect Immun 1997; 65:2454 - 2456
  • Pitzurra L, Perito S, Baldelli F, Bistoni F, Vecchiarelli A. Humoral response against Cryptococcus neoformans mannoprotein antigens in HIV-infected patients. Clin Exp Immunol 2003; 133:91 - 96
  • Pietrella D, Mazzolla R, Lupo P, Pitzurra L, Gomez MJ, Cherniak R, et al. Mannoprotein from Cryptococcus neoformans promotes T-helper type 1 anticandidal responses in mice. Infect Immun 2002; 70:6621 - 6627
  • Pietrella D, Cherniak R, Strappini C, Perito S, Mosci P, Bistoni F, et al. Role of mannoprotein in induction and regulation of immunity to Cryptococcus neoformans. Infect Immun 2001; 69:2808 - 2814
  • Vecchiarelli A. Immunoregulation by capsular components of Cryptococcus neoformans. Med Mycol 2000; 38:407 - 417
  • Pitzurra L, Cherniak R, Giammarioli M, Perito S, Bistoni F, Vecchiarelli A. Early induction of interleukin-12 by human monocytes exposed to Cryptococcus neoformans mannoproteins. Infect Immun 2000; 68:558 - 563
  • Dan JM, Wang JP, Lee CK, Levitz SM. Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides. PLoS ONE 2008; 3:2046
  • Mansour MK, Schlesinger LS, Levitz SM. Optimal T cell responses to Cryptococcus neoformans mannoprotein are dependent on recognition of conjugated carbohydrates by mannose receptors. J Immunol 2002; 168:2872 - 2879
  • Levitz SM, Nong S, Mansour MK, Huang C, Specht CA. Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans. Proc Natl Acad Sci USA 2001; 98:10422 - 10427
  • Baker LG, Specht CA, Donlin MJ, Lodge JK. Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans. Eukaryot Cell 2007; 6:855 - 867
  • Casadevall A, Mukherjee J, Devi SJ, Schneerson R, Robbins JB, Scharff MD. Antibodies elicited by a Cryptococcus neoformans-tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection. J Infect Dis 1992; 165:1086 - 1093
  • De Jesus M, Nicola AM, Rodrigues ML, Janbon G, Casadevall A. Capsular localization of the Cryptococcus neoformans polysaccharide component galactoxylomannan. Eukaryot Cell 2009; 8:96 - 103
  • Orendi JM, Verheul AF, De Vos NM, Visser MR, Snippe H, Cherniak R, et al. Mannoproteins of Cryptococcus neoformans induce proliferative response in human peripheral blood mononuclear cells (PBMC) and enhance HIV-1 replication. Clin Exp Immunol 1997; 107:293 - 299
  • Turner SH, Cherniak R, Reiss E. Fractionation and characterization of galactoxylomannan from Cryptococcus neoformans. Carbohydr Res 1984; 125:343 - 349
  • Zaragoza O, Fries BC, Casadevall A. Induction of capsule growth in Cryptococcus neoformans by mammalian serum and CO(2). Infect Immun 2003; 71:6155 - 6164
  • Casadevall A, Cleare W, Feldmesser M, Glatman-Freedman A, Goldman DL, Kozel TR, et al. Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies. Antimicrob Agents Chemother 1998; 42:1437 - 1446
  • Mondon P, Chang YC, Varma A, Kwon-Chung KJ. A novel episomal shuttle vector for transformation of Cryptococcus neoformans with the ccdB gene as a positive selection marker in bacteria. FEMS Microbiol Lett 2000; 187:41 - 45
  • Wickes BL, Edman U, Edman JC. The Cryptococcus neoformans STE12alpha gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific. Mol Microbiol 1997; 26:951 - 960
  • Wickes BL, Edman JC. The Cryptococcus neoformans GAL7 gene and its use as an inducible promoter. Mol Microbiol 1995; 16:1099 - 1109