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Research Paper

Replication and spread of CJD, kuru and scrapie agents in vivo and in cell culture

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Pages 188-199 | Received 24 Mar 2011, Accepted 19 Apr 2011, Published online: 01 May 2011

References

  • Manuelidis L. A 25 nm virion is the likely cause of transmissible spongiform encephalopathies. J Cell Biochem 2007; 100:897 - 915
  • Manuelidis L, Fritch W. Infectivity and host responses in Creutzfeldt-Jakob Disease. Virology 1996; 215:46 - 59
  • Manuelidis L, Liu Y, Mullins B. Strain-specific viral properties of variant Creutzfeldt-Jakob Disease (vCJD) are encoded by the agent and not by host prion protein. J Cell Biochem 2009; 106:220 - 231
  • Manuelidis L, Chakrabarty T, Miyazawa K, Nduom NA, Emmerling K. The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt-Jakob disease and scrapie agents. Proc Natl Acad Sci USA 2009; 106:13529 - 13534
  • Liu Y, Sun R, Chakrabarty T, Manuelidis L. A rapid accurate culture assay for infectivity in transmissible encephalopathies. J Neurovirol 2008; 14:352 - 361
  • Sun R, Liu Y, Zhang H, Manuelidis L. Quantitative recovery of scrapie agent with minimal protein from highly infectious cultures. Viral Immunol 2008; 21:293 - 302
  • Nishida N, Katamine S, Manuelidis L. Reciprocal interference between specific CJD and scrapie agents in neural cell cultures. Science 2005; 310:493 - 496
  • Arjona A, Simarro L, Islinger F, Nishida N, Manuelidis L. Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures. Proc Natl Acad Sci USA 2004; 101:8768 - 8773
  • Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, Suttie A, et al. Transmissions to mice indicate that “new variant” CJD is caused by the BSE agent. Nature 1997; 389:498 - 501
  • Manuelidis L, Lu ZY. Attenuated Creutzfeldt-Jakob Disease agents can hide more virulent infections. Neurosci Lett 2000; 293:163 - 166
  • Manuelidis L. Beneath the emperor's clothes: the body of data in scrapie and CJD. Annales de L'Institute Pasteur 1997; 8:311 - 326
  • Manuelidis L, Yu ZX, Barquero N, Mullins B. Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25 nm virus-like particles. Proc Natl Acad Sci USA 2007; 104:1965 - 1970
  • Büeler H, Aguzzi A, Sailer A, Greiner RA, Autenried P, Auget M, et al. Mice devoid of PrP are resistant to scrapie. Cell 1993; 73:1339 - 1347
  • Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982; 216:136 - 144
  • Prusiner S, Baldwin M, Collinge J, DeArmond S, Marsh R, Tateishi J, et al. Prions 1995; Wien Springer Verlag
  • Legname G, Baskakov I, Nguyen H, Riesner D, Cohen F, DeArmond S, et al. Synthetic mammalian prions. Science 2004; 305:673 - 676
  • Eklund CM, Kennedy RC, Hadlow WJ. Pathogenesis of scrapie virus infection in the mouse. J Infect Dis 1967; 117:15 - 22
  • Manuelidis EE, Gorgacz EJ, Manuelidis L. Viremia in experimental Creutzfeldt-Jakob disease. Science 1978; 200:1069 - 1071
  • Pincock S. Government confirms second case of vCJD transmitted by blood transfusion. Brit Med J 2004; 329:351
  • Gajdusek DC. Unconventional viruses and the origin and disappearance of kuru. Science 1977; 197:943 - 960
  • Jeffrey M, Gonzalez L, Espenes A, Press C, Martin S, Chaplin M, et al. Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep. J Pathol 2006; 209:4 - 14
  • Scherbel C, Pichner R, Groschup MH, Mueller-Hellwig S, Scherer S, Dietrich R, et al. Infectivity of scrapie prion protein (PrPSc) following in vitro digestion with bovine gastrointestinal microbiota. Zoonoses Public Health 2007; 54:185 - 190
  • Baker CA, Martin D, Manuelidis L. Microglia from CJD brain are infectious and show specific mRNA activation profiles. J Virol 2002; 76:10905 - 10913
  • Manuelidis L, Sklaviadis T, Akowitz A, Fritch W. Viral particles are required for infection in neurodegenerative Creutzfeldt-Jakob disease. Proc Natl Acad Sci USA 1995; 92:5124 - 5128
  • Manuelidis L. Transmissible encephalopathies: speculations and realities. Viral Immunol 2003; 16:123 - 139
  • Sklaviadis T, Akowitz A, Manuelidis EE, Manuelidis L. Nucleic acid binding proteins in highly purified Creutzfeldt-Jakob disease preparations. Proc Natl Acad Sci USA 1993; 90:5713 - 5717
  • Manuelidis L. Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD. J Neurovirol 2011; 17:131 - 145
  • Vorberg I, Raines A, Priola S. Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro. J Biol Chem 2004; 279:29218 - 29225
  • Mahal S, Baker C, Demczyk C, Smith E, Julius C, Weissmann C. Prion strain discrimination in cell culture: the cell panel assay. Proc Natl Acad Sci USA 2007; 104:20908 - 20913
  • Li J, Browning S, Mahal S, Oelschlegel A, Weissmann C. Darwinian evolution of prions in cell culture. Science 2010; 327:869 - 872
  • Manuelidis L. Vaccination with an attenuated CJD strain prevents expression of a virulent agent. Proc Natl Acad Sci USA 1998; 95:2520 - 2525
  • Baker C, Lu Z, Manuelidis L. Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. J Neurovirol 2004; 10:1 - 12
  • Manuelidis L. Transmissible encephalopathy agents: Virulence, geography and clockwork. Virulence 2010; 1:101 - 104
  • Lu ZH, Baker C, Manuelidis L. New molecular markers of early and progressive CJD brain infection. J Cell Biochem 2004; 93:644 - 652
  • Miyazawa K, Emmerling K, Manuelidis L. Proliferative arrest of neural cells induces prion protein synthesis, nanotube formation and cell-to-cell contacts. J Cell Biochem 2010; 111:239 - 247
  • Wadsworth J, Joiner S, Linehan J, Desbruslais M, Fox K, Cooper S, et al. Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice. Proc Natl Acad Sci USA 2008; 105:3885 - 3890
  • Miyazawa K, Manuelidis L. Agent-specific shadoo responses in transmissible encephalopathies. J Neuroimmune Pharmacol 2010; 5:155 - 163
  • Chiesa R, Piccardo P, Biasini E, Ghetti B, Harris D. Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities. J Neurosci 2008; 28:13258 - 13267
  • Sandberg M, Al-Doujaily H, Sharps B, Clarke A, Collinge J. Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature 2011; 470:540 - 542
  • Chen B, Morales R, Barria M, Soto C. Estimating prion concentration in fluids and tissues by quantitative PMCA. Nat Method 2010; 7:519 - 520
  • Shi S, Dong C, Wang G, Wang X, An R, Chen J, et al. PrP(Sc) of scrapie 263K propagates efficiently in spleen and muscle tissues with protein misfolding cyclic amplification. Virus Res 2009; 141:26 - 33
  • Karapetyan Y, Saß P, Mahal S, Sferrazza G, Sherman A, Sales N, et al. Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay. PLoS ONE 2009; 4:5730
  • Baker C, Lu ZY, Zaitsev I, Manuelidis L. Microglial activation varies in different models of Creutzfeldt-Jakob disease. J Virol 1999; 73:5089 - 5097
  • Manuelidis EE, Gorgacz EJ, Manuelidis L. Interspecies transmission of Creutzfeldt-Jakob disease to Syrian hamsters with reference to clinical syndromes and strains of agent. Proc Natl Acad Sci USA 1978; 75:3432 - 3436
  • Manuelidis L, Lu ZY. Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease. Proc Natl Acad Sci USA 2003; 100:5360 - 5365
  • Gousset K, Schiff E, Langevin C, Marijanovic Z, Caputo A, Browman D, et al. Prions hijack tunnelling nanotubes for intercellular spread. Nat Cell Biol 2009; 11:328 - 336 11
  • Brachmann A, Baxa U, Wickner R. Prion generation in vitro: amyloid of Ure2p is infectious. EMBO J 2005; 24:3082 - 3092