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Letter to the Editor

Paradoxical effect to caspofungin in Candida species does not confer survival advantage in a Drosophila model of candidiasis

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Pages 497-498 | Received 14 May 2013, Accepted 24 Jun 2013, Published online: 26 Jun 2013

References

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  • Shields RK, Nguyen MH, Du C, Press E, Cheng S, Clancy CJ. Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serum. Antimicrob Agents Chemother 2011; 55:2641 - 7; http://dx.doi.org/10.1128/AAC.00999-10; PMID: 21422223
  • Bizerra FC, Melo ASA, Katchburian E, Freymüller E, Straus AH, Takahashi HK, et al. Changes in cell wall synthesis and ultrastructure during paradoxical growth effect of caspofungin on four different Candida species. Antimicrob Agents Chemother 2011; 55:302 - 10; http://dx.doi.org/10.1128/AAC.00633-10; PMID: 21060107
  • Wiederhold NP, Kontoyiannis DP, Prince RA, Lewis RE. Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways. Antimicrob Agents Chemother 2005; 49:5146 - 8; http://dx.doi.org/10.1128/AAC.49.12.5146-5148.2005; PMID: 16304189
  • Betts RF, Nucci M, Talwar D, Gareca M, Queiroz-Telles F, Bedimo RJ, et al, Caspofungin High-Dose Study Group. A Multicenter, double-blind trial of a high-dose caspofungin treatment regimen versus a standard caspofungin treatment regimen for adult patients with invasive candidiasis. Clin Infect Dis 2009; 48:1676 - 84; http://dx.doi.org/10.1086/598933; PMID: 19419331
  • Chamilos G, Lionakis MS, Lewis RE, Lopez-Ribot JL, Saville SP, Albert ND, et al. Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species. J Infect Dis 2006; 193:1014 - 22; http://dx.doi.org/10.1086/500950; PMID: 16518764