915
Views
6
CrossRef citations to date
0
Altmetric
Brief Report

Increased virulence of neuraminidase inhibitor-resistant pandemic H1N1 virus in mice

Potential emergence of drug-resistant and virulent variants

, , , , , , , , , , , & show all
Pages 489-493 | Received 15 May 2013, Accepted 29 Jul 2013, Published online: 02 Aug 2013

References

  • WHO. Influenza A virus resistance to oseltamivir and other antiviral medicines.,2009.
  • Sheu TG, Deyde VM, Okomo-Adhiambo M, Garten RJ, Xu X, Bright RA, et al. Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008. Antimicrob Agents Chemother 2008; 52:3284 - 92; http://dx.doi.org/10.1128/AAC.00555-08; PMID: 18625765
  • Ives JA, Carr JA, Mendel DB, Tai CY, Lambkin R, Kelly L, et al. The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo. Antiviral Res 2002; 55:307 - 17; http://dx.doi.org/10.1016/S0166-3542(02)00053-0; PMID: 12103431
  • Moscona A. Global transmission of oseltamivir-resistant influenza. N Engl J Med 2009; 360:953 - 6; http://dx.doi.org/10.1056/NEJMp0900648; PMID: 19258250
  • Centers for Disease Control and Prevention (CDC). Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxis--North Carolina, 2009. MMWR Morb Mortal Wkly Rep 2009; 58:969 - 72; PMID: 19745803
  • Kiso M, Shinya K, Shimojima M, Takano R, Takahashi K, Katsura H, et al. Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses. PLoSPathog 2010; 6:e1001079; http://dx.doi.org/10.1371/journal.ppat.1001079; PMID: 20865125
  • Hamelin ME, Baz M, Abed Y, Couture C, Joubert P, Beaulieu E, et al. Oseltamivir-resistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferrets. PLoSPathog 2010; 6:e1001015; http://dx.doi.org/10.1371/journal.ppat.1001015; PMID: 20661429
  • Song MS, Lee JH, Pascua PN, Baek YH, Kwon HI, Park KJ, et al. Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea. J ClinMicrobiol 2010; 48:3204 - 11; http://dx.doi.org/10.1128/JCM.00053-10; PMID: 20610681
  • Berhane Y, Ojkic D, Neufeld J, Leith M, Hisanaga T, Kehler H, et al. Molecular characterization of pandemic H1N1 influenza viruses isolated from turkeys and pathogenicity of a human pH1N1 isolate in turkeys. Avian Dis 2010; 54:1275 - 85; http://dx.doi.org/10.1637/9422-061410-Reg.1; PMID: 21313850
  • Sakabe S, Ozawa M, Takano R, Iwastuki-Horimoto K, Kawaoka Y. Mutations in PA, NP, and HA of a pandemic (H1N1) 2009 influenza virus contribute to its adaptation to mice. Virus Res 2011; 158:124 - 9; http://dx.doi.org/10.1016/j.virusres.2011.03.022; PMID: 21458512
  • Ilyushina NA, Khalenkov AM, Seiler JP, Forrest HL, Bovin NV, Marjuki H, et al. Adaptation of pandemic H1N1 influenza viruses in mice. J Virol 2010; 84:8607 - 16; http://dx.doi.org/10.1128/JVI.00159-10; PMID: 20592084
  • Ye J, Sorrell EM, Cai Y, Shao H, Xu K, Pena L, et al. Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype?. PLoSPathog 2010; 6:e1001145; http://dx.doi.org/10.1371/journal.ppat.1001145; PMID: 20976194
  • Who. Geneva: World Health Organisation; 2011. Update on oseltamivir resistance to influenza H1N1 (2009) viruses. 2012.
  • Pascua PN, Song MS, Lee JH, Baek YH, Kwon HI, Park SJ, et al. Virulence and transmissibility of H1N2 influenza virus in ferrets imply the continuing threat of triple-reassortant swine viruses. ProcNatlAcadSci U S A 2012; 109:15900 - 5; http://dx.doi.org/10.1073/pnas.1205576109; PMID: 23019374
  • Rykkvin R, Kilander A, Dudman SG, Hungnes O. Within-patient emergence of the influenza A(H1N1)pdm09 HA1 222G variant and clear association with severe disease, Norway. Euro Surveill 2013; 18:18; PMID: 23351651
  • Song MS, Pascua PN, Lee JH, Baek YH, Lee OJ, Kim CJ, et al. The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model. J Virol 2009; 83:12325 - 35; http://dx.doi.org/10.1128/JVI.01373-09; PMID: 19793828
  • Zhou B, Li Y, Halpin R, Hine E, Spiro DJ, Wentworth DE. PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice. J Virol 2011; 85:357 - 65; http://dx.doi.org/10.1128/JVI.01694-10; PMID: 20962098
  • Potier M, Mameli L, Bélisle M, Dallaire L, Melançon SB. Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-alpha-D-N-acetylneuraminate) substrate. Anal Biochem 1979; 94:287 - 96; http://dx.doi.org/10.1016/0003-2697(79)90362-2; PMID: 464297
  • DeVries A, Wotton J, Lees C, Boxrud D, Uyeki T, Lynfield R. Neuraminidase H275Y and hemagglutinin D222G mutations in a fatal case of 2009 pandemic influenza A (H1N1) virus infection. Influenza Other Respi Viruses 2012; 6:e85 - 8; http://dx.doi.org/10.1111/j.1750-2659.2011.00329.x; PMID: 22243670
  • Rudneva I, Ignatieva A, Timofeeva T, Shilov A, Kushch A, Masalova O, et al. Escape mutants of pandemic influenza A/H1N1 2009 virus: variations in antigenic specificity and receptor affinity of the hemagglutinin. Virus Res 2012; 166:61 - 7; http://dx.doi.org/10.1016/j.virusres.2012.03.003; PMID: 22459010
  • Soundararajan V, Tharakaraman K, Raman R, Raguram S, Shriver Z, Sasisekharan V, et al. Extrapolating from sequence--the 2009 H1N1 ‘swine’ influenza virus. Nat Biotechnol 2009; 27:510 - 3; http://dx.doi.org/10.1038/nbt0609-510; PMID: 19513050
  • Duan S, Boltz DA, Seiler P, Li J, Bragstad K, Nielsen LP, et al. Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets. PLoSPathog 2010; 6:e1001022; http://dx.doi.org/10.1371/journal.ppat.1001022; PMID: 20686654
  • Pizzorno A, Bouhy X, Abed Y, Boivin G. Generation and characterization of recombinant pandemic influenza A(H1N1) viruses resistant to neuraminidase inhibitors. J Infect Dis 2011; 203:25 - 31; http://dx.doi.org/10.1093/infdis/jiq010; PMID: 21148493
  • Eshaghi A, Patel SN, Sarabia A, Higgins RR, Savchenko A, Stojios PJ, et al. Multidrug-resistant pandemic (H1N1) 2009 infection in immunocompetent child. Emerg Infect Dis 2011; 17:1472 - 4; PMID: 21801626
  • van der Vries E, Stelma FF, Boucher CA. Emergence of a multidrug-resistant pandemic influenza A (H1N1) virus. N Engl J Med 2010; 363:1381 - 2; http://dx.doi.org/10.1056/NEJMc1003749; PMID: 20879894

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.