The interdependence of antibody C and V regions on specificity and affinity

References

• Ehrlich P. Experimentelle Untersuchungen uber Immunitat. II. Ueber Abrin. Dtsch Med Wochenschr 1891; 17:1218 - 9; http://dx.doi.org/10.1055/s-0029-1206825
   Google Scholar
• Porter RR. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. Biochem J 1959; 73:119 - 26; PMID: 14434282
   PubMed Web of Science ®Google Scholar
• Kato K, Matsunaga C, Odaka A, Yamato S, Takaha W, Shimada I, Arata Y. Carbon-13 NMR study of switch variant anti-dansyl antibodies: antigen binding and domain-domain interactions. Biochemistry 1991; 30:6604 - 10; http://dx.doi.org/10.1021/bi00240a033; PMID: 2054358
   PubMed Web of Science ®Google Scholar
• Cooper LJ, Shikhman AR, Glass DD, Kangisser D, Cunningham MW, Greenspan NS. Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable domains. J Immunol 1993; 150:2231 - 42; PMID: 7680687
   PubMed Web of Science ®Google Scholar
• Michaelsen TE, Ihle O, Beckstrøm KJ, Herstad TK, Sandin RH, Kolberg J, Aase A. Binding properties and anti-bacterial activities of V-region identical, human IgG and IgM antibodies, against group B Neisseria meningitidis. Biochem Soc Trans 2003; 31:1032 - 5; http://dx.doi.org/10.1042/BST0311032; PMID: 14505474
   PubMed Web of Science ®Google Scholar
• Torosantucci A, Chiani P, Bromuro C, De Bernardis F, Palma AS, Liu Y, Mignogna G, Maras B, Colone M, Stringaro A, et al. Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence. PLoS One 2009; 4:e5392; http://dx.doi.org/10.1371/journal.pone.0005392; PMID: 19399183
   PubMed Web of Science ®Google Scholar
• Tudor D, Yu H, Maupetit J, Drillet AS, Bouceba T, Schwartz-Cornil I, Lopalco L, Tuffery P, Bomsel M. Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody. Proc Natl Acad Sci U S A 2012; 109:12680 - 5; http://dx.doi.org/10.1073/pnas.1200024109; PMID: 22723360
   PubMed Web of Science ®Google Scholar
• Pritsch O, Magnac C, Dumas G, Bouvet JP, Alzari P, Dighiero G. Can isotype switch modulate antigen-binding affinity and influence clonal selection?. Eur J Immunol 2000; 30:3387 - 95; http://dx.doi.org/10.1002/1521-4141(2000012)30:12<3387::AID-IMMU3387>3.0.CO;2-K; PMID: 11093156
   PubMed Web of Science ®Google Scholar
• Dam TK, Torres M, Brewer CF, Casadevall A. Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand. J Biol Chem 2008; 283:31366 - 70; http://dx.doi.org/10.1074/jbc.M806473200; PMID: 18806257
   PubMed Web of Science ®Google Scholar
• Eryilmaz E, Janda A, Kim J, Cordero RJ, Cowburn D, Casadevall A. Global structures of IgG isotypes expressing identical variable regions. Mol Immunol 2013; 56:588 - 98; http://dx.doi.org/10.1016/j.molimm.2013.06.006; PMID: 23911417
   PubMed Web of Science ®Google Scholar
• McLean GR, Torres M, Elguezabal N, Nakouzi A, Casadevall A. Isotype can affect the fine specificity of an antibody for a polysaccharide antigen. J Immunol 2002; 169:1379 - 86; PMID: 12133962
   PubMed Web of Science ®Google Scholar
• Torres M, Fernández-Fuentes N, Fiser A, Casadevall A. The immunoglobulin heavy chain constant region affects kinetic and thermodynamic parameters of antibody variable region interactions with antigen. J Biol Chem 2007; 282:13917 - 27; http://dx.doi.org/10.1074/jbc.M700661200; PMID: 17353196
   PubMed Web of Science ®Google Scholar
• Torres M, Fernandez-Fuentes N, Fiser A, Casadevall A. Exchanging murine and human immunoglobulin constant chains affects the kinetics and thermodynamics of antigen binding and chimeric antibody autoreactivity. PLoS One 2007; 2:e1310; http://dx.doi.org/10.1371/journal.pone.0001310; PMID: 18074033
   PubMed Web of Science ®Google Scholar
• Torres M, May R, Scharff MD, Casadevall A. Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype. J Immunol 2005; 174:2132 - 42; PMID: 15699144
   PubMed Web of Science ®Google Scholar
• Janda A, Eryilmaz E, Nakouzi A, Cowburn D, Casadevall A. Variable region identical immunoglobulins differing in isotype express different paratopes. J Biol Chem 2012; 287:35409 - 17; http://dx.doi.org/10.1074/jbc.M112.404483; PMID: 22930758
   PubMed Web of Science ®Google Scholar
• Correa A, Trajtenberg F, Obal G, Pritsch O, Dighiero G, Oppezzo P, Buschiazzo A. Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation. Acta Crystallogr D Biol Crystallogr 2013; 69:388 - 97; http://dx.doi.org/10.1107/S0907444912048664; PMID: 23519414
   PubMed Web of Science ®Google Scholar
• Xia Y, Janda A, Eryilmaz E, Casadevall A, Putterman C. The constant region affects antigen binding of antibodies to DNA by altering secondary structure. Mol Immunol 2013; 56:28 - 37; http://dx.doi.org/10.1016/j.molimm.2013.04.004; PMID: 23665381
   PubMed Web of Science ®Google Scholar
• Xia Y, Pawar RD, Nakouzi AS, Herlitz L, Broder A, Liu K, Goilav B, Fan M, Wang L, Li QZ, et al. The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies. J Autoimmun 2012; 39:398 - 411; http://dx.doi.org/10.1016/j.jaut.2012.06.005; PMID: 22841793
   PubMed Web of Science ®Google Scholar
• Hubbard MA, Thorkildson P, Kozel TR, Aucoin DP. Constant domains influence binding of mouse-human chimeric antibodies to the capsular polypeptide of Bacillus anthracis. Virulence 2013; 4:483 - 8; http://dx.doi.org/10.4161/viru.25711; PMID: 23863605
   PubMed Web of Science ®Google Scholar
• Hovenden M, Hubbard MA, Aucoin DP, Thorkildson P, Reed DE, Welch WH, Lyons CR, Lovchik JA, Kozel TR. IgG subclass and heavy chain domains contribute to binding and protection by mAbs to the poly γ-D-glutamic acid capsular antigen of Bacillus anthracis. PLoS Pathog 2013; 9:e1003306; http://dx.doi.org/10.1371/journal.ppat.1003306; PMID: 23637599
   PubMed Web of Science ®Google Scholar
• Kozel TR, Murphy WJ, Brandt S, Blazar BR, Lovchik JA, Thorkildson P, Percival A, Lyons CR. mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia. Proc Natl Acad Sci U S A 2004; 101:5042 - 7; http://dx.doi.org/10.1073/pnas.0401351101; PMID: 15051894
   PubMed Web of Science ®Google Scholar
• McCloskey N, Turner MW, Steffner P, Owens R, Goldblatt D. Human constant regions influence the antibody binding characteristics of mouse-human chimeric IgG subclasses. Immunology 1996; 88:169 - 73; http://dx.doi.org/10.1111/j.1365-2567.1996.tb00001.x; PMID: 8690447
   PubMed Web of Science ®Google Scholar
• Beenhouwer DO, Yoo EM, Lai CW, Rocha MA, Morrison SL. Human immunoglobulin G2 (IgG2) and IgG4, but not IgG1 or IgG3, protect mice against Cryptococcus neoformans infection. Infect Immun 2007; 75:1424 - 35; http://dx.doi.org/10.1128/IAI.01161-06; PMID: 17220317
   PubMed Web of Science ®Google Scholar